Un patient de 50 ans presentant un UM de l'oeil gauche, rebelle, a recu durant 20 mois du Cy qui a permis une cicatrisation corneenne. [infona.pl]

It has been hypothesized that antigen-presenting cells at the limbus can present the unveiled self-antigens via certain HLA class II molecules to T-cells, priming them. [eyewiki.aao.org]

• Pain

  Introduction Mooren's ulcer, also referred to as Mooren ulcer, is a rare, painful, inflammatory condition affecting one or both eyes that results in the destruction of corneal tissue. [oogziekenhuis.me]

  Pellucid marginal degeneration causes inferior corneal thinning and causes irregular against-the-rule astigmatism but lacks the inflammation and pain seen in Mooren's ulcer [4]. [eyewiki.aao.org]

• Surgical Procedure

  The response to surgical procedure and intravenous steroid treatment was poor and corneal perforation occurred. The affected cornea healed after 9 months of Cy treatment. [infona.pl]

• Severe Pain

  History and Physical examination Patients often experience severe pain, photophobia, and tearing along with a red inflamed eye. About one third of cases present bilaterally [21]. [eyewiki.aao.org]

• Ulcer

  An ophthalmologist makes the diagnosis of Mooren's ulcer once he is convinced that a patient's eye has changes that are characteristic of Mooren's ulcer and that conditions which can mimic Mooren's ulcer have been excluded. [oogziekenhuis.me]

  Purpose. - Mooren's ulcer (MU) is a chronic peripheral corneal ulceration featuring conjunctival immunoglobulin deposits. It is considered as the result of a limbic immune process with hyperactivation of T and B lymphocytes. [infona.pl]

• Anterior Uveitis

  Anterior uveitis occurs 6.8% of the time and can involve fine dusty keratic precipitates and posterior synechiae locally [2]. Complicated cataracts can occur in 2.3% [2]. [eyewiki.aao.org]

• Photophobia

  History and Physical examination Patients often experience severe pain, photophobia, and tearing along with a red inflamed eye. About one third of cases present bilaterally [21]. [eyewiki.aao.org]

The initial treatment of Mooren’s ulcer consists of topical corticosteroids. [eyewiki.aao.org]

The response to surgical procedure and intravenous steroid treatment was poor and corneal perforation occurred. The affected cornea healed after 9 months of Cy treatment. [infona.pl]

Treatment In the last 100 years, many treatments have been advocated for Mooren's ulcer. Currently, most ophthalmologists treat Mooren's ulcer with medications that suppress the immune system. [oogziekenhuis.me]

Prognosis Mooren's ulcer can range from mild cases affecting one eye that do not threaten vision to severe cases involving both eyes and threatening the vision. [oogziekenhuis.me]

The etiology remains unknown. [infona.pl]

Although the etiology for Mooren’s ulcer is unknown, there is evidence suggesting an autoimmune basis, and possibly genetic and environmental factors contribute to the pathogenesis. [eyewiki.aao.org]

Epidemiology Mooren’s ulceration is a rare disease. One study approximated the incidence to be 0.03% in China [2]. [eyewiki.aao.org]

It has also been shown that elevated NF-κB activity may be responsible for the pathology.[18] Pathophysiology It has been postulated that Mooren’s ulcer may result from an autoimmune etiology. [eyewiki.aao.org]