We describe the development of acute hypokalemic paralysis in a middle-aged Caucasian man with recently diagnosed thyrotoxicosis and severe, active Graves' opthalmopathy who developed progressive flaccid paralysis 12 hours following intravenous administration [ncbi.nlm.nih.gov]

The acetate is often prepared in long-acting forms while the water-soluble, rapid-acting succinate is suitable for intravenous administration and is used in the treatment of shock. methylprednisolone-21-dimethylaminoacetate a long-acting glucocorticoid [medical-dictionary.thefreedictionary.com]

Furthermore, with regard to the testing of high or mega-doses of the steroid in SCI patients, there was already considerable clinical experience with the intraveneous administration of doses as high, or higher, than 30 mg/kg in several clinical studies [rehab.research.va.gov]

polychondritis, synovitis of osteoarthritis (oral only). [drugs.com]

polychondritis †, polymyalgia rheumatica † and giant-cell (temporal) arteritis †, or mixed connective tissue disease syndrome †. a c High dosage may be required for acute situations; after a response has been obtained, drug must often be continued for [web.archive.org]

Adverse reactions CNS: headache, restlessness, nervousness, depression, euphoria, personality changes, psychoses, vertigo, paresthesias, insomnia, adhesive arachnoiditis, conus medullaris syndrome, increased intracranial pressure, seizures, meningitis [medical-dictionary.thefreedictionary.com]

Adverse reactions CNS: euphoria, insomnia, psychotic behavior, pseudotumor cerebri, vertigo, headache, paresthesia, seizures. [glowm.com]

[…] corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not affect the ultimate outcome or natural history of the disease Psychic derangements may appear when corticosteroids used, ranging from euphoria [reference.medscape.com]

Extreme mood changes: Tell your healthcare provider right away if you have some or all of the following symptoms... euphoria (intense feeling of happiness or joy) insomnia mood swings personality changes severe depression Stunted growth in children: Growth [rxwiki.com]

TRPC5-deficient mice exhibit a reduced innate fear response and impaired motor control. In addition, outgrowth of hippocampal and cerebellar neurons is retarded by TRPC5. [ncbi.nlm.nih.gov]

[…] result in glaucoma or may occasionally damage the optic nerve. a c d e m May enhance the establishment of secondary bacterial, fungal, and viral infections of the eye. d e Use with caution in patients with active ocular herpes simplex infections for fear [drugs.com]

We describe the development of acute hypokalemic paralysis in a middle-aged Caucasian man with recently diagnosed thyrotoxicosis and severe, active Graves' opthalmopathy who developed progressive flaccid paralysis 12 hours following intravenous administration [ncbi.nlm.nih.gov]

Neurological examination revealed Mini-Mental State Examination (MMSE) score of 5 of 30 points, leg hyper-reflexia with Babinski signs, and Parkinsonism. [ncbi.nlm.nih.gov]

Electrocardiogram showed slightly prolonged PR interval in sinus rhythm. Af occurred at high circulating levels of interferon-γ and interleukin (IL)-10, but not IL-6, IL-2, tumor necrosis factor-α, C-reactive protein or catecholamines. [ncbi.nlm.nih.gov]

In 2 of the patients, liver biopsy showed periportal fibrosis, piecemeal necrosis, and inflammatory cell infiltrates. A rechallenge test confirmed a causal association in 1 case. [ncbi.nlm.nih.gov]