Abstract In this report the effects of various receptor blockers on desimipramine (DMI)-induced prolactin (PRL) secretion in healthy male subjects are presented. [ncbi.nlm.nih.gov]

The first chapters of the book address the impact of migraine on a personal and societal level, the presentation, pathogenesis and treatment of migraine as well as the role of neurogenic inflammation. [books.google.com]

• Pathologist

  §Pathologist, Faulkner Hospital; clinical associate professor of pathology, Harvard Medical School. ¶Radiologist, Faulkner Hospital; instructor in radiology, Harvard Medical School. [doi.org]

• Pallor

  Heartburn Insomnia Redness You should contact a doctor immediately if you experience: Chest pains Difficulty breathing Back ache Difficulty passing urine Urine with an unusual color Unusual tiredness Numbness or tingling in hands or feet Rapid heartbeat Pallor [humanitas.net]

• Dyspnea

  Rarely observed reactions have included: acute myocardial infarction, transient chest pains, vasoconstriction, vasospasm, coronary arterial spasm, bradycardia, tachycardia, dyspnea, hematuria, thrombophlebitis, water intoxication, hallucinations, leg [ndrugs.com]

  We have experienced apatient complaining of dyspnea due to right massive collection of hemorrhagic pleural fluid, who was strongly suspected of pancreatic hydrothorax from the elevated amylase level in the pleural fluid. [ameblo.jp]

• Nasal Congestion

  congestion, diarrhea, diaphoresis, palpitation, rash, and foul taste. [ndrugs.com]

• Cyanosis

  Insomnia Redness You should contact a doctor immediately if you experience: Chest pains Difficulty breathing Back ache Difficulty passing urine Urine with an unusual color Unusual tiredness Numbness or tingling in hands or feet Rapid heartbeat Pallor or cyanosis [humanitas.net]

  In adults, peripheral vasospasm, with diminished or absent pulses, coldness, mottling and cyanosis, has been observed at a dose of 200 mg. Ischemic tissue damage has not been reported in acute overdosage with methysergide. [drugbank.ca]

• Tinnitus

  […] reactions have included: acute myocardial infarction, transient chest pains, vasoconstriction, vasospasm, coronary arterial spasm, bradycardia, tachycardia, dyspnea, hematuria, thrombophlebitis, water intoxication, hallucinations, leg cramps, dizziness, tinnitus [ndrugs.com]

• Facial Pain

  Reference programme: Diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 2nd edition, 2012. J Headache Pain 2012; 13 Suppl 1: S1–S29. Google Scholar 6. [doi.org]

• Excitement

  Pulm Pharmacol Ther. 2000;13(6):277-85. [ PubMed:11061982 ] Prins NH, Akkermans LM, Lefebvre RA, Schuurkes JA: Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle. [drugbank.ca]

• Renal Function Impairment

  function impairment, valvular heart disease, debilitation, or serious infection. [ncbi.nlm.nih.gov]

Treatment must be discontinued if symptoms suggesting fibrosis occur unless an alternative cause is confirmed The continued need for methysergide treatment must be reassessed every 6 months using a treatment-free interval of at least 4 weeks between treatment [gov.uk]

During treatment with methysergide, a treatment-free period of at least 4 weeks must be allowed between treatment courses at least every 6 months. [migrainetrust.org]

The continued need for treatment must be reassessed every six months using a treatment-free interval of at least four weeks between courses, states the DSU. [pharmaceutical-journal.com]

These symptoms led to diagnosis of Parkinson disease and treatment with L-Dopa + anticholinergics drugs. The treatment with antiparkinsonian drugs was suspended and no change in his clinical condition resulted. [ncbi.nlm.nih.gov]

Both groups were compared for prognosis. No 5-year survivor was noted in the both groups, and there was no significant difference in the prognosis between them. though prognoses of them were poor. [ameblo.jp]

Evaluating a person's intellectual capacity can also be helpful in determining a course of treatment and making a prognosis. [neurologychannel.com]

When one of the above arteriographic patterns is recognized, methysergide ingestion should be considered as a possible etiology. [ncbi.nlm.nih.gov]

In most patients (approximately 68%), no etiologic factor is found. Therefore, the term idiopathic RFP is used. [emedicine.medscape.com]

It is important to take chemical pleurisy into consideration when dealing with pleural effusion of unknown etiology. [ameblo.jp]

Page 12 - Gobel H, Petersen-Braun M, Soyka D: The epidemiology of headache in Germany: A nationwide survey of a representative sample on the basis of the headache classification of the International Headache Society. Cephalalgia 1994;14:97-106. ‎ [books.google.com]

Migraine: Manifestations, Pathophysiology, and Management, Second Edition, is a much expanded, updated monograph that focuses in detail on migraine's diverse variations, its pathophysiology, and its treatment. [books.google.com]

Its potent vasoactivity led to the hypothesis that altered serotonin metabolism was responsible for the pathophysiology of cerebrovascular disease (infarction & hemorrhage) with documentation of elevated levels of serotonin in CSF. [ncbi.nlm.nih.gov]

Daniel Segelcke and Karl Messlinger, Putative role of 5-HT2B receptors in migraine pathophysiology, Cephalalgia, 37, 4, (365), (2017). T. S. Gan’shina, A. A. Gorbunov, A. V. Gnezdilova, A. I. Turilova, L. M. Kostochka, B. M. Pyatin, N. I. [doi.org]

Based on the possible involvement of serotonin in migraine attacks, it was introduced in 1959 by Sicuteri as a preventive drug for migraine. [ncbi.nlm.nih.gov]

† Related Articles IN 1959 Sicuteri1 first reported the effectiveness of methysergide‡ in the prevention of migraine. [nejm.org]

As a result of this, the use of these medicines is being restricted to the prevention of severe intractable migraines and cluster headaches when standard medicines have failed. [ema.europa.eu]

The symptoms of fibrosis often take some time to appear and without screening the diagnosis may come too late to prevent damage to organs. [migrainetrust.org]

The NPS article Headache – Diagnosing, managing and preventing, offers a brief overview and links to other resources. [hps.com.au]