Also, the Mucositis Study Group will announce its 2020 awards for outstanding research presentations. [mascc.org]

Around 40% of all chemotherapy patients present side effect in the mouth; this number reaches 90% in children under 12 years of age. [scielo.br]

Oral care, including removal of dentures if present and frequent mouth rinses (with water or a solution made by dissolving a teaspoon of baking soda in 4 ounces of water) may also be helpful. [jamanetwork.com]

OM presents a significant burden because symptoms are often of such a severity that they can require an interruption, or may lead to dose reduction of cancer therapy. [healthengine.com.au]

The objective of this study was to present a review on this condition, its causes and its treatment to professional clinical dentists, in order to help minimize patient suffering. [spandidos-publications.com]

• Inflammation

  Colifoam also contains a corticosteroid to hep reduce inflammation and is a foam that is inserted into your rectum once or twice a day. [hse.ie]

  Mucositis is defined as an inflammation or ulceration of mucous membranes along the digestive tract, from the mouth to the anus. [cancercenter.com]

  Mucositis: Inflammation of the mucous membranes lining the digestive tract from the mouth to the anus. Mucositis is a common side effect of chemotherapy and of radiotherapy that involves any part of the digestive tract. [medicinenet.com]

  […] along the gastrointestinal (GI) tract, but oral mucositis refers to the particular inflammation and ulceration that occurs in the mouth. [en.wikipedia.org]

• Weakness

  Ten interventions, where there was more than one trial in the meta-analysis, showed some statistically significant evidence of a benefit (albeit sometimes weak) for either preventing or reducing the severity of mucositis, compared to either a placebo [cochrane.org]

  These problems are further complicated by the associated dry mouth and alterations in taste that can lead to anorexia, weight loss, and weakness due to poor nutrition. [healthengine.com.au]

  There is some weak evidence that oral cryotherapy reduces the duration of pain experience (very low quality evidence). [cochranelibrary.com]

• Fatigue

  Pain may cause fatigue, sadness, stress, or worry, and can affect your quality of life. Talk with your doctor about using opiates, a class of drugs that includes morphine, for effective pain relief. [cancercare.org]

  Pain can significantly impact a patient’s quality of life and trigger a cluster of symptoms including fatigue and depression. [touchoncology.com]

• Aspiration

  […] lidocaine.4,12 These products are used topically to treat mucositis pain in the oral cavity, but many clinicians recommend that they not be swallowed, as the product may be systemically absorbed or may reduce the gag reflex and place the patient at risk for aspiration [uspharmacist.com]

• Cough

  Ask your doctor about cough syrups that contain chlorpheniramine. These products can reduce secretions. Your doctor may also recommend cough medicines that contain guaifenesin, such as Robitussin DM or Humibid, to thin the mucus. [cancercare.org]

• Nausea

  One small study found that people taking a single dose of palifermin before their chemotherapy also experienced less nausea and constipation than those who did not. Palifermin is given by injection. [hse.ie]

  Mucositis is further complicated by the nausea and vomiting that often occur with treatment. [oralcancerfoundation.org]

  With recent advances in the prevention and management of other cancer treatment-related complications, such as nausea and neutropenia (low white blood cells), oral mucositis has emerged as one of the most debilitating and dose-limiting side effects of [aaom.com]

  The effective use of opiates requires balancing the desired effects of pain relief with undesired side effects, such as constipation, nausea and vomiting, and sedation. [touchoncology.com]

• Vomiting

  Mucositis is further complicated by the nausea and vomiting that often occur with treatment. [oralcancerfoundation.org]

  Side effects of octreotide are uncommon but can include: loss of appetite nausea (feeling sick) vomiting (being sick) abdominal (tummy) pain flatulence (wind) changes in blood sugar levels The side effects of octreotide can be minimised by injecting the [hse.ie]

  The effective use of opiates requires balancing the desired effects of pain relief with undesired side effects, such as constipation, nausea and vomiting, and sedation. [touchoncology.com]

  Alimentary mucositis affects the mucosa, causing mouth and throat pain, ulceration, abdominal pain, bloating, vomiting, and diarrhoea depending on the target tissue [4–6]. [hindawi.com]

• Constipation

  Common side effects of loperamide include constipation and dizziness. Rarer side effects of loperamide include cramps, drowsiness, skin rashes and bloating. [hse.ie]

  Narcotics for pain will also cause constipation, and appropriate stool softeners will need to be taken with them. [oralcancerfoundation.org]

  The effective use of opiates requires balancing the desired effects of pain relief with undesired side effects, such as constipation, nausea and vomiting, and sedation. [touchoncology.com]

• Choking

  Additionally, speech pathologists may be instrumental in teaching patients techniques on how to swallow and speak, improve salivary secretions, and to eat and drink without gagging or choking. [cancercenter.com]

  It is also possible that ice chips or cubes may be a potential choking hazard in children. There is also a lack of evidence on the effects of oral cryotherapy in low‐income and lower‐middle‐income countries. [cochranelibrary.com]

• Flatulence

  Side effects of octreotide are uncommon but can include: loss of appetite nausea (feeling sick) vomiting (being sick) abdominal (tummy) pain flatulence (wind) changes in blood sugar levels The side effects of octreotide can be minimised by injecting the [hse.ie]

• Dental Caries

  Radiation therapy of the head and neck frequently causes acute and late oral toxicities, including mucositis, trismus due to fibrosis, impaired or lost saliva production (xerostomia), and xerostomia-related radiation dental caries (cavities).1-6 Oral [oncologynurseadvisor.com]

  Patients with pulpal disease from dental caries or trauma, periodontal disease, and low-grade soft-tissue infections (especially those associated with partially erupted third molars) are at increased risk for bacteremia due to oral viridans streptococci [emedicine.medscape.com]

  For more information, see Dental Hygiene. [healthengine.com.au]

• Sialorrhea

  Clinical features The main symptom of OM is dysphagia, which may be mild or severe, together with nausea, sialorrhea, sometimes profuse, and infections. [haematologica.org]

• Dermatitis

  As such, photobiomodulation has been used for the prevention and treatment of various complications of oncologic treatments, including oral mucositis, radiation dermatitis, dysphagia, hyposalivation and xerostomia (dry mouth), dysgeusia, trismus, osteonecrosis [futuremedicine.com]

[…] oral mucositis are the following: World Health Organization (WHO) Oral Toxicity Scale: Combines both objective and functional elements into a single score National Cancer Institute Common Toxicity Criteria (NCI CTC): Scores functional elements only See Workup [emedicine.medscape.com]

Meanwhile, receiving treatment for mucositis can delay cancer treatments or cause additional side effects. Many cancer treatments affect the immune system, which is the body’s defense against infections. [medicalnewstoday.com]

“Most importantly, [patients] will not have to discontinue treatment,” Arany said. “People discontinue treatment because they can’t handle the oral mucositis. They are not eating well. Their overall immunity is down. [oncnursingnews.com]

Thus, the cancer treatment may be dramatically affected along with the patient's quality of life. [tmj.ro]

These were evaluated in patients with different types of cancer, undergoing different types of cancer treatment. Benefits may be restricted to the disease and treatment combinations evaluated. [cochrane.org]

Here are some ways you can care for your mouth before, during, and after treatment: Visit your dentist before treatment. [cancercare.org]

It is currently unknown whether photobiomodulation therapy directly targeted at the site of a malignant lesion has a negative impact on oncologic treatment (i.e., radiation therapy) or prognosis. [futuremedicine.com]

Due to its high incidence and clinical significance in patient prognosis, several studies were conducted to investigate the treatment and prevention of oral mucositis (11,18–20). [spandidos-publications.com]

Prognosis of oral mucositis The outlook for OM in the long-term is reasonably good as most lesions resolve within 2-4 weeks of stopping chemotherapy or radiation. [healthengine.com.au]

Prognosis Chemotherapy-induced oral mucositis is a self-limiting condition. [emedicine.medscape.com]

Incomplete outcome data Only two studies were at high risk of attrition bias (Askarifar 2015; Sorensen 2008), both due to differential attrition between groups, which may have been linked to prognosis. [cochranelibrary.com]

Oral mucositis occurs independently of oral mucosal infections of viral and fungal etiology, but it may be exacerbated by such concomitant infections. [emedicine.medscape.com]

This review of the pertinent literature includes the definition, clinical findings, incidence, etiology, pathophysiology, associated morbidity, prevention and treatment of this form of oral mucositis. [scielo.br]

In 2011, the FDA cleared episil oral liquid for the management and relief of pain of oral lesions with various etiologies, including oral mucositis/stomatitis which may be caused by chemotherapy or radiation therapy. [en.wikipedia.org]

Gelclair helps to soothe oral lesions of various etiologies—including OM caused by chemotherapy or radiation therapy—by adhering to the mucosa of the mouth and forming a protective barrier. [touchoncology.com]

Cancer Therapy-Induced Oral Mucositis - A Review of Epidemiology, Patophysiology, and Treatment 1 Department of Removable Prosthodontics, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, 2 Department of Periodontology [tmj.ro]

Epidemiology Frequency Some degree of oral mucositis occurs in approximately 40% of patients who receive cancer chemotherapy. [emedicine.medscape.com]

Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(suppl 9):1995-2025. 7. National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE). [uspharmacist.com]

Perspectives on Cancer Therapy-Induced Mucosal Injury: Pathogenesis, Measurement, Epidemiology, and Consequences for Patients. Cancer. 2004;100(S9):1995–2025. [PubMed] [Google Scholar] 14. Sonis ST, Peterson RL, Edwards LJ, et al. [ncbi.nlm.nih.gov]

Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004; 100(9 Suppl): 1995-2025. Epstein JB, Gorsky M, Guglietta A, Le N, Sonis ST. [healthengine.com.au]

Chemotherapy-induced damage differs from that of radiation in that radiation damage is considered as permanent risk areas throughout the patient’s life.25 Pathophysiology In 1998 a new theoretical model was described for the pathophysiology of radiotherapy-induced [scielo.br]

Therefore, oral mucositis can be a dose-limiting condition, disrupting a patient’s optimal cancer treatment plan and consequentially decreasing their chances of survival.[4] Pathophysiology[edit] The pathophysiology of mucositis is complex and multifactorial [en.wikipedia.org]

Because this toxicity clusters with dermatologic toxicities, rather than GI (as is the case with conventional mucositis) toxicities, this suggests that the underlying pathophysiology is likely very different. [emedicine.medscape.com]

Pathophysiology Historically, OM was thought to arise solely as a consequence of epithelial injury. [touchoncology.com]

Sonis (7), through several clinical and experimental observations, proposed that the stomatotoxicity of the drugs used leads to a complex pathophysiological mechanism underlying the development of oral mucositis, with a natural history including 4 biological [spandidos-publications.com]

Use of palifermin for the prevention of high-dose methotrexate-induced oral mucositis. Ann Oncol 2008;19:1644-9. [Crossref] [PubMed] Papas AJE, Sobel S, Olsen TO. Effects of preventive regimen on oral mucositis. J Dent Res IADR 1981;544:940. [cco.amegroups.com]

Many interventions have been studied for the prevention and treatment of oral mucositis [5]. [futuremedicine.com]

Different strategies are used to try and prevent this condition, and the review of trials found that some of these are effective. [cochrane.org]

So it's also very important to see a dentist and a dental hygienist to get any treatment and advice to treat or prevent any dental problems. [patient.info]

“A preventive treatment must be done every time you receive either radiation or chemotherapy. It should be done in a preventive therapy manner,” Arany said. [oncnursingnews.com]