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Mifepristone


Presentation

  • The use of progesterone receptor antagonists may present a novel immunotherapy to help fight cancer. A larger controlled study is needed.[ncbi.nlm.nih.gov]
  • Three weeks after misoprostol administration, fetal heart activity was present in 4/50 (8 %) in the 2-h interval group (p 0.118) and none of the 48-h interval group.[ncbi.nlm.nih.gov]
  • We present the patient's clinical, biochemical, and imaging findings. A 16-year-old girl presented with classic Cushing disease.[ncbi.nlm.nih.gov]
  • A woman with a twin pregnancy who changed her mind is presented. Twin pregnancies may need higher dosages of mifepristone than single pregnancies due to the presence of two corpora lutea and increased amount of trophoblast tissue.[ncbi.nlm.nih.gov]
  • The present study evaluated the palliative effect of mifepristone in a variety of different types of human cancer.[ncbi.nlm.nih.gov]
Osteoporosis
  • We hereby describe the first reported case of an adolescent female with Cushingoid features and morbid osteoporosis who was treated with mifepristone for its antiglucocorticoid effect (400 mg/day) in an attempt to prevent further bone loss.[ncbi.nlm.nih.gov]
Cognitive Deficit
  • Increased levels of cortisol during acute alcohol withdrawal have been linked to cognitive deficits and depression.[ncbi.nlm.nih.gov]

Workup

  • […] disease (pituitary adenoma) and ectopic corticotropin production from tumors arising outside of the pituitary. 1 Although these cancers are rare, the patients often present with CS, a fact that can compel physicians to perform a challenging complete workup[pediatrics.aappublications.org]

Treatment

  • To observe the effect of small-dose mifepristone conservative treatment and laparoscopic combined with mifepristone in the treatment of endometriosis.[ncbi.nlm.nih.gov]
  • Surgical intervention carries a risk of complications and, therefore, medical treatment appears to be a safe alternative. Unfortunately, the current medical treatment with misoprostol alone has complete evacuation rates between 53% and 87%.[ncbi.nlm.nih.gov]
  • Mifepristone treatment significantly reduced leiomyoma volume from 135.3 22.9 cc at enrollment to 101.2 22.4 cc after 3 months of treatment.[ncbi.nlm.nih.gov]
  • Medical management of early pregnancy loss is an alternative to uterine aspiration, but standard medical treatment with misoprostol commonly results in treatment failure.[ncbi.nlm.nih.gov]

Prognosis

Etiology

  • The etiology of the Möbius syndrome remains largely unknown and probably involves multiple factors.[ncbi.nlm.nih.gov]

Epidemiology

  • Audio Supplementary Data PDF Cite Citation Aimin Chen, Wei Yuan, Olav Meirik, Xianmi Wang, Shi-Zhong Wu, Lifeng Zhou, Lin Luo, Ersheng Gao, Yimin Cheng; Mifepristone-induced Early Abortion and Outcome of Subsequent Wanted Pregnancy, American Journal of Epidemiology[aje.oxfordjournals.org]
  • . , accessed Nov. 6, 2001; National Board of Health and Welfare (NBHW), Centre for Epidemiology, Aborter 1999 , Stockholm, Sweden: NBHW, 2000, Tables 5 and 10; and Hedberg C, unpublished tables, Stockholm, Sweden: Socialstyrelsen, 2001. 17 .[guttmacher.org]
Sex distribution
Age distribution

Prevention

  • […] safe and effective cancer metastatic preventive agent by targeting CTCs and preventing their adhesion-invasion to vascular intima.[ncbi.nlm.nih.gov]
  • Here, we demonstrated that a combination (HAMPT) of aspirin, lysine, mifepristone and doxycycline can effectively and safely prevent cancer metastasis.[ncbi.nlm.nih.gov]
  • The theory of its mechanism is that it prevents the secretion of a progesterone-induced immunomodulatory protein in the tumor microenvironment, or in the tumor cell itself, called the progesterone-induced blocking factor, which inhibits natural killer[ncbi.nlm.nih.gov]
  • Molecular and cellular assays further demonstrated that mifepristone had the ability to prevent breast cancer cells from migration and interfere with their adhesion to endothelial cells.[ncbi.nlm.nih.gov]
  • Also, the synthetic steroid acutely increased mRNA translation rate, which, if prevented, abrogated the splicing of XBP1 mRNA, a non-translatable readout of IRE1α activation.[ncbi.nlm.nih.gov]

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