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Microcytosis


Presentation

  • A total of 169 individuals (49.9%) presented alpha-thalassemia: 145 (42.8%) were heterozygous for the -alpha3.7 deletion (-alpha3.7/alphaalpha) and 18 (5.3%) homozygous (-alpha3.7/-alpha3.7), 5 (1.5%) were heterozygous for the nondeletional form alphaHphIalpha[ncbi.nlm.nih.gov]
  • A child with moderate renal failure, on high doses of aluminum compounds for treatment for hyperphosphatasemia, presented with unexplained microcytosis. The patient also had psychomotor delay.[ncbi.nlm.nih.gov]
  • When microcytosis is present in patients with anemia of chronic disease, the mean corpuscular volume (MCV) rarely if ever falls below 70 fL. The lowest MCV previously reported is 67 fL.[ncbi.nlm.nih.gov]
  • Only two patients in SRL group presented decreased transferrin saturation rate. Marked erythrocyte microcytosis without persistent anemia was observed in patients treated with SRL and MMF.[ncbi.nlm.nih.gov]
  • RESULTS: Compared with GPCA-/microcytosis, the positive counterparts presented with a lower mean serum vitamin B12 level (marginal significance), significantly higher mean RDW and serum homocysteine level, and significantly greater frequencies of vitamin[ncbi.nlm.nih.gov]
Family History of Anemia
  • Important history information includes nutritional intake (especially whole milk intake in children) 2 , 8 ; pica or cravings for ice, which are symptoms of iron deficiency anemia; occupational or residential exposure to toxins, such as lead; family history[aafp.org]
Vietnamese
  • The subjects were of Tai-dam, Vietnamese, Chinese, Laotian, and European origin.[ncbi.nlm.nih.gov]
Ankylosis
  • Abstract Progressive ankylosis (Ank and the human homolog, ANKH) is a transmembrane protein which regulates transport of inorganic pyrophosphate (PPi). ank/ank mice with a mutated ank gene, have calcification and bone ankylosis of the affected joints.[ncbi.nlm.nih.gov]
Progressive Loss of Vision
  • Retinitis pigmentosa (RP) is a highly heterogeneous group of disorders characterized by degeneration of the retinal photoreceptor cells and progressive loss of vision.[ncbi.nlm.nih.gov]

Workup

  • Step 3: Screen for JAK2 V617F JAK2 V617F mutation screening is now part of the diagnostic workup for thrombocytosis, according to the World Health Organization (WHO) diagnostic criteria for essential thrombocythemia and polycythemia vera.[ascopost.com]
  • Routine workup of the patient with anemia, advise: Hemoglobin and hematocrit. Red blood cell count. Blood indices. peripheral blood smear. Reticulocyte count. White blood cells count and platelets count.[labpedia.net]
Transferrin Saturation Decreased
  • saturation Decreased Normal to increased Normal to slightly decreased Normal to increased Table 4.[aafp.org]

Treatment

  • An intermittent source of aluminum contamination was suspected when water aluminum and total dissolved solutes (TDS) were measured at several sites in the water treatment facility of unit A.[ncbi.nlm.nih.gov]
  • It is desirable to routinely perform hemograms for all blood donors and further analyse the microcytic samples for Ferritin and HbA2 to diagnose IDA and BTT and to provide appropriate counselling/treatment.[ncbi.nlm.nih.gov]
  • A child with moderate renal failure, on high doses of aluminum compounds for treatment for hyperphosphatasemia, presented with unexplained microcytosis. The patient also had psychomotor delay.[ncbi.nlm.nih.gov]
  • RESULTS: SRL-treated animals had a reduced mean corpuscular volume (MCV) and elevated erythrocyte count compared with control animals after 15 weeks of treatment.[ncbi.nlm.nih.gov]
  • Of the seven patients whose results had been documented, four received iron deficiency treatment and/or follow-up; the other three received no treatment or follow-up.[bmcpediatr.biomedcentral.com]

Prognosis

  • ", keywords "Incidence, Microcytosis, Myelofibrosis, Prognosis, Survival", author "Ayalew Tefferi and Dingli, {David M} and Li, {Chin Yang} and Mesa, {Ruben A.[mayoclinic.pure.elsevier.com]
  • Purchase More plans and pricing Keywords anemia artery basophil blood blood smear count diagnosis disease eosinophil follow hematology hospital human lab laboratory lens leukemia life lymphocyte medical medicine microscope monocyte neutrophil platelet prognosis[123rf.com]
  • Differentiation between thalassemic and non thalassemic microcytosis has important clinical implications, because each has an entirely different pathogenesis, prognosis, and treatment [ 1 - 3 ].[ncbi.nlm.nih.gov]
  • Iron depletion may increase the risk of developing heart failure, and seems to adversely affect prognosis of existing heart failure [ 19 ]. The risk of chronic lead poisoning may be increased by iron depletion.[patient.info]
  • Prognosis Iron therapy should resolve the symptoms, signs and blood picture, unless there is a serious underlying cause. The depletion is likely to recur unless the cause is addressed. Prevention Adequate diet.[patient.info]

Etiology

  • The most common etiologies of iron deficiency anemia differ based on patient age and sex ( Table 3 2 , 5 , 8 , 9 ) .[aafp.org]
  • Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'.[icd10data.com]
  • Amenia classification on the basis of etiology: Increased RBCs destruction due to intra or extra red blood cells defects. Increased blood loss which may acute or chronic. Defective RBCs formation due to Lake of factors necessary for erythropoiesis.[labpedia.net]

Epidemiology

  • […] and Health UCL Provost and Vice Provost Offices School of Life and Medical Sciences Faculty of Pop Health Sciences Institute of Epidemiology and Health Primary Care and Population Health URI: Download activity - last month Download activity - last 12[discovery.ucl.ac.uk]
  • Age-related clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population. Am. J. Med. Genet. 32: 291–297. CrossRef Google Scholar 2. Weatherall DJ (1994). The thalassaemias.[link.springer.com]
  • Lin M, Zhong TY, Chen YG, Wang JZ, Wu JR ,et al.(2014) Molecular epidemiological characterization and health burden of thalassemia in Jiangxi Province, P. R. China. PLoS One 9:101505[omicsonline.org]
  • ., Epidemiology of haemoglobin disorders in Europe: an overview. Scand J Clin Lab Invest. 67, 39 (2007) R. Herklotz et al., Hämoglobinopathien ? Klinik und Diagnostik von Thalassämien und anomalen Hämoglobinen. Therap. Umschau 63, 35 (2006) A.[charite.de]
  • Epidemiology Iron depletion may be three times as common as iron deficiency anaemia (IDA), which has a prevalence of 2-5% of adult men and postmenopausal women in the developed world [ 3 ].[patient.info]
Sex distribution
Age distribution

Pathophysiology

  • Anemia of chronic disease: pathophysiology and laboratory diagnosis. Lab Hematol . 2005;11(1):14–23. 8. Jain S, Kamat D. Evaluation of microcytic anemia. Clin Pediatr (Phila) . 2009;48(1):7–13. 9. Hershko C, Skikne B.[aafp.org]
  • 1118 ) 4 Post-transplantation anaemia in adult and paediatric renal allograft recipients—Guy's Hospital experience , Nephrol Dial Transplant , 2006 , vol. 21 (pg. 1974 - 1980 ) 5 Anaemia after renal transplantation-role of immunosuppressive drugs and a pathophysiological[academic.oup.com]

Prevention

  • Recommendations to prevent and control iron deficiency in the United States. Centers for Disease Control and Prevention. MMWR Recomm Rep . 1998;47(RR-3):1–29. 17. Waterbury L. Anemia. In: Barker LR, Burton JR, Zieve PD.[aafp.org]
  • This information is important to prevent unnecessary iron supplementation since iron deficiency is the commonest cause of microcytosis.[omicsonline.org]

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