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Microglandular Adenosis

Microglandular Adenosis of Breast


Presentation

  • This report presents the pathologic findings in seven patients who developed carcinoma of the breast in association with MGA. The patients, aged 39-72, presented with firm masses that raised the clinical suspicion of carcinoma.[ncbi.nlm.nih.gov]
  • […] proliferation of uniform, cytologically bland glands in the breast which presents as a poorly cicumscribed mass.[medical-dictionary.thefreedictionary.com]
Anemia
  • Wang, Emergence of a DNA-damage response network consisting of Fanconi anemia and BRCA proteins, Nat. Rev. Genet. 8 (2007) 735-748. [34] J. Fridlyand, A.M. Snijders, B.[cyberleninka.org]
Hunting
  • Ilan Weinreb, Douglas R Gnepp, Nora M Laver, Aaron P Hoschar, Jennifer L Hunt, Raja R Seethala, E Leon Barnes, Runjan Chetty and Bayrdo Perez‐Ordoñez , Seromucinous hamartomas: a clinicopathological study of a sinonasal glandular lesion lacking myoepithelial[doi.org]
Hypertension
  • The patient had a history of hypertension, endometrial adenocarcinoma (treated in 1994), carcinoma of the right breast (treated in 1997 with breast-conserving surgery, axillary node dissection, radiation therapy, and 5 years of tamoxifen), and adenocarcinoma[sisjournal.org]
Breast Mass
  • These are performed by inserting a needle into a breast mass and removing cells or tissues, for further examination.[dovemed.com]
  • Most patients complain of a palpable breast mass that may arouse a clinical suspicion of breast cancer.[ncbi.nlm.nih.gov]
Excitement
  • Admittedly, Fletcher is not an breast pathologist, but at least it is a quick and easy reference anyone can look at: "[tubular carcinomas] excite a characteristic metachromatic stromal reaction which is not found in microglandular adenosis."[forums.studentdoctor.net]

Workup

  • A staging workup was also ordered, including a bone scan (degenerative changes), abdominal ultrasound, chest X-ray, liver function tests and renal panel (all within normal limits).[sisjournal.org]
  • During the workup, a CT scan of the chest found incidental mediastinal lymphadenopathy. An endobronchial ultrasound guided biopsy of mediastinal lymph nodes was performed during a follow-up visit.[med.nyu.edu]
  • At the end of the workup process, the patient underwent a bilateral nipple-sparing mastectomy with a previous removal of right retroareolar disk and sentinel lymph node, in addition to a laparoscopic bilateral salpingo-oophorectomy [13-21].[cyberleninka.org]
  • Immunohistochemical studies are often employed in the workup of spindle cell lesions of breast, especially in the group with a monophasic pattern. The most important task is to exclude the potential diagnosis of metaplastic CA .[sigmaaldrich.com]
  • (See Workup.) Increased public awareness and improved screening have led to earlier diagnosis, at stages amenable to complete surgical resection and curative therapies.[emedicine.medscape.com]
Lymphocytic Infiltrate
  • infiltrate (Figures 3 and 4).5,6 The epithelial cells may exhibit cytoplasmic clearing and granular changes comparable to those of microglandular adenosis.[archivesofpathology.org]
  • infiltration [ 5 ].[ncbi.nlm.nih.gov]

Treatment

  • The treatment of carcinoma arising in MGA will depend on the stage of the disease. Presently we do not know whether these carcinomas have unusual clinical or biological characteristics.[ncbi.nlm.nih.gov]
  • The following treatment methods for Microglandular Adenosis of Breast may be considered: A simple surgical excision and removal of the entire Microglandular Adenosis of Breast is normally sufficient treatment.[dovemed.com]

Prognosis

  • , despite histopathologic and immunohistochemical features usually associated with a poor prognosis.[ncbi.nlm.nih.gov]
  • The prognosis of invasive carcinoma arising in MGA varies in the literature. Some authors reported that patients with invasive carcinoma arising in MGA have a relatively favorable prognosis [ 3 , 7 ].[e-sciencecentral.org]
  • Microglandular Adenosis of Breast is a benign tumor, and hence, its prognosis is excellent.[dovemed.com]

Etiology

  • (Etiology) The exact cause of development of Microglandular Adenosis of Breast is currently not clearly understood. Studies have shown that such tumors may be caused by hormonal influence Certain gene mutations have also been reported in the tumors.[dovemed.com]
  • […] components) Common, benign, often accompanied by fibrosis Epidemiology Premenopausal: lesions with predominant epithelial component (proliferation of acini and ducts); nodular adenosis Postmenopausal: lesions with more sclerosis (sclerosing adenosis) Etiology[pathologyoutlines.com]
  • Small areas of fat necrosis are probably not uncommon, but clinically significant lesions are likely due to some sort of trauma, surgical procedure, biopsy, and radiation present in up to 50 % of patients; however the exact etiology is not always identified[oncohemakey.com]

Epidemiology

  • Definition / general Any hyperplastic process (see subtypes below) primarily involving glands (i.e. an increased number of glandular components) Common, benign, often accompanied by fibrosis Epidemiology Premenopausal: lesions with predominant epithelial[pathologyoutlines.com]
  • Surveillance Epidemiology and End Results (SEER). Cancer Stat Facts: Female Breast Cancer. National Cancer Institute. Available at . Accessed: January 17, 2019. Jatoi I, Anderson WF, Rosenberg PS.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology The current understanding of breast cancer etiopathogenesis is that invasive cancers arise through a series of molecular alterations at the cell level.[emedicine.medscape.com]

Prevention

  • These three distinct entities can be separated objectively and unequivocally and it is essential that this be done so as to prevent confusion.[ncbi.nlm.nih.gov]
  • The author collated important benign lesions and based on peer-reviewed publications documented the relative risk of subsequent cancer to allow the patient and the clinician to institute preventative measures where possible.[books.google.com]
  • Since prevention is generally not possible, it is important to be aware of the risk factors of breast lumps.[dovemed.com]
  • Prevention Especially important for the prevention of adenosis is the preservation of the first pregnancy, prolonged (at least 6 months) breastfeeding.[en.ladyjanet.biz]

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