There were differing vascular patterns of presentation: 2 patients presented with small-vessel (lacunar) infarctions, whereas 1 patient presented with a large-vessel infarct. [ncbi.nlm.nih.gov]

• Weight Loss

  […] heartbeat sores, ulcers, or white spots on the lips or tongue or inside the mouth swelling of the face, fingers, feet, abdominal or stomach area, or lower legs tearing tightness in the chest troubled breathing troubled breathing at rest unexplained weight [mayoclinic.org]

  Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication. [webmd.com]

  […] report signs or symptoms of adrenal insufficiency (including fatigue, appetite loss, nausea, vomiting, diarrhea, weight loss, weakness, and dizziness) after dosage reduction or drug withdrawal. • Advise diabetic patient to monitor blood glucose level [medical-dictionary.thefreedictionary.com]

  […] gain or weight loss  Mental depression, mood swings, mistaken feelings of self-importance or of being mistreated 21. [slideshare.net]

• Collapse

  For shock, give massive doses over at least 10 minutes to prevent arrhythmias and circulatory collapse. [glowm.com]

  If you think you or someone else may have overdosed on: Methylprednisolone (Medrol), call your doctor or the Poison Control center (800) 222-1222 If someone collapses or isn't breathing after taking Methylprednisolone (Medrol), call 911 911 What to Expect [everydayhealth.com]

  If the victim has collapsed or is not breathing, call local emergency services at 911. [methylprednisolone.com]

  If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Keep all appointments with your doctor and the laboratory. [nlm.nih.gov]

• Increased Susceptibility to Infections

  […] appetite, weight gain (with long-term use), Churg-Strauss syndrome, increased susceptibility to infection, aggravation or masking of infections, impaired wound healing, atrophy at injection site, local pain and burning, irritation, hypersensitivity reaction [medical-dictionary.thefreedictionary.com]

  […] effects: Anaphylactic reactions Kaposi’s sarcoma Mood swings Increased susceptibility to infection Impaired wound healing Elevated blood pressure Peptic ulcer Acne Muscle weakness Growth retardation Warnings Do not take Methylprednisolone with the following [discountacnemeds.com]

  Other: susceptibility to infections, acute adrenal insufficiency that may occur with increased stress (infection, surgery, or trauma) or abrupt withdrawal after long-term therapy. [glowm.com]

  Significant: Immunosuppression, increased susceptibility to infection, mask signs of infection; Kaposi's sarcoma, adrenal cortical atrophy (prolonged use); hypercortisolism or suppression of hypothalamic-pituitary-adrenal (HPA) axis (particularly in younger [mims.com]

  Increased susceptibility to infections (particularly thrush infections, chickenpox, shingles and measles ) and increased severity of infections. It's important to avoid contact with people who have chickenpox, shingles and measles during treatment. [netdoctor.co.uk]

• Intravenous Administration

  We describe the development of acute hypokalemic paralysis in a middle-aged Caucasian man with recently diagnosed thyrotoxicosis and severe, active Graves' opthalmopathy who developed progressive flaccid paralysis 12 hours following intravenous administration [ncbi.nlm.nih.gov]

  The acetate is often prepared in long-acting forms while the water-soluble, rapid-acting succinate is suitable for intravenous administration and is used in the treatment of shock. methylprednisolone-21-dimethylaminoacetate a long-acting glucocorticoid [medical-dictionary.thefreedictionary.com]

  Furthermore, with regard to the testing of high or mega-doses of the steroid in SCI patients, there was already considerable clinical experience with the intraveneous administration of doses as high, or higher, than 30 mg/kg in several clinical studies [rehab.research.va.gov]

• Anorexia

  […] intraocular pressure, nasal irritation, nasal septum perforation, sneezing, epistaxis, nasopharyngeal or oropharyngeal fungal infection, dysphonia, hoarseness, throat irritation GI: nausea, vomiting, abdominal distention, rectal bleeding, dry mouth, anorexia [medical-dictionary.thefreedictionary.com]

  • Teach patient early signs of adrenal insufficiency: fatigue, muscle weakness, joint pain, fever, anorexia, nausea, dyspnea, dizziness, and fainting. • Tell patient to carry a card identifying need for supplemental systemic steroids during stress. [glowm.com]

• Cough

  Methylprednisolone significantly decreased median pain scores on the day of surgery: at rest (numeric rating scale 1.6 vs 2.0, P = 0.019) and after mobilization to a sitting position (numeric rating scale 1.7 vs 2.5, P = 0.004) but not during arm abduction and coughing [ncbi.nlm.nih.gov]

  Check with your doctor immediately if any of the following side effects occur: Incidence not known Black, tarry stools blindness bloating bloody vomit blurred vision bone pain change in vision chest pain chills confusion constipation cough dark urine [mayoclinic.org]

  Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. [mskcc.org]

  […] wound that will not heal; blurred vision, tunnel vision, eye pain, or seeing halos around lights; severe depression, changes in personality, unusual thoughts or behavior; new or unusual pain in an arm or leg or in your back; bloody or tarry stools, coughing [rxlist.com]

  Chronic Bronchitis Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least 3 months, 2 years in a row. [medicinenet.com]

• Loss of Appetite

  […] of appetite loss of consciousness lower back or side pain mental depression mood changes muscle pain, cramps, or weakness nausea nervousness noisy, rattling breathing numbness or tingling in the hands, feet, or lips pain in the back, ribs, arms, or legs [mayoclinic.org]

  Stopping the drug abruptly can cause loss of appetite, upset stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss. [nlm.nih.gov]

  Symptoms can include: loss of appetite lack of energy nausea vomiting headache fever joint or muscle pain skin irritation weight loss low blood pressure (may make you feel dizzy or faint) Disclaimer: Our goal is to provide you with the most relevant and [healthline.com]

• Euphoria

  Adverse reactions CNS: headache, restlessness, nervousness, depression, euphoria, personality changes, psychoses, vertigo, paresthesias, insomnia, adhesive arachnoiditis, conus medullaris syndrome, increased intracranial pressure, seizures, meningitis [medical-dictionary.thefreedictionary.com]

  Adverse reactions CNS: euphoria, insomnia, psychotic behavior, pseudotumor cerebri, vertigo, headache, paresthesia, seizures. [glowm.com]

  […] corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not affect the ultimate outcome or natural history of the disease Psychic derangements may appear when corticosteroids used, ranging from euphoria [reference.medscape.com]

  Extreme mood changes: Tell your healthcare provider right away if you have some or all of the following symptoms... euphoria (intense feeling of happiness or joy) insomnia mood swings personality changes severe depression Stunted growth in children: Growth [rxwiki.com]

  […] shown corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not affect the outcome or natural history of the disease Psychic derangements may appear when corticosteroids are used, ranging from euphoria [rxlist.com]

• Withdrawn

  If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly. [rxlist.com]

  […] keloids, psoriatic plaques, alopecia areata, discoid lupus erythematosus, necrobiosis lipoidica diabeticorum, granuloma annulare d m unresponsive to topical therapy. c Rarely indicated for psoriasis † ; c if used, exacerbation may occur when the drug is withdrawn [web.archive.org]

• Lethargy

  […] conditions (e.g., rheumatoid arthritis, ulcerative colitis) require daily glucocorticoid therapy because symptoms of the underlying disease cannot be controlled by alternate-day therapy. c Discontinuance of Therapy A steroid withdrawal syndrome consisting of lethargy [web.archive.org]

• Urinary Retention

  We describe a 3-year-old girl who presented with fever, weakness in all four limbs, urinary retention, respiratory distress and altered sensorium. [ncbi.nlm.nih.gov]

I had my whole spine MRI, including the lumbar just recently, and over these years I've probably had the best workup done, as far Version: pfdsolmv10718 Supersedes: pfdsolmv10218 Page 2 of 28 SOLU-MEDROL ACT-O-VIAL 500 mg/4 mL The vial compartment with [its.ecnet.jp]

• Glucose Increased

  Calcium, potassium, thyroxine, triiodothyronine: decreased levels Cholesterol, glucose: increased levels Nitroblue tetrazolium test for bacterial infection: false-negative result Drug-herbs. [medical-dictionary.thefreedictionary.com]

• Prolonged PR Interval

  Electrocardiogram showed slightly prolonged PR interval in sinus rhythm. Af occurred at high circulating levels of interferon-γ and interleukin (IL)-10, but not IL-6, IL-2, tumor necrosis factor-α, C-reactive protein or catecholamines. [ncbi.nlm.nih.gov]

longer treatment may be required. [drugs.com]

CONCLUSIONS: The combined treatment was more effective in reducing lumbar facet pain and improving the functional index than either treatment alone. This approach should be the preferred treatment. [ncbi.nlm.nih.gov]

However, RHS has, per se, a poorer prognosis than idiopathic facial palsy (Bell's palsy). [ncbi.nlm.nih.gov]

Influence of high dose methylprednisolone therapy on prognosis of acute transverse myelitis in children.. 2005; 20(3): 190-192 Sorumlu Yazar: Müferet Ergüven, Türkiye [journalagent.com]

What This Study Adds: High doses of methylprednisolone therapy lead to less frequent stricture formation in grade IIb esophageal burns in children who ingested caustic substances and may improve prognosis. [pediatrics.aappublications.org]

[…] corticosteroids were used, with the question of ‘one dose of corticosteroids does not fit for all patients’ to remain a hot point of interest.14 In this retrospective study, we investigated the effect of 3-day methylprednisolone pulses (MPs) on the prognosis [jim.bmj.com]

High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment. [ncbi.nlm.nih.gov]

It is unclear whether this late onset case of meningitis is directly attributable to the contaminated steroid injection or arose from an unrelated etiology. [cdc.gov]

[…] and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. [ncbi.nlm.nih.gov]

Discussion We describe epidemiologic and laboratory data from a multistate outbreak of fungal infections associated with injection of contaminated methylprednisolone acetate from a single compounding pharmacy. [nejm.org]

Vestibular neuronitis: epidemiological survey by questionnaire in Japan. Acta Otolaryngol Suppl 1993 ;503: 9 - 12 3. Ruttin B. Zur Differentialdiagnose der Labyrinth- und Hörnerverkrankungen. Z Ohrenheilkunde 1909 ;57: 327 - 333 4. Nylen CO. [doi.org]

Author information 1 a Section for Surgical Pathophysiology, Copenhagen University Hospital. 2 b The Lundbeck Foundation Centre for Fast-Track Hip and Knee Arthroplasty, Copenhagen. 3 c Physical Medicine & Rehabilitation Research-Copenhagen (PMR-C), Department [ncbi.nlm.nih.gov]

Dolhnikoff M, Mauad T, Bethlem EP, Carvalho CR (2007) Pathology and pathophysiology of pulmonary manifestations in leptospirosis. Braz J Infect Dis 11:142-148. [omicsonline.org]

SOME NEW NEUROPROTECTIVE OR NEURORESTORATIVE APPROACHES Novel Scavengers of ROS In view of the clear role of reactive oxygen or oxygen radical-induced LP in the pathophysiology of post-traumatic spinal cord degeneration, and the demonstrated benefits [rehab.research.va.gov]

[…] are distributed into milk and could suppress growth, interfere with endogenous glucocorticoid production, or cause other adverse effects in nursing infants. c d m Discontinue nursing or the drug. m Pediatric Use The effects of glucocorticoids on the pathophysiology [web.archive.org]

However, the roles of corticosteroids and nonsteroidal anti-inflammatory drugs in PPS prevention remains unclear. This study aimed to determine whether the intraoperative use of single-dose methylprednisolone can effectively prevent PPS. [ncbi.nlm.nih.gov]

Lupron temporarily suppresses pituitary and ovarian hormone production and prevents ovulation from occurring prior to oocyte retrieval. [web.archive.org]

The short-term use of corticosteroids antepartum for the prevention of respiratory distress syndrome does not seem to pose a risk to the fetus or newborn infant. [drugs.com]