We also present the positions of the FDA, manufacturer, and national organizations of allergists and immunologists on the possible role of montelukast in suicidality. [dx.doi.org]

We propose that eosinophilic cystitis in children who present with peripheral eosinophilia will often require long-term treatment. [ncbi.nlm.nih.gov]

• Hypoxemia

  Bronchoalveolar lavage could not be performed due to bronchospasm and severe hypoxemia; however, mucosal biopsies were obtained, which revealed eosinophil leukocytes in the lumen and walls of small vessels. [ncbi.nlm.nih.gov]

• Osteopenia

  However, side effects due to long term use of steroids such as growth stunting and bone osteopenia should also be considered before recommending. Trial registered at CTRI no. REF/2012/09/004035. [ncbi.nlm.nih.gov]

• Urinary Urgency

  When montelukast 10 mg was initiated for allergic rhinitis symptoms, a substantial improvement in urinary urgency and pain during therapy was noted. This improvement subsequently disappeared when montelukast was stopped. [ncbi.nlm.nih.gov]

• Neurologic Manifestation

  Abstract Churg-Strauss syndrome (CSS) is a disseminated small vessel vasculitis characterized by late-onset asthma, upper airways disease, eosinophilia and late neurological manifestations such as peripheral neuropathy. [ncbi.nlm.nih.gov]

• Bilateral Pulmonary Infiltrates

  Although her chest X-ray was normal a week earlier, she had widespread bilateral pulmonary infiltrates on admission. She had leukocytosis (12.5 × 10(9)/l) with eosinophilia (15.6%). Her total IgE count was 550 U/ml. [ncbi.nlm.nih.gov]

Further cases and comparative studies are required to develop an evidence base for treatment of this condition. [ncbi.nlm.nih.gov]

Some of these cases are characterized by severe prognosis (i.e. neurological deficit and fatal hepatotoxicity). Key Message: The use of montelukast can be burdened by several ADRs, of which physicians should be aware in their clinical practice. [ncbi.nlm.nih.gov]

This rare vasculitis presents a broad range of clinical manifestations, sometimes characterized by a severe prognosis and permanent sequelae. CSS affects especially adult patients of both genders. [karger.com]

Prognosis for spontaneous resolution of OSA in children. Chest 2015 ;148: 1204 – 1213. 17. Trosman SJ, Eleff DJ, Krishna J, Anne S. [atsjournals.org]

We have also taken into account that the study was performed in patients with a late diagnosis of BOS (mean time of diagnosis around 5y after LTx), and it is known that late-onset BOS patients have a better prognosis than rapid decliners and early-onset [journals.plos.org]

Briggs, Freeman, & Yaffe – Montelukast is not teratogenic in animals, and few adverse outcomes in humans do not demonstrate a pattern that suggests a common etiology. [americanpregnancy.org]

In recent years, increasing evidence has suggested that regulatory T-cells are involved in various skin diseases and play a pivotal role in the etiology of AD. [peertechz.com]

More accurate epidemiological studies, in order to discover risk factors favouring montelukast-associated ADRs, are demanded. © 2014 S. Karger AG, Basel. [ncbi.nlm.nih.gov]

Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA; 5 Department of Clinical Pharmacy, School of Pharmacy, University of Colorado, Aurora, CO, USA; 6 Division of Epidemiology [dx.doi.org]

The US Food and Drug Administration began investigating Montelukast in 2008 and a review conducted in 2014 noted that there was "a lack of well-designed epidemiologic studies that can lead to the quantification of the suicide/suicide attempt risk level [abc.net.au]

Eosinophilic peritonitis is a recognised complication of peritoneal dialysis and has an incompletely understood pathophysiology. [ncbi.nlm.nih.gov]

Drugs used in the treatment of asthma must be targeted at reversing three principle pathophysiologic features: bronchoconstriction, mucus plugging/hypersecretion and inflammation. [dx.doi.org]

(via oxoacid ) leukotriene antagonist A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. [ebi.ac.uk]

In addition, it has been shown that LTRAs may have a potential role in preventing atherosclerosis progression. [ncbi.nlm.nih.gov]

Daily administration for the chronic treatment of asthma has not been established to prevent acute episodes of EIB. [drugs.com]