We used the vigilance promoting drug modafinil to prevent such attacks in a case presented with endozepine stupor. [ncbi.nlm.nih.gov]

• Asymptomatic

  Upon withdrawal of the drug, the patient experienced recurrent episodes and on reinstitution of modafinil she has remained asymptomatic in the following one year. [ncbi.nlm.nih.gov]

• Dysphoric Mood

  His dysphoric mood and lethargy improved and his level of anhedonia and amotivation decreased. In literature, only one case study has been reported on modafinil dependence at higher doses. [doi.org]

• Sexual Dysfunction

  Premature ejaculation (PE) is considered to be the most common form of male sexual dysfunction. [ncbi.nlm.nih.gov]

• Hyperactivity

  Drugs under investigation for attention-deficit hyperactivity disorder. Curr Opin Investig Drugs 2002 ; 3: 1207 – 11. Google Scholar Medline 4. [oadoi.org]

  The drug resolved both the inattention/hyperactivity symptoms as well as the amphetamine abuse. Modafinil may be a suitable candidate treatment for adults with ADHD and stimulant abuse. [ncbi.nlm.nih.gov]

• Agitation

  We describe 2 cases in which administration of modafinil exacerbated agitation and hallucinations in DLB, and we also review data that may explain the mechanisms underlying this effect. [ncbi.nlm.nih.gov]

  Mental illness: Modafinil may reactivate certain mental disorders or cause confusion and agitation. [chealth.canoe.com]

  […] urinating uncontrolled movements of the face, mouth, or tongue unusual bleeding or bruising unusual tiredness or weakness Get emergency help immediately if any of the following symptoms of overdose occur while taking modafinil: Symptoms of Overdose Agitation [drugs.com]

  Side effects which have been reported by patients include: Headache Diarrhoea Nervousness or anxiety Agitation confusion Tremors Insomnia Hypertension (high blood pressure) Palpitations Tachycardia Angioedema Psychosis Depression or other behavioural [unitedpharmacies-uk.md]

• Akinesia

  The profound akinesia induced by reserpine (4 mg/kg s.c.; 5 h before testing) was reversed by ( )amphetamine 2 mg/kg but not by modafinil 40 mg/kg. [ncbi.nlm.nih.gov]

  In addition, modafinil fails to reverse reserpine-induced akinesia, whereas dextroamphetamine, a dopamine releasing agent (DRA), is able to do so. [en.wikipedia.org]

• Stupor

  Endozepine-4 stupor is a rare disorder. It presents with recurrent episodes of stupor and coma. Endozepine-4 levels are elevated during an attack with electroencephalogram showing fast activity during the ictal phase. [ncbi.nlm.nih.gov]

• Fine Tremor

  Physical examination was within normal limits except for fine tremors. His blood investigations gave the following values hemoglobin - 12.4 gm%;, WBC count - 6300 cells/mm 3 ; platelet count - 2.4 lakhs/mm 3 ;, random blood sugar - 122 mg/dl. [doi.org]

• Dyslipidemia

  As co-morbidities the patient demonstrated overweight (IMC 29), systemic arterial hypertension and dyslipidemia. [ncbi.nlm.nih.gov]

Next, we addressed the translational value of the observed effects by testing PBMCs from Narcolepsy type 1 patients that underwent Modafinil treatment. [ncbi.nlm.nih.gov]

We did not include studies comparing different types of cancer‐modifying treatment and the effect on prognosis and quality of life. We also excluded those studies which did not focus on pharmacological treatment. [doi.org]

Deficits in the dopamine receptor system are involved in the etiology of apathy; modafinil's increased dopaminergic transmission is thought to help alleviate apathy. [ncbi.nlm.nih.gov]

Thus, despite numerous investigations, the etiology of SLE-associated cognitive dysfunction remains unclear. There is no known means for preventing cognitive dysfunction in SLE. [clinicaltrials.gov]

Michael Thorpy, Current concepts in the etiology, diagnosis and treatment of narcolepsy, Sleep Medicine, 2, 1, (5), (2001). Michael H. Silber, Sleep disorders, Neurologic Clinics, 19, 1, (173), (2001). [doi.org]

Patients completed the Center for Epidemiological Studies-Depression Scale (CES-D) and Profile of Mood States depression-dejection subscale at baseline and posttest. [ncbi.nlm.nih.gov]

Epidemiology, evaluation of the sleepy patient, diagnostic investigations including neuroimaging, subjective and objective testing, cognitive effects of sleepiness, motor vehicle driving issues, medico-legal aspects of sleepiness, and therapy are also [books.google.it]

Nelson KB : Epidemiology of Cerebral Palsy in the Year 2000. Presented at the 29th annual meeting of the Child Neurology Society, St. Louis, MO, October 28, 2000. [dx.doi.org]

In accord with this mission, this peer-reviewed, rapid-publication, international journal publishes both basic and clinical contributions from all disciplines and research areas relevant to the pathophysiology and treatment of major psychiatric disorders [elsevier.com]

Circadian rhythm sleep disorders: pathophysiology and treatment. J Clin Neurophysiol 1996 ;13: 17 - 31 20. Zisapel N. Circadian rhythm sleep disorders: pathophysiology and potential approaches to management. CNS Drugs 2001 ;15: 311 - 328 21. [nejm.org]

This effect may also interact with underlying pathophysiology in this system, manifest in either neurochemical disturbances and/or altered responses to cognitive demands 35, 36, 37, 38, 39. [nature.com]

We used the vigilance promoting drug modafinil to prevent such attacks in a case presented with endozepine stupor. [ncbi.nlm.nih.gov]

Modafinil dose-dependently prevented the decline in motor activity normally produced by MPTP treatment. [springerlink.com]

We test modafinil, a novel wake-promoting agent, as monotherapy for atypical depression in a double-blind, placebo-controlled, relapse prevention trial after open-label treatment. [oadoi.org]