Un patient de 50 ans presentant un UM de l'oeil gauche, rebelle, a recu durant 20 mois du Cy qui a permis une cicatrisation corneenne. [infona.pl]

It has been hypothesized that antigen-presenting cells at the limbus can present the unveiled self-antigens via certain HLA class II molecules to T-cells, priming them. [eyewiki.aao.org]

• Relapsing Polychondritis

  Other collagen vascular diseases in which peripheral ulcerative keratitis can occur include systemic lupus erythematosus, systemic sclerosis, and relapsing polychondritis [4]. [eyewiki.aao.org]

• Suggestibility

  We suggest that immunosuppressive therapy using IV monthly Cy may be proposed in severe rebel MU. Identifiers Authors User assignment Assign yourself or invite other person as author. It allow to create list of users contirbution. [infona.pl]

  While the unilateral form has been said to be readily treatable, other studies have suggested otherwise [1]. [eyewiki.aao.org]

  No one knows what this trigger is, but suggestions have included prior eye surgery, prior eye trauma and a variety of infections. [oogziekenhuis.me]

• HLA-DQ2

  The same study found that only one out of 10 patients with another form of destructive sclerokeratitis expressed the HLA-DR17 allele and three expressed HLA-DQ2. [eyewiki.aao.org]

The response to surgical procedure and intravenous steroid treatment was poor and corneal perforation occurred. The affected cornea healed after 9 months of Cy treatment. [infona.pl]

The initial treatment of Mooren’s ulcer consists of topical corticosteroids. [eyewiki.aao.org]

Treatment In the last 100 years, many treatments have been advocated for Mooren's ulcer. Currently, most ophthalmologists treat Mooren's ulcer with medications that suppress the immune system. [oogziekenhuis.me]

Prognosis Mooren's ulcer can range from mild cases affecting one eye that do not threaten vision to severe cases involving both eyes and threatening the vision. [oogziekenhuis.me]

The etiology remains unknown. [infona.pl]

Although the etiology for Mooren’s ulcer is unknown, there is evidence suggesting an autoimmune basis, and possibly genetic and environmental factors contribute to the pathogenesis. [eyewiki.aao.org]

Epidemiology Mooren’s ulceration is a rare disease. One study approximated the incidence to be 0.03% in China [2]. [eyewiki.aao.org]

It has also been shown that elevated NF-κB activity may be responsible for the pathology.[18] Pathophysiology It has been postulated that Mooren’s ulcer may result from an autoimmune etiology. [eyewiki.aao.org]