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Methicillin

Dimethoxyphenyl Penicillin


Presentation

  • AIMS: The aim of this paper was to present the clinical features of patients with musculoskeletal sources of methicillin-sensitive Staphylococcus aureus (MSSA) septicaemia.[ncbi.nlm.nih.gov]
  • This case illustrates a severe clinical presentation and management of MSSA infections.[ncbi.nlm.nih.gov]
  • A 56-year-old man with alcohol-associated cirrhosis, arterial hypertension and diabetes, presented with a 1-month history of fever, lumbar back pain and lower limb weakness.[ncbi.nlm.nih.gov]
  • This article presents three cases of Staphylococcus argenteus obtained from clinical samples.[ncbi.nlm.nih.gov]
  • The present authors recognise that the current contribution has limitations. For example, the findings of the present systematic review may be influenced by the study that enrolled the largest number of patients with S. aureus VAP 21.[erj.ersjournals.com]
Hypertension
  • A 56-year-old man with alcohol-associated cirrhosis, arterial hypertension and diabetes, presented with a 1-month history of fever, lumbar back pain and lower limb weakness.[ncbi.nlm.nih.gov]
Back Pain
  • Back pain was the presenting symptom in these patients, with a positive predictive value of 100%. A total of 24 patients had a total of 42 arthroplasties of the hip or knee in situ .[ncbi.nlm.nih.gov]
  • A 56-year-old man with alcohol-associated cirrhosis, arterial hypertension and diabetes, presented with a 1-month history of fever, lumbar back pain and lower limb weakness.[ncbi.nlm.nih.gov]
Dysuria
  • Acute interstitial nephritis may be accompanied by rash, fever, dysuria, proteinuria, eosinophilia, and hematuria. [ Ref ] The frequency of acute interstitial nephritis is higher with methicillin than other penicillinase-resistant penicillins and has[drugs.com]
Limb Weakness
  • A 56-year-old man with alcohol-associated cirrhosis, arterial hypertension and diabetes, presented with a 1-month history of fever, lumbar back pain and lower limb weakness.[ncbi.nlm.nih.gov]

Workup

Blood Culture Positive
  • The patient had persistent blood cultures positive for MSSA. A transesophageal echocardiogram showed a 1.1 cm vegetation in the mitral valve, and the patient had bilateral pleural effusions that grew MSSA.[ncbi.nlm.nih.gov]

Treatment

  • The spread of resistance among such organisms against major drugs is alarming as it limits the treatment options for serious infections. Traditionally, Vancomycin had remained a mainstay of treatment of Methicillin-Resistant Staphylococci.[ncbi.nlm.nih.gov]
  • During treatment, the patient's condition progressed with anasarca and renal failure with nephrotic-range proteinuria. The renal biopsy showed a membranoproliferative glomerulonephritis with IgA deposition.[ncbi.nlm.nih.gov]
  • The two decolonization treatments consisted of the application of intranasal mupirocin 2 % and washing with chlorhexidine soap (40 mg/mL) (mupi/CHX) or application of intranasal povidone-iodine and washing with povidone-iodine soap (PVPI), with each treatment[pdf.manuscriptpro.com]
  • The rate of clinical success, defined as cure with antibiotic treatment and no need for further treatment or improvement and step-down to oral therapy, among patients with MRSAB was 56.3%.[ajhp.org]

Prognosis

  • Thus elucidation of the impact of resistance on patient outcome may be essential in defining the prognosis of the individual patient with S. aureus VAP.[erj.ersjournals.com]
  • Is methicillin resistance associated with a worse prognosis in Staphylococcus aureus ventilator-associated pneumonia? Clin Infect Dis. 2005 ; 41 : 1224 – 31. 51.[ajhp.org]
  • Is methicillin resistance associated with a worse prognosis in Staphylococcus aureus ventilator-associated pneumonia? Clin Infect Dis . 2005 ; 41 : 1224 – 31 . 51 .[ajhp.org]

Etiology

  • Etiology/Causes The bacteria Staphylococcus aureus lives on the skin of one third of the population who do not present with any symptoms. [4] However, they still have the ability to spread the bacteria through touch and through the air, contaminating[physio-pedia.com]

Epidemiology

  • Preventing Infection. 1400 Crystal Drive, Suite 900 Arlington, VA 22202 (p)202-789-1890 (f)202-789-1899 info@apic.org Association for Professionals in Infection Control and Epidemiology, Inc.[apic.org]
  • ‡Member, Department of Epidemiology and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania; formerly, research fellow in medicine, Harvard Medical School and Thorndike Memorial Laboratory.[nejm.org]
  • Epidemiological evidence has always suggested that resistance arose around this period, when the mecA gene encoding methicillin resistance carried on an SCC mec element, was horizontally transferred to an intrinsically sensitive strain of S. aureus .[biorxiv.org]
  • Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology Accuracy of Different Bioinformatics Methods in Detecting Antibiotic Resistance and Virulence Factors from Staphylococcus aureus Whole-Genome Sequences[pnas.org]
Sex distribution
Age distribution

Prevention

  • -Spanish (PDF) School Resources Prevention of MRSA Infections in Schools - Centers for Disease Control and Prevention Workplace Resources MRSA Infection and the Workplace - Thurston County Public Health and Social Services Department MRSA Resources for[doh.wa.gov]
  • This page contains MRSA prevention resources and education for both healthcare professionals and consumers. Spreading Knowledge.[apic.org]
  • A more detailed summary of these prevention strategies is available on the Centers for Disease Control and Prevention Web site [available here ].[psnet.ahrq.gov]
  • […] to our program; members of the MRSA Prevention Initiative Data Workgroup (Caroline Sausman, R.N., Cheryl L.[nejm.org]
  • Visit the Centers for Disease Control and Prevention website at . September 2018[vdh.virginia.gov]

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