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Microangiopathy

Disease of Capillaries


Presentation

  • We report an elderly patient presenting with an extensive form of CCV involving the trunk, upper and lower limbs. She was treated with Multiplex PDL 595-nm/Nd:YAG 1,064-nm laser and optimized pulsed light.[ncbi.nlm.nih.gov]
  • A diagnostic and therapeutic approach is presented, based on international guidelines, disease registries and published trials.[ncbi.nlm.nih.gov]
  • Especially, the SWV in the pancreatic body was significantly higher when microangiopathy was present (p 0.01).[ncbi.nlm.nih.gov]
  • Case Description: We are presenting a case of 26 year old pregnant female presented with elevated BP.[mds.marshall.edu]
  • The 2 youngest patients presented with concomitant pulmonary and renal disease; in the older patients, PAH was preceded by rTMA from age 2.5 to 7 years.[pediatrics.aappublications.org]
Localized Edema
  • Abstract Diabetic microangiopathy, including retinopathy, is characterized by abnormal growth and leakage of small blood vessels, resulting in local edema and functional impairment of the depending tissues.[ncbi.nlm.nih.gov]
Epistaxis
  • Creatinine levels deteriorated, falling to 3.92 mg/dl (0.73 mg/dl on admission), hematocrit fell to 22.6% and thrombocytopenia to 18 000/μl, causing repeated epistaxis.[archbronconeumol.org]
Apraxia
  • Furthermore, gait apraxia appeared predominantly in those with frontal lobe or basal ganglia lesions.[journals.plos.org]
Papilledema
  • Patients with mHTN present with elevated blood pressure and papilledema, often with retinal hemorrhage and exudates. 22 The most common reported neuroimaging findings are PRES, parenchymal hemorrhage, and infarctions.[ajnr.org]

Workup

  • Clinical Workup The clinical measures examined were blood chemistry, cardiovascular assessment, clinical tests and physiological recordings.[journals.plos.org]
Nephrolithiasis
  • Anxiety Bipolar Depression Obsessive Compulsive Disorder Pediatrics Psychosis Psychosomatic Acute Kidney Injury Chronic Kidney Disease Fluids & Electrolytes Glomerulonephritis Hemodialysis Hypertension REFERENCE BOOK Screening for Hypertension CTFPHC Nephrolithiasis[qxmd.com]
HDL Increased
  • Triglycerides and LDL decreased, while HDL increased across the groups according to WML/lacunar infarct severity, however, there was no significant effect on WML/lacunar infarct grading.[journals.plos.org]

Treatment

  • The review suggested that there may be an association between interferon beta treatment and thrombotic microangiopathy and between interferon beta treatment and nephrotic syndrome.[gov.uk]
  • Please discuss any and all treatment options with your healthcare professional.[web.archive.org]
  • In the first half of the webinar, the clinical presentation of aHUS wil be discussed with pertinent distinguishing findings, laboratory diagnosis, and recommended treatment.[aspho.org]
  • A number of medicines, such as calcium dobesilate, are being marketed for the specific treatment of microangiopathy. The efficacy of calcium dobesilate has been described e.g. in patients with diabetic retinopathy or diabetic nephropathy.[en.wikipedia.org]
  • We also highlight how new insights into pathogenic mechanisms of vascular damage in diabetes may indicate new targets for prevention and treatment. Copyright 2017 Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]

Prognosis

  • Research in Respiratory Intensive Care Onco-Hematology) European Respiratory Journal 2016 47: 688-690; DOI: 10.1183/13993003.01276-2015 Abstract Better pathophysiological understanding of PTTM could result in specific targeted therapies and improve prognosis[erj.ersjournals.com]
  • In post kidney transplantation TMA have a better prognosis, and if limited to the allograft, resolution is reported around to 80%.[kidneypathology.com]
  • Frequency of microangiopathic hemolytic anemia in patients with systemic lupus erythematosus exacerbation: Distinction from thrombotic thrombocytopenic purpura, prognosis, and outcome. Arthritis Rheum. 2005 Dec;53(6):982-5. (10.)[aprendeenlinea.udea.edu.co]
  • Tacrolimus or cyclosporine was administered successively to every LDLT recipient after surgery, but it remains unknown whether long exposure to the agents might affect the prognosis.[cjasn.asnjournals.org]
  • […] changes in 1/3 and hypertension in 50% Pathogenesis : related to Shiga-like toxin, which promotes adhesion of white blood cells to endothelium; also increases endothelin and decreases nitrous oxide production, causing vasoconstriction Adult HUS/TTP Poor prognosis[pathologyoutlines.com]

Etiology

  • Multiple etiological factors include vascular endothelial cell damage due to shiga toxin; factor h deficiency; and aberrant von willebrand factor formation.[icd10data.com]
  • HUS can be classified as Shiga toxin-associated HUS, which typically presents in the setting of a diarrheal infection, or atypical HUS, which describes all forms of HUS without an obvious etiology, including those caused by inherited or acquired defects[ajkdblog.org]
  • One proposed mechanism of PRES is that severe hypertension leads to failed autoregulation and subsequent hyperperfusion with endothelial injury and vasogenic edema. 25 The other hypothesized etiology is vasoconstriction and hypoperfusion resulting in[ajnr.org]

Epidemiology

  • Several large epidemiological studies, eg, the Prevention of REnal and Vascular ENdstage Disease (PREVEND) and European Prospective Investigation of Cancer-Norfolk (EPICNorfolk) studies, showed that microalbuminuria was associated with a higher risk of[medicographia.com]
  • Department of Epidemiology and Bio-statistics Peking University Health Science Center Beijing China[doi.org]
  • Infectious (eg, HIV ) Disseminated intravascular coagulation (DIC) Malignant hypertension Pregnancy associated (eg, preeclampsia/eclampsia/ H emolysis, E levated L iver enzyme levels, L ow P latelet count ( HELLP ) Monitoring Persistent ADAMTS13 Background Epidemiology[arupconsult.com]
Sex distribution
Age distribution

Pathophysiology

  • OBJECTIVES: The progression and pathophysiology of neuropathy in impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) is poorly understood, especially in relation to autophagy.[ncbi.nlm.nih.gov]
  • Vincent for the GrrrOH: Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologie (Group for Research in Respiratory Intensive Care Onco-Hematology) European Respiratory Journal 2016 47: 688-690; DOI: 10.1183/13993003.01276-2015 Abstract Better pathophysiological[erj.ersjournals.com]
  • Dixon, MD, Cincinnati Children’s Hospital Medical Center Thrombotic microangiopathy (TMA) syndromes encompass a diverse group of disorders that have a common pathophysiologic pathway.[aspho.org]
  • There is possible parallel and/or overlap in the pathophysiology of TMA and PRES.[ajnr.org]

Prevention

  • We also highlight how new insights into pathogenic mechanisms of vascular damage in diabetes may indicate new targets for prevention and treatment. Copyright 2017 Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]
  • CTFPHC REFERENCE BOOK Screening for Colorectal Cancer CTFPHC REFERENCE BOOK Screening for Cognitive Impairment CTFPHC REFERENCE BOOK Screening for Depression CTFPHC REFERENCE BOOK Screening for Developmental Delay CTFPHC Review Canadian Task Force on Preventive[qxmd.com]
  • The offending agent suspected of causing the TMA should be promptly discontinued to prevent further progression of injury. If the offending agent needs to be redosed, caution should be taken to re-introduce the drug at a lower dose.[ajkdblog.org]
  • Thought to be a sequel to chronic edema disease. dietetic microangiopathy one of the less commonly occurring lesions that can be prevented by the dietary addition of selenium and vitamin E. thrombotic microangiopathy formation of thrombi in the arterioles[medical-dictionary.thefreedictionary.com]

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