We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019 [patientslikeme.com]

However, most people with endocrine disease complain of fatigue and weakness. Blood and urine tests to check your hormone levels can help your doctors determine if you have an endocrine disorder. [webmd.com]

A person may have hyperparathyroidism for many years with no symptoms or have symptoms such as kidney stones, bone thinning, nausea and vomiting, high blood pressure (hypertension), weakness, and fatigue. [endocrineweb.com]

These can cause skin rashes, weight loss and diabetes mellitus as well as fatigue, shortness of breath and lightheadedness as a consequence of anaemia. [yourhormones.info]

HPT can cause weakened bones, pain, fatigue, and kidney stones; when associated with MEN1, HPT is more difficult to cure because all the parathyroid glands are affected by multiple tumors. [genome.gov]

We report a 21-year-old patient with speech problems, autistic traits, dysmorphic facial features, broad thumbs with short distal phalanges and a pancreatic gastrinoma. Array-CGH demonstrated a 0.57 Mb de novo deletion in chromosome 11q13.1. [ncbi.nlm.nih.gov]

We decided to leave a portion of the reimplanted parathyroid gland with possible metastatic thymic carcinoid in his forearm because of the presence a widespread metastatic disease and his intellectual disability that would result in noncompliance with [ncbi.nlm.nih.gov]

The patient presented with complaints of nocturnal pain in the lower back, accompanied by numbness around the anus and intermittent claudication for approximately 1 year. [ncbi.nlm.nih.gov]

A 53-year-old woman presented with nausea and severe primary hyperparathyroidism. Computed tomography revealed parathyroid masses, shown later to be bilateral parathyroid carcinomas and adenomas. [ncbi.nlm.nih.gov]

Abdominal pain may be due to dyspepsia, peptic ulcer disease, constipation, or pancreatitis, all of which more commonly occur in the presence of hypercalcaemia, as does nausea and anorexia. [endobible.com]

A person may have hyperparathyroidism for many years with no symptoms or have symptoms such as kidney stones, bone thinning, nausea and vomiting, high blood pressure (hypertension), weakness, and fatigue. [endocrineweb.com]

Symptoms due to excessive parathyroid hormone production include: Tiredness, weakness Muscle or bone pain Nausea and vomiting Indigestion, constipation Recurrent fractures due to thinning of bone Kidney stone formation leading to back pain, blood in urine [dovemed.com]

Abdominal pain may be due to dyspepsia, peptic ulcer disease, constipation, or pancreatitis, all of which more commonly occur in the presence of hypercalcaemia. [endobible.com]

Zollinger-Ellison syndrome may include severe gastric ulcers, abdominal pain, loss of appetite, chronic diarrhea, malnutrition, and subsequent weight loss. Other non-beta islet cell tumors associated with MEN1 are discussed below. [en.wikipedia.org]

When I was just starting my oncology fellowship, I developed abdominal pain that felt like appendicitis, but it was actually caused by a high calcium level (hypercalcemia). [mygenecounsel.com]

High levels of gastrin, ulcers, inflammation of the esophagus, diarrhea and abdominal pain Headaches and changes in vision Problems with sexual function and fertility Acromegaly (enlargement of the bones) Cushing’s syndrome Excess production of breast [mdanderson.org]

A 51-year-old man visited the emergency department with recurrent epigastric pain. [ncbi.nlm.nih.gov]

• ZES – esophagitis, vomiting, epigastric pain, diarrhea, duodenal ulcers, jejunal ulcers • 40% manifest before age of 40. • Frequently multiple and malignant. • Pancreatic has worse prognosis due to liver metastasis. • Other poor prognostic factors [slideshare.net]

A 51-year-old man visited the emergency department with recurrent epigastric pain. [ncbi.nlm.nih.gov]

Somatostatin-receptor scintigraphy with [(111)In] DTPA octreotide demonstrated a strong uptake of the radiotracer in the left lateral segment at the site of the hepatic mass. [ncbi.nlm.nih.gov]

At age 75, Dual Energy X-ray Absoptiometry (DEXA) revealed osteoporosis and sestamibi scan showed a left parathyroid adenoma. Criteria for parathyroidectomy were met, and she underwent parathyroidectomy. [ncbi.nlm.nih.gov]

These symptoms can progress into further complications, such as muscle weakness, osteoporosis, kidney stones, mental and behavioural changes. [medic8.com]

If left untreated,the long term effects of hypercalcaemia can include osteoporosis and renal stones. 2. Pancreatic neuroendocrine tumours May occur in up to 75% of MEN1 patients. [genomicseducation.hee.nhs.uk]

Common symptoms associated with hypercalcemia include polydipsia, polyuria, constipation, and generalized malaise. [emedicine.com]

The need for frequent urination (polyuria). Blocked bowels or constipation. Fatigue. These symptoms can progress into further complications, such as muscle weakness, osteoporosis, kidney stones, mental and behavioural changes. [medic8.com]

The commonest manifestation of this is increased thirst, followed by polyuria and nocturia. Increased urinary calcium loss also predisposes to renal stone formation and hence renal colic. [endobible.com]

Remarkably, she also reported primary amenorrhea and was found to have an invasive pituitary lactotroph adenoma, which was treated with cabergoline and external beam radiotherapy. [ncbi.nlm.nih.gov]

A 35-year-old woman who had undergone bilateral inferior parathyroidectomy for primary hyperparathyroidism was referred to our hospital to evaluate the cause of irregular menses, galactorrhea, and paroxysmal headache. [ncbi.nlm.nih.gov]

Has the patient developed a new headache or neuralgia? Assess for red flag symptoms: headaches present on waking and worse on coughing or leaning forward are more suggestive of increased intracranial pressure. [endobible.com]

Local tumor expansion may cause visual disturbance, headache, and hypopituitarism. Pituitary tumors in MEN 1 patients appear to be larger and behave more aggressively than sporadic pituitary tumors. [en.wikipedia.org]

Mental confusion and headaches. Perspiration and palpitations. Treatments include surgery to eradicate the tumours and chemotherapy for cancerous tumours. [medic8.com]

She complained of dizziness, occasional palpitation, weakness, hunger, sweating, and generalized tonic-clonic seizure that lasted for 5 minutes early in the morning. [ncbi.nlm.nih.gov]

On follow-up, hypercalcemia with high parathyroid hormone (PTH) levels was detected, associated with nephrolithiasis and low bone mineral density in the spine and hip. [ncbi.nlm.nih.gov]

Clinical manifestations can include hypercalcemia, nephrolithiasis, and bone abnormalities (osteitis fibrosa cystica). Common symptoms associated with hypercalcemia include polydipsia, polyuria, constipation, and generalized malaise. [emedicine.com]

Asymptomatic hypercalcemia is the most common manifestation: about 25% of patients have evidence of nephrolithiasis or nephrocalcinosis. [en.wikipedia.org]

Tumours may hypersecrete hormone, causing hypercalcaemia and recurrent nephrolithiasis (hyperparathyroidism), Zollinger-Ellison syndrome (hypergastrinaemia), hypoglycaemia (hyperinsulinaemia), amenorrhoea (hyperprolactinaemia) or acromegaly (excess growth [patient.info]

She was treated with total parathyroidectomy followed by resection of the mediastinal mass with resolution of the hypercalemia. [ncbi.nlm.nih.gov]

Radiologic examination showed an anterior mediastinal mass and a parathyroid tumor. Blood analysis revealed high levels of parathyroid hormone and adrenocorticotropic hormone. Urine cortisol and 17-hydroxycorticoids levels were also elevated. [ncbi.nlm.nih.gov]

increased risk of stomach ulcers Glucagon: increased risk of diabetes mellitus Parathyroid hormone: increased risk of hypercalcemia and kidney stones Vasoactive intestinal peptide: severe diarrhea Cause Multiple endocrine neoplasia type 1 (MEN1) is [news-medical.net]

Gastrinomas • Elevated serum fasting gastrin. • Increased basal gastric acid secretion. • Secretin stimulated gastrin test. 25. [slideshare.net]

Recent studies indicate a general role of menin in carcinogenesis, affecting the prevalence and clinical course of common non-endocrine tumors such as breast cancer, hepatocellular carcinoma and melanoma. [ncbi.nlm.nih.gov]