This article presents an in-depth discussion of a case involving a nearly 10-year-old boy with a history of an unspecified form of MD, who presented for endodontic treatment of tooth No. 30 under deep sedation. [ncbi.nlm.nih.gov]

Both mechanism and treatment for pulmonary hypertension complicated with mitochondrial disease are unclear. Further study is necessary. [ncbi.nlm.nih.gov]

What is the prognosis for mitochondrial disease? The prognosis for patients with mitochondrial myopathies varies greatly, depending largely on the type of disease and the degree of involvement of various organs. [medicinenet.com]

The diagnostic journey may be characterized by heightened levels of uncertainty due to the delayed diagnosis and the absence of a clear prognosis, among other factors. [ncbi.nlm.nih.gov]

Meet other parents and patients in our closed Facebook group. back to top What is the Prognosis for Someone? The prognosis is variable. Some people live a normal life and are minimally affected; others can be severely compromised with the disease. [mitoaction.org]

PROGNOSIS Prognosis depends upon which disorder, which symptoms and the severity of those symptoms. Some of the conditions we thought were uniformly progressive and fatal are not (Leigh syndrome, for example). [childneurologyfoundation.org]

Sensory ataxic neuropathy may be the predominant and presenting manifestation of a mitochondrial disorder, and a mitochondrial etiology should be included in its differential diagnosis. [ncbi.nlm.nih.gov]

However, most other etiologies are due to one or more deficiencies in Complexes I – V of the respiratory chain that ultimately reduce molecular oxygen to water and synthesize ATP from ADP and inorganic phosphate. [aasmnet.org]

The stage has now been reached at which there is a good understanding of both the genetic basis of the disease and its epidemiology, but just how the blindness that follows from the death of cells in the optic nerve can be prevented remains to be a pharmacological [ncbi.nlm.nih.gov]

The epidemiology of Leber hereditary optic neuropathy in the north east of England. Am. J. Hum. Genet. 72, 333–339 (2003) 10. Taylor, R. W. & Turnbull, D. M. Mitochondrial DNA mutations in human disease. Nature Rev. Genet. 6, 389–402 (2005) 11. [doi.org]

The epidemiology of Leber hereditary optic neuropathy in the North East of England. American Journal of Human Genetics 72, 333-339 (2003) Owens, K. N., et al. Genomic sequencing in the service of human rights. [nature.com]

Recent epidemiological studies indicate a population prevalence of ASD in about one in 166 children [2] and of mitochondrial disease in about one in 5–10,000 children [30], [31]. [journals.plos.org]

Epidemiology Edit About 1 in 4,000 children in the United States will develop mitochondrial disease by the age of 10 years. [en.m.wikipedia.org]

We report on the anaesthetic management of a paediatric patient with mitochondrial disease, and briefly discuss the pathophysiology and anaesthetic implications of these disorders. [ncbi.nlm.nih.gov]

In this review, we will interrogate the different NT techniques, including a discussion on the available safety and efficacy data of these technologies for mtDNA disease prevention. [ncbi.nlm.nih.gov]

Photograph: Neil Harding/Getty Families at risk of passing on devastating genetic diseases to their children should be allowed to have a ground-breaking but controversial IVF procedure involving biological material from three “parents” to prevent the [theguardian.com]