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Morganella Morganii


Presentation

  • Herein, the authors present a rare, previously unreported case of M morganii septicemia (as confirmed by positive blood culture), secondary to myiasis of the lower extremities.[ncbi.nlm.nih.gov]
  • However, 1 week after first surgery, her condition deteriorate presenting bone erosion in distal phalanx of ring finger from X-ray. Considering severity of illness, we decide to perform digital amputation.[ncbi.nlm.nih.gov]
  • A clinical case report of M. morganii infection complicating preterm rupture of membranes is presented.[ncbi.nlm.nih.gov]
  • We present a case of a healthy gravid individual who presented with chorioamnionitis and neonatal seizures associated with M. morganii. This organism, which causes severe morbidity, is fortunately rare in obstetrics and gynecology.[ncbi.nlm.nih.gov]
  • In this report we present a case of chorioamnionitis caused by Morganella morganii. The case was complicated by a life-threatening Adult Respiratory Distress Syndrome.[ncbi.nlm.nih.gov]
Swelling
  • A 58-year-old Chinese female complains about whitlow with pain and swelling for 2 weeks. She has a history of diabetes for 10 years.[ncbi.nlm.nih.gov]
  • On examination of the knee, erythema, warmth, tenderness and swelling was observed. Arthrocentesis performed on his left knee indicated the presence of straw-coloured, cloudy fluid without crystals.[ncbi.nlm.nih.gov]
  • However, his eye became more inflamed with mucopurulent discharge, and the ophthalmic examination was difficult to perform due to severe periorbital swelling ( Figure 1 ).[nature.com]
  • Radiographs of the right foot revealed soft tissue swelling with the presence of air and osteopenia of the right small phalanx, and the magnetic tomography imaging of the same region revealed periosteal reaction, cortical destruction, and soft tissue[journals.lww.com]
Gangrene
  • Bacterial species other than Clostridium should be considered in all cases of gas gangrene.[ncbi.nlm.nih.gov]
  • Thirteen patients (54%) suffered from skin and soft tissue infections, five from pyelonephritis, three from female genital tract infections, one from pneumonia, one from gangrenous appendicitis, and one from tonsillitis.[ncbi.nlm.nih.gov]
  • PubMed Central PubMed Google Scholar Ghosh S, et al: Fatal Morganella morganii bacteraemia in a diabetic patient with gas gangrene. Journal of medical microbiology. 2009, 58 (7): 965-967. 10.1099/jmm.0.008821-0.[doi.org]
Splenectomy
  • Splenectomy and immunosuppression for chronic GVH-D are likely to have favored the development of this rare infectious complication after BMT.[ncbi.nlm.nih.gov]
  • The authors conclude that splenectomy could have been a predisposing factor for the development of this unusual complication.[doi.org]
Asymptomatic
  • Abstract We report a case of Morganella morganii acute endophthalmitis following clear corneal phacoemulsification cataract surgery in which a coincident asymptomatic chronic urinary tract infection was detected postoperatively.[ncbi.nlm.nih.gov]
Lower Abdominal Pain
  • A 54-year-old menopausal woman visited the emergency room with lower abdominal pain, vomiting, and fever for 4 days. Pelvic examination revealed lifting tenderness over the right adnexum without motion tenderness of the uterus.[ncbi.nlm.nih.gov]
Vomiting
  • A 54-year-old menopausal woman visited the emergency room with lower abdominal pain, vomiting, and fever for 4 days. Pelvic examination revealed lifting tenderness over the right adnexum without motion tenderness of the uterus.[ncbi.nlm.nih.gov]
Lacrimation
  • During careful intraoperative examination the abscess was seen to directly extend from the lacrimal sac. Cultures were taken and grew Morganella morganii, a Gram negative rod uncommon in ocular and periocular infections.[ncbi.nlm.nih.gov]
Corneal Infiltrate
  • A 52-year-old female patient presented with marked bilateral corneal infiltration and hypopyon without any usual predisposing factors for bilateral infectious keratitis.[ncbi.nlm.nih.gov]
Ecthyma
  • Abstract Ecthyma gangrenosum is considered as a pathognomonic sign of Pseudomonas aeruginosa sepsis. Lesions similar to ecthyma gangrenosum may be caused by other organisms.[ncbi.nlm.nih.gov]
  • Several reports indicate M. morganii causes sepsis, ecthyma, endophthalmitis, and chorioamnionitis, and more commonly urinary tract infections, soft tissue infections, septic arthritis, meningitis, and bacteremia, often with fatal consequences.In a rare[en.wikipedia.org]
  • Ecthyma gangrenosum-like eruption associated with Morganella morganii infection. Br J Dermatol. 1998 Sep. 139(3):520-1. [Medline]. Dutta S, Narang A. Early onset Neonatal Sepsis due to Morganella morganii.[emedicine.medscape.com]
Skin Lesion
  • The presence of organisms in the bullae, demonstrated by Gram strain and culture, and the acral location of the bullae suggest that the skin lesions were due directly to blood-borne infection.[ncbi.nlm.nih.gov]
Dermatitis
  • Topical corticosteroid-induced rosacea-like dermatitis was diagnosed by dermatologist because of the characteristic eruptions and long history of using the corticosteroids-containing cosmetic creams on her face.[ncbi.nlm.nih.gov]

Workup

Calymmatobacterium Granulomatis
  • granulomatis, Cardiobacterium hominis, Chromobacterium, Eikenella corrodens, Gardnerella vaginalis, Streptobacillus moniliformis, Zymomonas[web2.uwindsor.ca]

Treatment

  • The mother responded to treatment with ampicillin, metronidazole, and gentamicin following delivery and had an uncomplicated recovery.[ncbi.nlm.nih.gov]
  • We consider that this report could be helpful to physicians implementing treatments for infections caused by XDR GNB, including colistin-carbapenem-resistant GNB.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: All isolates showed resistance to most common antibiotics, which limits options for treatment. This study provided useful information for selecting antibiotics to precisely target infections caused by M morganii.[ncbi.nlm.nih.gov]
  • Multivariate analysis indicated that inappropriate antibiotic treatment (odds ratio, 4.8, p 0.002) was the only independent risk factor for mortality.[ncbi.nlm.nih.gov]
  • Late initiation of appropriate antibiotic treatment was probably responsible for the fatal outcome. This case illustrates the pathogenic potential of M. morganii in immunocompromised hosts.[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis The prognosis depends on the type of infection and the particular host. Data suggest that inappropriate antimicrobials (ones that an organism is resistant to) are associated with a worse outcome. Tucci V, Isenberg HD.[emedicine.medscape.com]

Etiology

  • Currently, there are no known reported cases in the literature of M. morganii as an etiologic pathogen for a postoperative foot infection.[ncbi.nlm.nih.gov]
  • In 1906 Morgan isolated, from the stools of infants with "summer diarrhea," a previously undescribed gram-negative bacterium, Morgan's bacillus No. 1, which he considered of possible etiologic significance.[doi.org]
  • It has become clear after years of experience in determining the current taxonomic stature of human isolates that recognizing the correct classification is often a key to ascribing appropriate etiologic relationships to these strains.[doi.org]
  • Presenting signs, etiology, bacteriology and localisation. Acta Paediatr Scand. 1983 Nov. 72(6):879-83. [Medline]. Casanova-Roman M, Sanchez-Porto A, Casanova-Bellido M.[emedicine.medscape.com]

Epidemiology

  • In this review, we summarized the epidemiology of M. morganii, particularly on its resistance profile and resistant genes, as well as the disease spectrum and risk factors for its infection. Copyright 2016 The Author(s). Published by Elsevier Ltd..[ncbi.nlm.nih.gov]
  • The nosocomial infection due to this proteeae invites further study of its epidemiologic evolution.[ncbi.nlm.nih.gov]
  • An epidemiological retrospective survey showed that finer strain recognition in M. morganii can be achieved by using both methods than either method alone. Approximately 30% of strains were haemolytic.[ncbi.nlm.nih.gov]
  • The incidence of these strains invites continuous monitoring of such multidrug-resistant strains and the further study of their epidemiologic evolution.[ncbi.nlm.nih.gov]
  • Samonis Clinical and Epidemiological Study Abstract Background: Morganella morganii is a commensal Gram-negative bacillus of the intestinal tract of humans and other mammals and reptiles.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Diagnosis requires a high index of suspicion and imaging tests. [3] Pathophysiology M morganii has been associated with urinary tract infections, sepsis, pneumonia, wound infections, musculoskeletal infections, CNS infections, pericarditis, chorioamnionitis[emedicine.medscape.com]

Prevention

  • Hence, F. ulmaria exhibits inhibitory activity against bacterial HDC and might be effective for preventing food poisoning caused by histamine. Received: July 19, 2015; Accepted: November 11, 2015;[jfoodprotection.org]
  • Early diagnosis, treatment, and active surveillance play an important role in prevention of complications.[woundsresearch.com]
  • PubMed Central PubMed Google Scholar Klemm P, Vejborg RM, Hancock V: Prevention of bacterial adhesion. Applied microbiology and biotechnology. 2010, 88 (2): 451-459. 10.1007/s00253-010-2805-y.[doi.org]

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