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Mucinous Cystadenocarcinoma of the Ovary

Mucinous Cystadenocarcinoma of Ovary


Presentation

  • Abstract The present case is that of a 27 years old woman who had received right oophorectomy for ovarian cancer nine years previously. The histological diagnosis at that time was mucinous cystadenocarcinoma with anaplastic areas.[ncbi.nlm.nih.gov]
  • Case presentation The authors describe a 57-year-old Brazilian woman who presented with an increase in abdominal girth in February 2003. Imaging studies showed a giant abdominal pelvic mass with probable origin in the right ovary.[jmedicalcasereports.biomedcentral.com]
Ascitic Fluid
  • Precipitin-inhibition reactions demonstated that the adsorbed antiserum to human ovarian mucinous cystadenocarcinoma mixed with tissue extracts of dysgerminoma and serous cystadenocarcinoma, and ascitic fluid of papillary embryonal adenocarcinoma of the[ncbi.nlm.nih.gov]
  • D, ascitic fluid demonstrates bland mucinous columnar epithelial cells with low-grade nuclei, arranged in strips, sheets, and nests, in the background of abundant mucin, also seen in the cell block (inset).[jaoa.org]
  • fluid for routine tests and cytopathological evaluations.[jmedicalcasereports.biomedcentral.com]
Loss of Appetite
  • There was no history of loss of appetite or weight. She was a known case of rheumatoid arthritis from the past 2 years and she was on irregular treatment. Clinically, her abdomen was uniformly distended up to 34 weeks’ size.[jpgo.org]
  • […] of appetite Weight loss Fatigue, feeling tired easily Frequent urination (polyuria) and difficulty while urinating Frequent pain during sex (dyspareunia) Abnormal menstrual bleeding Some of the other features of Mucinous Adenocarcinoma of Ovary include[dovemed.com]
Adnexal Mass
  • MD-Medical Data 2014;6(1): 023-027 Originalni lanci/ Original More information MR diagnostics of adnexal masses MR diagnostics of adnexal masses Poster No.: C-1499 Congress: ECR 2017 Type: Educational Exhibit Authors: O. Nikolic, J. Ostojic, M.[healthdocbox.com]
  • B and C, bilateral adnexal masses (arrow), omental caking, diffuse disease with peritoneal involvement including the diaphragmatic surface and liver capsule, and an inflamed appendix (asterisk) secreting mucinous material (triangles).[jaoa.org]
  • Most of sonographically indeterminate adnexal masses turn out to be common benign entities that can be readily diagnosed by magnetic resonance imaging.[link.springer.com]
  • Ultrasound typically large cystic adnexal mass multilocular with numerous thin septations loculations may contain low-level internal echogenicity due to increased mucin content different locules may contain various degrees of echogenicity MRI Mucinous[radiopaedia.org]
  • Subjective assessment of adnexal masses with the use of ultrasonography: an analysis of interobserver variability and experience. Ultrasound Obstet Gynecol 1999;13:11–16. 2. Valentin L.[e-ultrasonography.org]
Pelvic Pain
  • Case Report A 27-year-old unmarried female presented with complaints of right-sided pelvic pain and a sensation of fullness in her lower abdomen.[cjhr.org]
  • In such cases, the signs and symptoms associated with the accompanying syndrome may exist Following are the common signs and symptoms associated with this tumor type: Abdominal pain (the pain is usually a pelvic pain) Abdominal swelling due to the mass[dovemed.com]
  • It affects women during the reproductive years and may cause chronic pelvic pain associated with menstruation. The ovaries are involved in approximately 75% of patients with endometriosis.[radiologyassistant.nl]
  • Physical examination shows no abnormal vaginal discharge or evidence of pelvic pain but does reveal redness on the lower side of the left breast.[quizlet.com]
  • Most of these tumors are asymptomatic; the most common symptoms are abdominal mass, abdominal and/or pelvic pain, and infertility, many are discovered during abdominal or pelvic surgery for other pathology.[glowm.com]
Urinary Retention
  • Clinically, the differential diagnosis of large abdominal masses should include: uterine enlargement (pregnancy, fibromyomatosis); pelvic endometriosis; (pregnancy, abdominal cysts); abdominal pregnancy; urinary retention (full bladder); intestinal tumors[jmedicalcasereports.biomedcentral.com]

Workup

  • Physical examination and careful systemic workup were negative. The diagnosis of a (primary) skin mucinous carcinoma was confirmed. KEYWORDS – Adenocarcinoma, mucinous.[revista.spdv.com.pt]
  • On top of the renal amyloidosis his medical workup revealed presence of sensorineural hearing loss (up to 30 dB in frequency of 6,000 Hz). Within 2 days of anakinra therapy all his systemic features disappeared.[frontiersin.org]
Dyslipidemia
  • She underwent an appendectomy and cholecystectomy, respectively, at the ages of 16 and 29, and had arterial hypertension and dyslipidemia. She denied the use of tobacco, alcohol or illicit drugs.[jmedicalcasereports.biomedcentral.com]
Ovarian Mass
  • Intraoperatively a left sided huge ovarian mass of variable consistency with intact capsule, with no surface growth was found. There was no evidence of ascites or metastasis to peritoneum or paraaortic or pelvic lymph nodes.[jpgo.org]
  • Figure 1: Above (a) intraoperative picture of ovarian mass. (b) Postoperative ovarian mass and excised omentum. (c) Ultrasound shows ovarian mass with both solid, cystic components and loculations with thin-walled septa.[ccij-online.org]
  • mass with vascularization in some of the septations Benign cystic lesions: Mucinous cystadenoma with a septated cystic ovarian mass Benign cystic lesions: Mucinous cysteadenoma Benign cystic lesions: Mucinous cysteadenoma Benign cystic lesions: Mucinous[ultrasoundcases.info]
  • Discussion Giant ovarian masses are extremely rare.[cancerjournal.net]
  • It includes a standardized methodology for the US evaluation of ovarian masses and definitions of the ultrasonographic parameters of ovarian masses [ 6, 8, 9 ].[e-ultrasonography.org]

Treatment

  • The survival rate of patients with advanced-stage mucinous cystadenocarcinoma of the ovary is dismal and no best treatment is known.[ncbi.nlm.nih.gov]
  • Mucinous epithelial ovarian cancer: A separate entity requiring specific treatment. J Clin Oncol 2004;22:1040-4. 6. Guruprasad B, Jacob LA. Mucinous cystadenocarcinoma of ovary: Changing treatment paradigms. World J Obstet Gynecol 2012;10:42-5. 7.[ccij-online.org]
  • CONCLUSION In the past the standard treatment for all advanced stage epithelial ovarian cancer was cytoreductive surgery followed by standard postoperative treatment with platinum based chemotherapy.[wjgnet.com]
  • The primary treatment for early stage mucinous neoplasm is surgical (total abdominal hysterectomy, bilateral salpingo-oophorectomy, and surgical staging as with serous tumors).[jpgo.org]
  • What will you tell the family about risks/benefits of the available treatment options Table III.[cancertherapyadvisor.com]

Prognosis

  • The prognosis was related to the most aggressive area of the tumor as the histologic grade was based on the maximum number of mitoses per high-powered field.[ncbi.nlm.nih.gov]
  • In early stage ovarian cancer, systematic lymph node dissection is required for meticulous staging, which is helpful for adjuvant treatment planning and to explain prognosis.[ccij-online.org]

Etiology

  • Abstract To elucidate the genetic etiology of sporadic epithelial ovarian carcinoma, we examined replication errors (RER) in its two common types, serous cystadenocarcinoma (SAC) and mucinous cystadenocarcinoma (MAC).[ncbi.nlm.nih.gov]
  • Etiology Thought to largely derive from ovarian epithelial inclusions, which itself is derived from fallopian tube epithelium. Location They can be bilateral in 15% of cases.[radiopaedia.org]
  • Cell. vol. 140. 2010. pp. 784(A review of current thinking about the etiology of autoinflammatory diseases and recent advances that offer new opportunities for therapeutic intervention.) Ombrello, MJ, Kastner, DL.[cancertherapyadvisor.com]
  • Etiology MWS is due to dominant mutation in the NLRP3 (1q44) gene which encodes cryopyrin.[orpha.net]
  • Causes Of Ovarian Mucinous Cystadenoma The etiology of benign mucinous cystadenoma of ovary is not fully understood. These tumors develop spontaneously.[tandurust.com]

Epidemiology

  • Summary Epidemiology The prevalence of MWS is unknown. However a French survey through genetic laboratories has reported 135 cases and estimated CAPS prevalence at 1/360,000.[orpha.net]
  • Mutations in the autoinflammatory cryopyrin-associated periodic syndrome gene: epidemiological study and lessons from eight years of genetic analysis in France. Ann Rheum Dis. 2011;70(3):495–499. 2.[dovepress.com]
  • Genetic epidemiological studies of early-onset deafness in the US school-age population. Am J Med Genet 1993;46:486-91. Morton NE. Genetic epidemiology of hearing impairment. Ann N Y Acad Sci 1991;630:16-31. Davis A, Parving A.[kjorl.org]
  • […] female genital tract understand the concept of borderline tumors and how to distinguish them from carcinomas be able to describe clinical features including relevant associations be able to suggest possible clinical outcomes and response to treatment Epidemiology[med-ed.virginia.edu]
Sex distribution
Age distribution

Pathophysiology

  • In: Pharmacotherapy: A pathophysiologic approach.8th ed. Dipiro JT, Talbert RL, Yee GC et al., New York: McGraw-Hill; 2008: 2361-75.[en.wikipedia.org]
  • Progressively, they could develop various psychological problems such as drug addictions or severe depression leading to suicide.10 Understanding CAPS pathophysiology has allowed efficacious treatment targeting IL-1β.[dovepress.com]
  • Pharmacotherapy: A pathophysiologic approach 2361-2375. GorgoneS, MinnitiC, IlaquaA, BarbusciaM (2008) Giant mucinous cystadenoma in a young patient. A Case Report g Chir 29: 42-44.[omicsonline.org]
  • Treatment for PCOD must be based on the needs and desires of the individual patient, and on the pathophysiology of the patient's particular abnormalities. When pregnancy is desired, ovulation induction with clomiphene is indicated.[science.gov]

Prevention

  • Mucinous Cystadenoma Prevention and Treatment Mucinous Cystadenoma usually do not shrink by themselves they may remain as non- interfering in some cases. Smaller sized cystadenomas can be removed by laparoscopic method.[mucinous.org]
  • It is too soon to tell if early medication treatment for MWS or NOMID/CINCA will prevent or decrease the development of hearing loss, but there is great hope that it will make a significant difference.[autoinflammatory.org]
  • Rapid sequence induction and intubation would, therefore, be required to prevent acid aspiration syndrome. All the above mentioned concerns were addressed in the anesthetic plan formulated for the present patient.[karnatakaanaesthj.org]
  • How can Mucinous Adenocarcinoma of Ovary be Prevented? The cause of Mucinous Adenocarcinoma of Ovary is unknown. Hence, there are no known methods to prevent the tumor occurrence.[dovemed.com]

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