Presentation
Edited by two internationally recognized pioneers in the area, this volume presents up-to-date information on the chemical, biological, physical, and societal hazards that confront children in today's world: pesticides, indoor and outdoor air pollution [books.google.com]
Other manifestations of chronic exposure are as follows: Anorexia Hepatotoxicity Renal toxicity CNS disturbances Skin irritation See Presentation for more detail. Diagnosis The history of exposure is the most important piece of information. [emedicine.medscape.com]
Clinical presentation included epigastric pain, abdominal swelling, bloody diarrhoea, hepatomegaly, splenomegaly, and ascites. [flipper.diff.org]
Entire Body System
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Infertility
In this study, the possible effect of Methoxychlor was investigated on the hormone level of LH, FSH, testosterone, spermatogenesis and its possible role in male infertility. [eprints.skums.ac.ir]
Methoxychlor was banned after it was found to mimic estrogen, acting as a reproductive toxin leading to infertility in animals. It turned up in human breast milk, and it is assumed to be able to cross the placenta. [newsweek.com]
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Pediatric Disease
It presents carefully documented data on rising rates of disease in children, offers a critical summary of new research linking pediatric disease with environmental exposures, and explores the cellular, molecular, and epigenetic mechanisms underlying [books.google.com]
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Disability
Amid mounting evidence that children are exquisitely sensitive to their environment-and that exposure during their developmental "windows of susceptibility" can trigger cellular changes that lead to disease and disability in infancy, childhood, and across [books.google.com]
Gastrointestinal
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Nausea
Mild Poisoning or Early Symptoms of Acute Poisoning headache, fatigue, weakness, dizziness, restlessness, nervousness, perspiration, nausea, diarrhea, loss of appetite, loss of weight, thirst, moodiness, soreness in joints, skin irritation, eye irritation [articles.extension.org]
[…] euphoria with auditory or visual hallucinations and perceptual disturbances Seizures Agitation, lethargy, or unconsciousness Other signs and symptoms include the following: Pulmonary - Cough, shortness of breath Dermatologic - Skin rash Gastrointestinal - Nausea [emedicine.medscape.com]
Chronic xylene exposure may result in more serious symptoms: leukopenia (depression of WBC’s), depression of blood clotting factors, liver and renal damage, increase in biliary enzymes, nausea, vomiting, headache and dizziness. [metabolichealing.com]
DDT general factsheet. 1999 CLINICAL ACUTE POISONING Acute effects likely in humans due to low to moderate exposure may include nausea, diarrhea, increased liver enzyme activity, irritation (of the eyes, nose or throat), disturbed gait, malaise and excitability [flipper.diff.org]
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Vomiting
Severe or Acute Poisoning fever, intense thirst, increased rate of breathing, vomiting, uncontrollable muscle twitches, pinpoint pupils, convulsions, inability to breathe, unconsciousness. [articles.extension.org]
diarrhea, and abdominal pain Nervous system - Headache, dizziness, or paresthesias of the face, tongue, and extremities Ingestion produces the following manifestations: Nausea and vomiting Confusion, tremor, myoclonus, coma, and seizures Respiratory [emedicine.medscape.com]
Chronic xylene exposure may result in more serious symptoms: leukopenia (depression of WBC’s), depression of blood clotting factors, liver and renal damage, increase in biliary enzymes, nausea, vomiting, headache and dizziness. [metabolichealing.com]
Acute toxicity of pesticides causes a range of effects on bees, which can include agitation, vomiting, wing paralysis, arching of the abdomen similar to sting reflex, and uncoordinated movement. [en.wikipedia.org]
Workup
[…] prolongation, nonspecific ST-segment changes Gastrointestinal - Transaminitis and hyperbilirubinemia Hematologic - Leukocytosis and prolonged activated partial thromboplastin time (aPTT) Renal - Acidemia, azotemia, creatinine elevation, hyperkalemia See Workup [emedicine.medscape.com]
Treatment
الصفحة 22 - Symptoms of poisoning appeared in as short a time as 3 hours and as long as 14 days after treatment. Deaths occurred in from 3 hours to 14 days after symptoms appeared. [books.google.com]
None of the pretreatment taxa disappeared and in fact many new ones appeared, during the 10 weeks immediately following the treatment. [cambridge.org]
See Treatment and Medication for more detail. [emedicine.medscape.com]
Moreover, the p,p'-DDT-stimulated proliferation of HepG2 cells could be reversed after NAC or β-catenin siRNA co-treatment. [flipper.diff.org]
[…] dermal absorption, high lipid storage, early and late seizures occur -Endosulfan ( thiodan, cyclodan, others) high acute oral toxicity, high dermal absorption, low lipid storage, strong sulfur odor - Heptachlor (Drinox), restriced; fire ant control; soil treatment [quizlet.com]
Prognosis
The prognosis in patients exposed to organochlorine compounds depends on the amount and type of exposure. [emedicine.medscape.com]
Epidemiology
Highly toxic organochlorines include: Aldrin Dieldrin [12] Endrin [13] Endosulfan [14, 15] Moderately toxic organochlorines include: Chlordane DDT Heptachlor Kepone Lindane Mirex Toxaphene Epidemiology United States statistics Organochlorine pesticides [emedicine.medscape.com]
Limited epidemiological studies suggest that occupational pesticide exposures are associated with AD. serum levels of dichlorodiphenyldichloroethylene (DDE), the metabolite of the pesticide dichlorodiphenyltrichloroethane (DDT), were found to be elevated [flipper.diff.org]
Pathophysiology
Pathophysiology Organochlorines are well absorbed orally and by inhalation. Transdermal absorption is variable. [emedicine.medscape.com]
Prevention
With this volume's emphasis upon integrating theory and practice, readers will find practical approaches to channeling scientific findings into evidence-based strategies for preventing and identifying the environmental hazards that cause disease in children [books.google.com]
Understanding and cooperation among growers and beekeepers are essential to prevent, or at least to minimize, the loss of honeybees due to the toxic effects of pesticides. [fao.org]
Decontamination may be indicated to prevent continued absorption, as well as exposure of health care personnel. For dermal decontamination, remove clothing and wash skin with soap and water. This is best performed in the field. [emedicine.medscape.com]
This data should be used to raise awareness of the risks of OCs exposure and to help establish health policies in order to avoid its use worldwide and thus, to prevent its propagation. Prenatal and Postnatal Exposure to DDT by Breast Milk Analysis. [flipper.diff.org]