Presentation
The use of progesterone receptor antagonists may present a novel immunotherapy to help fight cancer. A larger controlled study is needed. [ncbi.nlm.nih.gov]
The present study is intended to know the effectiveness and complications by oral versus vaginal route administration of misoprostol. Subjects and Methods The present nonrandomized clinical trial was conducted at Dr. [ijhas.in]
Entire Body System
- Fatigue
The patient, a 14-year-old girl with an 18-month history of metastatic neuroendocrine carcinoma, suffered from fatigue, profound myopathy, irritability, and depression. [ncbi.nlm.nih.gov]
Risks Other common side effects include: fatigue, headaches, dizziness, nausea, vomiting, diarrhea and low-back pain. [medical-dictionary.thefreedictionary.com]
• Central Nervous System : Dizziness, headache, anxiety, fatigue, unusual tiredness or weakness. • Metabolic : Swelling in the extremities and decreased appetite. • Musculoskeletal : Joint pain. • Miscellaneous : Back pain, fever. [medindia.net]
- Buffalo Hump
The patient's striae, weight gain, and buffalo hump markedly improved, and further bone loss was halted. [ncbi.nlm.nih.gov]
- Intravenous Drugs
Other literature describes infectious illnesses in intravenous drug users and in organ transplant recipients. [web.archive.org]
Gastrointestinal
- Nausea
If a woman has a lot of nausea and is worried about vomiting up the pills, she can take a medicine that treats vomiting and nausea (called antiemetic medicine ) before she uses the medicines. [consult.womenhelp.org]
Nausea, vomiting, diarrhea, weakness, or dizziness may occur. [webmd.com]
The AE rates for fatigue, headache, nausea, and peripheral edema declined significantly at weeks 16 to 24 (all P CONCLUSIONS: The majority of clinical responders in the SEISMIC trial received mifepristone doses ≥600 mg/day suggesting that higher doses [ncbi.nlm.nih.gov]
Skin
- Skin Lesion
Mifepristone clearly improved skin lesions and diabetes associated with hypercorticism. The beneficial effect lasted for about 10 months. In both cases, recurrent hypertension and hypokalemia eventually required adrenalectomy. [ncbi.nlm.nih.gov]
Psychiatrical
- Suicidal Ideation
[…] within the previous 2 years Veteran has current suicidal ideation Veteran is pregnant or breastfeeding or plans to become pregnant within the year (male or female) not willing to use appropriate forms of contraception during the study and for at least [clinicaltrials.gov]
Urogenital
- Enlarged Uterus
However, with each of the two 6-month courses of mifepristone (9 months apart) she developed massive simple endometrial hyperplasia and a markedly enlarged uterus. This reversed to normal after cessation of mifepristone treatment. [ncbi.nlm.nih.gov]
Neurologic
- Headache
The AE rates for fatigue, headache, nausea, and peripheral edema declined significantly at weeks 16 to 24 (all P CONCLUSIONS: The majority of clinical responders in the SEISMIC trial received mifepristone doses ≥600 mg/day suggesting that higher doses [ncbi.nlm.nih.gov]
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More Common Abdominal or stomach pain or uterine cramping back pain diarrhea dizziness headache nausea or [drugs.com]
Also called RU486 (a trademark) ‘Headache is the symptom most commonly reported either with estrogen plus progestin treatment or with mifepristone alone.’ [en.oxforddictionaries.com]
– May cause: gastrointestinal disturbances, vaginal bleeding, uterine contractions, headache. – Breast-feeding : no contra-indication for a single dose; to be avoided if multiple doses – Do not use mifepristone in ectopic or molar pregnancy. – Storage [medicalguidelines.msf.org]
• Central Nervous System : Dizziness, headache, anxiety, fatigue, unusual tiredness or weakness. • Metabolic : Swelling in the extremities and decreased appetite. • Musculoskeletal : Joint pain. • Miscellaneous : Back pain, fever. [medindia.net]
Workup
Tyrer said, they ''have an extensive workup, they are counseled and examined, they have a urine test, a pelvic exam, they have a surgical procedure that may require general anesthesia, they have recovery time, and they must come back in two weeks for [web.archive.org]
[…] disease (pituitary adenoma) and ectopic corticotropin production from tumors arising outside of the pituitary. 1 Although these cancers are rare, the patients often present with CS, a fact that can compel physicians to perform a challenging complete workup [pediatrics.aappublications.org]
Prognosis
A lot of people do not realize that left untreated, the prognosis for this condition is worse than most cancers. [consultqd.clevelandclinic.org]
Enzalutamide is an anti‐androgen‐receptor inhibitor that has been shown to improve prognosis in patients with CRPC [ 11 ]. [doi.org]
Etiology
The etiology of the Möbius syndrome remains largely unknown and probably involves multiple factors. [ncbi.nlm.nih.gov]
Epidemiology
Published by Oxford University Press on behalf of the International Epidemiological Association [ncbi.nlm.nih.gov]
Dobyns, Infantile hydrocephalus: A review of epidemiology, classification and causes, European Journal of Medical Genetics, 57, 8, (359), (2014). [dx.doi.org]
Vazquez, Morbidity and mortality in Cushing’s disease: an epidemiological approach. Clin. Endocrinol. (Oxf) 40, 479–484 (1994) CrossRef Google Scholar 12. J. Lindholm, S. Juul, J.O. [doi.org]
Participants also stressed that surveillance and communication efforts should continue to be refined and focused on enhancing the epidemiological data about, and awareness among clinicians of, both diseases. [web.archive.org]
Pathophysiology
The mechanisms underlying the pathophysiology of severe psychiatric illnesses are complex, involving multiple neuronal and neurochemical pathways. [ncbi.nlm.nih.gov]
Vitale et al., Pathophysiology of diabetes mellitus in Cushing’s syndrome. Neuroendocrinology 92 (Suppl 1), 77–81 (2010) CrossRef PubMed Google Scholar 22. T. Mancini, B. Kola, F. Mantero, M. Boscaro, G. [doi.org]
Clinical Syndromes, Pathophysiology and Host Factors – Nine presenters discussed various clinical aspects of both C. sordellii and C. difficile. [web.archive.org]
Prevention
[…] safe and effective cancer metastatic preventive agent by targeting CTCs and preventing their adhesion-invasion to vascular intima. [ncbi.nlm.nih.gov]
Antagonists bind to the receptors blocking any chemical signal from binding, thus preventing a chemical reaction from occurring. [embryo.asu.edu]
Indeed, the ability to prevent pregnancy may well turn out to be a much more significant characteristic [4]. [gfmer.ch]