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Mitomycin


Presentation

  • He consequently presented severe stenosis at the origin of the cervical esophagus that needed repeated balloon dilatations.[ncbi.nlm.nih.gov]
  • It can present as pneumaturia, fecaluria, and recurrent urinary tract infections, not unlike symptoms of enterovesical fistulas.[ncbi.nlm.nih.gov]
  • The AEs reported have little variation with respect to the dose of MMC used, presenting different "profiles" related to the device used for its administration.[ncbi.nlm.nih.gov]
  • A 40-year-old woman presented with ocular discomfort in both eyes that had persisted for several months.[ncbi.nlm.nih.gov]
  • A 33-year-old woman who underwent bilateral trabeculectomy with adjunctive mitomycin C, 11 years earlier presented with redness and blurred vision in her right eye.[ncbi.nlm.nih.gov]
Congestive Heart Failure
  • Cardiac Toxicity: Congestive heart failure, often treated effectively with diuretics and cardiac glycosides, has rarely been reported. Almost all patients who experienced this side effect had received prior doxorubicin therapy.[ndrugs.com]
Abdominal Pain
  • Nausea , vomiting , stomach / abdominal pain , or loss of appetite may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting .[webmd.com]
  • Nausea , vomiting , stomach/ abdominal pain , or loss of appetite may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting.[medicinenet.com]
  • Nausea, vomiting, stomach/ abdominal pain, or loss of appetite may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting.[medicinenet.com]
Vascular Disease
  • Diagnostic evaluation of other causes of pneumonia, including infection and collagen-vascular diseases, was negative. The autopsy demonstrated diffuse alveolar damage in the lung; there were no remarkable findings in other organs.[ncbi.nlm.nih.gov]
Retinal Hemorrhage
  • Funduscopy revealed a small intravitreal hemorrhage and multiple, extended retinal hemorrhages in all quadrants of the fundus.[ncbi.nlm.nih.gov]
  • This condition may manifest as multiple retinal hemorrhages, edema of the optic disc, macular edema, or a sudden decrease in visual acuity postoperatively.[ncbi.nlm.nih.gov]
Alopecia
  • Adverse Reactions: Thrombocytopenia, leukopenia (cumulative myelosuppression); inj site reactions (eg, cellulitis), stomatitis, alopecia, renal toxicity, pulmonary toxicity (eg, pulmonary infiltrates); discontinue if occurs; hemolytic uremic syndrome,[empr.com]
  • Adverse reactions GI: nausea, vomiting, anorexia, mouth ulcers, stomatitis GU: renal failure, hemolytic uremic syndrome Hematologic: anemia, leukopenia, thrombocytopenia Respiratory: pulmonary toxicity, interstitial pneumonitis Skin: reversible alopecia[medical-dictionary.thefreedictionary.com]
  • Overdose and treatment Signs and symptoms of overdose include myelosuppression, nausea, vomiting, and alopecia.[glowm.com]
  • In addition, there may be nausea and vomiting, loss of appetite ( anorexia ), stomach problems, fatigue, fever , hair loss ( alopecia ), and lung problems. If bleeding does occur, there may be damage to the surrounding skin. Bob Kirsch[encyclopedia.com]
  • Stomatitis and alopecia also occur frequently. Rashes are rarely reported.[ndrugs.com]
Dermatitis
  • We describe two cases of palm and plantar dermatitis after such treatment. We describe two types of dermatitis pathogenesis during treatment with intravesical Mitomycin C: contact dermatitis and delayed hypersensitivity dermatitis.[ncbi.nlm.nih.gov]
  • A severe per ocular contact dermatitis of the left eye developed two days after starting MMC. The patch test result was positive. The per ocular dermatitis resolved after discontinuation of the topical MMC and treatment with a topical corticosteroid.[ncbi.nlm.nih.gov]
  • The most common grade 3 or 4 hematologic toxicity was neutropenia (n 3), while the most frequent severe non-hematologic toxicity was radiation dermatitis (n 6, 30%).[ncbi.nlm.nih.gov]
  • Dermatitis data was extrapolated from the narratives provided by the physicians and a graded according to the Dermatitis Grading Scale from the BCCA Care of Radiation Skin Reactions standard [ 21 ].[ro-journal.biomedcentral.com]
Kidney Failure
  • Mitomycin can damage red blood cells, which may cause irreversible kidney failure.[everydayhealth.com]
  • Mitomycin can also damage red blood cells, which may cause irreversible kidney failure.[uofmhealth.org]
  • Mitomycin can damage red blood cells, which may cause irreversible kidney failure .[emedicinehealth.com]
  • Less common, but important side effects can include: Hemolytic Uremic Syndrome (HUS): This medication can also cause a rare syndrome called hemolytic uremic syndrome (HUS) that destroys red blood cells, damages blood vessels, and can lead to kidney failure[oncolink.org]

Workup

Staphylococcus Aureus
  • After 10 µL of perfusate had been plated on agar plate inoculated by standard strains of either Escherichia coli (strain 25922) or Staphylococcus aureus (strain 25923), it was incubated at 37 C for 24 h.[ncbi.nlm.nih.gov]

Treatment

  • Treatment Carcinoma of Anal Canal 1 2 Terminated Treatment Colorectal Cancers 1 2 Terminated Treatment Hepatocellular,Carcinoma 1 2 Terminated Treatment Malignant Neoplasm of Pancreas 2 2 Terminated Treatment Metastatic Cancers 1 2 Terminated Treatment[drugbank.ca]
  • To evaluate the safety and efficacy of photorefractive keratectomy (PRK) with Mitomycin C (MMC) for the treatment of severe pediatric anisometropia and amblyopia resistant to more conservative treatment modalities.[ncbi.nlm.nih.gov]
  • To know the dermatologic side effects of intravesical treatment with Mitomycin C in non muscle invasive bladder cancer. We describe two cases of palm and plantar dermatitis after such treatment.[ncbi.nlm.nih.gov]
  • Mitomycin C concentration and treatment regimen should be reevaluated to improve the safety of this treatment protocol.[ncbi.nlm.nih.gov]
  • […] the American Urologic Association (AUA) and European Association of Urology (EAU) consider MMC as a standard treatment for immediate single-dose postoperative treatment and for adjuvant therapy in low and intermediate-risk NMIBC.Despite the popularity[ncbi.nlm.nih.gov]

Prognosis

  • Despite the dramatic presentation, the prognosis remains favorable.[ncbi.nlm.nih.gov]
  • These studies aim to identify biomarkers associated with prognosis or response to treatment. Ethical considerations The protocol gained central ethics approval in June 2013.[bmccancer.biomedcentral.com]
  • Management of corneal NV in such cases is important, not only because it may induce lipid deposition and alter visual acuity, but also because it worsens the prognosis for subsequent penetrating keratoplasty (PK) (5) .[sboportal.org.br]

Etiology

  • Lorenz Adult laryngotracheal stenosis: etiology and surgical management Curr Opin Otolaryngol Head Neck Surg, 11 (2003), pp. 467-472 [8.] A. Brichet, C. Verkindre, J. Dupont, M.L. Carlier, J.[revportpneumol.org]
  • Adult laryngotracheal stenosis: etiology and surgical management. Curr Opin Otolaryngol Head Neck Surg, 11 (2003), pp. 467-472 [8.] A. Brichet, C. Verkindre, J. Dupont, M.L. Carlier, J. Darran.[journalpulmonology.org]
  • Physical activity and cancer prevention: Etiologic evidence and biological mechanisms. J Nutr. 2002;132:3456S-64S. Al-Zadjali M, Keller C, Larkey LK, Albertini L. Evaluation of intervention research in weight reduction in post menopausal women.[revistabiomedica.org]
  • If other etiologies are eliminated, Mitomicina C Sandoz (Mitomicina C Sandoz) therapy should be discontinued. Steroids have been employed as treatment of this toxicity, but the therapeutic value has not been determined.[ndrugs.com]

Epidemiology

  • Program, National Taiwan University, Taipei, Taiwan. 6 Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan. 7 Center for Biotechnology, National Taiwan University, Taipei, Taiwan. 8 Institute of Epidemiology[ncbi.nlm.nih.gov]
  • Epidemiological studies indicate that obesity is associated with an increased risk of 20-25% with several types of cancer. Objective. The frequency of chromosome aberrations was evaluated in lymphocytes from postmenopausal obese and non-obese women.[scielo.org.co]
  • . : The epidemiology of bladder cancer. The second look. Cancer, 40: 1246 – 1949, 1977. Google Scholar 3) Soloway, M.S. : Rationale for intensive intravesical chemotherapy for superficial bladder cancer. J. Urol., 123: 461 – 466, 1980.[journals.sagepub.com]
  • (Accessed July 22, 2013) Grulich AE, Poynten IM, Machalek DA, Jin F, Templeton DJ, Hillman RJ: The epidemiology of anal cancer.[ro-journal.biomedcentral.com]
  • Endogenous hormones and ovarian cancer: Epidemiology and current hypotheses. Cancer Epidemiol Biomarkers Prev. 2005;14:98-107. Maffini MV, Calabro JM, Soto AM, Sonnenschein C.[revistabiomedica.org]
Sex distribution
Age distribution

Pathophysiology

  • To our knowledge this factor has not been previously postulated in the pathophysiology of ocular decompression retinopathy.[ncbi.nlm.nih.gov]
  • Based on tumor pathophysiology, pH-sensitive liposomes could provide better tumor-targeted effects. The aim of this study was to investigate the possibility of diminishing the side effect of mitomycin C by using pH-sensitive liposomes.[ncbi.nlm.nih.gov]

Prevention

  • Although intravesical Bacillus Calmette-Guerìn (BCG) is considered the best choice for high-risk patients and MMC for the low-risk group, both MMC and BCG can be given to prevent recurrence in intermediate-risk patients.[ncbi.nlm.nih.gov]
  • It is assumed that trabeculectomy may become the surgical treatment of choice in order to prevent further damage to the optic nerve despite recurring attack of PSS.[ncbi.nlm.nih.gov]
  • Recently, some investigators reported great success using endoscopy-guided topical application of mitomycin-C to prevent scar formation and restenosis in children with benign esophageal strictures unresponsive to balloon dilation.[ncbi.nlm.nih.gov]
  • Prevention and treatment of scar formation have been difficult in certain areas of the head and neck.[tracheostomy.com]
  • Minimally invasive surgery was performed on the cholesterol granuloma with endoscopic assistance, and topical mitomycin (0.4 mg/mL) was administered to prevent scarring of the newly created drainage/ventilation route.[ncbi.nlm.nih.gov]

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