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Methylprednisolone

6 Methylprednisolone


Presentation

  • There were differing vascular patterns of presentation: 2 patients presented with small-vessel (lacunar) infarctions, whereas 1 patient presented with a large-vessel infarct.[ncbi.nlm.nih.gov]
Intravenous Administration
  • We describe the development of acute hypokalemic paralysis in a middle-aged Caucasian man with recently diagnosed thyrotoxicosis and severe, active Graves' opthalmopathy who developed progressive flaccid paralysis 12 hours following intravenous administration[ncbi.nlm.nih.gov]
  • The acetate is often prepared in long-acting forms while the water-soluble, rapid-acting succinate is suitable for intravenous administration and is used in the treatment of shock. methylprednisolone-21-dimethylaminoacetate a long-acting glucocorticoid[medical-dictionary.thefreedictionary.com]
  • There have been a few reports of cardiac arrhythmias and/or circulatory collapse and/or cardiac arrest associated with the rapid intravenous administration of large doses of methylprednisolone (greater than 500 mg administered over a period of less than[medicines.org.uk]
Relapsing Polychondritis
  • polychondritis, synovitis of osteoarthritis (oral only).[drugs.com]
  • polychondritis †, polymyalgia rheumatica † and giant-cell (temporal) arteritis †, or mixed connective tissue disease syndrome †. a c High dosage may be required for acute situations; after a response has been obtained, drug must often be continued for[web.archive.org]
Reiter's Syndrome
  • ., rheumatoid arthritis, juvenile arthritis, psoriatic arthritis, acute gouty arthritis, posttraumatic osteoarthritis, synovitis of osteoarthritis, epicondylitis, acute nonspecific tenosynovitis, ankylosing spondylitis, Reiter syndrome †, rheumatic fever[drugs.com]
Splenectomy
  • […] congenital (erythroid) hypoplastic anemia. a d e f m High or even massive dosages decrease bleeding tendencies and normalize blood counts; does not affect the course or duration of hematologic disorders. c Glucocorticoids, immune globulin IV (IGIV), or splenectomy[drugs.com]
Macroglossia
  • A 35-year-old woman is described who developed an atypical reaction of isolated macroglossia after receiving intravenous methylprednisolone sodium succinate for myasthenic crisis.[ncbi.nlm.nih.gov]

Workup

  • I had my whole spine MRI, including the lumbar just recently, and over these years I've probably had the best workup done, as far Version: pfdsolmv10718 Supersedes: pfdsolmv10218 Page 2 of 28 SOLU-MEDROL ACT-O-VIAL 500 mg/4 mL The vial compartment with[its.ecnet.jp]
Plasmodium Falciparum
  • Cerebral Malaria Glucocorticoids are not effective and can have detrimental effects in the management of cerebral malaria caused by Plasmodium falciparum ; no longer recommended for this condition. c Acute Spinal Cord Injury Some evidence indicates that[drugs.com]

Treatment

  • CONCLUSIONS: The combined treatment was more effective in reducing lumbar facet pain and improving the functional index than either treatment alone. This approach should be the preferred treatment.[ncbi.nlm.nih.gov]
  • ; longer treatment may be required.[drugs.com]

Prognosis

  • However, RHS has, per se, a poorer prognosis than idiopathic facial palsy (Bell's palsy).[ncbi.nlm.nih.gov]
  • What This Study Adds: High doses of methylprednisolone therapy lead to less frequent stricture formation in grade IIb esophageal burns in children who ingested caustic substances and may improve prognosis.[pediatrics.aappublications.org]
  • Influence of high dose methylprednisolone therapy on prognosis of acute transverse myelitis in children. . 2005; 20(3): 190-192 Sorumlu Yazar: Müferet Ergüven, Türkiye[journalagent.com]
  • Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol . 2007;18(12):3177-3183. PubMed Google Scholar Crossref 4. Lv J, Zhang H, Zhou Y, Li G, Zou W, Wang H.[jamanetwork.com]

Etiology

  • High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment.[ncbi.nlm.nih.gov]
  • It is unclear whether this late onset case of meningitis is directly attributable to the contaminated steroid injection or arose from an unrelated etiology.[cdc.gov]

Epidemiology

  • […] and Reproductive Health, Reproductive Epidemiology Research Center , Royan Institute for Reproductive Biomedicine, ACECR , Tehran , Iran.[ncbi.nlm.nih.gov]
  • Discussion We describe epidemiologic and laboratory data from a multistate outbreak of fungal infections associated with injection of contaminated methylprednisolone acetate from a single compounding pharmacy.[nejm.org]
  • ., T.B.) and Epidemiology and Biometrics (K.P.M.), University of Munich, Munich; and the Department of Neurology, University of Mainz, Mainz (M.D., S.B.) — both in Germany. Address reprint requests to Dr.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Author information 1 a Section for Surgical Pathophysiology , Copenhagen University Hospital. 2 b The Lundbeck Foundation Centre for Fast-Track Hip and Knee Arthroplasty , Copenhagen. 3 c Physical Medicine & Rehabilitation Research-Copenhagen (PMR-C),[ncbi.nlm.nih.gov]
  • Dolhnikoff M, Mauad T, Bethlem EP, Carvalho CR (2007) Pathology and pathophysiology of pulmonary manifestations in leptospirosis. Braz J Infect Dis 11:142-148.[omicsonline.org]
  • […] are distributed into milk and could suppress growth, interfere with endogenous glucocorticoid production, or cause other adverse effects in nursing infants. c d m Discontinue nursing or the drug. m Pediatric Use The effects of glucocorticoids on the pathophysiology[drugs.com]
  • SOME NEW NEUROPROTECTIVE OR NEURORESTORATIVE APPROACHES Novel Scavengers of ROS In view of the clear role of reactive oxygen or oxygen radical-induced LP in the pathophysiology of post-traumatic spinal cord degeneration, and the demonstrated benefits[rehab.research.va.gov]

Prevention

  • However, the roles of corticosteroids and nonsteroidal anti-inflammatory drugs in PPS prevention remains unclear. This study aimed to determine whether the intraoperative use of single-dose methylprednisolone can effectively prevent PPS.[ncbi.nlm.nih.gov]
  • -The short-term use of corticosteroids antepartum for the prevention of respiratory distress syndrome does not seem to pose a risk to the fetus or newborn infant.[drugs.com]

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