We present 5 cases of progressive hemiparetic corticospinal tract degeneration, identified by the clinical presentation and the exclusion of other etiologies using serological, imaging, and electrodiagnostic studies. © 2015 S. [karger.com]

In this article, we describe a case of a middle-aged woman (initial presentation and three years follow-up) who presented with progressive ascending hemiparesis with clinically isolated upper motor neuron signs and normal sensory examination. [x-mol.com]

We describe a case (initial presentation and one year follow-up) of progressive ascending hemiplegia with clinical isolated upper neuron signs and normal sensory examination, discussing its nosological status, electromyographic findings, differential [mdpi.com]

However, only minor clinical and EMG involvement of LMN, which are not severe enough to meet ALS diagnostic criteria, may be present. [ncbi.nlm.nih.gov]

Physical examination (4 and 8 years after presentation) The gait was unsteady and broad-based. [link.springer.com]

• Weakness

  Examination revealed facial asymmetry, mild pyramidal weakness in the upper and lower limbs with spasticity, brisk reflexes, and upgoing plantar on the right only. Sensory examination was normal. [n.neurology.org]

  However, their pattern of weakness, unlike in typical PLS, was notably asymmetric. [karger.com]

  There was subtle weakness of the left upper limb (MRC grade 4 +) and the left hand was clumsy, with more obvious pyramidal weakness in the left lower limb (MRC grade 4). [link.springer.com]

  Parametric Mapping, SPM, analysis versus controls, uncorrected p < 0.005 at voxel level, p < 0.05 at cluster level, corrected for multiple comparisons) hypometabolism in motor and premotor areas of both hemispheres, mainly contralateral to the limbs weakness [tandfonline.com]

  The patient received monthly intravenous immunoglobulin (IVIG) for three years with no progression of her weakness. To our best knowledge, the response of Mills' syndrome to such an IVIG program has not been reported in the literature so far. [x-mol.com]

• Heart Disease

  His research aims to understand the mechanisms of myocardial injury in patients with heart disease, and to identify novel approaches to improve risk stratification and clinical outcomes in these patients. [esc365.escardio.org]

• Muscle Spasticity

  Inter-rater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther. 1987;67:206–207. [PubMed] [Google Scholar] 5. Fornai F, Siciliano G, Manca MA, Murri L, Paparelli A, Ruggieri S. Lithium in ALS: from the bench to the bedside. [ncbi.nlm.nih.gov]

• Urinary Urgency

  The following year, she began to experience numbness in the right hand as well as low back pain and urinary urgency. A course of intravenous methylprednisolone provided no benefit. [link.springer.com]

• Hyperreflexia

  His neurological examination showed only mild facial asymmetry and asymmetric spasticity as well as hyperreflexia affecting the right upper limb. [karger.com]

  Neurological examination showed left hemiparesis3 with hyperreflexia, spastic hypertonia4 and Babinski sign. Although, on the right side, just the patellar jerk was increased, it was less intensely then the left one, with no signs of fasciculations. [ncbi.nlm.nih.gov]

  Mild pyramidal weakness (Medical Research Council (MRC) grade 4) and hyperreflexia were noted in the right upper and lower limb. [link.springer.com]

• Descending Paralysis

  Zurück zum Zitat Mills CK (1906) Unilateral ascending paralysis and unilateral descending paralysis. Their clinical varieties and their pathologic causes. [springermedizin.de]

  References Mills CK: Unilateral ascending paralysis and unilateral descending paralysis. JAMA 1906;47:1638-1645. Pringle CE, Hudson AJ, Munoz DG, Kiernan JA, Brown WF, Ebers GC: Primary lateral sclerosis. [karger.com]

  By 1906, Mills had gathered a further seven cases of the syndrome, including one case where symptoms began in the arm, leading to the additional epithet ‘unilateral descending paralysis’ [22]. [link.springer.com]

• Limb Weakness

  weakness in a patient with a 10-year history of slowly progressive left-sided hemiparesis. [tandfonline.com]

  On neurological examination, the right upper limb weakness was noted to be worse distally in the arm, with both proximal and distal pyramidal weakness in the right leg. There was normal strength in the left arm and leg. [karger.com]

• Paresis

  Discussion This patient presented a progressive ascending motor neuron disease, with a clear asymmetric involvement, with slow paresis progression. [ncbi.nlm.nih.gov]

  A similar temporal relationship to trauma was noted in a previous case report, in which paresis began developing soon after the patient had sustained open fractures of the same limb [28]. [link.springer.com]

• Babinski Sign

  Neurological examination showed left hemiparesis3 with hyperreflexia, spastic hypertonia4 and Babinski sign. Although, on the right side, just the patellar jerk was increased, it was less intensely then the left one, with no signs of fasciculations. [ncbi.nlm.nih.gov]

Traditionally, Carpal Tunnel treatment has been limited to decompression surgeries, physiotherapy, and prescription medicines. [newtownchiroandpt.com]

Plectin-targeted lisosomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer. Theronostics 8(10):2782-98. [med.virginia.edu]

Her only past medical history of note was of curative (local) treatment for ductal breast carcinoma (11 years after onset of neurological symptoms). There was no family history of neurological disease. [link.springer.com]

[…] case (initial presentation and one year follow-up) of progressive ascending hemiplegia with clinical isolated upper neuron signs and normal sensory examination, discussing its nosological status, electromyographic findings, differential diagnosis and prognosis [mdpi.com]

UMN-ALS is different from classical ALS in the progression rate and time of survival, which enables a better long-term prognosis. [ncbi.nlm.nih.gov]

If our criteria are satisfied, based on our experience and review of the literature, a number of statements can be made with regard to prognosis. First, no patient with the condition has yet died directly from Mills’ syndrome. [link.springer.com]

We present 5 cases of progressive hemiparetic corticospinal tract degeneration, identified by the clinical presentation and the exclusion of other etiologies using serological, imaging, and electrodiagnostic studies. © 2015 S. [karger.com]

A syndrome is a collective of symptoms and signs that could have many etiologies. [ncbi.nlm.nih.gov]

Targetable immune regulatory molecule expression in high-grade serous ovarian carcinomas in African-American women: A study of PD-L1 and IDO in 112 Cases from the African American Cancer Epidemiology Study (AACES). [med.virginia.edu]

Predominantly unilateral primary degeneration of corticospinal pathways is the supposed underlying pathophysiological mechanism. [tandfonline.com]

Killien, B Mills, AV Lele, MS Vavilala JAMA network open 2 (8), e199448-e199448, 201952019Prior arrest, substance use, mental disorder, and intent-specific firearm injury BM Mills, PS Nurius, RL Matsueda, FP Rivara, A Rowhani-Rahbar American journal of preventive [scholar.google.com]

Financial health & the pathology trainee: Fiscal prevention, diagnosis, and targeted therapy for young physicians. Arch Path Lab Med 2018;142(1):12-15. S Zadeh, L Duska, AM Mills. Androgen receptor expression in endometrial carcinoma. [med.virginia.edu]