We describe an unusual case of multiple symmetric lipomatosis (MSL) that presented with severe polyneuropathy, and review the literature. [ncbi.nlm.nih.gov]

• Abdominal Pain

  In addition, there are frequently gastrointestinal symptoms such as, for example, heartburn, abdominal pain, nausea and vomiting. [dercums_data.tripod.com]

• Hearing Impairment

  The diagnosis of a mitochondrial cytopathy was based on the typical clinical symptoms and signs, including chronic progressive external ophthalmoplegia, hearing impairment, cerebellar ataxia, proximal myopathy, and polyneuropathy, and on molecular genetic [ncbi.nlm.nih.gov]

• Secondary Amenorrhea

  We describe the case of a 33 year-old woman with MSL and secondary amenorrhea. [ncbi.nlm.nih.gov]

• Myoclonus

  As a unique finding, the A-- G(8344) myoclonus epilepsy and ragged-red fibers point mutation was found in peripheral nerve, muscle, and adipose tissue. [ncbi.nlm.nih.gov]

  Mitochondrial disfunction with myoclonus epilepsy and ragged-red fibers point mutation in nerve, muscle and adipose tissue of a patient with multiple symmetric lipomatosis Muscle Nerve 1997 20 : 833–839. 39 Holme E, Larsson NG, Oldfors A, Tulinius M, [nature.com]

  Further studies have demonstrated that MSL is associated with myoclonus epilepsy and ragged red fibers syndrome ( 17, 18 ). [spandidos-publications.com]

• Headache

  Common side effects include shakiness, headache, fast heart rate, dizziness, serious side effects may include worsening bronchospasm, irregular heartbeat, and low blood potassium levels. [wikivisually.com]

  Headache (tension headache, migraine, cervicogenic headache). [dercums_data.tripod.com]

• Chronic Progressive External Ophthalmoplegia

  The diagnosis of a mitochondrial cytopathy was based on the typical clinical symptoms and signs, including chronic progressive external ophthalmoplegia, hearing impairment, cerebellar ataxia, proximal myopathy, and polyneuropathy, and on molecular genetic [ncbi.nlm.nih.gov]

An association of the disease with malignancies of the aerodigestive tract has been described by some authors. [4] Workup of the disease includes clinical examination, sonography, computerised tomography and fine needle aspiration cytology. [doi.org]

To date, there is no effective medical treatment of MSL. Surgical treatment is based on 2 options, namely, lipectomy and/or liposuction. In this retrospective study, we compare traditional lipectomy with ultrasound-assisted liposuction. [ncbi.nlm.nih.gov]

Interruption of alcohol abuse and surgical excision are the only effective treatments. We report the case of a 54-years-old man with Madelung’s disease. [minervamedica.it]

Prognosis MSL is basically a benign condition but in some cases there may be serious physical, cosmetic and psychological repercussions. Associated disorders may affect the prognosis. [orpha.net]

[…] appear to have no effect on disease progression, these measures associated with surgery can decrease the recurrence rate, 6 as a longitudinal study showed that the amount of alcohol consumed is directly associated with the onset of the disease. 3 The prognosis [bjorl.org]

Treatment and prognosis Treatment centers around surgical removal, including liposuction, lipectomy or injection lipolysis. [radiopaedia.org]

The etiology remains unknown; however, the association with high alcohol consumption is very strong. Several issues about the possible metabolic role of lipomatous adipose tissue have been discussed. [ncbi.nlm.nih.gov]

Summary Epidemiology MSL primarily affects men and has a sex ratio of 15:1 to 30:1, depending on the region.The disorder may occur in all ethnic groups.. [orpha.net]

Both of the patients presented in this report present an epidemiological profile in agreement with the literature, including long-term heavy alcohol use. The etiology of multiple symmetric lipomatosis is unknown 1-6. [rbcp.org.br]

Must be differentiated from other tumors, particularly liposarcomas because treatment protocols differ Epidemiology Lipomas can occur at any age but most commonly occur in middle-aged adults, typically in the 40- to 60-year-old age group, and more likely [unboundmedicine.com]

Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme – The International Classification of Diseases is the international standard diagnostic tool for epidemiology, health management and clinical purposes. [wikivisually.com]

Possible risk factors include obesity, alcohol abuse, liver disease, glucose intolerance, and soft tissue trauma (see “Etiology and Pathophysiology”). [unboundmedicine.com]

AD is a multifactorial disease and its pathophysiology has been linked to immunological mechanisms demonstrated by immunoglobulin profiles. [medicaljournals.se]

Although there might be a genetic predisposition, most cases are sporadic with exact risk factors and pathophysiology unknown [ 4 ]. [omicsonline.org]

Although there might be a genetic predisposition, most cases are sporadic with exact risk factors and pathophysiology unknown [ 5 ]. [clinmedjournals.org]

Lipomas are not encapsulated, have an infiltrative nature, have a fibrous component, and are extensively vascularized, usually preventing their complete removal 2. [rbcp.org.br]

The cause of the disease remains unknown, but its incidence strongly correlates with alcohol abuse; abstinence from alcohol prevents disease progression. [en.wikipedia.org]

In some cases, it is very difficult to prevent the bleeding during the surgery. Liposuction is the least traumatic procedure, and therefore it is suggested as a complementary treatment. [rarediseases.info.nih.gov]

[…] trachea and development of neuropathies. 2 Final comments The identification of this rare disease, the appropriate investigation for the exclusion of differential diagnosis, and early surgical approach as observed in the present case, are important to prevent [bjorl.org]

In conclusion, these findings are consistent with the hypothesis that in a metabolic sense, fat depots such as in MSL may be metabolically innocent, possibly by preventing lipotoxicity. [care.diabetesjournals.org]