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Midodrine


Presentation

  • A 48-year-old male who ingested an eight ounce bottle of Rogaine presented to the emergency department. The patient presented with a blood pressure of 57/45 mmHg and a pulse of 84 beats per minute.[ncbi.nlm.nih.gov]
  • We present a case of AGEP with erythroderma following use of midodrine in a 58-year-old man.[ncbi.nlm.nih.gov]
  • Presentation of two cases. Midodrine hydrochloride successfully treated two cases of orthostatic hypotension that had been refractory to classic treatment interventions.[ncbi.nlm.nih.gov]
  • A 43-year-old man presented with recurrent syncope and dizziness after he had a dual chamber pacemaker fitted for presumed sino-atrial disease.[ncbi.nlm.nih.gov]
  • The aim of the present study was to evaluate the effects of antihypotensive agents, midodrine hydrochloride (MID) and L-threo-3,4-dihydroxyphenylserine (L-DOPS), on OH after HD.[ncbi.nlm.nih.gov]
Sepsis
  • The vasoplegic profile of sepsis would be a potential target for midodrine therapy. While its use to mediate recovery from septic shock has been suggested, there is a paucity of clinical data supporting its use.[ncbi.nlm.nih.gov]
  • Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008 ;36: 296 – 327. DOI 10.1097/01.CCM.0000298158.12101.41 Google Scholar Crossref Medline ISI[doi.org]
  • […] the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation [Recruiting] The aim of this study is to evaluate the effect of prolonged administration of albumin and midodrine on the prevention of complications (renal failure, sepsis[druglib.com]
Orthopnea
  • All the patients improved in their symptoms of orthopnea and shortness of breath.[ncbi.nlm.nih.gov]
Hypertension
  • Midodrine was discontinued when supine hypertension was noticed. However, his supine hypertension continued until day 19 after discontinuation.[ncbi.nlm.nih.gov]
  • However, midodrine, but not droxidopa, significantly increases risk of supine hypertension.[ncbi.nlm.nih.gov]
  • Midodrine, a drug used to treat symptomatic orthostatic hypotension, may cause or exacerbate supine hypertension. We describe a case of a patient taking midodrine who exhibited severe hypertension during general anesthesia.[ncbi.nlm.nih.gov]
  • . 1 21 (See Supine Hypertension under Cautions.)[drugs.com]
  • Surgeons should minimize the use of vasoconstrictors in patients treated with midodrine to avoid hypertensive complications.[ncbi.nlm.nih.gov]
Quadriplegia
  • The highest systolic blood pressure (more than 200 mm Hg) was seen in patients with quadriplegia. No other significant side effect was recorded. The average dose of midodrine required for ejaculation was 18.7 mg.[ncbi.nlm.nih.gov]

Treatment

  • CONCLUSION: Our findings indicate that additional Midodrine treatment is less effective in patients with VVS not responding to non-pharmacological treatment than reported as first-line treatment.[ncbi.nlm.nih.gov]
  • We aimed to evaluate the efficacy of a promising treatment for type 1 HRS.[ncbi.nlm.nih.gov]
  • RESULTS: Orthostatic systolic and diastolic BP drops improved significantly at 3 months after treatment in all treatment groups.[ncbi.nlm.nih.gov]
  • It is the first drug to be licensed in the UK for the treatment of orthostatic hypotension. Here we consider the evidence for midodrine in the treatment of severe orthostatic hypotension and how it fits with current management strategies.[ncbi.nlm.nih.gov]
  • Treatment with terlipressin has currently the best efficacy pedigree, inducing hepatorenal syndrome reversal in a high proportion of patients.[ncbi.nlm.nih.gov]

Prognosis

  • Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites. Gastroenterology 1993 ;105: 229 – 36. Google Scholar Crossref Medline ISI 9. Cárdenas, A Gines, P. Hepatorenal syndrome.[doi.org]
  • Fluid accumulation and ascites are nearly universal in patients with decompensated liver disease, and their development in a cirrhotic patient generally portrays poor prognosis. 1 , 2 The current hypothesis on the pathophysiology of ascites is that profound[ncbi.nlm.nih.gov]
  • Gastroenterology and Hepatology Indiana University School of Medicine Indianapolis, Indiana Fluid accumulation and ascites are nearly universal in patients with decompensated liver disease, and their development in a cirrhotic patient generally portrays poor prognosis[gastroenterologyandhepatology.net]

Etiology

  • This is the first report showing that midodrine has the potential to improve post-spaceflight orthostatic hypotension and suggesting that reduced venous return contributes to the etiology.[ncbi.nlm.nih.gov]
  • […] persistence of droxidopa and midodrine in patients with orthostatic hypotension (OH) or neurogenic orthostatic hypotension (nOH) when medication cost was not a factor Background : nOH is a sustained drop in blood pressure upon standing with a neurogenic etiology[mdsabstracts.org]
  • It is used in treating patients with orthostatic hypotension and hypotension resulting from various etiologies. Its use in pregnancy falls into category C.[omicsonline.org]

Epidemiology

  • Effects of study precision and risk of bias in networks of interventions: a network meta-epidemiological study. Int J Epidemiol. 2013 ;42: 1120 - 1131. doi: 10.1093/ije/dyt074 Google Scholar Crossref Medline 29. Salanti, G, Dias, S, Welton, NJ.[doi.org]
  • […] treatment and prevention of neurally mediated reflex (neurocardiogenic) syncope. 2004 Sep [Efficacy and safety of a herbal drug containing hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders/results of a retrospective epidemiologic[drugs.ncats.io]
  • Introduction Epidemiological studies suggest that at least 40% of the population will experience at least one episode of syncope in their lifetime. 1 The list of potential therapies available to treat hypotension and reduce the likelihood of syncope is[bjcardio.co.uk]
  • Epidemiologic features of isolated syncope: the Framingham Study. Stroke 1985; 16 :626–9. 2. Task Force for the Diagnosis and Management of Syncope, European Society of Cardiology (ESC), European Heart Rhythm Association (EHRA) et al .[bjcardio.co.uk]
  • Linguistic Variant - Portuguese, Brazil) 2015AB LNC-RU-RU (LOINC Linguistic Variant - Russian, Russia) 2015AB LNC-TR-TR (LOINC Linguistic Variant - Turkish, Turkey) 2015AB LNC-ZH-CN (LOINC Linguistic Variant - Chinese, China) 2015AB MCM (Glossary of Clinical Epidemiologic[doctor.am]
Sex distribution
Age distribution

Pathophysiology

  • This finding is consistent with the hypothesis that dysautonomia plays a major part in the pathophysiology of CFS and that therapies directed at the autonomic nervous system may be effective in the treatment of CFS.[ncbi.nlm.nih.gov]
  • Rigshospitalet, Section for Surgical Pathophysiology Layout table for additonal information Responsible Party: Oeivind Jans, M.D, Research Fellow, Rigshospitalet, Denmark ClinicalTrials.gov Identifier: NCT01707953 History of Changes Other Study ID Numbers[clinicaltrials.gov]
  • Discussion The pathophysiology of ascites is complex, and various mechanisms have been proposed.[gastroenterologyandhepatology.net]
  • Fluid retention in cirrhosis: pathophysiology and management. QJM. 2008; 101 :71–85. [ PubMed ] [ Google Scholar ] 2. Gines P, Quintero E, Arroyo V, et al. Compensated cirrhosis: natural history and prognostic factors.[ncbi.nlm.nih.gov]
  • Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. 2004 Jun 3 Pharmacology of orthostatic hypotension in Parkinson's disease: from pathophysiology[drugs.ncats.io]

Prevention

  • Various vasoconstrictors have also been used to prevent PICD, but there are few studies about the usage of midodrine.[ncbi.nlm.nih.gov]
  • Vasoconstrictors, e.g. terlipressin, may also prevent PICD. The aim was to compare the less expensive vasoconstrictor midodrine, an alpha-adrenoceptor agonist, with albumin in preventing PICD.[ncbi.nlm.nih.gov]
  • There are no reports of use of midodrine in the prevention of PICD. In this pilot study, we evaluated midodrine and albumin in the prevention of PICD.[ncbi.nlm.nih.gov]
  • STRUCTURE OF STUDY: The prevention of syncope trial IV (POST 4) is a multicenter, international, randomized, placebo-controlled study of midodrine in the prevention of vasovagal syncope.[ncbi.nlm.nih.gov]
  • PCD results from vasodilatation, which reduces effective blood volume, and is prevented by intravenous administration of albumin. Vasoconstrictors could be used instead of albumin and, with longer use, prevent PCD and delay ascites recurrence.[ncbi.nlm.nih.gov]

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