Presentation
The Russell Museum is dedicated to drawing connections between innovations spanning a period of more than 200 years – from the hospital’s charter in 1811 to present day. [massgeneral.org]
Among drug-abusers, 13/42 patients (31%) presented opium hypersensitivity confirmed by challenge tests. [elsevier.es]
He had presented the initial data at the AAST meeting held in September 2018, and the full paper was eagerly awaited. [rebelem.com]
A thorough understanding of opioid reactions is necessary, as safety considerations and therapeutic alternatives vary depending on the severity and presentation of the reaction. [pharmacytimes.com]
[…] bundle branch block may not be detected in some cases. 1, 2 Although it is considered that tramadol may cause Brugada syndrome by blocking the voltage-dependent sodium channels, there is only one case report published in the literature. 3 Herein, we present [dovepress.com]
Entire Body System
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Unconsciousness
If you are injured or rendered unconscious and unable to communicate the nature of your drug allergy to your caretakers, then they may administer the drug, unknowingly creating more problems. [myidentitydoctor.com]
These include: cough, diarrhea, anxiety, skin redness, slurred speech, swelling of the face, wheezing, unconsciousness, nausea, vomiting, hives, nasal congestion, and abdominal pain. [premierallergyohio.com]
Symptoms can include: irregular heartbeat trouble breathing swelling unconsciousness Anaphylaxis can be fatal if it’s not treated right away. [healthline.com]
[…] breathing, coughing, wheezing, or high-pitched breathing sounds Difficulty swallowing Dizziness or lightheadedness Hives, itchiness, redness of the skin Nasal congestion Nausea or vomiting Palpitations Slurred speech Swelling of the face, eyes, or tongue Unconsciousness [medlineplus.gov]
There is a great deal of difference between treating someone who is unconscious and in cardiac arrest (so needs resuscitation) and someone who is in the early stages of anaphylaxis. However, the point is that anaphylaxis progresses rapidly. [patient.info]
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Hyperthermia
ST-segment elevations can be seen particularly in patients receiving propofol infusion and attention should be paid to electrolyte disturbances such as hyperkalemia, hypokalemia, and hypercalcemia; and hyperthermia and bradycardia which may trigger arrhythmia [dovepress.com]
malignant hyperthermia, the difficult airway). It is hoped that this and other such studies will afford the basis for continued practice improvements. [anesthesiology.pubs.asahq.org]
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Goiter
Her medical history included thyroidectomy due to multinodular goiter, Brugada syndrome, and penicillin and morphine allergy. [dovepress.com]
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Infectious Mononucleosis
mononucleosis/glandular fever). • drug-drug interactions: one drug modifies the effect of another e.g. beta blocking antihypertensives will interfere with the actions of adrenaline in the treatment of anaphylaxis. [allergy.org.nz]
Respiratoric
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Nasal Congestion
The itchy, uncomfortable symptoms of nasal congestion are related to this histamine-regulated response. Doctors will sometimes avoid prescribing morphine because it has the potential to prompt bronchospasm. [livestrong.com]
People who have these negative reactions to morphine may experience mild symptoms, such as minor skin rashes, nasal congestion, or a headache. Moderate reactions include bronchospasms, which are more serious and are similar to asthma attacks. [laurenshope.com]
These include: cough, diarrhea, anxiety, skin redness, slurred speech, swelling of the face, wheezing, unconsciousness, nausea, vomiting, hives, nasal congestion, and abdominal pain. [premierallergyohio.com]
congestion Nausea or vomiting Palpitations Slurred speech Swelling of the face, eyes, or tongue Unconsciousness The health care provider will examine the person and ask about what might have caused the condition. [medlineplus.gov]
Gastrointestinal
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Nausea
If you have been administered morphine and experience a skin rash, sun-sensitive skin, aching joints, aching muscles, swollen lymph nodes, itchiness, nausea, vomiting, or congestion, then you may have a morphine allergy (and potentially other types of [myidentitydoctor.com]
Some of the adverse effects of opioid use include: Nausea and vomiting: The use of opioids stimulates opioid receptors present in the gastrointestinal tract as well as in the vomiting centre of the brain to cause nausea and vomiting. [news-medical.net]
If the effect is receptor-related, equianalgesic doses of different opioids are expected to produce the same amount of nausea. [uspharmacist.com]
Mild reactions such as rash or pruritus ( n 254) or nausea and vomiting ( n 124) constituted the bulk of reports ( Table 1 ). [academic.oup.com]
Adverse effects make up 80% of all adverse drug reactions. 3 Common opioid-related adverse effects include nausea, vomiting, constipation, drowsiness, confusion, androgen deficiency, and urinary retention. [pharmacytimes.com]
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Regurgitation
Echocardiography showed mild pulmonary hypertension (systolic blood pressure 30 mmHg), moderate pulmonary insufficiency, 1st–2nd degree tricuspid regurgitation, and Stage 1 left ventricular diastolic dysfunction. [dovepress.com]
Workup
Blocks
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Right Bundle Branch Block
In addition, ST elevation and right bundle branch block were not evident in the precordial leads. [dovepress.com]
Treatment
There is no established treatment protocol to prevent tachyarrhythmias in Brugada syndrome. [dovepress.com]
The doctor failed to ensure the woman was given information a reasonable patient would expect, so could not give give her informed consent to the treatment. [nzherald.co.nz]
They serve the function of quickly bringing your doctor or caregiver up to speed, allowing them to provide the most accurate and speedy treatment while ensuring that they do not accidentally cause a dangerous allergic reaction. [myidentitydoctor.com]
Whilst treatment is ongoing, a person with anaphylaxis will be closely monitored. [patient.info]
Prognosis
What Is the Prognosis for a Drug Allergy? Most people who have mild to moderately severe allergic reactions to a drug do very well with prompt recognition and treatment. [emedicinehealth.com]
Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. Ann Intern Med. 2015;162(1):55-63. doi: 10.7326/M14-0697 PubMed Google Scholar Crossref 49. [jamanetwork.com]
What is the outlook (prognosis) for anaphylaxis? If you have had a confirmed anaphylactic reaction, you should be referred to an allergy specialist. Generally you would be seen in a hospital outpatient clinic by a consultant immunologist. [patient.info]
Etiology
The etiology of this relative and absolute increase in reactions to antibiotics is unclear, but it may be due to a more widespread use of antibiotics in the community. [anesthesiology.pubs.asahq.org]
Epidemiology
Because most anesthesiologists witness only a few such reactions in a lifetime, mechanistic and epidemiologic studies such as this provide insights that can contribute directly to clinical practice. [anesthesiology.pubs.asahq.org]
These results strongly support the need for further epidemiological studies designed to investigate the possible link between pholcodine exposure and hypersensitivity reactions to NMBAs. [worldallergy.org]
S465 - 528 ) 22 Anaphylaxis in the United States: an investigation into its epidemiology, Arch Intern Med, 2001, vol. 161 (pg. 15 - 21 ) 23 Clinical experience with penicillin skin testing in a larger inner-city STD clinic, JAMA, 1993, vol. 270 (pg. 2456 [academic.oup.com]
Pathophysiology
Pathophysiology : the biologic basis for disease in adults and children (Seventh edition. ed.). Elsevier – Health Sciences Division. ISBN 9780323088541. CS1 maint: Extra text: authors list ( link ) "Scombroid fish poisoning. DermNet NZ". [en.wikipedia.org]
Therefore, an anaphylactic reaction restricted to a single clinical symptom (e.g. bronchospasm, tachycardia) can easily be misdiagnosed because many other pathophysiological conditions may have identical clinical manifestations. [worldallergy.org]
Prevention
[…] to verbally advocate for yourself in an emergency situation, having your allergies and/or medical conditions listed on your medical ID jewelry will not only help First Responders and ER physicians treat you properly and effectively, it will also help prevent [laurenshope.com]
Morphine allergy occurs when your immune system overreacts to the presence of morphine and treats it as a hostile substance, releasing histamine and other preventative measures that result in allergy symptoms. [myidentitydoctor.com]
There is no established treatment protocol to prevent tachyarrhythmias in Brugada syndrome. [dovepress.com]
Take steps to prevent shock. Have the person lie flat, raise the person's feet about 12 inches (30 centimeters), and cover the person with a coat or blanket. [medlineplus.gov]
Immunotherapy of precancerous skin lesions may prevent squamous cell carcinoma - 3/21/2019, Research A study led by a Massachusetts General Hospital investigator finds that a treatment previously shown to clear the precancerous skin lesions called actinic [massgeneral.org]