There were differing vascular patterns of presentation: 2 patients presented with small-vessel (lacunar) infarctions, whereas 1 patient presented with a large-vessel infarct. [ncbi.nlm.nih.gov]

• Intravenous Administration

  We describe the development of acute hypokalemic paralysis in a middle-aged Caucasian man with recently diagnosed thyrotoxicosis and severe, active Graves' opthalmopathy who developed progressive flaccid paralysis 12 hours following intravenous administration [ncbi.nlm.nih.gov]

  The acetate is often prepared in long-acting forms while the water-soluble, rapid-acting succinate is suitable for intravenous administration and is used in the treatment of shock. methylprednisolone-21-dimethylaminoacetate a long-acting glucocorticoid [medical-dictionary.thefreedictionary.com]

  Furthermore, with regard to the testing of high or mega-doses of the steroid in SCI patients, there was already considerable clinical experience with the intraveneous administration of doses as high, or higher, than 30 mg/kg in several clinical studies [rehab.research.va.gov]

• Relapsing Polychondritis

  polychondritis, synovitis of osteoarthritis (oral only). [drugs.com]

  polychondritis †, polymyalgia rheumatica † and giant-cell (temporal) arteritis †, or mixed connective tissue disease syndrome †. a c High dosage may be required for acute situations; after a response has been obtained, drug must often be continued for [web.archive.org]

• Euphoria

  Adverse reactions CNS: headache, restlessness, nervousness, depression, euphoria, personality changes, psychoses, vertigo, paresthesias, insomnia, adhesive arachnoiditis, conus medullaris syndrome, increased intracranial pressure, seizures, meningitis [medical-dictionary.thefreedictionary.com]

  Adverse reactions CNS: euphoria, insomnia, psychotic behavior, pseudotumor cerebri, vertigo, headache, paresthesia, seizures. [glowm.com]

  […] corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not affect the ultimate outcome or natural history of the disease Psychic derangements may appear when corticosteroids used, ranging from euphoria [reference.medscape.com]

  Extreme mood changes: Tell your healthcare provider right away if you have some or all of the following symptoms... euphoria (intense feeling of happiness or joy) insomnia mood swings personality changes severe depression Stunted growth in children: Growth [rxwiki.com]

• Fear

  TRPC5-deficient mice exhibit a reduced innate fear response and impaired motor control. In addition, outgrowth of hippocampal and cerebellar neurons is retarded by TRPC5. [ncbi.nlm.nih.gov]

  […] result in glaucoma or may occasionally damage the optic nerve. a c d e m May enhance the establishment of secondary bacterial, fungal, and viral infections of the eye. d e Use with caution in patients with active ocular herpes simplex infections for fear [drugs.com]

• Flaccid Paralysis

  We describe the development of acute hypokalemic paralysis in a middle-aged Caucasian man with recently diagnosed thyrotoxicosis and severe, active Graves' opthalmopathy who developed progressive flaccid paralysis 12 hours following intravenous administration [ncbi.nlm.nih.gov]

• Babinski Sign

  Neurological examination revealed Mini-Mental State Examination (MMSE) score of 5 of 30 points, leg hyper-reflexia with Babinski signs, and Parkinsonism. [ncbi.nlm.nih.gov]

I had my whole spine MRI, including the lumbar just recently, and over these years I've probably had the best workup done, as far Version: pfdsolmv10718 Supersedes: pfdsolmv10218 Page 2 of 28 SOLU-MEDROL ACT-O-VIAL 500 mg/4 mL The vial compartment with [its.ecnet.jp]

• Prolonged PR Interval

  Electrocardiogram showed slightly prolonged PR interval in sinus rhythm. Af occurred at high circulating levels of interferon-γ and interleukin (IL)-10, but not IL-6, IL-2, tumor necrosis factor-α, C-reactive protein or catecholamines. [ncbi.nlm.nih.gov]

• Liver Biopsy

  In 2 of the patients, liver biopsy showed periportal fibrosis, piecemeal necrosis, and inflammatory cell infiltrates. A rechallenge test confirmed a causal association in 1 case. [ncbi.nlm.nih.gov]

CONCLUSIONS: The combined treatment was more effective in reducing lumbar facet pain and improving the functional index than either treatment alone. This approach should be the preferred treatment. [ncbi.nlm.nih.gov]

However, RHS has, per se, a poorer prognosis than idiopathic facial palsy (Bell's palsy). [ncbi.nlm.nih.gov]

What This Study Adds: High doses of methylprednisolone therapy lead to less frequent stricture formation in grade IIb esophageal burns in children who ingested caustic substances and may improve prognosis. [pediatrics.aappublications.org]

Influence of high dose methylprednisolone therapy on prognosis of acute transverse myelitis in children.. 2005; 20(3): 190-192 Sorumlu Yazar: Müferet Ergüven, Türkiye [journalagent.com]

Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol. 2007;18(12):3177-3183. PubMed Google Scholar Crossref 4. Lv J, Zhang H, Zhou Y, Li G, Zou W, Wang H. [jamanetwork.com]

High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment. [ncbi.nlm.nih.gov]

It is unclear whether this late onset case of meningitis is directly attributable to the contaminated steroid injection or arose from an unrelated etiology. [cdc.gov]

[…] and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. [ncbi.nlm.nih.gov]

Discussion We describe epidemiologic and laboratory data from a multistate outbreak of fungal infections associated with injection of contaminated methylprednisolone acetate from a single compounding pharmacy. [nejm.org]

T.B.) and Epidemiology and Biometrics (K.P.M.), University of Munich, Munich; and the Department of Neurology, University of Mainz, Mainz (M.D., S.B.) — both in Germany. Address reprint requests to Dr. [doi.org]

Author information 1 a Section for Surgical Pathophysiology, Copenhagen University Hospital. 2 b The Lundbeck Foundation Centre for Fast-Track Hip and Knee Arthroplasty, Copenhagen. 3 c Physical Medicine & Rehabilitation Research-Copenhagen (PMR-C), Department [ncbi.nlm.nih.gov]

Dolhnikoff M, Mauad T, Bethlem EP, Carvalho CR (2007) Pathology and pathophysiology of pulmonary manifestations in leptospirosis. Braz J Infect Dis 11:142-148. [omicsonline.org]

[…] are distributed into milk and could suppress growth, interfere with endogenous glucocorticoid production, or cause other adverse effects in nursing infants. c d m Discontinue nursing or the drug. m Pediatric Use The effects of glucocorticoids on the pathophysiology [drugs.com]

SOME NEW NEUROPROTECTIVE OR NEURORESTORATIVE APPROACHES Novel Scavengers of ROS In view of the clear role of reactive oxygen or oxygen radical-induced LP in the pathophysiology of post-traumatic spinal cord degeneration, and the demonstrated benefits [rehab.research.va.gov]

However, the roles of corticosteroids and nonsteroidal anti-inflammatory drugs in PPS prevention remains unclear. This study aimed to determine whether the intraoperative use of single-dose methylprednisolone can effectively prevent PPS. [ncbi.nlm.nih.gov]

The short-term use of corticosteroids antepartum for the prevention of respiratory distress syndrome does not seem to pose a risk to the fetus or newborn infant. [drugs.com]