Abstract A case of chronic non-neuronopathic Gaucher's disease is presented. The diagnosis was based on the finging of typical Gaucher cells in the bone marrow spleen. The patient also had a benign monoclonal gammapathy. [ncbi.nlm.nih.gov]

Further, our first case suggests that a monoclonal gammopathy may not be present at the onset of disease but may present later in the course. [omicsonline.org]

• Oligoarthritis

  The cases had oligoarthritis or polyarthritis mimicking rheumatoid arthritis. However, rheumatoid factor was absent in all patients, and distal interphalangeal joints were involved in two cases and sacroiliitis in one. [ncbi.nlm.nih.gov]

Complete hematologic workup with serum and urine protein electrophoresis, immunofixation, and serum-free light-chain assay is required. [theisn.org]

A kappa-lambda ratio below 0.37 or above 3 is rarely seen in chronic kidney disease and should prompt workup for MGUS. 16 Tests in combination. [mdedge.com]

Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3. Blood 2011;117:4701–5. Google Scholar 7. [degruyter.com]

BM examination should be part of the diagnostic workup for all IgA and IgM M-proteins. [haematologica.org]

Thus, renal biopsy along with detailed hematologic workup is essential to link the presence of the paraprotein to the associated renal disease. [cjasn.asnjournals.org]

It is evident that a period of at least three years of close observation without treatment should be the routine. "Prophylactic" treatment of BMG with cytostatic drugs should never be attempted. [ncbi.nlm.nih.gov]

Conclusions : Exudative maculopathy unresponsive to conventional treatment may suggest an underlying hematologic condition. [iovs.arvojournals.org]

The treatment of MGRS-related kidney diseases should be tailored to the clone responsible. In the past, part of the reticence for withholding treatment was that alkylators were the only antiplasma cell therapies available. [bloodjournal.org]

Those who failed to improve with the initial treatment received an alternative second or third treatment at the discretion of the treating physician. [jnnp.bmj.com]

Characterization of primary systemic amyloidosis, clinical manifestations and disease prognosis. [cima.unav.edu]

In addition, serum FLC measurements have shown utility in determining the prognosis of and in detecting and monitoring light chain amyloidosis. [aacc.org]

A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med 2002;346:564–9. Google Scholar 5. Dispenzieri A, Katzmann JA, Kyle RA, Larson DR, Melton LJ 3rd, Colby CL, et al. [degruyter.com]

Monoclonal gammopathy is identified in 10% of patients with idiopathic peripheral neuropathy, and the presence of a monoclonal protein may have significant implications regarding the etiology, progression, and prognosis of the neuropathy. [medlink.com]

Prognosis MGUS is generally considered benign and has no ill effects on overall health or survival. However, regular check-ups are essential, since myeloma typically develops in 1% to 2% of MGUS patients per year. [cancer.uams.edu]

Monoclonal gammopathy is identified in 10% of patients with idiopathic peripheral neuropathy, and the presence of a monoclonal protein may have significant implications regarding the etiology, progression, and prognosis of the neuropathy. [medlink.com]

Only a few case reports in the past have implicated visceral leishmaniasis as an etiology of monoclonal gammopathy. 2-4 In one case, the patient had a monoclonal triple band. 2 In few cases BMA did not reveal LD bodies, and antileishmanial serology was [scielo.br]

Etiologic Factors for MGUS and Prospects for Primary Prevention Recent observations offer important clues, indicating that genetic predisposition and potentially preventable environmental factors may play a key role in the development of MGUS. [clincancerres.aacrjournals.org]

[…] include IgH translocation, hyperdiploidy and cyclin D dysregulation Secondary genetic events include: NRAS, KRAS and BRAF mutations NFkB pathway mutations TP53, PTEN and RB inactivation Most non-IgM MGUS cases are IgG, followed by IgA, biclonal and IgD Etiology [pathologyoutlines.com]

Repeat CT of his chest revealed a new right lower lobe consolidation abutting the diaphragm with surrounding ground-glass opacity most consistent with pneumonia and two new lung nodules that were likely infectious in etiology. [omicsonline.org]

“Monoclonal gammopathy of undetermined significance and smoldering myeloma: new insights into pathophysiology and epidemiology”. Hematology Am Soc Hematol Educ Program. vol. 2010. 2010. pp. 295-302. [cancertherapyadvisor.com]

Detailed classification of MGUS: A roadmap for monitoring patients Extensive epidemiologic and clinical studies have refined the classification of MGUS 3-5 and related disorders ( TABLES 2-4 ), 3 providing physicians with guidance on how to monitor patients [mdedge.com]

J Clin Pathol 35:63–68 PubMed CrossRef Google Scholar Salmon SE, Kyle RA (1994) Silicone gels, induction of plasma cell tumors, and genetic susceptibility in mice: a call for epidemiologic investigation of women with silicone breast implants. [link.springer.com]

History of the Rochester Epidemiology Project. Mayo Clin Proc 1996 ;71: 266 - 274 16. Kyle RA, Katzmann JA, Lust JA, Dispenzieri A. Immunochemical characterization of immunoglobulins. In: Rose NR, Hamilton RG, Detrik B, eds. [nejm.org]

"Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: a review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease". [en.wikipedia.org]

“Monoclonal gammopathy of undetermined significance and smoldering myeloma: new insights into pathophysiology and epidemiology”. Hematology Am Soc Hematol Educ Program. vol. 2010. 2010. pp. 295-302. [cancertherapyadvisor.com]

More prevalent in African Americans than Caucasians (2 - 3 fold) ( Leukemia 2014;28:1537 ) More common in men than women (1.5:1) Non-IgM MGUS represents up to 85% of MGUS cases Pathophysiology Origin is clonal mature plasma cells residing in the bone [pathologyoutlines.com]

[…] numbness or tingling. [1] Severe renal disease has also been found in a subset of those with monoclonal gammopathy. [1] MGUS is usually detected by chance when the patient has a blood test for another condition or as part of standard screening. [1] Pathophysiology [en.wikipedia.org]

These techniques will no doubt increase our understanding of the pathophysiology and advance the treatment of these patients. [degruyter.com]

Pathophysiology The reason for the monoclonal expansion of a single Ig-secreting plasma cell population in what appears to be a nonmalignant manner is unknown in most cases. Most cases involve IgG or IgA monoclonal cell populations. [emedicine.medscape.com]

Etiologic Factors for MGUS and Prospects for Primary Prevention Recent observations offer important clues, indicating that genetic predisposition and potentially preventable environmental factors may play a key role in the development of MGUS. [clincancerres.aacrjournals.org]

This progression cannot be prevented. [merckmanuals.com]

In some cases, treatment aimed at preventing progression to active myeloma is indicated. Prognosis MGUS is generally considered benign and has no ill effects on overall health or survival. [cancer.uams.edu]

Blood disorders affect one or more parts of the blood and prevent your blood from doing its job. They can be acute or chronic. Many blood disorders are inherited. [icdlist.com]

Asymptomatic Patients Practice guidelines do not recommend routine screening for MGUS in the general population because of the lack of proven benefit and the absence of curative or preventive therapy. [ashclinicalnews.org]