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Metoprolol


Presentation

  • We present a case involving a 66-year-old woman with a history of childhood somnambulism who presented with a recent recurrence of sleepwalking.[ncbi.nlm.nih.gov]
  • It has been estimated that up to 27% of all medical emergencies presenting to emergency departments are due to hypertension, predominantly in the adult population.[ncbi.nlm.nih.gov]
  • Abstract We report the case of a young man who presented with a rapid, narrow-complex atrial fibrillation.[ncbi.nlm.nih.gov]
  • Three days after her initial presentation and cessation of metoprolol treatment, she was transferred to our clinic to be considered for permanent pacemaker implantation.[ncbi.nlm.nih.gov]
  • (OR, 27.8; 95% CI, 4.704-272.894; p 0.001); a history of calcium channel blocker use prior to ED presentation was a negative predictor of β-blocker use for initial rate control (OR, 0.1; 95% CI, 0.005-0.265; p 0.002).[ncbi.nlm.nih.gov]
Intravenous Administration
  • In a patient with hypertensive crisis following abrupt cessation of clonidine hydrochloride and metoprolol tartrate, intravenous administration of labetalol hydrochloride rapidly reduced blood pressure and heart rate to precrisis levels.[ncbi.nlm.nih.gov]
  • In addition, the absolute bioavailability of the drug (ie, relative to intravenous administration) following sublingual administration was found to be significantly higher (91.06% 13.28%), as compared with that after oral tablet administration (39.37%[ncbi.nlm.nih.gov]
  • During the intravenous administration of metoprolol tartrate, blood pressure, heart rate, and electrocardiogram should be carefully monitored.[globalrph.com]
Developmental Delay
  • We discuss the case of a 12-year-old female with spastic cerebral palsy and global developmental delay secondary to neonatal asphyxia who presented to the emergency department after having a seizure at home.[ncbi.nlm.nih.gov]
Burning Pain
  • She also presented with pruritic burning pain throughout her body accompanied by chills.[ncbi.nlm.nih.gov]
Exertional Dyspnea
  • A 38-year-old female had felt exertional dyspnea for six months. Physical examination and laboratory data including angiotensin-converting enzyme, failed to diagnose sarcoidosis.[ncbi.nlm.nih.gov]
Hypoventilation
  • Clinical signs included coma, seizures, hypoventilation, unmeasurable blood pressure, nodal bradycardia, and metabolic acidosis.[ncbi.nlm.nih.gov]
Nausea
  • According to the manufacturer, the most common digestive problems that occur in 1 to 9.9 percent of people taking the medication include nausea, diarrhea, constipation and abdominal pain.[livestrong.com]
  • Effects Metoprolol succinate side effects include constipation, dizziness, headache, dry mouth, heartburn, drowsiness, nausea, difficulty sleeping, muscle aches, stomach pain and vomiting.[healthfully.com]
  • Side effects include fever, impotence, sore throat, nausea, depression, insomnia, constipation, memory loss, and high blood pressure.[medicinenet.com]
  • Contact your doctor if you experience these symptoms and if they do not go away: dizziness or lightheadedness runny nose fatigue depression nausea dry mouth stomach pain vomiting heartburn, gas or bloating constipation rash or itching cold hands and feet[helprx.info]
Vomiting
  • Overdose symptoms include heart failure, cardiac arrest, coma, loss of consciousness, vomiting, coma, extremely low blood pressure, slow heartbeat and atrioventricular block.[healthfully.com]
  • […] or stiffness numbness of the fingers or toes pain, swelling, or redness in the joints rash sore throat sores, ulcers, or white spots on the lips or in the mouth unpleasant breath odor unusual bleeding or bruising upper right abdominal or stomach pain vomiting[medicalpublications.org]
  • Call your doctor if you are sick with vomiting or diarrhea , or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use hydrochlorothiazide and metoprolol.[emedicinehealth.com]
  • Less common possible side effects include vomiting, heartburn, dry mouth and stomach gas. Rarely, metoprolol has been linked to liver inflammation.[livestrong.com]
  • Contact your doctor if you experience these symptoms and if they do not go away: dizziness or lightheadedness runny nose fatigue depression nausea dry mouth stomach pain vomiting heartburn, gas or bloating constipation rash or itching cold hands and feet[helprx.info]
Orthostatic Hypotension
  • If patient is hypotensive or has bradycardia, consult prescriber before giving dose. • Watch for orthostatic hypotension in at-risk patients, particularly the elderly. • Assess glucose levels in diabetic patient.[medical-dictionary.thefreedictionary.com]
Auditory Hallucination
  • Clinical features included confusion/disorientation in all subjects, agitation in 13, aggression in 6, visual hallucinations in 7, auditory hallucinations in 1, paranoid delusions in 3, vivid dreams in 2 and language disturbances in 3 persons.[ncbi.nlm.nih.gov]
Delusion
  • Clinical features included confusion/disorientation in all subjects, agitation in 13, aggression in 6, visual hallucinations in 7, auditory hallucinations in 1, paranoid delusions in 3, vivid dreams in 2 and language disturbances in 3 persons.[ncbi.nlm.nih.gov]
Headache
  • Migraine Headache Migraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on...[medicinenet.com]
  • It is used to treat high blood pressure, fast or irregular heartbeat, chest pain, migraine headache and tremors. This medication is available as an injection, tablet, or your pharmacist may be able to make a liquid.[cincinnatichildrens.org]
  • Migraine according to the International Headache Society (IHS) criteria 1.3. At least one of the following migrainous symptoms during at least two vertiginous attacks: migrainous headache, photophobia, phonophobia, visual or other auras 1.4.[isrctn.com]
  • Metoprolol is also used to prevent migraine headaches. In New Zealand metoprolol comes as tablets. Dose The dose of metoprolol will be different for different people.[healthnavigator.org.nz]
Coarse Tremor
  • A case report is presented documenting definite beneficial effect of metoprolol, a beta-selective adrenoceptor antagonist, in alleviating neuroleptic-induced coarse tremors. The tremors could not be controlled with antiparkinsonian agents.[ncbi.nlm.nih.gov]

Workup

  • An extensive workup revealed the patient had gallstones, however, her hypertension did not resolve with pain control and, ultimately, cholecystectomy.[ncbi.nlm.nih.gov]

Treatment

  • A single oral dose of metoprolol (100 mg) was administered with water (treatment A) and sarpogrelate (100 mg bid.; a total dose of 200 mg and treatment B), or after pretreatment of sarpogrelate for three days (100 mg tid.; treatment C).[ncbi.nlm.nih.gov]
  • Initial treatment of bradycardia and hypotension included glucagon, atropine, dopamine, and norepinephrine. Despite these treatment modalities, the patient developed cardiac arrest.[ncbi.nlm.nih.gov]
  • After discontinuation of the drug and repetitive topical treatment with tacrolimus a complete remission of the lesions could be achieved.[ncbi.nlm.nih.gov]
  • Abstract Medical treatment is the main clinical strategy for controlling patients with chronic stable angina and improving their quality of life (QoL).[ncbi.nlm.nih.gov]
  • Fifty patients were administered metoprolol succinate treatment (1 x 50 mg), whereas the remaining 50 patients were administered carvedilol treatment (2 x 12.5 mg). Thereafter, all of the patients underwent coronary angiography.[ncbi.nlm.nih.gov]

Prognosis

  • This patient is alive for one year after treatment and the combination therapy seems to contribute to good prognosis.[ncbi.nlm.nih.gov]
  • OBJECTIVE: Serum gamma-glutamyltransferase (GGT) and uric acid levels measured in patients with acute coronary syndrome without ST segment elevation (NSTEMI) are important in diagnosis and in predicting the prognosis of the disease.[ncbi.nlm.nih.gov]
  • ., (1998) [ 20 ] showed that metoprolothe in the dosage of 100 mg per day reduced the tone of the sympathetic nervous system, improved prognosis for the disease in patients with AP with II-III NYHA functional class.[hoajonline.com]
  • The importance of the findings in this study for the prognosis of patients is unknown, but the result could inspire to further studies of the importance of vascular insulin sensitivity given the favorable effects of carvedilol compared to metoprolol observed[cardiab.biomedcentral.com]

Etiology

  • The diagnosis of somnambulism was confirmed polysomnographically and linked etiologically to the start of using metoprolol, a lipophilic beta-blocker, for treating her hypertension.[ncbi.nlm.nih.gov]
  • Caverno-occlusive and autonomic dysfunction has been proposed as a new concept in the etiology of erectile dysfunction in young men. 6 Moxonidine is a centrally acting sympatholytic antihypertensive agent, which binds selectively and with high affinity[nature.com]
  • "Hyposalivation and Xerostomia: Etiology, Complications, and Medical Management". Dent. Clin. North Am. 60 (2): 435–43. doi : 10.1016/j.cden.2015.11.003. PMID 27040294. a b "Metoprolol". Drugs.com. Archived from the original on 2010-01-21.[en.wikipedia.org]

Epidemiology

  • Clinical epidemiological investigations have demonstrated that hypertensive patients treated with β1-selective β-blockers have a higher bone mineral density (BMD) and lower fracture risk.[ncbi.nlm.nih.gov]
  • Pasternak, from the department of epidemiology research at Statens Serum Institut, Copenhagen, Denmark, and colleagues found that compared with metoprolol succinate users, the adjusted HR for all-cause mortality for carvedilol users was 0.99 (95% CI,[healio.com]
Sex distribution
Age distribution

Pathophysiology

  • Author information 1 Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Hospital Universitario Central de Asturias, Oviedo, Spain. 2 Myocardial Pathophysiology Area, Centro Nacional de[ncbi.nlm.nih.gov]
  • Pediatrics, Kaifeng Children's Hospital, Henan, China. 3 University of California San Diego, La Jolla, California, United States of America. 4 Department of Medical Statistics, Peking University First Hospital, Beijing, China. 5 Department of Physiology and Pathophysiology[ncbi.nlm.nih.gov]
  • The pathophysiology may be either failure of venous return or progressive vasodilation, both due to inappropriately low sympathetic outflow. Sympathetic stimulation might be involved early in the reflex cascade.[clinicaltrials.gov]
  • View Article PubMed Google Scholar Lipinski B: Pathophysiology of oxidative stress in diabetes mellitus. J Diabetes Complications. 2001, 15: 203-210. 10.1016/S1056-8727(01)00143-X.[cardiab.biomedcentral.com]

Prevention

  • Given the limited therapeutic options, a placebo-controlled clinical trial of metoprolol for the prevention of VVS in older patients is needed.[ncbi.nlm.nih.gov]
  • BACKGROUND: Beta-blockers are a first choice migraine preventive medication. So far it is unknown how they exert their therapeutic effect in migraine.[ncbi.nlm.nih.gov]
  • Since beta-blocking agents may cause similar side effects, as described during practolol treatment, on should still be alert to this possibility during long-term treatment with (new) beta-blocking agents, which may allow us to prevent serious damage that[ncbi.nlm.nih.gov]
  • Increasing physicians' awareness of drug-induced severe bradyarrhythmia might prevent unnecessary implantation of permanent pacemakers.[ncbi.nlm.nih.gov]
  • My dose My metoprolol dose I am taking metoprolol for - c hoose the option that applies to you: Heart failure After a heart attack (to prevent heart damage) Irregular heart beat High blood pressure Prevent migraine headaches __________________________[healthnavigator.org.nz]

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