Also, the Mucositis Study Group will announce its 2020 awards for outstanding research presentations. [mascc.org]

Around 40% of all chemotherapy patients present side effect in the mouth; this number reaches 90% in children under 12 years of age. [scielo.br]

Oral care, including removal of dentures if present and frequent mouth rinses (with water or a solution made by dissolving a teaspoon of baking soda in 4 ounces of water) may also be helpful. [jamanetwork.com]

OM presents a significant burden because symptoms are often of such a severity that they can require an interruption, or may lead to dose reduction of cancer therapy. [healthengine.com.au]

The objective of this study was to present a review on this condition, its causes and its treatment to professional clinical dentists, in order to help minimize patient suffering. [spandidos-publications.com]

• Pain

  Mucositis symptoms may be alleviated with over-the-counter and prescription pain medications, prescribed by the licensed physicians on the pain management team. Learn more about pain management [cancercenter.com]

  […] treating mucositis pain is to use bland rinses or oral sodium bicarbonate rinses. [uspharmacist.com]

  […] required to control the pain of OM. [touchoncology.com]

  Control of pain is critical, and systemic pain medication may be required if topical agents are ineffective. Swishing ice chips in the mouth can provide relief. [jamanetwork.com]

  Pain Control Pain from mucositis can range from mild to severe. To help manage pain, try the following. Suck on ice chips or popsicles, and sip cool drinks often throughout the day. [headandneck.org]

• Inflammation

  Colifoam also contains a corticosteroid to hep reduce inflammation and is a foam that is inserted into your rectum once or twice a day. [hse.ie]

  Mucositis is defined as an inflammation or ulceration of mucous membranes along the digestive tract, from the mouth to the anus. [cancercenter.com]

  Mucositis: Inflammation of the mucous membranes lining the digestive tract from the mouth to the anus. Mucositis is a common side effect of chemotherapy and of radiotherapy that involves any part of the digestive tract. [medicinenet.com]

  […] along the gastrointestinal (GI) tract, but oral mucositis refers to the particular inflammation and ulceration that occurs in the mouth. [en.wikipedia.org]

• Severe Pain

  This can vary from just soreness and redness to severe pain and mouth ulceration. Difficulty with eating and drinking. Dry mouth and lips. [patient.info]

  Severe pain from oral mucositis may limit the patients to a liquid-only diet and when oral alimentation is impossible, feeding via percutaneous endoscopic gastrostomy is needed (World Health Organization’s grades 3 and 4, respectively) [3,4]. [futuremedicine.com]

  Complications OM can cause severe pain and trouble eating, resulting in depression in some people. [healthengine.com.au]

  or can’t eat or drink If your child has severe pain, he or she may need medicine through an IV. [urmc.rochester.edu]

• Swelling

  […] taste Less common side effects include swelling of the face or mouth. [hse.ie]

  Symptoms of mucositis include redness, swelling, irritation, pain, and sores in the mouth. A child with mucositis may have trouble eating, drinking, swallowing, and talking. [urmc.rochester.edu]

  Oral mucositis is tissue swelling in the mouth. Radiation therapy or chemotherapy may cause mucositis. Follow your health care provider's instructions on how to care for your mouth. Use the information below as a reminder. [medlineplus.gov]

  A person with cancer may have swelling inside the mouth and throat that can lead to painful mouth sores. This condition is called mucositis. [cancer.net]

• Underweight

  A child may also be at higher risk for mouth mucositis because of: Poor dental and mouth care Loss of body fluid (dehydration) Being underweight Other long-term (chronic) health problems Smoking, using chewing tobacco, or drinking alcohol What are the [urmc.rochester.edu]

• Cough

  Ask your doctor about cough syrups that contain chlorpheniramine. These products can reduce secretions. Your doctor may also recommend cough medicines that contain guaifenesin, such as Robitussin DM or Humibid, to thin the mucus. [cancercare.org]

• Nausea

  One small study found that people taking a single dose of palifermin before their chemotherapy also experienced less nausea and constipation than those who did not. Palifermin is given by injection. [hse.ie]

  Mucositis is further complicated by the nausea and vomiting that often occur with treatment. [oralcancerfoundation.org]

  With recent advances in the prevention and management of other cancer treatment-related complications, such as nausea and neutropenia (low white blood cells), oral mucositis has emerged as one of the most debilitating and dose-limiting side effects of [aaom.com]

  The effective use of opiates requires balancing the desired effects of pain relief with undesired side effects, such as constipation, nausea and vomiting, and sedation. [touchoncology.com]

• Diarrhea

  The frequent watery diarrhea following bortezomib administration is probably due to intestinal neuropathy rather than to mucositis. [haematologica.org]

  Nausea, pain, vomiting, diarrhea, a sore or dry mouth may make eating difficult. Thus, maintaining adequate nutrition is an important challenge for oral cancer patients. [oralcancerfoundation.org]

• Abdominal Pain

  It may also be caused by radiation treatments to the abdominal or pelvic region. Telltale signs typically appear two weeks after the start of treatment and can include diarrhea, abdominal pain, bloating, rectal bleeding and anal or rectal ulcers. [cancercenter.com]

  Alimentary mucositis affects the mucosa, causing mouth and throat pain, ulceration, abdominal pain, bloating, vomiting, and diarrhoea depending on the target tissue [4–6]. [hindawi.com]

• Poor Oral Hygiene

  A number of oral conditions have been presented and should be taken into consideration as predisposing factors for patient deterioration: poor oral hygiene, caries associated with periapical pathologies and periodontal disease. [spandidos-publications.com]

  Good oral hygiene and comprehensive patient education form the basic components of OM preventive interventions.10 Evidence-based information on the ONS PEP® card11 recommends initiation and maintenance of oral hygiene protocols. [oncology.tv]

  Other risk factors include: Poor oral hygiene Poor dental health Smoking or using tobacco products, including chewing tobacco Using alcohol Not drinking enough fluids Dry mouth Sex — Women are more likely to develop mucositis than men Age — Younger patients [headandneck.org]

  Age, poor renal function, prolonged exposure to steroids, and poor oral hygiene also contribute to the development of OM. Literature Review Unfortunately, OM is an inevitable, costly, and debilitating consequence of cancer therapy. [touchoncology.com]

  Comorbidities, infections, poor oral hygiene and prolonged treatment with steroids are some patient-related factors. [haematologica.org]

• Oral Ulcers

  Comparison of oral mucositis assessment scales.7,58 The Oral Mucositis Index (OMI) considers the severity of OM in terms of erythema, ulceration, atrophy and edema (Table 4), each graded on a scale from 0 to 3 (0=none, 3=severe). [haematologica.org]

  Prognosis of oral mucositis Treatment of oral mucositis References What is oral mucositis? Oral mucositis (OM) refers to an inflammatory, erosive, and/or ulcerative process inside the mouth, which is usually caused by radiation or chemotherapy. [healthengine.com.au]

  Oral mucositis is a condition that is characterized by ulcerative lesions in the mucosa of patients undergoing radiotherapy or chemotherapy. [spandidos-publications.com]

[…] oral mucositis are the following: World Health Organization (WHO) Oral Toxicity Scale: Combines both objective and functional elements into a single score National Cancer Institute Common Toxicity Criteria (NCI CTC): Scores functional elements only See Workup [emedicine.medscape.com]

Meanwhile, receiving treatment for mucositis can delay cancer treatments or cause additional side effects. Many cancer treatments affect the immune system, which is the body’s defense against infections. [medicalnewstoday.com]

“Most importantly, [patients] will not have to discontinue treatment,” Arany said. “People discontinue treatment because they can’t handle the oral mucositis. They are not eating well. Their overall immunity is down. [oncnursingnews.com]

Thus, the cancer treatment may be dramatically affected along with the patient's quality of life. [tmj.ro]

These were evaluated in patients with different types of cancer, undergoing different types of cancer treatment. Benefits may be restricted to the disease and treatment combinations evaluated. [cochrane.org]

Here are some ways you can care for your mouth before, during, and after treatment: Visit your dentist before treatment. [cancercare.org]

It is currently unknown whether photobiomodulation therapy directly targeted at the site of a malignant lesion has a negative impact on oncologic treatment (i.e., radiation therapy) or prognosis. [futuremedicine.com]

Due to its high incidence and clinical significance in patient prognosis, several studies were conducted to investigate the treatment and prevention of oral mucositis (11,18–20). [spandidos-publications.com]

Prognosis of oral mucositis The outlook for OM in the long-term is reasonably good as most lesions resolve within 2-4 weeks of stopping chemotherapy or radiation. [healthengine.com.au]

Prognosis Chemotherapy-induced oral mucositis is a self-limiting condition. [emedicine.medscape.com]

Incomplete outcome data Only two studies were at high risk of attrition bias (Askarifar 2015; Sorensen 2008), both due to differential attrition between groups, which may have been linked to prognosis. [cochranelibrary.com]

Oral mucositis occurs independently of oral mucosal infections of viral and fungal etiology, but it may be exacerbated by such concomitant infections. [emedicine.medscape.com]

This review of the pertinent literature includes the definition, clinical findings, incidence, etiology, pathophysiology, associated morbidity, prevention and treatment of this form of oral mucositis. [scielo.br]

In 2011, the FDA cleared episil oral liquid for the management and relief of pain of oral lesions with various etiologies, including oral mucositis/stomatitis which may be caused by chemotherapy or radiation therapy. [en.wikipedia.org]

Gelclair helps to soothe oral lesions of various etiologies—including OM caused by chemotherapy or radiation therapy—by adhering to the mucosa of the mouth and forming a protective barrier. [touchoncology.com]

Cancer Therapy-Induced Oral Mucositis - A Review of Epidemiology, Patophysiology, and Treatment 1 Department of Removable Prosthodontics, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, 2 Department of Periodontology [tmj.ro]

Epidemiology Frequency Some degree of oral mucositis occurs in approximately 40% of patients who receive cancer chemotherapy. [emedicine.medscape.com]

Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(suppl 9):1995-2025. 7. National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE). [uspharmacist.com]

Perspectives on Cancer Therapy-Induced Mucosal Injury: Pathogenesis, Measurement, Epidemiology, and Consequences for Patients. Cancer. 2004;100(S9):1995–2025. [PubMed] [Google Scholar] 14. Sonis ST, Peterson RL, Edwards LJ, et al. [ncbi.nlm.nih.gov]

Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004; 100(9 Suppl): 1995-2025. Epstein JB, Gorsky M, Guglietta A, Le N, Sonis ST. [healthengine.com.au]

Chemotherapy-induced damage differs from that of radiation in that radiation damage is considered as permanent risk areas throughout the patient’s life.25 Pathophysiology In 1998 a new theoretical model was described for the pathophysiology of radiotherapy-induced [scielo.br]

Therefore, oral mucositis can be a dose-limiting condition, disrupting a patient’s optimal cancer treatment plan and consequentially decreasing their chances of survival.[4] Pathophysiology[edit] The pathophysiology of mucositis is complex and multifactorial [en.wikipedia.org]

Because this toxicity clusters with dermatologic toxicities, rather than GI (as is the case with conventional mucositis) toxicities, this suggests that the underlying pathophysiology is likely very different. [emedicine.medscape.com]

Pathophysiology Historically, OM was thought to arise solely as a consequence of epithelial injury. [touchoncology.com]

Sonis (7), through several clinical and experimental observations, proposed that the stomatotoxicity of the drugs used leads to a complex pathophysiological mechanism underlying the development of oral mucositis, with a natural history including 4 biological [spandidos-publications.com]

Use of palifermin for the prevention of high-dose methotrexate-induced oral mucositis. Ann Oncol 2008;19:1644-9. [Crossref] [PubMed] Papas AJE, Sobel S, Olsen TO. Effects of preventive regimen on oral mucositis. J Dent Res IADR 1981;544:940. [cco.amegroups.com]

Many interventions have been studied for the prevention and treatment of oral mucositis [5]. [futuremedicine.com]

Different strategies are used to try and prevent this condition, and the review of trials found that some of these are effective. [cochrane.org]

So it's also very important to see a dentist and a dental hygienist to get any treatment and advice to treat or prevent any dental problems. [patient.info]

“A preventive treatment must be done every time you receive either radiation or chemotherapy. It should be done in a preventive therapy manner,” Arany said. [oncnursingnews.com]