Presentation
History and Physical The presentation of nocardiosis is variable and depends greatly on the organ systems involved in the infection. Primary Cutaneous Nocardiosis This form of nocardiosis presents in the form of skin and skin structure infections. [statpearls.com]
Here, we present a rare case of porphyria cutanea tarda in a 15 years old male who presented with multiple targetoid plaques. Keywords: Erythema-multiforme; porphyria cutanea tarda; targetoid... [read.qxmd.com]
This case is being presented due to the unusual and varied manifestation of Type II lepra reaction in a 34 year old female patient. [ncbi.nlm.nih.gov]
Case Reports Case 1 A 39 year-old-male, on the 2nd month multidrug therapy-MB (MDT-MB) treatment presented with painful punched-out ulcers over the back, arms, and legs of 1 week duration. [ijmyco.org]
Entire Body System
- Pathologist
This new edition is an absolute must for practicing dermatopathologists and general pathologists who sign out skin biopsies. [books.google.es]
Victor G Prieto, MD, PhD is a member of the following medical societies: American Association for the Advancement of Science, American Medical Association, American Society for Clinical Pathology, American Society of Dermatopathology, College of American Pathologists [medscape.com]
It is important for oral pathologists and general dentists to differentiate from other vesicullobullous lesions from drug induced EM for prompt management and proper follow-up. Notes Financial or Other Competing Interests None. [ncbi.nlm.nih.gov]
Finally, the lack of medical equipment and experienced pathologists in basic hospitals limits further investigation of aetiology. In the current case, erythema multiforme was not distinctive. The patient had no peripheral nerve damage. [ann-clinmicrob.biomedcentral.com]
Pathologists should be familiar with the morphological aspects of this disease and should examine the biopsy specimens and skin smears for evidence of leprosy whenever EM is suspected. [scielo.br]
Respiratoric
- Pneumonia
(previously called Chlamydia pneumoniae) Chlamydophila psittaci (previously called Chlamydia psittaci) Clostridium Clostridium botulinum Clostridium difficile Clostridium perfringens (previously called Clostridium welchii) Clostridium tetani Corynebacterium [en.wikipedia.org]
Comprehensive yet succinct, this source discusses all clinical infectious diseases from pneumonia and empyema to central nervous system and antibiotic-related infections. [books.google.es]
Care should be given to distinguish it from the following: Bacterial pneumonia Cellulitis Community-acquired pneumonia Fungal pneumonia Glioblastoma multiforme Histoplasmosis Kaposi sarcoma Lung abscess Mycobacterium avium complex Non-Hodgkin lymphoma [statpearls.com]
Erythema multiforme may be associated with herpes simplex infection, mycoplasma pneumonia, or other medical conditions such as streptococcal infection, tuberculosis (TB), or may result from exposure to chemicals or medications. [nicklauschildrens.org]
Cardiovascular
- Hypertension
Delivery Models Health Care Economics, Insurance, Payment Health Care Policy Health Care Quality Health Care Reform Health Care Safety Health Care Workforce Health Disparities Health Informatics Health Policy Hematology History of Medicine Humanities Hypertension [jamanetwork.com]
Musculoskeletal
- Numbness of the Feet
Three months before consultation, he complained about numbness on his feet. Physical examination showed thickening of both ulnar, great auricular, and peroneus communis nerves. [ijmyco.org]
- Myalgia
Systemic manifestations are fever, arthralgia, malaise, headache, and myalgia. [11], [12] Blood examination shows leukocytosis with high neutrophillia. [ijmyco.org]
Skin
- Erythema
ERYTHEMA MULTIFORME ASSOCIATED WITH MYCOBACTERIUM TUBERCULOSIS INFECTION. [revista.spdv.com.pt]
Erythema multiforme (EM) Erythema multiforme minor of the hands (note the blanching centers of the lesion) Specialty Dermatology Erythema multiforme ( EM ) is a skin condition of unknown cause; it is a type of erythema possibly mediated by deposition [en.wikipedia.org]
Both erythema multiforme and Steven-Johnson syndrome may be induced by medications, but infectious agents are also considered to be a major cause of erythema multiforme. [emedicine.medscape.com]
- Eruptions
"Conjunctivitis from erythema multiforme, a skin eruption, can also cause blindness. " 多形性红斑有时会伴发严重的结膜炎,亦可致盲。 It is not, like the Cathedral of Bourges, the magnificent, light,multiform, tufted, bristling efflorescent product of the pointed arch. [hujiang.com]
Patients may experience itching and burning at the site of the eruption [ 20 ]. [ncbi.nlm.nih.gov]
Seroconversion occurs in most people within 45 days of infection, but can take upto three months During this stage approximately 90% of infected individuals will be symptomatic Symptoms are often non-specific with a transient, generalised, maculopapular eruption [pcds.org.uk]
The lesions recurred once monthly at the same sites, mimicking a fixed drug eruption. [readbyqxmd.com]
Joel T Levis, MD, PhD, FACEP, FAAEM Fall 2011 - Volume 15 Number 4 https://doi.org/10.7812/TPP/ 11-115 Erythema multiforme (EM) is a type of delayed hypersensitivity skin reaction triggered by infection or certain drugs. 1 It consists of a polymorphous eruption [thepermanentejournal.org]
- Skin Disease
Microbiota and immune-mediated skin diseases—An overview. Microorganisms. 2019;7(9):279. doi:10.3390/microorganisms7090279 21. Nørreslet LB, Agner T, Clausen ML. The skin microbiome in inflammatory skin diseases. [dovepress.com]
Skin lesions in leprosy are easily confused with skin diseases and autoimmune diseases. In clinical practice, misdiagnosis of leprosy is not uncommon. [ann-clinmicrob.biomedcentral.com]
Methods A total of 107 patients (36 EN, 27 NV, and 44 others) with vasculitis and 40 control cases with other skin diseases were recruited and their skin lesion samples were subjected to real time polymerase chain reaction (PCR) analysis of the IS6110 [journals.plos.org]
- Skin Rash
Forty days after the therapy, he presented with severe skin rashes with multiple mucous membrane involvement... [readbyqxmd.com]
She received formal anti-MTB treatment, and she had no relapse of lower limb skin rashes during the one year follow-up. [journals.plos.org]
Workup
Microbiology
- Pseudomonas
Therefore, for example, Pseudomonas reads should be considered Pseudomonas -like reads. [microbiomejournal.biomedcentral.com]
Highlights include: the latest research on MRSA and VRE 100 high quality illustrations four new chapters on: military TB infections related to immunosuppressive immunomodulating agents therapy for MRSA and VRE therapy for MDR klebsiella, pseudomonas, [books.google.es]
Similar protocols Protocol publication […] lstonia, Mycobacterium, Propionibacterium, Staphylococcus, Acinetobacter, or Pseudomonas, where a genus level assignment was used. [omictools.com]
[…] mexican N[edit] Neisseria Neisseria gonorrhoeae Neisseria meningitidis P[edit] Pasteurella Pasteurella multocida Pasteurella tularensis Peptostreptococcus Porphyromonas gingivalis Prevotella melaninogenica (previously called Bacteroides melaninogenicus) Pseudomonas [en.wikipedia.org]
[…] genitalium Mycoplasma hominis Mycoplasma penetrans Mycoplasma pneumoniae N Neisseria Neisseria gonorrhoeae Neisseria meningitidis Nocardia asteroides P Pasteurella Pasteurella multocida Pasteurella tularensis Peptostreptococcus Porphyromonas gingivalis Pseudomonas [bionity.com]
- Chlamydia
Chlamydia trachomatis Chlamydophila Chlamydophila pneumoniae (previously called Chlamydia pneumoniae) Chlamydophila psittaci (previously called Chlamydia psittaci) Clostridium Clostridium botulinum Clostridium difficile Clostridium perfringens (previously [en.wikipedia.org]
The type species Chlamydia trachomatis (Busacca) Rake 1957 is differentiated from the second species Chlamydia psittaci (Lillie 1930) comb. nov., by a simple key using tests that can be performed readily in the laboratory. [microbiologyresearch.org]
Streptococci,pneumococci, Neisseria meningitidis, Mycobacterium, Pneumococcus, Salmonella species, Staphylococci, Mycoplasma, Chlamydia Fungal (Coccidioides ) Parasitic (Trichomonas,Toxoplasma gondii Viral ( Herpes simplex) Drug reactions, most commonly [dailyrounds.org]
Microbacterium multiforme [ ] (UMLS (CSP) C0598149) =Rickettsia or Chlamydia ; 6. 25 minutes post challenge (UMLS (HL7) C1547071) =Temporal Concept =Time delay post challenge; 56. microbial [ ] (UMLS (CSP) C0599840) =Organism 7. 3 minutes post challenge [medindex.am]
- Streptococcus Pneumoniae
[…] mutans Streptococcus oralis Streptococcus pneumoniae Streptococcus pyogenes Streptococcus rattus Streptococcus salivarius Streptococcus sanguis Streptococcus sobrinus T[edit] Treponema U[edit] Ureaplasma urealyticum V[edit] Vibrio Vibrio cholerae Vibrio [en.wikipedia.org]
[…] mutans Streptococcus oralis Streptococcus pneumoniae Streptococcus pyogenes Streptococcus rattus Streptococcus salivarius Streptococcus sanguis Streptococcus sobrinus T Treponema Treponema pallidum Treponema denticola V Vibrio Vibrio cholerae Vibrio [bionity.com]
Treatment
Prophylaxis (treatment of latent tuberculosis infection) Secondary prophylaxis following successful treatment of disease is unnecessary, however, re-infection can occur. [hivmanagement.ashm.org.au]
All forms of TB and exposure need prompt evaluation and treatment. TB is a preventable disease, even in those who have been exposed to an infected person. [medlineplus.gov]
Because of the potential resistance to sulfonamides, it is important to start treatment based on drug susceptibility results. Outcomes There are only small cases series on outcomes of Nocardia treatment. [statpearls.com]
The patient’s fever was controlled at 3 days after treatment, and her systemic erythema and superficial lymph node swelling were reduced at 3 months after treatment. At 1 year after treatment, the patient was followed up by telephone. [ann-clinmicrob.biomedcentral.com]
Prognosis
The prognosis of nocardiosis is variable. [statpearls.com]
Nonetheless, for a very small number of people, it can take up to three months for the test to give an accurate result Management The life expectancy for patients with HIV has increased dramatically The best prognosis is in those diagnosed and treated [pcds.org.uk]
Prognosis The prognosis of untreated MAC infection therapy is poor. [hivmanagement.ashm.org.au]
Etiology
Etiology and Pathophysiology The exact pathophysiology of EM is incompletely understood but appears to be the result of a TH1-mediated immune response to an inciting event such as infection or drug exposure. [unboundmedicine.com]
McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. [books.google.es]
Many suspected etiologic factors have been reported to cause erythema multiforme (EM). [emedicine.medscape.com]
Skin biopsy is not necessary when the clinical picture is clear, as biopsy findings in EM are nonspecific. 2 Management of EM involves determining the etiology, when possible, and treating the suspected infection or discontinuing the causal drug. [thepermanentejournal.org]
However, there is little evidence to demonstrate the etiologic role of MTB in the pathogenesis of EN and NV. [journals.plos.org]
Epidemiology
Epidemiology Incidence Annual U.S. incidence is estimated at 1 ). Prevalence Peak incidence in 20s to 40s; rare 50 years of age Slight male predominance is observed. [unboundmedicine.com]
Dissemination throughout the remainder of the body may occur from either of these initial inoculations. [2] Epidemiology Nocardiosis has an infection incidence rate of approximately 500 to 1000 cases per year in the United States. [statpearls.com]
Erythema multiforme: a review of epidemiology, pathogenesis, clinical features, and treatment. Dent Clin North Am. 2013;57(4):583–96. Article Google Scholar Maeda Y. Diagnosis of leprosy: serological aspects. [ann-clinmicrob.biomedcentral.com]
Conventional and molecular epidemiology of macrolide resistance among new Mycobacterium avium complex isolates recovered from HIV-infected patients. Clin Infect Dis 2005;41:1041-4. [20] Zolopa A, Andersen J, Powderly W, et al. [hivmanagement.ashm.org.au]
Wang T, Xue F, Chen Y, Ma Y, Liu Y (2012) The spatial epidemiology of tuberculosis in Linyi City, China, 2005–2010. BMC Public Health 12: 885. View Article Google Scholar 17. [journals.plos.org]
Pathophysiology
Etiology and Pathophysiology The exact pathophysiology of EM is incompletely understood but appears to be the result of a TH1-mediated immune response to an inciting event such as infection or drug exposure. [unboundmedicine.com]
Pathophysiology of atopic dermatitis: clinical implications. Allergy Asthma Proc. 2019;40(2):84–92. doi:10.2500/aap.2019.40.4202 5. Kong HH, Oh J, Deming C. [dovepress.com]
Prevention
TB is a preventable disease, even in those who have been exposed to an infected person. Skin testing for TB is used in high-risk populations or in people who may have been exposed to TB, such as health care workers. [medlineplus.gov]
All patients with evidence of latent TB infection should receive treatment for the prevention of active disease (often called prophylaxis). [hivmanagement.ashm.org.au]
Acyclovir or valacyclovir may help prevent herpes-related recurrent EM. [unboundmedicine.com]
Herpes simplex virus suppression and even prophylaxis (with acyclovir ) has been shown to prevent recurrent erythema multiforme eruption. [ citation needed ] Treatment [ edit ] Erythema multiforme is frequently self-limiting and requires no treatment. [en.wikipedia.org]