In turn, neuroendocrine dysfunction due to genetic or other deficits can lead, for example, to infertility, impotence, precocious or delayed puberty, defective or excessive growth, obesity and anorexia, Cushing’s Syndrome, hypertension or thyroid disorders [books.google.com]

Low levels of gonadotropins cause infertility, decrease in sex drive, erectile dysfunction, and irregular menstrual cycles. [cancer.net]

 Women usually present with amenorrhea, infertility and galactorrhea.  Men often present with impotence, loss of libido and infertility.  If tumor extends outside of sella, visual field defects or other mass effects may be seen. 31. [slideshare.net]

In women, this can lead to infertility. Large pituitary tumors can slightly elevate blood prolactin levels. Doctors think this occurs because of compression of the pituitary stalk, the connection between the brain and the pituitary gland. [pituitary.ucla.edu]

Patients with pituitary adenomas may present initially with symptoms of endocrine dysfunction such as infertility, decreased libido, and galactorrhea, or with neurologic symptoms such as headache and visual changes. [aafp.org]

SNOMED CT (R) was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO." [doctor.am]

This case highlights the need for a pathologist to select the tissue for analysis before performing any molecular study. [journals.plos.org]

"Practical pituitary pathology: what does the pathologist need to know?". Archives of Pathology & Laboratory Medicine. 132 (8): 1231–40. doi : 10.1043/1543-2165(2008)132[1231:PPPWDT]2.0.CO;2 (inactive 2019-02-18). PMID 18684022. [en.wikipedia.org]

Krassas G, Pontikides N, Dumas A, Frystyk J, Chen JW, Flyvbjerg A, 2004 The effect of long-term somatostatin analogue treatment on free and total insulin-like growth factor (IGF) -I, -II, and IGF binding protein -1, -2, and -3 serum levels in euthyroid [hormones.gr]

[…] or thyrotroph cell, adenomas are the least frequent pituitary adenomas. [59] Clinically, they may present with inappropriately elevated TSH levels and hyperthyroidism, but these tumors may also arise in the setting of hypothyroidism or in clinically euthyroid [emedicine.medscape.com]

Somatostatin analogues, such as octreotide.[ 3, 4 ] Transsphenoidal surgery is the treatment of choice for patients with thyrotropic adenomas.[ 1 ] Adjuvant radiation therapy may be employed when surgery is known to be noncurative even if the patient is still euthyroid [cancer.gov]

[…] insulinlike growth factor 1 Excess growth hormone Elevated (76 to 328 ng per mL [10 to 43 nmol per L])‡ High sensitivity Normally elevated during pregnancy May be low in patients with poorly controlled diabetes mellitus, liver disease, hypothyroidism, and malnutrition [aafp.org]

Also, patients with hepatic or renal failure, hypothyroidism, malnutrition, severe infection, hepatic disease, or poorly controlled diabetes mellitus may have abnormal IGF-1 levels compared with healthy individuals [ 47 – 49 ]. [ojrd.biomedcentral.com]

In turn, neuroendocrine dysfunction due to genetic or other deficits can lead, for example, to infertility, impotence, precocious or delayed puberty, defective or excessive growth, obesity and anorexia, Cushing’s Syndrome, hypertension or thyroid disorders [books.google.com]

Unrecognized adrenocorticotrophic hormonal deficiency in the postoperative period can cause fatigue, anorexia, nausea, vomiting, hypotension, fever, metabolic changes, and rarely death. 22 In response, different institutions have implemented disparate [cns.org]

Symptoms of severe hypopituitarism include: Loss of appetite Weight loss or weight gain Fatigue Decreased energy Decreased mental function Dizziness Changes in hormonal function can cause electrolyte imbalance in the blood, typically low sodium levels [pituitary.ucla.edu]

In turn, neuroendocrine dysfunction due to genetic or other deficits can lead, for example, to infertility, impotence, precocious or delayed puberty, defective or excessive growth, obesity and anorexia, Cushing’s Syndrome, hypertension or thyroid disorders [books.google.com]

It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. [bioportfolio.com]

Complications of Acromegaly Cardiovascular  Ischemic heart disease  Cardiomyopathy  Congestive heart failure  Arrhythmias  Hypertension Respiratory  Kyphosis  Obstructive sleep apnea Metabolic  Diabetes mellitus/IGT  Hyperlipidemia Neurologic [slideshare.net]

Common manifestations are central weight gain, hypertension, and changes in memory, mood, and concentration. [ojrd.biomedcentral.com]

Cushing disease Symptoms Labile mood, proximal muscle weakness, skin changes, changes in facial features, weight gain, depression, hirsutism, decrease in libido, menstrual changes Signs Thin skin, striae/bruising, central obesity, moon facies, plethora, hypertension [aafp.org]

Clinical Findings of Acromegaly Symptoms and signs at presentation Overall prevalence (%) Facial change, acral enlargement, and soft-tissue swelling 100 Excessive sweating 83 Acroparesthesiae/ carpal tunnel syndrome 68 Tiredness and lethargy 53 Headaches [slideshare.net]

Symptoms could include: Fatigue Seizures Clinically Nonfunctioning Pituitary Adenomas: Diagnosis Imaging scans are one method doctors use to diagnose clinically nonfunctioning pituitary adenomas. [pituitary.ucla.edu]

 Other complications: optic nerve damage, seizures, radionecrosis of brain tissue. Pituitary, 100-162. 28. [slideshare.net]

Rarely – Seizures – Stroke – CSF Leak Classic visual deficit for Pituitary Adenoma a. Bilateral temporal hemianopsia is classic visual deficit b. Will lose sight of the lateral visual fields that hit the nasal portion of the eye i. [brainscape.com]

Adjacent brain such as the frontal or temporal lobes may be compressed, resulting in personality problems and seizures. [thamburaj.com]

They also tend to occur insidiously, so that many patients are not aware of them until they are specifically tested. 15 Other neurologic presentations, such as cerebrospinal fluid rhinorrhea, seizures, and pituitary apoplexy, can occur but are uncommon [aafp.org]

One of the most exciting development in medicine today is the pharmacogenomics revolution - enocrinologists and geneticists need to understand how personalized medicine will fit into the daily care of patients. [books.google.com]