We present here a consanguineous Turkish family clinically diagnosed with MCPH and without linkage to any of the known loci (MCPH1-MCPH7). [ncbi.nlm.nih.gov]

[…] the identifica-tion of five loci: MCPH1 on 8p23,5 MCPH2 on 19q13,6 MCPH3 on 9q34,7 MCPH4 on 15q15-q21,8 and MCPH5 on 1q31.9 10 MCPH1, 2, and 3 were mapped in northern Pakistani families, MCPH4 in a Moroccan family, and MCPH5 in northern Pakistani and Turkish [citeseerx.ist.psu.edu]

Interestingly, none of our northern Pakistani families link to the MCPH4 locus, 10 which was identified in a Turkish population. [jmg.bmj.com]

The c.215C T alteration was absent from 180 alleles of Turkish and 180 alleles of German control subjects. Sequencing genomic DNA of patient 2 detected a homozygous missense mutation c.223T C in exon 3 of the MCPH1 gene. [karger.com]

Microcephaly is a neurodevelopmental condition characterized by microcephaly present at birth, decreased cerebral cortex size, and non-progressive mental retardation with the absence of visceral abnormalities. [centogene.com]

mental retardation (borderline IQ is possible). [ncbi.nlm.nih.gov]

Between E7.5 and E8.5. the knockout embryos are smaller, display pericardial swelling, midline neural tube defects, failure of neural tube closure and holoprosencephaly. Failure in left-right specification. [ncbi.nlm.nih.gov]