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Mucinous Cystadenocarcinoma of the Ovary

Mucinous Cystadenocarcinoma of Ovary


Presentation

  • Abstract The present case is that of a 27 years old woman who had received right oophorectomy for ovarian cancer nine years previously. The histological diagnosis at that time was mucinous cystadenocarcinoma with anaplastic areas.[ncbi.nlm.nih.gov]
  • The tumor-associated antigen(s) of mucinous cystadenocarcinoma, which were demonstrated by Ouchterlony double diffusion, were not present in tissue extract of pooled normal ovaries and cystic fluid of benigh tubo-ovarian cyst.[ncbi.nlm.nih.gov]
  • We present the case of a 36-year-old woman with ovarian mucinous cystadenocarcinoma who underwent exploratory laparotomy during pregnancy, revealing Stage 1c at gestational week 15.[ncbi.nlm.nih.gov]
  • As a villous adenomatous component was present in the mucosal area, the colonic tumor was considered a primary tumor.[ncbi.nlm.nih.gov]
  • Histological the neoplasm presents an acinar or glandular pattern as well as solid sheets of cells with intracellular mucus. The solid growth shows more cellular atypia and stratification.[poja-collection-microscopic-anatomy.com]
Ascitic Fluid
  • Precipitin-inhibition reactions demonstated that the adsorbed antiserum to human ovarian mucinous cystadenocarcinoma mixed with tissue extracts of dysgerminoma and serous cystadenocarcinoma, and ascitic fluid of papillary embryonal adenocarcinoma of the[ncbi.nlm.nih.gov]
  • The tumor cells were obtained from the ascitic fluid of a 54-year-old Japanese woman while she was undergoing surgery.[ncbi.nlm.nih.gov]
  • D, ascitic fluid demonstrates bland mucinous columnar epithelial cells with low-grade nuclei, arranged in strips, sheets, and nests, in the background of abundant mucin, also seen in the cell block (inset).[jaoa.org]
Excitement
  • With the emergence of more robust clinicopathologic, molecular, and genetic data over the past decade, we are clearly in the midst of an exciting paradigm shift that challenges the status quo of treating all women with a diagnosis of epithelial ovarian[wjgnet.com]
Adnexal Mass
  • B and C, bilateral adnexal masses (arrow), omental caking, diffuse disease with peritoneal involvement including the diaphragmatic surface and liver capsule, and an inflamed appendix (asterisk) secreting mucinous material (triangles).[jaoa.org]
  • Ultrasound typically large cystic adnexal mass multilocular with numerous thin septations loculations may contain low-level internal echogenicity due to increased mucin content different locules may contain various degrees of echogenicity MRI Mucinous[radiopaedia.org]
Pelvic Pain
  • Case Report A 27-year-old unmarried female presented with complaints of right-sided pelvic pain and a sensation of fullness in her lower abdomen.[cjhr.org]

Workup

Ovarian Mass
  • Consistent with previous studies, POMCs appear to develop from benign and borderline POMTs, which tend to be the largest ovarian masses overall and usually involve only one ovary; MOMCs are often much smaller and bilateral.[jcp.bmj.com]
  • Specimen II was bilateral salpingo-ophorectomy specimens with left ovarian mass of size 5x4x2 cm with attached tube of 2 cm. External surface was nodular. Cut section showed solid and cystic areas with an yellowish area near surface.[casereports.in]

Treatment

  • BACKGROUND: The survival rate of patients with advanced-stage mucinous cystadenocarcinoma of the ovary is dismal and no best treatment is known.[ncbi.nlm.nih.gov]
  • CONCLUSION In the past the standard treatment for all advanced stage epithelial ovarian cancer was cytoreductive surgery followed by standard postoperative treatment with platinum based chemotherapy.[wjgnet.com]
  • Article / Publication Details First-Page Preview Abstract Background: The survival rate of patients with advanced-stage mucinous cystadenocarcinoma of the ovary is dismal and no best treatment is known.[karger.com]
  • There is no real good treatment for this ovarian condition. The occurrence of mucinous cystadenoma can be prevented by the right diet from the young age.[mucinous.org]
  • Treatment Of Mucinous Cystadenoma Of Ovary Benign mucinous cystadenoma of ovary treatment depends on the size of tumor. If the tumor is extremely small, usually no treatment is necessary. The tumor is benign.[tandurust.com]

Prognosis

  • The prognosis was related to the most aggressive area of the tumor as the histologic grade was based on the maximum number of mitoses per high-powered field.[ncbi.nlm.nih.gov]
  • The distinction between these lesions and foci of anaplastic carcinoma is important because of the poor prognosis of the latter. We have studied the potential value of immunohistochemistry in the differential diagnosis of these two lesions.[ncbi.nlm.nih.gov]
  • The incidence of RER was not related to the patients' age, stage, histologic grade, or prognosis. The MAC patients in stages I and II showed a relatively high incidence of RER (30%).[ncbi.nlm.nih.gov]
  • Hiramatsu H, Kataoka Y, Kudoh K, Ishii K, Yamamoto K, Kita T, Tode T, Kikuchi Y, Nagata I: Prognosis of patients with primary epithelial ovarian carcinoma who were not successfully cytoreduced. Oncol Rep 1998;4:107–110.[karger.com]
  • Treatment and prognosis A mucinous cystadenoma is benign with excellent prognosis (c.f. borderline mucinous tumors of the ovary or mucinous cystadenocarcinoma of the ovary).[radiopaedia.org]

Etiology

  • Abstract To elucidate the genetic etiology of sporadic epithelial ovarian carcinoma, we examined replication errors (RER) in its two common types, serous cystadenocarcinoma (SAC) and mucinous cystadenocarcinoma (MAC).[ncbi.nlm.nih.gov]
  • Etiology Thought to largely derive from ovarian epithelial inclusions, which itself is derived from fallopian tube epithelium. Location They can be bilateral in 15% of cases.[radiopaedia.org]
  • Causes Of Ovarian Mucinous Cystadenoma The etiology of benign mucinous cystadenoma of ovary is not fully understood. These tumors develop spontaneously.[tandurust.com]

Pathophysiology

  • In: Pharmacotherapy: A pathophysiologic approach.8th ed. Dipiro JT, Talbert RL, Yee GC et al., New York: McGraw-Hill; 2008: 2361-75.[en.wikipedia.org]

Prevention

  • Mucinous Cystadenoma Prevention and Treatment Mucinous Cystadenoma usually do not shrink by themselves they may remain as non- interfering in some cases. Smaller sized cystadenomas can be removed by laparoscopic method.[mucinous.org]
  • Rapid sequence induction and intubation would, therefore, be required to prevent acid aspiration syndrome. All the above mentioned concerns were addressed in the anesthetic plan formulated for the present patient.[karnatakaanaesthj.org]

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