A case of repeated methylergonovine-induced spasm of a saphenous vein bypass graft in a 56-year-old man is presented. Prior to the operation, spasm was induced by methylergonovine in the stenosed right coronary artery. [ncbi.nlm.nih.gov]

Case 3 Patient presented to the headache clinic with a diagnosis of episodic migraine without aura which started 7 years ago. Episodic headache attacks lasting for 1–3 days occurring on average 5–6 times a month. [frontiersin.org]

The following examples will further illustrate the present invention and enable others skilled in the art to understand it more completely. [google.com]

If methergine is not present. Active management of the third stage of labor should be used routinely. Pharmaceutically termed dinoprost, is a naturally occurring prostaglandin used in medicine to induce labor. [snakes-safe.tk]

• Fever

  […] report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue breathing problems chest pain or tightness confusion fast, slow, or pounding heartbeat fever [es.bartonhealth.org]

  N/V/D, fever chills, facial flushing, headache, hypertension or hypotension, tachycardia, pulmonary edema Carboprost, Tromethamine (Hemabate, Prostin/15M) -contraindications women with hypersensitivity to carboprost or other prostaglandins; acute pelvic [quizlet.com]

  Taken from the above link: Physical Symptoms after an abortion that are cause for concern: Fever over 100 degr... ... Updated 3 years ago in Methergine. Tue, Apr 15 '14, 12:47 PM No registration is needed. [medschat.com]

• Fatigue

  Assess exercise tolerance frequently (BP, heart rate, respiration, fatigue levels), and terminate exercise immediately if any untoward responses occur (see Appendix L). [fadavispt.mhmedical.com]

  3.7 (53-80) 67.5 ± 5.1 60 minutes (95-117) 104.5 ± 4.43 (54-75) 59.7 ± 3.4 (53-80) 67.4 ± 4.8 P < 0.0001 < 0.0001 < 0.0001 Nausea (84.8%) and vomiting (84%) were the most frequent side effects related with methylergonovine administration, followed by fatigue [doi.org]

• Vomiting

  GI: nausea, vomiting, diarrhea, foul taste. GU: hematuria. Musculoskeletal: leg cramps. Respiratory: dyspnea. Skin: diaphoresis. Other: thrombophlebitis. Effects on lab test results • May decrease prolactin level. [glowm.com]

  This drug should not be given IV as it may result in bronchospasm, hypertension, vomiting, or anaphylaxis. Carboprost must be refrigerated when stored. 7 The reported side effects include nausea, vomiting, diarrhea, bronchospasm, and hypertension. [uspharmacist.com]

  Abdominal pain (caused by uterine contractions), nausea and vomiting have occurred occasionally. [rxlist.com]

  Nausea and vomiting occurred 70 min after placenta delivery, heart rate decreased, arterial blood pressure increased and there was chest pain. After excluding cardiac ischaemia, 0.5 mg atropine sulphate was administered intravenously. [ncbi.nlm.nih.gov]

  Toxicity Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting. Biotrnasformation / Drug Metabolism Hepatic, with extensive first-pass metabolism. [druglib.com]

• Nausea

  The patient had mild headache and nausea, and antiemetic 4 mg ondansetron was given intravenously. Continuous monitoring for 4 h showed spontaneous chest pain relief and blood pressure improvement. [ncbi.nlm.nih.gov]

  GI: nausea, vomiting, diarrhea, foul taste. GU: hematuria. Musculoskeletal: leg cramps. Respiratory: dyspnea. Skin: diaphoresis. Other: thrombophlebitis. Effects on lab test results • May decrease prolactin level. [glowm.com]

  Abdominal pain (caused by uterine contractions), nausea and vomiting have occurred occasionally. [rxlist.com]

  Toxicity Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting. Biotrnasformation / Drug Metabolism Hepatic, with extensive first-pass metabolism. [druglib.com]

  Hypertension, nausea, blurred vision, and headaches also may occur. Adverse effects are more common after IV administration. methylergometrine maleate, methylergonovine maleate a compound used as an oxytocic. [medical-dictionary.thefreedictionary.com]

• Hypertension

  Contraindications Hypertension; toxemia; pregnancy; and hypersensitivity. Drug Interactions CYP 3A4 Inhibitors (e.g. [druglib.com]

  Immediate Unknown 45 min I.M. 2-5 min Unknown 3 hr Contraindications and precautions Contraindicated in pregnant women and patients with hypertension, toxemia, or sensitivity to ergot preparations. [glowm.com]

  Dobutamine: (Major) The concomitant administration of ergot alkaloids and sympathomimetics has resulted in dangerous hypertension. [pdr.net]

  Additive vasospasm; risk of hypertension. yohimbine methylergonovine, yohimbine. Mechanism: pharmacodynamic synergism. Contraindicated. Additive vasospasm; risk of hypertension. [reference.medscape.com]

• Hypotension

  Diffuse spasm resulting in hypotension and ventricular fibrillation occurred with intravenous methylergonovine maleate administration. [ncbi.nlm.nih.gov]

  Toxicity Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting. Biotrnasformation / Drug Metabolism Hepatic, with extensive first-pass metabolism. [druglib.com]

  Adverse Reactions >10%: Cardiovascular: Hypertension 1% to 10%: Gastrointestinal: Nausea, vomiting Overdosage/Toxicology Symptoms include vasospastic effects, nausea, vomiting, lassitude, impaired mental function, hypotension, hypertension, unconsciousness [syrianclinic.com]

  Use caution if the woman has a history of asthma, hypotension or hypertension, anemia, jaundice, diabetes, epilepsy, previous uterine surgery Carboprost, Tromethamine (Hemabate, Prostin/15M)- nursing considerations should be refridgerated. [quizlet.com]

• Suggestibility

  Alexander Shulgin in TiHKAL suggests ergonovine is responsible, instead. The seeds of many species of morning glory contain ergoline alkaloids such as the psychedelic ergonovine and ergine (LSA). [diki.pl]

  It is also an active metabolite of methysergide and previous studies suggest that it could be effective against refractory headache and cluster headache. [ncbi.nlm.nih.gov]

  Review of the literature suggests that coronary artery spasm after transplantation is often associated with severe transplant coronary artery disease and may be associated with a poor prognosis. [mayoclinic.pure.elsevier.com]

• Headache

  An uncontrolled pilot study of 20 episodic cluster headache patients confirmed its effectiveness and tolerability as an adjunct cluster headache prophylactic. [ncbi.nlm.nih.gov]

  It is also an active metabolite of methysergide and previous studies suggest that it could be effective against refractory headache and cluster headache. [doi.org]

• Seizure

  Treat seizures with anticonvulsants and hypercoagulability with heparin; use vasodilators to improve blood flow as required. Gangrene may require surgical amputation. [glowm.com]

  Complications of ergot alkaloids in neonates include respiratory depression, seizures, and death. CASE REPORT A term infant was inadvertently given 0.1 mg of methylergonovine intramuscularly in the right thigh. [ncbi.nlm.nih.gov]

  Toxicity Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting. Biotrnasformation / Drug Metabolism Hepatic, with extensive first-pass metabolism. [druglib.com]

  If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Keep all appointments with your doctor. Do not let anyone else take your medication. [nlm.nih.gov]

• Confusion

  CONCLUSIONS Because of the potential for serious adverse events, vigilance is required to prevent accidental administration of methylergonovine to the neonate as a result of possible confusion with vitamin K in the early post-partum period. [ncbi.nlm.nih.gov]

  Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue breathing problems chest pain or tightness confusion fast, slow [es.bartonhealth.org]

  […] as: pain, swelling, warmth, or redness under your skin; seizure (convulsions); feeling like you might pass out; pounding heartbeats or fluttering in your chest; slow heart rate, trouble breathing; blood in your urine; severe weakness, muscle cramps, confusion [cardiosmart.org]

Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2007; 1:CD003249. g. Perinatal HIV Guidelines Working Group. [drugs.com]

Treatment for primary postpartum haemorrhage. Cochrane Database Syst Rev. 2007; 1:CD003249. [PubMed 17253486] g. Perinatal HIV Guidelines Working Group. [web.archive.org]

misoprostol treatment and ergometrine treatment, respectively: 0–32%, 1–45% and 0–37%. [onlinelibrary.wiley.com]

Treatment of oral overdose requires that the patient drink tap water, milk, or vegetable oil to delay absorption. Follow with gastric lavage or emesis and then activated charcoal and cathartics. [glowm.com]

Review of the literature suggests that coronary artery spasm after transplantation is often associated with severe transplant coronary artery disease and may be associated with a poor prognosis. [ncbi.nlm.nih.gov]

[…] clinical symptoms of left-sided substernal chest pain, radiating to the left upper extremity, with associated shortness of breath, and electrocardiographic changes almost immediately after intramyometrial administration of Methergine suggest cardiac etiology [anesthesiology.pubs.asahq.org]

The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveries. Anesth Analg. 2010 May 1;110(5):1368-73. Oyelese Y, Ananth CV. Postpartum hemorrhage: epidemiology, risk factors, and causes. [lupinpharmaceuticals.com]

These and other observations emphasize the importance of the physiological or pathophysiological state in determining the spectrum and intensity of effects produced in animals or patients. [web.archive.org]

[…] and control of excessive bleeding following vaginal childbirth Pharmacology Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. [druglib.com]

Recent WHO guidelines on the prevention of PPH recommend that oxytocin be used by skilled clinical staff, but this should not prevent staff who are skilled in administering uterotonics (but not skilled in active management) from administering the drug [uspharmacist.com]

These include ergotamine, prescribed for migraine headache; and ergonovine, administered to mothers immediately after childbirth to prevent hemorrhage. Alexander Shulgin in TiHKAL suggests ergonovine is responsible, instead. [diki.pl]

Evaluation/Desired Outcomes Contractions that maintain uterine tone and prevent postpartum hemorrhage. methylergonovine /meth·yl·er·go·no·vine/ ( meth″il-er″go-no´vēn ) an oxytocic, used as the maleate salt to prevent or combat postpartum or postabortion [medical-dictionary.thefreedictionary.com]

Methylergonovine is a semi-synthetic ergot alkaloid used for the prevention and control of postpartum haemorrhage. [biospectrumindia.com]