Presentation
The recommended dose of NAC is presented in Table 2. [cureus.com]
(b) Micronodules of the right lungs are present. [ncbi.nlm.nih.gov]
If swallowing difficulty is present, providing adequate long-term nutrition under the supervision of a specialist nutritionist is recommended. [occup-med.biomedcentral.com]
Amazingly they found it present in all people tested, with women of childbearing age having the highest levels. [oshmanlaw.com]
Esophageal mucosal oedema (grading 1 Zargar’s score) and several gastric necrotic areas (grading 3a) were present. The duodenum revealed few scattered superficial erosions. [flore.unifi.it]
Entire Body System
- Unconsciousness
Symptoms of this include: Irritation to the nose and/or throat Headaches Dizziness Drowsiness Confusion Nausea If there is a high level of exposure to MEK, a person may faint, blackout or become unconscious. [cllegal.co.uk]
Two and half hours after an injected 0.25-0.5 g 4-MEC dose and thirty minutes after GBL ingestion, a 39-year-old man became unconscious and presented after admission to the hospital, transient apnea needing oxygenation and stimulation. [bdoc.ofdt.fr]
Symptoms of MEK Solvent poisoning when breathed in or swallowed: Irritation to the nose and throat Dizziness Headaches Nausea Drowsiness Confusion Exposure to high levels of MEK can result in fainting and unconsciousness If drawn into the lungs, it can [cuteinjury.co.uk]
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. [chemicalbook.com]
- Fatigue
In this research, symptoms of acute neurotoxicity were dominant are fatigue (80%), headache (77.8%), nausea (71.1%), dizziness (66.7%), and feeling of intoxication (53.3%). [ijcom.org]
The effects may be headaches, dizziness, fatigue, narcosis (acts like a narcotic), nausea, vomiting, and cause you to pass out. Methyl ethyl ketone vapour irritates the eyes, nose, and throat. Prolonged contact with the skin will cause irritation. [npi.gov.au]
- Gastric Lavage
In case 1, the acute stage of poisoning was treated by gastric lavage. Both patients underwent catharsis, and no gastrointestinal perforation or gastric flatulence was observed. [ncbi.nlm.nih.gov]
- Painter
Case Report A 42-year-old male car painter accidentally ingested about 150 ml of solution of 40% MEKP in dimethyl phtalate out of a glass while he was painting a car. He felt severe burning abdominal pain but he did not vomit. [omicsonline.org]
- Surgical Procedure
Conclusion: Pneumobilia, typically visualized as a large air confluence within the central portion of the liver, can be a complication of endoscopic or surgical procedures involving the biliary tract. [flore.unifi.it]
Respiratoric
- Respiratory Insufficiency
It may lead to abdominal burns, gastrointestinal bleeding, necrosis, perforation of the stomach, stricture of the esophagus, severe metabolic acidosis, acute liver failure, rhabdomyolysis, respiratory insufficiency, toxic myocarditis, and temporary cardiac [omicsonline.org]
Gastrointestinal
- Nausea
In this research, symptoms of acute neurotoxicity were dominant are fatigue (80%), headache (77.8%), nausea (71.1%), dizziness (66.7%), and feeling of intoxication (53.3%). [ijcom.org]
Higher exposures are expected to cause central nervous system depression with symptoms such as headache, nausea, dizziness, drowsiness, and confusion. [oldsite.osh.org.il]
Symptoms of this include: Irritation to the nose and/or throat Headaches Dizziness Drowsiness Confusion Nausea If there is a high level of exposure to MEK, a person may faint, blackout or become unconscious. [cllegal.co.uk]
Symptoms of MEK Solvent poisoning when breathed in or swallowed: Irritation to the nose and throat Dizziness Headaches Nausea Drowsiness Confusion Exposure to high levels of MEK can result in fainting and unconsciousness If drawn into the lungs, it can [cuteinjury.co.uk]
She immediately developed nausea and vomiting. She then fell into coma without limb convulsions, accompanied by foaming at the mouth. [ncbi.nlm.nih.gov]
- Abdominal Pain
The patient arrived at the hospital after about 70 minutes of ingestion complaining of drowsiness, oral and abdominal pain. He had history of being a heavy smoker, and cannabis addict. [omicsonline.org]
If there is severe abdominal pain, tenderness, rebound pain and muscle tension in the whole abdomen, a diet should be banned and conservative treatment should be performed. [ncbi.nlm.nih.gov]
The presence of stridor, odynophagia (pain on swallowing), abdominal guarding and rigidity however, indicate the presence of distal GI injuries [11]. [occup-med.biomedcentral.com]
- Hematemesis
On the second day altered hematemesis and melena stopped and vasopressors were weaned off. Follow up cardiac, renal, and liver enzymes started to slightly decline. [omicsonline.org]
A nasogastric tube was not inserted because of suspected upper gastrointestinal injury, marked by the presence of hematemesis. Intravenous infusions of N- N-acetylcysteine (NAC) and pantoprazole were commenced and continued for 48 hours. [cureus.com]
- Melena
On the second day altered hematemesis and melena stopped and vasopressors were weaned off. Follow up cardiac, renal, and liver enzymes started to slightly decline. [omicsonline.org]
- Severe Abdominal Pain
If there is severe abdominal pain, tenderness, rebound pain and muscle tension in the whole abdomen, a diet should be banned and conservative treatment should be performed. [ncbi.nlm.nih.gov]
Skin
- Formication
Apart from metabolic acidosis, formic acid can induce a variety of neurological complications among which optic nerve toxicity is the most prevalent (16–17). [tandfonline.com]
Sigurdsson J, Björnsson A, Gudmundsson ST (1983) Formic acid burn--local and systemic effects. Report of a case.BurnsInclThermInj 9: 358-361. [omicsonline.org]
Finally, during MEKP decay, various organic acids are formed, e.g. formic acid, which induce acidosis and optic neuropathy. [flore.unifi.it]
Hemodialysis is highly beneficial in removing any accumulated organic acids, particularly formic acid, thus correcting metabolic acidosis and halting further neurologic and organ damage. [cureus.com]
- Ulcer
Four weeks later upper gastrointestinal endoscopy was performed revealing no signs of esophageal or stomach ulcerations or strictures. Complete blood count, and liver enzymes were normal. [omicsonline.org]
Scarring following acute phase ulcerative lesions of the gastrointestinal tract is the predominant problem in survivors. [tandfonline.com]
On local examination of the oral cavity, the oral mucosa was found to be edematous and had multiple ulcers extending up to the posterior pharyngeal wall. The tongue was ulcerated and coated. [cureus.com]
Hence we recommend early insertion of a nasogastric tube within the first 24 hours unless severe edema or ulceration precludes its use. To prevent further GI injury, proton pump blockers should be used. [occup-med.biomedcentral.com]
Psychiatrical
- Fear
Oral antacid was started on the second day for fear of any chemical reaction that may occur with the remaining MEKP in the stomach which can cause further injury. [omicsonline.org]
Neurologic
- Headache
In this research, symptoms of acute neurotoxicity were dominant are fatigue (80%), headache (77.8%), nausea (71.1%), dizziness (66.7%), and feeling of intoxication (53.3%). [ijcom.org]
Higher exposures are expected to cause central nervous system depression with symptoms such as headache, nausea, dizziness, drowsiness, and confusion. [oldsite.osh.org.il]
Symptoms of this include: Irritation to the nose and/or throat Headaches Dizziness Drowsiness Confusion Nausea If there is a high level of exposure to MEK, a person may faint, blackout or become unconscious. [cllegal.co.uk]
Symptoms of MEK Solvent poisoning when breathed in or swallowed: Irritation to the nose and throat Dizziness Headaches Nausea Drowsiness Confusion Exposure to high levels of MEK can result in fainting and unconsciousness If drawn into the lungs, it can [cuteinjury.co.uk]
The effects may be headaches, dizziness, fatigue, narcosis (acts like a narcotic), nausea, vomiting, and cause you to pass out. Methyl ethyl ketone vapour irritates the eyes, nose, and throat. Prolonged contact with the skin will cause irritation. [npi.gov.au]
- Confusion
Higher exposures are expected to cause central nervous system depression with symptoms such as headache, nausea, dizziness, drowsiness, and confusion. [oldsite.osh.org.il]
Symptoms of this include: Irritation to the nose and/or throat Headaches Dizziness Drowsiness Confusion Nausea If there is a high level of exposure to MEK, a person may faint, blackout or become unconscious. [cllegal.co.uk]
After 30 min, he woke up, but remained confused for 4 hours. He was discharged 13 hours later without particular symptoms. [bdoc.ofdt.fr]
Symptoms of MEK Solvent poisoning when breathed in or swallowed: Irritation to the nose and throat Dizziness Headaches Nausea Drowsiness Confusion Exposure to high levels of MEK can result in fainting and unconsciousness If drawn into the lungs, it can [cuteinjury.co.uk]
Symptoms may include headache, nausea, dizziness, drowsiness and confusion. A severe exposure can cause unconsciousness. Skin Contact: May cause mild irritation. Can be absorbed through the skin, but harmful effects are not expected. [ccohs.ca]
Workup
Other Pathologies
- Hepatic Necrosis
Karhunen PJ, Ojanperä I, Lalu K, Vuori E (1990) Peripheral zonal hepatic necrosis caused by accidental ingestion of methyl ethyl ketone peroxide.HumExpToxicol 9: 197-200. [omicsonline.org]
Peripheral zonal hepatic necrosis caused by accidental ingestion of methyl ethyl ketone peroxide. Hum Exp Toxicol 1990; 9: 197–200. [PubMed] [Google Scholar] 7. Bates N, Driver CP, Bianchi A. [ncbi.nlm.nih.gov]
Upon systemic absorption, the aforementioned free radicals in MEKP produce its deleterious effects on the hepatocytes, leading to extensive hepatic necrosis, potentially inducing acute liver failure, which has been reported as the primary culprit for [cureus.com]
Laboratory
- Leukocytosis
Over the next three days his activated partial thromboplastin time, hemoglobin, and renal functions returned to normal but slight leukocytosis was still present. His echocardiography follow up was normal with ejection fraction 60%. [omicsonline.org]
He had a neutrophil leukocytosis (Table 1). Arterial blood gas analysis showed a high anion gap metabolic acidosis with a pH of 7.21. Serum potassium was elevated at 6.4 mmol/L, which persisted through the first week of hospital stay. [occup-med.biomedcentral.com]
Treatment
Similar articles Accidental ingestion of methyl ethyl ketone peroxide: N-acetylcysteine treatment and toxicological analysis. [pubmed.ncbi.nlm.nih.gov]
No special treatment had been provided. The patient then visited our hospital for further treatment. [ncbi.nlm.nih.gov]
There were two main goals in the treatment plan of this case. [omicsonline.org]
N/A Treatment Technique Heterotrophic plate count N/A Treatment Technique Legionella N/A Treatment Technique Turbidity N/A Treatment Technique Viruses (enteric) N/A Treatment Technique Total coliforms N/A Indicator used in tiered monitoring protocol [mass.gov]
Treatment of rats with 40 mg/kg of MEKP quickly induced lipid peroxidation in vivo, and from one to four hours after treatment caused a depression in the plasma content of vitamin E and the liver content of glutathione, as well as elevations in serum [tandfonline.com]
Epidemiology
Authors Denta Aditya Episana Master of Occupational Medicine, Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta Aria Kekalih Division of Epidemiology and Biostatistics, Department of Community Medicine, Faculty of Medicine [ijcom.org]
Pathophysiology
[…] experimental data, lipid peroxidation of target organs due to free radicals liberated from MEKP and toxicity due to the generation of organic acids such as acetic acid, formic acid, and propionic acid as a result of MEKP metabolism seem to be the dominant pathophysiological [tandfonline.com]
Prevention
The second goal was to reverse and prevent any further systemic injury through preventing further lipid peroxidation by administering free radical scavengers as N-acetylcysteine, vitamin E, and vitamin C. [omicsonline.org]
Prevent entry into waterways, sewers, basements or confined areas. DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST. (ERG, 2016) Protective Clothing Skin: Wear appropriate personal protective clothing to prevent skin contact. [cameochemicals.noaa.gov]
【UN (DOT)】 2550 Exposure Controls/Personal Protection Back to Contents 【Personal Protection】 Wear appropriate clothing to prevent any reasonable probability of skin contact. Wear eye protection to prevent any possibility of eye contact. [chemicalbook.com]
Limited human pregnancy exposure data prevents an evidence-based assessment of the risk posed by maternal MEK exposure to the developing fetus. [medicinesinpregnancy.org]
(AAR, 2003) Protective Clothing Skin : Wear appropriate personal protective clothing to prevent skin contact. Eyes : Wear appropriate eye protection to prevent eye contact. [conestogafuels.com]