A case of repeated methylergonovine-induced spasm of a saphenous vein bypass graft in a 56-year-old man is presented. Prior to the operation, spasm was induced by methylergonovine in the stenosed right coronary artery. [ncbi.nlm.nih.gov]

Case 3 Patient presented to the headache clinic with a diagnosis of episodic migraine without aura which started 7 years ago. Episodic headache attacks lasting for 1–3 days occurring on average 5–6 times a month. [frontiersin.org]

Letter Kefzol (cefazolin) all presentations 2/28/2003 Eli Lilly and Company Letter Kefurox (cefuroxime) all presentations 2/28/2003 Eli Lilly and Company Letter Kemadrin (procyclidine hydrochloride) 6/6/2008 King Pharmaceuticals 800-776-3637 Letter from [johalimedical.com]

The following examples will further illustrate the present invention and enable others skilled in the art to understand it more completely. [google.com]

• Hyperthermia

  Serotonin syndrome is characterized by rapid development of hyperthermia, hypertension, myoclonus, rigidity, autonomic instability, mental status changes (e.g., delirium or coma), and in rare cases, death. [pdr.net]

• Dysgeusia

  Incidence not known palpitations / Early / Incidence not known peripheral vasoconstriction / Rapid / Incidence not known sinus tachycardia / Rapid / Incidence not known hematuria / Delayed / Incidence not known confusion / Early / Incidence not known Mild dysgeusia [pdr.net]

• Weak Pulse

  Overdose and treatment Signs and symptoms of overdose include seizures, gangrene, nausea, vomiting, diarrhea, dizziness, changing blood pressure, weak pulse, chest pain, abdominal pain, tingling, and numbness and coldness in limbs. [glowm.com]

• Photophobia

  Case 1 The patient having developed migraine headaches since teenage years presented to the headache clinic with complaints of persistent bilateral throbbing headaches with photophobia, phonophobia, and nausea on a constant daily basis for last 4 months [frontiersin.org]

  All patients reported photophobia, phonophobia, nausea and vomiting at baseline. Previous analgesic intake included paracetamol (55%), aspirin (16%), ibuprofen (16%), metamizole (9,6%), diclofenac (8%), and combined analgesics (6.4%). [doi.org]

• Facial Pain

  View Article PubMed Google Scholar Headache Classification Committee of the International Headache Society: Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988, 8 (Suppl 7): 1-96. [doi.org]

  Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988; 8 (Suppl 7):1–96. [ PubMed ] [ Google Scholar ] Cohen J. Statistical power analysis for the behavioral sciences. 2. [ncbi.nlm.nih.gov]

• Akathisia

  Some conventional neuroleptics, as prochlorperazine and chlorpromazine, have been used by parenteral route in the acute management of migraine [ 21 ], being akathisia is the most common side effect associated with intravenous prochlorperazine and postural [doi.org]

• Neuralgia

  View Article PubMed Google Scholar Headache Classification Committee of the International Headache Society: Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988, 8 (Suppl 7): 1-96. [doi.org]

  Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988; 8 (Suppl 7):1–96. [ PubMed ] [ Google Scholar ] Cohen J. Statistical power analysis for the behavioral sciences. 2. [ncbi.nlm.nih.gov]

• Expressive Aphasia

  Published interaction reports between intravenously administered methylene blue and serotonergic psychiatric agents have documented symptoms including lethargy, confusion, delirium, agitation, aggression, obtundation, myoclonus, expressive aphasia, hypertonia [pdr.net]

• Aphasia

  Published interaction reports between intravenously administered methylene blue and serotonergic psychiatric agents have documented symptoms including lethargy, confusion, delirium, agitation, aggression, obtundation, myoclonus, expressive aphasia, hypertonia [pdr.net]

• Myoclonus

  Serotonin syndrome is characterized by rapid development of hyperthermia, hypertension, myoclonus, rigidity, autonomic instability, mental status changes (e.g., delirium or coma), and in rare cases, death. [pdr.net]

Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2007; 1:CD003249. [PubMed 17253486] g. Perinatal HIV Guidelines Working Group. [web.archive.org]

Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2007; 1:CD003249. g. Perinatal HIV Guidelines Working Group. [drugs.com]

misoprostol treatment and ergometrine treatment, respectively: 0–32%, 1–45% and 0–37%. [onlinelibrary.wiley.com]

Brand Names Methergine® Generic Available No Synonyms Methylergometrine Maleate; Methylergonovine Maleate Pharmacological Index Ergot Derivative Use Prevention and treatment of postpartum and postabortion hemorrhage caused by uterine atony or subinvolution [syrianclinic.com]

Review of the literature suggests that coronary artery spasm after transplantation is often associated with severe transplant coronary artery disease and may be associated with a poor prognosis. [ncbi.nlm.nih.gov]

[…] clinical symptoms of left-sided substernal chest pain, radiating to the left upper extremity, with associated shortness of breath, and electrocardiographic changes almost immediately after intramyometrial administration of Methergine suggest cardiac etiology [anesthesiology.pubs.asahq.org]

The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveries. Anesth Analg. 2010 May 1;110(5):1368-73. Oyelese Y, Ananth CV. Postpartum hemorrhage: epidemiology, risk factors, and causes. [lupinpharmaceuticals.com]

These and other observations emphasize the importance of the physiological or pathophysiological state in determining the spectrum and intensity of effects produced in animals or patients. [web.archive.org]

Evaluation/Desired Outcomes Contractions that maintain uterine tone and prevent postpartum hemorrhage. methylergonovine /meth·yl·er·go·no·vine/ ( meth″il-er″go-no´vēn ) an oxytocic, used as the maleate salt to prevent or combat postpartum or postabortion [medical-dictionary.thefreedictionary.com]

Methylergonovine is a semi-synthetic ergot alkaloid used for the prevention and control of postpartum haemorrhage. [biospectrumindia.com]

Intravenous injection of 5 IU oxytocin immediately after delivery of fetal anterior shoulder is the treatment of choice for prevention of PPH in patients with natural course of labor. [oadoi.org]

[…] mol Methylergobasin Melting Point 172 o C Methylergobasin H 2 O Solubility 25 mg/mL Methylergobasin State Solid Methylergobasin LogP 1.01 Methylergobasin Dosage Forms Injection (intramuscular or intravenous); Tablet Methylergobasin Indication For the prevention [pharmacycode.com]