Abstract In this report the effects of various receptor blockers on desimipramine (DMI)-induced prolactin (PRL) secretion in healthy male subjects are presented. [ncbi.nlm.nih.gov]

The first chapters of the book address the impact of migraine on a personal and societal level, the presentation, pathogenesis and treatment of migraine as well as the role of neurogenic inflammation. [books.google.com]

• Weakness

  Although methysergide is an ergot alkaloid, it is a weak vasoconstrictor and oxytocic. Methysergide is a more potent antagonist of peripheral serotonin receptors than other ergot alkaloids. [migraines.org]

  It is suggested that it might be due to the weak anticholinergic and/or antihistaminic properties of metergoline. [ncbi.nlm.nih.gov]

  • Miscellaneous : Weakness, joint pain, muscle pain, and mydriasis. Store it at room temperature and away from sunlight and moisture. [medindia.net]

  You still, though, should let your doctor know if you experience any of the following: body pains diarrhea dizziness drowsiness facial flush heartburn insomnia nausea vomiting weakness The following are serious side effects. [health.howstuffworks.com]

  […] immediately if you experience: Chest pains Difficulty breathing Back ache Difficulty passing urine Urine with an unusual color Unusual tiredness Numbness or tingling in hands or feet Rapid heartbeat Pallor or cyanosis of the hands or fingers Strong muscle weakness [humanitas.net]

• Inflammation

  The first chapters of the book address the impact of migraine on a personal and societal level, the presentation, pathogenesis and treatment of migraine as well as the role of neurogenic inflammation. [books.google.com]

  Gallium scintigraphy may demonstrate increased uptake, depending on the activity of inflammation. [emedicine.medscape.com]

  • Caution should be exercised in patients with history of autoimmune disease, hardening/inflammation of the arteries, blood clots, Raynaud's disease, stroke, uncontrolled high blood pressure, heart disease, scarring caused by a drug, severe infection [medindia.net]

  Peripherally, the drug inhibits serotonin-induced platelet aggregation, inflammation, and vasoconstriction. Serotonin is considered to be the chemical mediator controlling headaches, by either directly or indirectly lowering the pain threshold. [migraines.org]

  50mg/kg), fraction 2 (F2, molecular weight higher than 1 kDa, 1, 10, and 50mg/kg), and the references drugs morphine (5mg/kg), acetilsalicilic acid (200mg/kg), prometazine (30 mg/kg), and metisergide (5mg/kg) were evaluated on models of analgesia and inflammation [ncbi.nlm.nih.gov]

• Swelling

  • Metabolic : Swelling in the extremities, weight gain, decrease in white blood cells and eosinophilia. • Miscellaneous : Weakness, joint pain, muscle pain, and mydriasis. Store it at room temperature and away from sunlight and moisture. [medindia.net]

  You will need to work closely with your doctor if you experience any of these: blood pressure that's too low, called hypotension a narrowing of your blood vessels, called vasoconstriction a rapid heartbeat edema, or swelling a white blood cell deficiency [health.howstuffworks.com]

  Unusual tiredness Numbness or tingling in hands or feet Rapid heartbeat Pallor or cyanosis of the hands or fingers Strong muscle weakness Weight gain Severe dizziness (especially while standing) Vision problems Confusion Difficulty speaking Rash Itch Swelling [humanitas.net]

  Rash, Difficulty in sleeping (insomnia, Drowsiness, Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain, Weight gain, Dizziness, Leg cramps, Excessive fluid retention in the body tissues, resulting in swelling [canadapharmacyonline.com]

  These blood vessels swell, causing the pain and visual disturbances that often happen during an attack. Deseril prevents the attack by affecting the blood vessels in the brain. [nps.org.au]

• Weight Gain

  Weight gain has occurred with methysergide therapy. Maintain a healthy diet and exercise program to prevent weight gain. [drugs.com]

  • Metabolic : Swelling in the extremities, weight gain, decrease in white blood cells and eosinophilia. • Miscellaneous : Weakness, joint pain, muscle pain, and mydriasis. Store it at room temperature and away from sunlight and moisture. [medindia.net]

  Adverse Effects Retroperitoneal fibrosis Weight gain Edema Images: Related links to external sites (from Bing) Ontology: Methysergide (C0025842) Definition (MSH) An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. [fpnotebook.com]

  gain Severe dizziness (especially while standing) Vision problems Confusion Difficulty speaking Rash Itch Swelling of face, lips, tongue or throat Contraindications and warnings associated with the use of Methysergide Methysergide can compromise the [humanitas.net]

  Minor side effects with methysergide include: diarrhea dizziness or lightheadedness heartburn nausea, vomiting weight gain Let your doctor know about these side effects if they do not go away or if they annoy you. [migraines.org]

• Fever

  Serious side effects with methysergide include: chest pain or tightness cold hands or feet confusion or hallucinations (hearing and seeing things that are not really there) difficulty breathing fast or pounding heartbeat fever or chills increase or decrease [migraines.org]

  For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. [ndrugs.com]

  This syndrome is characterised by a constellation of symptoms (confusion, fever, shivering, diaphoresis, ataxia, hyperreflexia, myoclonus or diarrhoea) in the setting of the recent addition of a serotonergic agent. [doi.org]

• Dyspnea

  Rarely observed reactions have included: acute myocardial infarction, transient chest pains, vasoconstriction, vasospasm, coronary arterial spasm, bradycardia, tachycardia, dyspnea, hematuria, thrombophlebitis, water intoxication, hallucinations, leg [ndrugs.com]

  We have experienced apatient complaining of dyspnea due to right massive collection of hemorrhagic pleural fluid, who was strongly suspected of pancreatic hydrothorax from the elevated amylase level in the pleural fluid. [ameblo.jp]

• Pneumonia

  There is a great possibility of false negative or pleuritis carcinomatosa with non cacerous pleural effusion, if lung cancer is adenocarcinoma with no combined disease such as atelectasis or pneumonia and located in contact with pleura, even though cytology [ameblo.jp]

• Vomiting

  Minor side effects with methysergide include: diarrhea dizziness or lightheadedness heartburn nausea, vomiting weight gain Let your doctor know about these side effects if they do not go away or if they annoy you. [migraines.org]

  Methysergide also significantly impaired performance of a psychomotor task on the first day of high-dose administration and increased ratings of several subjective measures, including "Vomiting," "Stomach Pain," and "Miserable." [ncbi.nlm.nih.gov]

  • Gastrointestinal : Nausea, vomiting, diarrhea, heartburn and abdominal pain. • Central Nervous System : Seizures, sleeplessness, drowsiness, mild euphoria, dizziness, incoordination, lightheadedness, tingling. • Skin : Facial flush, hair loss. • Metabolic [medindia.net]

  You still, though, should let your doctor know if you experience any of the following: body pains diarrhea dizziness drowsiness facial flush heartburn insomnia nausea vomiting weakness The following are serious side effects. [health.howstuffworks.com]

  Methysergide passes into breast milk and can cause vomiting and diarrhea in a nursing infant. Do not take methysergide if you are breast-feeding a baby. How should I take methysergide? Take methysergide exactly as directed by your doctor. [drugs.com]

• Nausea

  Minor side effects with methysergide include: diarrhea dizziness or lightheadedness heartburn nausea, vomiting weight gain Let your doctor know about these side effects if they do not go away or if they annoy you. [migraines.org]

  • Gastrointestinal : Nausea, vomiting, diarrhea, heartburn and abdominal pain. • Central Nervous System : Seizures, sleeplessness, drowsiness, mild euphoria, dizziness, incoordination, lightheadedness, tingling. • Skin : Facial flush, hair loss. • Metabolic [medindia.net]

  You still, though, should let your doctor know if you experience any of the following: body pains diarrhea dizziness drowsiness facial flush heartburn insomnia nausea vomiting weakness The following are serious side effects. [health.howstuffworks.com]

  Among the other possible side effects of Methysergide include the following: Nausea Vomiting Diarrhea Dizziness Drowsiness Stomach problems Heartburn Insomnia Redness You should contact a doctor immediately if you experience: Chest pains Difficulty breathing [humanitas.net]

  SIDE EFFECTS: Nausea, vomiting, diarrhea, dizziness, drowsiness, stomach upset, heartburn, trouble sleeping, and flushing may occur. [medicinenet.com]

• Diarrhea

  Minor side effects with methysergide include: diarrhea dizziness or lightheadedness heartburn nausea, vomiting weight gain Let your doctor know about these side effects if they do not go away or if they annoy you. [migraines.org]

  • Gastrointestinal : Nausea, vomiting, diarrhea, heartburn and abdominal pain. • Central Nervous System : Seizures, sleeplessness, drowsiness, mild euphoria, dizziness, incoordination, lightheadedness, tingling. • Skin : Facial flush, hair loss. • Metabolic [medindia.net]

  You still, though, should let your doctor know if you experience any of the following: body pains diarrhea dizziness drowsiness facial flush heartburn insomnia nausea vomiting weakness The following are serious side effects. [health.howstuffworks.com]

  Methysergide passes into breast milk and can cause vomiting and diarrhea in a nursing infant. Do not take methysergide if you are breast-feeding a baby. How should I take methysergide? Take methysergide exactly as directed by your doctor. [drugs.com]

  Among the other possible side effects of Methysergide include the following: Nausea Vomiting Diarrhea Dizziness Drowsiness Stomach problems Heartburn Insomnia Redness You should contact a doctor immediately if you experience: Chest pains Difficulty breathing [humanitas.net]

• Abdominal Pain

  Vasoconstriction also can precipitate chest (angina) or abdominal pain. Methysergide is structurally similar to the hallucinogen lysergic acid diethylamide (LSD). [migraines.org]

  • Gastrointestinal : Nausea, vomiting, diarrhea, heartburn and abdominal pain. • Central Nervous System : Seizures, sleeplessness, drowsiness, mild euphoria, dizziness, incoordination, lightheadedness, tingling. • Skin : Facial flush, hair loss. • Metabolic [medindia.net]

  […] or chest; shortness of breath; pain, coldness or numbness in your legs or arms; severe abdominal pain; or loss of vision. [netdoctor.co.uk]

  Rash, Difficulty in sleeping (insomnia, Drowsiness, Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain, Weight gain, Dizziness, Leg cramps, Excessive fluid retention in the body tissues, resulting in swelling [canadapharmacyonline.com]

  Like all medicines methylergometrine can cause side effects, including: Common: increase in blood pressure headache hypotension Uncommon: abdominal pain nausea and vomiting Rare: heart attack transient chest pain narrowing of blood vessels vasospasm, [euromeds-doctor.com]

• Pyrosis

  Adverse GI effects are common during therapy with methysergide and include nausea/vomiting, diarrhea, pyrosis (heartburn), and abdominal pain. Gradual dosage increase and administration with food help to minimize these reactions. [migraines.org]

• Heart Disease

  Steve Miller and Brigid Colleen Flynn, Valvular Heart Disease and Postoperative Considerations, Seminars in Cardiothoracic and Vascular Anesthesia, 19, 2, (130), (2015). [doi.org]

  • Caution should be exercised in patients with history of autoimmune disease, hardening/inflammation of the arteries, blood clots, Raynaud's disease, stroke, uncontrolled high blood pressure, heart disease, scarring caused by a drug, severe infection [medindia.net]

  liver or renal function impairment, valvular heart disease, debilitation, or serious infection. [ncbi.nlm.nih.gov]

  They need to know if you have any of these conditions: chest pain heart or blood vessel disease infection kidney disease liver disease lung disease peptic ulcer phlebitis rheumatoid arthritis tobacco smoker an unusual or allergic reaction to methysergide [migraines.org]

• Flushing

  • Skin : Facial flush, hair loss. • Metabolic : Swelling in the extremities, weight gain, decrease in white blood cells and eosinophilia. • Miscellaneous : Weakness, joint pain, muscle pain, and mydriasis. [medindia.net]

  You still, though, should let your doctor know if you experience any of the following: body pains diarrhea dizziness drowsiness facial flush heartburn insomnia nausea vomiting weakness The following are serious side effects. [health.howstuffworks.com]

  Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. [webmd.com]

  SIDE EFFECTS: Nausea, vomiting, diarrhea, dizziness, drowsiness, stomach upset, heartburn, trouble sleeping, and flushing may occur. [medicinenet.com]

  Continue to take methysergide and talk to your doctor if you experience nausea, vomiting, heartburn, or abdominal pain; diarrhea or constipation; drowsiness, dizziness, or lightheadedness; weakness or poor coordination; insomnia; a rash or facial flushing [drugs.com]

• Euphoria

  • Central Nervous System : Seizures, sleeplessness, drowsiness, mild euphoria, dizziness, incoordination, lightheadedness, tingling. • Skin : Facial flush, hair loss. • Metabolic : Swelling in the extremities, weight gain, decrease in white blood cells [medindia.net]

  When using the drug may dyspeptic symptoms, insomnia, euphoria and other side effects. In rare cases, there is a special side effect - inflammatory fibrosis in various organs. [en.medicine-cure.com]

  Aromatic heteropolycyclic compound Molecular FrameworkAromatic heteropolycyclic compoundsExternal Descriptors monocarboxylic acid amide ( CHEBI:584020 ) ergot alkaloid ( CHEBI:584020 ) OntologyPhysiological effect Health effect: Observation: Tachycardia Euphoria [hmdb.ca]

• Headache

  Reference programme: Diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 2nd edition, 2012. J Headache Pain 2012; 13 Suppl 1: S1–S29. Google Scholar 6. [doi.org]

  This position was supported by the International Headache Society. [ncbi.nlm.nih.gov]

  Methysergide (1-methyl-D-lysergic acid butanolamide or UML-491) is a prescription drug formerly used for prophylaxis of cluster headaches/migraine headaches, but is no longer recommended due to retroperitoneal/retropulmonary fibrosis. [dbpedia.org]

  Treatment of primary headache: cluster headache. In: Standards of care for headache diagnosis and treatment. Chicago (IL): National Headache Foundation. 2004. [Full Text]. [Guideline] Beithon J, Gallenberg M, Johnson K, et al. [medscape.com]

  Many headache entities are discussed for the first time, such as chronic migraines; primary headache attributed to sexual activity; primary stabbing, cough, exertional, and thunderclap headaches; hypnic headaches; and new daily persistent headaches. [books.google.com]

• Dizziness

  • It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication. • Most Common : Fibrotic complications and heart diseases. • Gastrointestinal : Nausea, vomiting, diarrhea, heartburn and abdominal pain. • [medindia.net]

  Among the other possible side effects of Methysergide include the following: Nausea Vomiting Diarrhea Dizziness Drowsiness Stomach problems Heartburn Insomnia Redness You should contact a doctor immediately if you experience: Chest pains Difficulty breathing [humanitas.net]

  You may get dizzy or drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how methysergide affects you. [migraines.org]

  SIDE EFFECTS: Nausea, vomiting, diarrhea, dizziness, drowsiness, stomach upset, heartburn, trouble sleeping, and flushing may occur. [medicinenet.com]

  You still, though, should let your doctor know if you experience any of the following: body pains diarrhea dizziness drowsiness facial flush heartburn insomnia nausea vomiting weakness The following are serious side effects. [health.howstuffworks.com]

• Stroke

  Since the "natural history of human stroke" results in a 30-40% mortality within the first three weeks, an aggressive new attempt should be directed to increasing the number of survivors in this initial period of high risk. [ncbi.nlm.nih.gov]

  The neurologist strokes or scratches, heel-to-toe, the outer side of the sole of the foot and in patients over the age of 2, the toes normally curl downward in response. If the toes fan upward, a brain or spinal cord injury is indicated. [neurologychannel.com]

  • Caution should be exercised in patients with history of autoimmune disease, hardening/inflammation of the arteries, blood clots, Raynaud's disease, stroke, uncontrolled high blood pressure, heart disease, scarring caused by a drug, severe infection [medindia.net]

  Case-control study of migraine and risk of ischaemic stroke in young women. Br Med J 1995; 310:830-3. ‎ [books.google.com]

  […] if you have hypertension (high blood pressure) if you have eclampsia or preeclampsia if you are pregnant In particular, you must tell the doctor if you: have angina or other heart problems have blood vessel disease have high blood pressure have had a stroke [euromeds-doctor.com]

• Tingling

  • Central Nervous System : Seizures, sleeplessness, drowsiness, mild euphoria, dizziness, incoordination, lightheadedness, tingling. • Skin : Facial flush, hair loss. • Metabolic : Swelling in the extremities, weight gain, decrease in white blood cells [medindia.net]

  Dizziness Drowsiness Stomach problems Heartburn Insomnia Redness You should contact a doctor immediately if you experience: Chest pains Difficulty breathing Back ache Difficulty passing urine Urine with an unusual color Unusual tiredness Numbness or tingling [humanitas.net]

  Ischemia, resulting from peripheral vasoconstriction or vasospasm during therapy with methysergide, can manifest as itching; numbness or tingling of fingers, toes, or face; limb pain; cold hands/feet; or leg weakness. [migraines.org]

  Most of these symptoms, especially those that affect the nose, are more likely to occur if you use the nasal spray: stuffy nose tingling or pain in the nose or throat dryness in the nose nosebleed taste changes upset stomach vomiting dizziness extreme [medlineplus.gov]

  Contact your doctor immediately if you experience chest pain, rapid heartbeat, shortness of breath, painful urination, tingling in the hands or feet, or leg cramps. Also report any numbness, pain, tingling or cold sensation of the hands or feet. [norphar.com]

• Insomnia

  You still, though, should let your doctor know if you experience any of the following: body pains diarrhea dizziness drowsiness facial flush heartburn insomnia nausea vomiting weakness The following are serious side effects. [health.howstuffworks.com]

  Among the other possible side effects of Methysergide include the following: Nausea Vomiting Diarrhea Dizziness Drowsiness Stomach problems Heartburn Insomnia Redness You should contact a doctor immediately if you experience: Chest pains Difficulty breathing [humanitas.net]

  When using the drug may dyspeptic symptoms, insomnia, euphoria and other side effects. In rare cases, there is a special side effect - inflammatory fibrosis in various organs. [en.medicine-cure.com]

  Rash, Difficulty in sleeping (insomnia, Drowsiness, Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain, Weight gain, Dizziness, Leg cramps, Excessive fluid retention in the body tissues, resulting in swelling [canadapharmacyonline.com]

  Continue to take methysergide and talk to your doctor if you experience nausea, vomiting, heartburn, or abdominal pain; diarrhea or constipation; drowsiness, dizziness, or lightheadedness; weakness or poor coordination; insomnia; a rash or facial flushing [drugs.com]

• Neutropenia

  Neutropenia and eosinophilia have rarely been reported. Patient Information: Methysergide tablets What do methysergide tablets do? METHYSERGIDE (Sansert®) is one of a group of medicines known as ergot alkaloids. [migraines.org]

Treatment must be discontinued if symptoms suggesting fibrosis occur unless an alternative cause is confirmed The continued need for methysergide treatment must be reassessed every 6 months using a treatment-free interval of at least 4 weeks between treatment [gov.uk]

During treatment with methysergide, a treatment-free period of at least 4 weeks must be allowed between treatment courses at least every 6 months. [migrainetrust.org]

The continued need for treatment must be reassessed every six months using a treatment-free interval of at least four weeks between courses, states the DSU. [pharmaceutical-journal.com]

These symptoms led to diagnosis of Parkinson disease and treatment with L-Dopa + anticholinergics drugs. The treatment with antiparkinsonian drugs was suspended and no change in his clinical condition resulted. [ncbi.nlm.nih.gov]

Both groups were compared for prognosis. No 5-year survivor was noted in the both groups, and there was no significant difference in the prognosis between them. though prognoses of them were poor. [ameblo.jp]

Evaluating a person's intellectual capacity can also be helpful in determining a course of treatment and making a prognosis. [neurologychannel.com]

When one of the above arteriographic patterns is recognized, methysergide ingestion should be considered as a possible etiology. [ncbi.nlm.nih.gov]

In most patients (approximately 68%), no etiologic factor is found. Therefore, the term idiopathic RFP is used. [emedicine.medscape.com]

It is important to take chemical pleurisy into consideration when dealing with pleural effusion of unknown etiology. [ameblo.jp]

Page 12 - Gobel H, Petersen-Braun M, Soyka D: The epidemiology of headache in Germany: A nationwide survey of a representative sample on the basis of the headache classification of the International Headache Society. Cephalalgia 1994;14:97-106. ‎ [books.google.com]

Migraine: Manifestations, Pathophysiology, and Management, Second Edition, is a much expanded, updated monograph that focuses in detail on migraine's diverse variations, its pathophysiology, and its treatment. [books.google.com]

Its potent vasoactivity led to the hypothesis that altered serotonin metabolism was responsible for the pathophysiology of cerebrovascular disease (infarction & hemorrhage) with documentation of elevated levels of serotonin in CSF. [ncbi.nlm.nih.gov]

Daniel Segelcke and Karl Messlinger, Putative role of 5-HT2B receptors in migraine pathophysiology, Cephalalgia, 37, 4, (365), (2017). T. S. Gan’shina, A. A. Gorbunov, A. V. Gnezdilova, A. I. Turilova, L. M. Kostochka, B. M. Pyatin, N. I. [doi.org]

Based on the possible involvement of serotonin in migraine attacks, it was introduced in 1959 by Sicuteri as a preventive drug for migraine. [ncbi.nlm.nih.gov]

† Related Articles IN 1959 Sicuteri1 first reported the effectiveness of methysergide‡ in the prevention of migraine. [nejm.org]

As a result of this, the use of these medicines is being restricted to the prevention of severe intractable migraines and cluster headaches when standard medicines have failed. [ema.europa.eu]

The symptoms of fibrosis often take some time to appear and without screening the diagnosis may come too late to prevent damage to organs. [migrainetrust.org]

The NPS article Headache – Diagnosing, managing and preventing, offers a brief overview and links to other resources. [hps.com.au]