Presentation
There were differing vascular patterns of presentation: 2 patients presented with small-vessel (lacunar) infarctions, whereas 1 patient presented with a large-vessel infarct. [ncbi.nlm.nih.gov]
Entire Body System
- Intravenous Administration
We describe the development of acute hypokalemic paralysis in a middle-aged Caucasian man with recently diagnosed thyrotoxicosis and severe, active Graves' opthalmopathy who developed progressive flaccid paralysis 12 hours following intravenous administration [ncbi.nlm.nih.gov]
The acetate is often prepared in long-acting forms while the water-soluble, rapid-acting succinate is suitable for intravenous administration and is used in the treatment of shock. methylprednisolone-21-dimethylaminoacetate a long-acting glucocorticoid [medical-dictionary.thefreedictionary.com]
- Relapsing Polychondritis
polychondritis, synovitis of osteoarthritis (oral only). [drugs.com]
There is no evidence that tapering the dosage after improvement will prevent a relapse. [web.archive.org]
- Splenectomy
[…] congenital (erythroid) hypoplastic anemia. a d e f m High or even massive dosages decrease bleeding tendencies and normalize blood counts; does not affect the course or duration of hematologic disorders. c Glucocorticoids, immune globulin IV (IGIV), or splenectomy [web.archive.org]
Psychiatrical
- Euphoria
Adverse reactions CNS: headache, restlessness, nervousness, depression, euphoria, personality changes, psychoses, vertigo, paresthesias, insomnia, adhesive arachnoiditis, conus medullaris syndrome, increased intracranial pressure, seizures, meningitis [medical-dictionary.thefreedictionary.com]
Adverse reactions CNS: euphoria, insomnia, psychotic behavior, pseudotumor cerebri, vertigo, headache, paresthesia, seizures. [glowm.com]
[…] corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not affect the ultimate outcome or natural history of the disease Psychic derangements may appear when corticosteroids used, ranging from euphoria [reference.medscape.com]
Extreme mood changes: Tell your healthcare provider right away if you have some or all of the following symptoms... euphoria (intense feeling of happiness or joy) insomnia mood swings personality changes severe depression Stunted growth in children: Growth [rxwiki.com]
Workup
I had my whole spine MRI, including the lumbar just recently, and over these years I've probably had the best workup done, as far Version: pfdsolmv10718 Supersedes: pfdsolmv10218 Page 2 of 28 SOLU-MEDROL ACT-O-VIAL 500 mg/4 mL The vial compartment with [its.ecnet.jp]
X-Ray
- Pericardial Effusion
The presence and severity of pericardial effusion was determined by echocardiography, with chest X-ray used to assess pleural effusion. [ncbi.nlm.nih.gov]
effusions and the need for drainage procedures and decreases mortality (probably through control of hemodynamically threatening effusion) in acute tuberculous pericarditis. [web.archive.org]
Microbiology
- Plasmodium Falciparum
Cerebral Malaria Glucocorticoids are not effective and can have detrimental effects in the management of cerebral malaria caused by Plasmodium falciparum ; no longer recommended for this condition. c Acute Spinal Cord Injury Some evidence indicates that [web.archive.org]
Treatment
CONCLUSIONS: The combined treatment was more effective in reducing lumbar facet pain and improving the functional index than either treatment alone. This approach should be the preferred treatment. [ncbi.nlm.nih.gov]
longer treatment may be required. [drugs.com]
Prognosis
However, RHS has, per se, a poorer prognosis than idiopathic facial palsy (Bell's palsy). [ncbi.nlm.nih.gov]
Influence of high dose methylprednisolone therapy on prognosis of acute transverse myelitis in children.. 2005; 20(3): 190-192 Sorumlu Yazar: Müferet Ergüven, Türkiye [journalagent.com]
What This Study Adds: High doses of methylprednisolone therapy lead to less frequent stricture formation in grade IIb esophageal burns in children who ingested caustic substances and may improve prognosis. [pediatrics.aappublications.org]
Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol. 2007;18(12):3177-3183. PubMed Google Scholar Crossref 4. Lv J, Zhang H, Zhou Y, Li G, Zou W, Wang H. [jamanetwork.com]
Etiology
High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment. [ncbi.nlm.nih.gov]
It is unclear whether this late onset case of meningitis is directly attributable to the contaminated steroid injection or arose from an unrelated etiology. [cdc.gov]
Epidemiology
[…] and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. [ncbi.nlm.nih.gov]
Discussion We describe epidemiologic and laboratory data from a multistate outbreak of fungal infections associated with injection of contaminated methylprednisolone acetate from a single compounding pharmacy. [nejm.org]
Vestibular neuronitis: epidemiological survey by questionnaire in Japan. Acta Otolaryngol Suppl 1993 ;503: 9 - 12 3. Ruttin B. Zur Differentialdiagnose der Labyrinth- und Hörnerverkrankungen. Z Ohrenheilkunde 1909 ;57: 327 - 333 4. Nylen CO. [doi.org]
Pathophysiology
Author information 1 a Section for Surgical Pathophysiology, Copenhagen University Hospital. 2 b The Lundbeck Foundation Centre for Fast-Track Hip and Knee Arthroplasty, Copenhagen. 3 c Physical Medicine & Rehabilitation Research-Copenhagen (PMR-C), Department [ncbi.nlm.nih.gov]
Dolhnikoff M, Mauad T, Bethlem EP, Carvalho CR (2007) Pathology and pathophysiology of pulmonary manifestations in leptospirosis. Braz J Infect Dis 11:142-148. [omicsonline.org]
[…] are distributed into milk and could suppress growth, interfere with endogenous glucocorticoid production, or cause other adverse effects in nursing infants. c d m Discontinue nursing or the drug. m Pediatric Use The effects of glucocorticoids on the pathophysiology [web.archive.org]
Prevention
However, the roles of corticosteroids and nonsteroidal anti-inflammatory drugs in PPS prevention remains unclear. This study aimed to determine whether the intraoperative use of single-dose methylprednisolone can effectively prevent PPS. [ncbi.nlm.nih.gov]
The short-term use of corticosteroids antepartum for the prevention of respiratory distress syndrome does not seem to pose a risk to the fetus or newborn infant. [drugs.com]
Lupron temporarily suppresses pituitary and ovarian hormone production and prevents ovulation from occurring prior to oocyte retrieval. [web.archive.org]