These are usually eyes with high hyperopia, which may present staphyloma in the coloboma area (when present), with consequent high myopia. Figure 1. Microcornea and microphthalmia on the right. [eoftalmo1.hospedagemdesites.ws]

If possible, treatment should be initiated at around 6 months of age. [eoftalmo1.hospedagemdesites.ws]

This was followed by coloboma with microcornea, which has a moderate prognosis; coloboma with microcornea and microphthalmia, which has a poor prognosis; and microphthalmia with cyst, which has the worst prognosis (27). [eoftalmo1.hospedagemdesites.ws]

Another classification of the MAC spectrum is based on the phenotype determined by embryology and genetic etiology (Table 4). [eoftalmo1.hospedagemdesites.ws]

Abstract We report an epidemiological and genetic study attempting complete ascertainment of subjects with microphthalmia, anophthalmia, and coloboma (MAC) born in Scotland during a 16 year period beginning on 1 January 1981. [ncbi.nlm.nih.gov]

It is expected that novel treatment approaches will be possible at an early stage of eye development in the fetus, which may prevent the occurrence of genetic changes or failures during the vital period of eye formation. REFERENCES 1. [eoftalmo1.hospedagemdesites.ws]