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Methylene Blue

Blue N Methylene


Presentation

  • The present study showed the PMP presented acceptable adsorbance, high adsorption rate and recovery efficiency. Thus, we believe that the PMP was a promising candidate for MB cleanup. Copyright 2018 Elsevier B.V. All rights reserved.[ncbi.nlm.nih.gov]
Intravenous Administration
  • At concentrations reported in the literature after intravenous administration, MAO B would be partially inhibited but MAO A would be completely inhibited.[ncbi.nlm.nih.gov]
  • Most cases from the FDA's Adverse Event Reporting System (AERS) of serotonin syndrome in patients given serotonergic psychiatric medications and methylene blue occurred in the context of parathyroid surgery, which involved the intravenous administration[fda.gov]
  • Slow intravenous administration of physostigmine in doses of 1 to 4 mg (0.5 to 1 mg in children) repeated as needed in one to two hours to reverse severe antimuscarinic symptoms.Administration of small doses of diazepam to control excitement and seizures.Artificial[rxlist.com]
  • Beyond an occasional idiosyncratic drug reaction or mild pressor effect, the intravenous administration of indigo carmine is generally well tolerated.[apsf.org]
Dysgeusia
  • Common Adverse Effects Pain in extremity, chromaturia, dysgeusia, feeling hot, dizziness, hyperhidrosis, nausea, skin discoloration, headache. 200 Large IV doses: Nausea, 1 200 vomiting, 9 200 abdominal pain, 1 200 precordial pain, 1 200 dizziness, 1[drugs.com]
Heart Failure
  • Abstract We are presenting an electrochemical immunosensor for the determination of Galectin-3 (Gal-3), a biomarker of heart failure.[ncbi.nlm.nih.gov]
Eczema
  • Eczema herpeticum. Treatment with methylene blue and light. Arch Dermatol. 1975; 111:1174-5. [PubMed 170870] 100. Food and Drug Administration.[web.archive.org]
  • Eczema herpeticum. Treatment with methylene blue and light. Arch Dermatol. 1975; 111:1174-5. 100. Food and Drug Administration.[drugs.com]
Hyperhidrosis
  • Common Adverse Effects Pain in extremity, chromaturia, dysgeusia, feeling hot, dizziness, hyperhidrosis, nausea, skin discoloration, headache. 200 Large IV doses: Nausea, 1 200 vomiting, 9 200 abdominal pain, 1 200 precordial pain, 1 200 dizziness, 1[drugs.com]
Abnormal Eye Movement
  • Postoperatively, she demonstrated symptoms and signs of serotonin syndrome; specifically tachycardia, agitation, dystonia and abnormal eye movements. These clinical findings spontaneously resolved themselves over the subsequent 48 hr.[ncbi.nlm.nih.gov]
Myopathy
  • Placebo VPS Renal failure, Resp failure or Myopathy 0/28 (0%) vs. 4/28 (14.3%) P 0.05 – SVT 2/28 (7.1%) vs. 8/28 (28.6%) P 0.03 – Sepsis & MSOF both 0/28 vs.7/28 (25%) P 0.005 Ozal et al, 2005, Turkey 100 patients at high risk of VPS scheduled for CABG[web.archive.org]
  • Placebo VPS Renal failure, Resp failure or Myopathy 0/28 (0%) vs. 4/28 (14.3%) P 0.05 – SVT 2/28 (7.1%) vs. 8/28 (28.6%) P 0.03 – Sepsis & MSOF both 0/28 vs.7/28 (25%) P 0.005 Ozal et al, 2005, Turkey 100 patients at high risk of VPS scheduled for[bestbets.org]
Psychiatric Symptoms
  • The dosing of methylene blue for treatment of ifosfamide neurotoxicity varies, depending upon its use simultaneously as an adjuvant in ifosfamide infusion, versus its use to reverse psychiatric symptoms that manifest after completion of an ifosfamide[en.wikipedia.org]
Compulsive Disorder
  • The patient had a background of obsessive compulsive disorder treated with paroxetine. Postoperatively, she demonstrated symptoms and signs of serotonin syndrome; specifically tachycardia, agitation, dystonia and abnormal eye movements.[ncbi.nlm.nih.gov]
Dystonia
  • Postoperatively, she demonstrated symptoms and signs of serotonin syndrome; specifically tachycardia, agitation, dystonia and abnormal eye movements. These clinical findings spontaneously resolved themselves over the subsequent 48 hr.[ncbi.nlm.nih.gov]
Oliguria
  • Patient group Study type (level of evidence) Outcomes Key results Study Weaknesses Andrade et al, 1996, Brazil 6 patients who developed vasoplegic syndrome (VPS) during cardiac surgery with/without cardiopulmonary bypass Criteria for VPS- tachycardia, oliguria[web.archive.org]

Workup

  • Her infectious workup was negative. She was eventually transferred from the PICU to the chronic ventilator unit on a laptop ventilator for additional inpatient care.[pediatrics.aappublications.org]

Treatment

  • Methylene blue may play a role in the treatment of distributive shock when standard treatment fails.[ncbi.nlm.nih.gov]

Prognosis

  • The purpose of this article is to analyze the incidence of the postoperative vasoplegic syndrome, to consider its prognosis, and to evaluate the effect of intravenous methylene blue on mortality. Cardiac surgery patients were consecutively included.[ncbi.nlm.nih.gov]
  • Likewise, physicians have a duty to inform patients about anything relevant, such as test results or their diagnosis or prognosis. I find this to be the most fuzzy area, however. Certainly, factual information needs to be given to patients.[sciencebasedmedicine.org]

Etiology

  • Robert O Wright, William J Lewander and Alan D Woolf, Methemoglobinemia: Etiology, Pharmacology, and Clinical Management, Annals of Emergency Medicine, 34, 5, (646), (1999).[doi.org]
  • Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med. 1999; 34:646-56. [PubMed 10533013] 132. Peter C, Hongwan D, Küpfer A et al. Pharmacokinetics and organ distribution of intravenous and oral methylene blue.[web.archive.org]
  • Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med. 1999; 34:646-56. 132. Peter C, Hongwan D, Küpfer A et al. Pharmacokinetics and organ distribution of intravenous and oral methylene blue.[drugs.com]

Epidemiology

  • Heidelberg, Germany (3) Centre de Recherche en Santé de Nouna, PO Box 02, Nouna, Burkina Faso (4) Institute of Medical Biometrics and Informatics, Ruprecht-Karls-University, Heidelberg, Germany (5) Institute of Medical Informatics, Biostatistics, and Epidemiology[doi.org]
  • […] thrombophlebitis 9 reported; extravasation has caused tissue necrosis. 113 Oral † : Adverse GI effects and dysuria reported. 9 Topical † application: Skin may become stained; skin stains may be removed by hypochlorite solution. 9 Specific Populations Pregnancy Epidemiologic[drugs.com]
Sex distribution
Age distribution

Pathophysiology

  • Many studies suggest that the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway plays a significant role in the pathophysiology of distributive shock.[ncbi.nlm.nih.gov]
  • Methylene blue has been used to treat ifosfamide-induced encephalopathy, but the exact pathophysiologic mechanisms responsible are not known. Methylene blue may reverse the neurotoxic effects of the ifosfamide metabolites.[mhmedical.com]

Prevention

  • The results provide an explanation for the preventive action of methylene blue in ifosfamide neurotoxicity, because the generation of chloroacetaldehyde (a potential neurotoxin of ifosfamide metabolism) is prevented in liver mitochondria and extrahepatic[ncbi.nlm.nih.gov]
  • Highlights General disease prevention and treatment for fresh and saltwater Aids in general disease prevention and treatment of fungal infections Effective prevention against fungal infection on aquarium fish eggs Overview General disease prevention and[drsfostersmith.com]

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