Presentation
Complex III is present in the mitochondria of all animals and all aerobic eukaryotes and the inner membranes of most eubacteria. Mutations in Complex III cause exercise intolerance as well as multisystem disorders. [en.wikipedia.org]
Entire Body System
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Physician
The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. [rarediseases.info.nih.gov]
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Feeding Difficulties
difficulties in infancy 0008872 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290 Global developmental delay 0001263 Hallucinations Hallucination Sensory hallucination [ more ] 0000738 Hyperreflexia Increased reflexes 0001347 [rarediseases.info.nih.gov]
Gastrointestinal
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Failure to Thrive
[…] to thrive Faltering weight Weight faltering [ more ] 0001508 Feeding difficulties in infancy 0008872 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290 Global developmental delay 0001263 Hallucinations Hallucination Sensory [rarediseases.info.nih.gov]
Liver, Gall & Pancreas
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Liver Dysfunction
dysfunction 0001410 Decreased mitochondrial complex III activity in liver tissue 0006558 Depressivity Depression 0000716 EEG abnormality 0002353 Elevated hepatic transaminase High liver enzymes 0002910 Emotional lability Emotional instability 0000712 [rarediseases.info.nih.gov]
Skin
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Brittle Hair
hair 0002299 Cataract Clouding of the lens of the eye Cloudy lens [ more ] 0000518 Cerebellar atrophy Degeneration of cerebellum 0001272 Cerebral atrophy Degeneration of cerebrum 0002059 Cholangitis Bile duct inflammation 0030151 Cholestasis Slowed or [rarediseases.info.nih.gov]
Neurologic
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Hyperreflexia
Weight faltering [ more ] 0001508 Feeding difficulties in infancy 0008872 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290 Global developmental delay 0001263 Hallucinations Hallucination Sensory hallucination [ more ] 0000738 Hyperreflexia [rarediseases.info.nih.gov]
Treatment
You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments. [rarediseases.info.nih.gov]
Prevention
Antimycin A locks the b hemes in the reduced state by preventing their re-oxidation at the Qi site, which, in turn, causes the steady-state concentrations of the Qo semiquinone to rise, the latter species reacting with oxygen to form superoxide. [en.wikipedia.org]