Seizures are present in 50-58% of patients. Age of seizure onset is not well defined, but generally they start in infancy or childhood [9-11]. [ncbi.nlm.nih.gov]

Seizures are present in 50-58% of patients. Age of seizure onset is not well defined, but generally they start in infancy or childhood [9–11]. [ijponline.biomedcentral.com]

Figures FIG. 1 Clinical appearance of the present patient at different ages. A: In first evaluation at age of 3 years. B: In second evaluation at age 17 years of age. [pubmed.ncbi.nlm.nih.gov]

• Cerebral Palsy

  palsy 4462 B00309 Charlie M syndrome 4463 B00325, B00326 1q4 monosomy del(1)(q42 or q43-qter) (1q42 or q43-qter monosomy) 4464 B00327 1q25-q32 trisomy dup(q25-q32) [Dup(1q) syndrome] 4465 B00328 1q32-qter trisomy dup(1)(q32-qter) [Dup(1q) syndrome] 4466 [syndromefinder.ncchd.go.jp]

[…] and, in many cases, psychiatric treatment was administered for several years without any improvement [39]. [ncbi.nlm.nih.gov]

Infantile spasms, particularly frequent in male patients, are usually associated with a poor long-term prognosis (Fig. 1) [19,51,62-65]. [ncbi.nlm.nih.gov]

Infantile spasms, particularly frequent in male patients, are usually associated with a poor long-term prognosis (Fig. 1) [19, 51, 62–65]. [ijponline.biomedcentral.com]

Seizures in children with Down syndrome: etiology, characteristic and outcome. Dev Med Child Neurol. 1991;33:191–200. [PubMed] [Google Scholar] Stafstrom CE. Epilepsy in Down syndrome: clinical aspects and possible mechanisms. [ncbi.nlm.nih.gov]

Article Google Scholar Stafstrom CE, Patxot DF, Gilmore HE, Wisniewski KE: Seizures in children with Down syndrome: etiology, characteristic and outcome. Dev Med Child Neurol. 1991, 33: 191-200. [ijponline.biomedcentral.com]