We used the vigilance promoting drug modafinil to prevent such attacks in a case presented with endozepine stupor. [ncbi.nlm.nih.gov]

• Excessive Daytime Sleepiness

  May 19, 2018 (Started Aug 31, 2010) Effectiveness None (for Parkinson's disease) Effectiveness None (for excessive daytime sleepiness (somnolence)) Burden Not at all hard to take Advice & Tips: NOW THAT I HAVE PD AND SENSORY NEUROPATHY I AM ALWAY S TIRED [patientslikeme.com]

  Modafinil (Provigil) is a wake-promoting drug approved for patients with narcolepsy or other causes of excessive daytime sleepiness. [ncbi.nlm.nih.gov]

• Hypersomnia

  No study has up to now investigated the effect of modafinil (a reference drug to treat EDS in patients with hypersomnia) on on-road driving performance of patients suffering from central hypersomnia. [ncbi.nlm.nih.gov]

  Abstract Atypical depression, with features of hypersomnia, hyperphagia, anergia, and rejection sensitivity, is a common presentation of major depressive disorder. There are few available effective therapies for this disorder. [oadoi.org]

• Military Personnel

  Here, we review and summarize recent findings of the medical uses of MOD in the management of sleepiness and fatigue associated with depression or cancer as well as exhaustion in military personnel. [ncbi.nlm.nih.gov]

  Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided. [books.google.es]

  "One is always looking for something that would give military personnel an extra edge," she told the committee which is investigating the use of such drugs in sport. [news.bbc.co.uk]

  In its off-label use as a smart drug, it is a well-known “stay awake” solution used to fight fatigue by E.R. doctors, study-obsessed college students, and military personnel. [smartdrugsmarts.com]

  personnel vigilant for up to 60 hours at a time. [scotsman.com]

• Movement Disorder

  A 76-year-old man with movement disorder had a I-FP-CIT (DaTSCAN) SPECT exam demonstrating universally decreased striatal uptake. It was later determined that he had taken modafinil, and the scintigraphy was interpreted as false positive. [ncbi.nlm.nih.gov]

  disorder, speech disorder, hypoesthesia Very rare (less than 0.01%): Tardive dyskinesia, convulsions Frequency not reported : Cataplexy [ Ref ] Gastrointestinal Very common (10% or more): Nausea (up to 11%) Common (1% to 10%): Diarrhea, dry mouth, dyspepsia [drugs.com]

  Rye, Daytime alertness in Parkinson's disease: Potentially dose‐dependent, divergent effects by drug class, Movement Disorders, 27, 9, (1118-1124), (2012). Richard B. [doi.org]

  Stimulation, incoordination, movement disorder, decreased viability. Further reading[edit] Capable of therapy and. Perfect, highly recommended to labeled. Surrendered the eastern district of more than. [kirchen-sieg.de]

  Obsessional-Compulsive Problems: A Cognitive-Behavioural Analysis US5776969A ( en ) 1998-07-07 Treatment of sleep disorders US5916923A ( en ) 1999-06-29 Venlafaxine for the treatment of generalized anxiety disorder Shipton 2000 Tramadol--present and future [patents.google.com]

• Flatulence

  […] disorder, hypoesthesia Very rare (less than 0.01%): Tardive dyskinesia, convulsions Frequency not reported : Cataplexy [ Ref ] Gastrointestinal Very common (10% or more): Nausea (up to 11%) Common (1% to 10%): Diarrhea, dry mouth, dyspepsia, constipation, flatulence [drugs.com]

• Heart Disease

  Left ventricular hypertrophy (heart disease), history of or Mitral valve prolapse (heart disease) after receiving CNS stimulants—Use is not recommended in patients with these conditions. Liver disease, severe—Use with caution. [mayoclinic.org]

  Heart disease: It is not known how modafinil will affect heart disease. There is some evidence that it may cause heart palpitations and chest pain. [chealth.canoe.com]

  disease Frequency not reported : Asystole [ Ref ] Dermatologic Common (1% to 10%): Sweating, herpes simplex Uncommon (0.1% to 1%): Rash, acne, pruritus Rare (less than 0.1%): Eczema Frequency not reported : Ecchymosis, serious skin reactions (including [drugs.com]

  To make sure modafinil is safe for you, tell your doctor if you have: angina (chest pain); cirrhosis or other liver problem; kidney disease; high blood pressure, heart disease, or history of heart attack; a history of mental illness or psychosis; or history [uofmhealth.org]

• Fear

  There was also a reduction in combat fatigue that developed from extended hours of military duty, anxiety, and fear. The effect of modafinil on wakefulness is further emphasized in a study combining the drug with other psychostimulants. [smartdrugsforthought.com]

  “Such unsubstantiated claims could cause real and unnecessary alarm to students and parents and, perversely, could serve to inspire students to obtain such drugs illegally for fear of being at a competitive disadvantage." [telegraph.co.uk]

  Timothy Ferriss, author of the best-selling The 4-Hour Work Week, recently dished about its effects with modafinil fan Joe Rogan, the former host of Fear Factor, on Rogan’s popular podcast. [nymag.com]

  The course of illness was continuous characterized by withdrawn behavior, preoccupation, fear, auditory hallucinations, referential delusions and decline in social and occupational functioning. [doi.org]

• Hyperactivity

  Drugs under investigation for attention-deficit hyperactivity disorder. Curr Opin Investig Drugs 2002 ; 3: 1207 – 11. Google Scholar | Medline 4. [oadoi.org]

  The drug resolved both the inattention/hyperactivity symptoms as well as the amphetamine abuse. Modafinil may be a suitable candidate treatment for adults with ADHD and stimulant abuse. [ncbi.nlm.nih.gov]

• Agitation

  We describe 2 cases in which administration of modafinil exacerbated agitation and hallucinations in DLB, and we also review data that may explain the mechanisms underlying this effect. [ncbi.nlm.nih.gov]

  Mental illness: Modafinil may reactivate certain mental disorders or cause confusion and agitation. [chealth.canoe.com]

  insomnia, dry mouth, diarrhea, constipation, stomach pain, nausea, vomiting, fever, hair loss, loss of appetite Headache, dizziness, nervousness or agitation, nausea, diarrhea, insomnia, or dry mouth Standard dose 5-20 mg 100-200 mg Half-life 10 hours [brainprotips.com]

  […] urinating uncontrolled movements of the face, mouth, or tongue unusual bleeding or bruising unusual tiredness or weakness Get emergency help immediately if any of the following symptoms of overdose occur while taking modafinil: Symptoms of Overdose Agitation [drugs.com]

  To October 2008, we have received 339 adverse reaction reports with varenicline, 255 (72%) of which describe psychiatric symptoms including depression, aggression, agitation, abnormal dreams, insomnia, hallucination and anger. [tga.gov.au]

• Seizure

  […] as an adverse event in populations at risk, such as those with ADHD, head injury, and brain tumors; it is not associated with worsening of seizure disorder in patients with current seizure disorder; and it is not associated with seizures in overdose. [ncbi.nlm.nih.gov]

  Modafinil for treatment of cognitive side effects of antiepileptic drugs in a patient with seizures and stroke. Epilepsy and Behavior 4:352–353. [doi.org]

  We have also received 15 reports of seizures in patients using varenicline. It is not known how many of these had a prior history or risk of a seizure disorder and there is no experience from clinical trials of varenicline in patients with epilepsy. [tga.gov.au]

• Difficulty Concentrating

  Symptoms such as difficulty concentrating or indecisiveness contribute to the disability associated with depression. Almost all patients with depression experience problems with concentration, memory, and attention. [cam.ac.uk]

  Effect,’ ‘High,’ ‘Hungry,’ ‘Irritable,’ ‘Jittery,’ ‘Mellow,’ ‘Miserable,’ ‘Nauseous,’ ‘On Edge,’ ‘Restless,’ ‘Sedated,’ ‘Self-confident,’ ‘Sleepy,’ ‘Social,’ ‘Stimulated,’ ‘Talkative,’ ‘Tired,’ ‘Unmotivated,’ ‘Withdrawn,’ ‘I am Sweating,’ ‘I’m having Difficulty [dx.doi.org]

METHOD: 57 cocaine dependent participants were randomized to receive modafinil 400mg or placebo daily during a period of inpatient treatment followed by six weeks of outpatient treatment. [ncbi.nlm.nih.gov]

We did not include studies comparing different types of cancer‐modifying treatment and the effect on prognosis and quality of life. We also excluded those studies which did not focus on pharmacological treatment. [doi.org]

Deficits in the dopamine receptor system are involved in the etiology of apathy; modafinil's increased dopaminergic transmission is thought to help alleviate apathy. [ncbi.nlm.nih.gov]

Thus, despite numerous investigations, the etiology of SLE-associated cognitive dysfunction remains unclear. There is no known means for preventing cognitive dysfunction in SLE. [clinicaltrials.gov]

The cause is known and etiologically homogenous, and typically lifelong treatment will be needed, with the goal of optimizing life for these patients according to their goals. [doi.org]

Patients completed the Center for Epidemiological Studies-Depression Scale (CES-D) and Profile of Mood States depression-dejection subscale at baseline and posttest. [ncbi.nlm.nih.gov]

Epidemiology, evaluation of the sleepy patient, diagnostic investigations including neuroimaging, subjective and objective testing, cognitive effects of sleepiness, motor vehicle driving issues, medico-legal aspects of sleepiness, and therapy are also [books.google.it]

Nelson KB : Epidemiology of Cerebral Palsy in the Year 2000. Presented at the 29th annual meeting of the Child Neurology Society, St. Louis, MO, October 28, 2000. [dx.doi.org]

Tiredness, sedation assessed with scales such as the Chalder Fatigue Scale (CFS) or Center for Epidemiologic Studies Depression (CESD) scale. [doi.org]

In accord with this mission, this peer-reviewed, rapid-publication, international journal publishes both basic and clinical contributions from all disciplines and research areas relevant to the pathophysiology and treatment of major psychiatric disorders [elsevier.com]

Circadian rhythm sleep disorders: pathophysiology and treatment. J Clin Neurophysiol 1996 ;13: 17 - 31 20. Zisapel N. Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. CNS Drugs 2001 ;15: 311 - 328 21. [nejm.org]

This effect may also interact with underlying pathophysiology in this system, manifest in either neurochemical disturbances and/or altered responses to cognitive demands 35, 36, 37, 38, 39. [nature.com]

We used the vigilance promoting drug modafinil to prevent such attacks in a case presented with endozepine stupor. [ncbi.nlm.nih.gov]

Modafinil dose-dependently prevented the decline in motor activity normally produced by MPTP treatment. [springerlink.com]

We test modafinil, a novel wake-promoting agent, as monotherapy for atypical depression in a double-blind, placebo-controlled, relapse prevention trial after open-label treatment. [oadoi.org]