The age range at presentation is broad (28-82 years). [uscapknowledgehub.org]

This report presents the pathologic findings in seven patients who developed carcinoma of the breast in association with MGA. The patients, aged 39-72, presented with firm masses that raised the clinical suspicion of carcinoma. [ncbi.nlm.nih.gov]

[…] proliferation of uniform, cytologically bland glands in the breast which presents as a poorly cicumscribed mass. [medical-dictionary.thefreedictionary.com]

Some amount of fat was present within the lesion but no distinct margin or pseudocapsule was present. Suspicious microcalcifications were not noted in the mass. [synapse.koreamed.org]

• Asymptomatic

  Small-sized tumors may be asymptomatic and show no signs and symptoms Microglandular Adenosis of Breast is indicative of a higher risk for breast cancer into the future. [dovemed.com]

  Diagnosis is frequently made by a pathologist, as the condition is often clinically asymptomatic. [brieflands.com]

  The disease usually affects the middle aged to older women and is usually asymptomatic. Occasionally, patients may present with nipple inversion, retraction, discharge, or a subareolar mass that may mimic a breast cancer [ 4 ]. [oncohemakey.com]

• Axillary Lymphadenopathy

  There was no axillary lymphadenopathy. Mammography revealed a high density mass with ill-defined spiculated margins, characterized as BIRADS category 4C. [ccij-online.org]

  No axillary lymphadenopathy was palpable. She had no personal or family history of breast cancer. Bilateral mammogram showed a 2-cm irregular mass with spiculated margins in the 11 o’clock position of the left breast (Figure 1). [brieflands.com]

  In the rare cases when serous carcinoma of the ovary/peritoneum initially presents as a breast mass with or without axillary lymphadenopathy, IHC for GCDFP-15, mammaglobin, and WT1 can be extremely useful. [sigmaaldrich.com]

• Suggestibility

  Recent studies have suggested that MGA may be a non-obligate precursor of invasive carcinomas that are negative for hormone receptors and lack HER-2 overexpression (triple-negative phenotype). [ncbi.nlm.nih.gov]

  In an earlier report from this institution we suggested that MGA might serve as the substrate for the development of mammary carcinoma. [journals.lww.com]

  Suggested Reading • BI-RADS assessment category 4, suspicious; biopsy should be considered. [radiologykey.com]

• Breast Mass

  MGA often produces a palpable mass that mimics breast cancer on breast examination. [ncbi.nlm.nih.gov]

  […] of Breast may include the presence of a mass in the breast. [dovemed.com]

• Nipple Retraction

  In some patients, the fat necrosis causes a fibrotic response that results in an irregular solid mass (illustrated in this case), which may be associated with skin thickening and nipple retraction. [radiologykey.com]

  In this patient this is not a normal variant, since there are associated features, that indicate the possibility of malignancy like skin thickening, thickened septa and subtle nipple retraction. [radiologyassistant.nl]

  Skin changes and nipple retraction were not found. No axillary lymphadenopathy was palpable. She had no personal or family history of breast cancer. [brieflands.com]

  Occasionally, patients may present with nipple inversion, retraction, discharge, or a subareolar mass that may mimic a breast cancer [ 4 ]. [oncohemakey.com]

  Nipple retraction was observed. She had no medical or familial history of cancer. [synapse.koreamed.org]

During the workup, a CT scan of the chest found incidental mediastinal lymphadenopathy. An endobronchial ultrasound guided biopsy of mediastinal lymph nodes was performed during a follow-up visit. [med.nyu.edu]

A staging workup was also ordered, including a bone scan (degenerative changes), abdominal ultrasound, chest X-ray, liver function tests and renal panel (all within normal limits). [sisjournal.org]

Immunohistochemical studies are often employed in the workup of spindle cell lesions of breast, especially in the group with a monophasic pattern. The most important task is to exclude the potential diagnosis of metaplastic CA. [sigmaaldrich.com]

At the end of the workup process, the patient underwent a bilateral nipple-sparing mastectomy with a previous removal of right retroareolar disk and sentinel lymph node, in addition to a laparoscopic bilateral salpingo-oophorectomy [13-21]. [cyberleninka.org]

(See Workup.) Increased public awareness and improved screening have led to earlier diagnosis, at stages amenable to complete surgical resection and curative therapies. [emedicine.medscape.com]

Outlines the steps after diagnosis to guide you through formulating a treatment or patient care plan. [books.google.com]

[…] of fibrocystic changes Clinical features Can present as a mass (as nodular adenosis or adenosis tumor) or as calcifications on imaging Prognostic factors With some types (sclerosing adenosis), the risk of subsequent breast cancer is 1.5 - 2x higher Treatment [pathologyoutlines.com]

Treatment of adenosis A medicamentous method of treatment (with diffuse disease of the mammary gland) and surgical (excision of the affected area of the tissue in a focal form) is used. [en.ladyjanet.biz]

Related terms sclerosing adenosis Health care ; Cancer treatment A benign condition in which scar-like tissue is found in a gland, such as the breast lobules or the prostate. [ue.termwiki.com]

Management can be problematic, and despite treatment, recurrence and complications such as abscess and fistula formation are frequent [ 19 ]. The treatment sometimes spans over several years. [oncohemakey.com]

despite histopathologic and immunohistochemical features usually associated with a poor prognosis. [ncbi.nlm.nih.gov]

[…] carcinomas are composed of epithelial cells (cytokeratin positive, actin negative) that are strongly immunoreactive for S-100 protein and cathepsin D; and with a median follow-up of nearly 5 years, patients with these carcinomas had a relatively favorable prognosis [semanticscholar.org]

Most cases of carcinoma arising in microglandular adenosis have a relatively favorable prognosis despite having histopathologic and immunohistochemical features that are usually associated with a poor prognosis (such as estrogen and progesterone receptor [archivesofpathology.org]

The prognosis of invasive carcinoma arising in MGA varies in the literature. Some authors reported that patients with invasive carcinoma arising in MGA have a relatively favorable prognosis [ 3, 7 ]. [e-sciencecentral.org]

[…] components) Common, benign, often accompanied by fibrosis Epidemiology Premenopausal: lesions with predominant epithelial component (proliferation of acini and ducts); nodular adenosis Postmenopausal: lesions with more sclerosis (sclerosing adenosis) Etiology [pathologyoutlines.com]

(Etiology) The exact cause of development of Microglandular Adenosis of Breast is currently not clearly understood. Studies have shown that such tumors may be caused by hormonal influence Certain gene mutations have also been reported in the tumors. [dovemed.com]

Small areas of fat necrosis are probably not uncommon, but clinically significant lesions are likely due to some sort of trauma, surgical procedure, biopsy, and radiation present in up to 50 % of patients; however the exact etiology is not always identified [oncohemakey.com]

Rare, represented in case reports and series and small studies No specific known epidemiologic associations (reported in women over a wide age range) Sites No specific location in breast Pathophysiology Gain of somatic mutations including TP53, PIK3CA [pathologyoutlines.com]

The international variation in breast cancer rates: an epidemiological assessment. Breast Cancer Res Treat. 1991 May. 18 Suppl 1:S11-7. [Medline]. Kaaks R. Nutrition, hormones, and breast cancer: is insulin the missing link?. [emedicine.medscape.com]

[…] disease GB20.Z - benign breast disease, unspecified Epidemiology Rare, represented in case reports and series and small studies No specific known epidemiologic associations (reported in women over a wide age range) Sites No specific location in breast Pathophysiology [pathologyoutlines.com]

Pathophysiology The current understanding of breast cancer etiopathogenesis is that invasive cancers arise through a series of molecular alterations at the cell level. [emedicine.medscape.com]

The author collated important benign lesions and based on peer-reviewed publications documented the relative risk of subsequent cancer to allow the patient and the clinician to institute preventative measures where possible. [books.google.com]

These three distinct entities can be separated objectively and unequivocally and it is essential that this be done so as to prevent confusion. [ncbi.nlm.nih.gov]

Prevention Especially important for the prevention of adenosis is the preservation of the first pregnancy, prolonged (at least 6 months) breastfeeding. [en.ladyjanet.biz]

Since prevention is generally not possible, it is important to be aware of the risk factors of breast lumps. [dovemed.com]