No signs or symptoms of coronary heart disease were present in the whole series. [ncbi.nlm.nih.gov]

Case presentation A male patient, 47 years old, white, without comorbidities, alcoholic for 20 years, presented to this unit with a complaint of bulging in the bilateral supraclavicular region, painless, which had been progressively growing for the past [bjorl.org]

• Abdominal Pain

  In addition, there are frequently gastrointestinal symptoms such as, for example, heartburn, abdominal pain, nausea and vomiting. [dercums_data.tripod.com]

• Melena

  March 1, 2018 A 49-year-old man presented to the emergency department with hematemesis and 2 episodes of melena. Examination findings included resting tachycardia and melenic stool. Blood pressure was 95/50 mm Hg. [consultant360.com]

• Acrocyanosis

  This form of neuropathy affects up to 90% of patients over the course of the disease and may manifest as paresthesias, cramps, resting tachycardia, postural hypotension, segmental hyperhidrosis, erectile dysfunction, and acrocyanosis, among others 4. [rbcp.org.br]

• Myoclonus

  As a unique finding, the A-->G(8344) myoclonus epilepsy and ragged-red fibers point mutation was found in peripheral nerve, muscle, and adipose tissue. [ncbi.nlm.nih.gov]

  Mitochondrial disfunction with myoclonus epilepsy and ragged-red fibers point mutation in nerve, muscle and adipose tissue of a patient with multiple symmetric lipomatosis Muscle Nerve 1997 20 : 833–839. 39 Holme E, Larsson NG, Oldfors A, Tulinius M, [nature.com]

  Further studies have demonstrated that MSL is associated with myoclonus epilepsy and ragged red fibers syndrome ( 17, 18 ). [spandidos-publications.com]

• Headache

  Common side effects include shakiness, headache, fast heart rate, dizziness, serious side effects may include worsening bronchospasm, irregular heartbeat, and low blood potassium levels. [wikivisually.com]

  Headache (tension headache, migraine, cervicogenic headache). [dercums_data.tripod.com]

• Chronic Progressive External Ophthalmoplegia

  The diagnosis of a mitochondrial cytopathy was based on the typical clinical symptoms and signs, including chronic progressive external ophthalmoplegia, hearing impairment, cerebellar ataxia, proximal myopathy, and polyneuropathy, and on molecular genetic [ncbi.nlm.nih.gov]

An association of the disease with malignancies of the aerodigestive tract has been described by some authors. [4] Workup of the disease includes clinical examination, sonography, computerised tomography and fine needle aspiration cytology. [doi.org]

To date, there is no effective medical treatment of MSL. Surgical treatment is based on 2 options, namely, lipectomy and/or liposuction. In this retrospective study, we compare traditional lipectomy with ultrasound-assisted liposuction. [ncbi.nlm.nih.gov]

Interruption of alcohol abuse and surgical excision are the only effective treatments. We report the case of a 54-years-old man with Madelung’s disease. [minervamedica.it]

To date, there is no effective medical treatment of MSL. Surgical treatment is based on 2 options, namely, lipectomy and/or liposuction. In this retrospective study, we compare traditional lipectomy with ultrasound -assisted liposuction. [journals.lww.com]

Although cases have been published in which SAHS has improved after surgical treatment of MSL, when we take into account the limited long-term effectiveness of this therapeutic option and the success of continuous positive airway pressure (CPAP) treatment [archbronconeumol.org]

Prognosis MSL is basically a benign condition but in some cases there may be serious physical, cosmetic and psychological repercussions. Associated disorders may affect the prognosis. [orpha.net]

Treatment and prognosis Treatment centers around surgical removal, including liposuction, lipectomy or injection lipolysis. [radiopaedia.org]

[…] appear to have no effect on disease progression, these measures associated with surgery can decrease the recurrence rate, 6 as a longitudinal study showed that the amount of alcohol consumed is directly associated with the onset of the disease. 3 The prognosis [bjorl.org]

The etiology remains unknown; however, the association with high alcohol consumption is very strong. Several issues about the possible metabolic role of lipomatous adipose tissue have been discussed. [ncbi.nlm.nih.gov]

Although great progress has been made in understanding epidemiology and etiology of the syndrome, much about the syndrome remains mysterious. [books.google.com]

Summary Epidemiology MSL primarily affects men and has a sex ratio of 15:1 to 30:1, depending on the region.The disorder may occur in all ethnic groups.. [orpha.net]

Both of the patients presented in this report present an epidemiological profile in agreement with the literature, including long-term heavy alcohol use. The etiology of multiple symmetric lipomatosis is unknown 1-6. [rbcp.org.br]

Must be differentiated from other tumors, particularly liposarcomas because treatment protocols differ Epidemiology Lipomas can occur at any age but most commonly occur in middle-aged adults, typically in the 40- to 60-year-old age group, and more likely [unboundmedicine.com]

Possible risk factors include obesity, alcohol abuse, liver disease, glucose intolerance, and soft tissue trauma (see “Etiology and Pathophysiology”). [unboundmedicine.com]

AD is a multifactorial disease and its pathophysiology has been linked to immunological mechanisms demonstrated by immunoglobulin profiles. [medicaljournals.se]

Although there might be a genetic predisposition, most cases are sporadic with exact risk factors and pathophysiology unknown [ 4 ]. [omicsonline.org]

Although there might be a genetic predisposition, most cases are sporadic with exact risk factors and pathophysiology unknown [ 5 ]. [clinmedjournals.org]

The cause of the disease remains unknown, but its incidence strongly correlates with alcohol abuse; abstinence from alcohol prevents disease progression. [en.wikipedia.org]

Lipomas are not encapsulated, have an infiltrative nature, have a fibrous component, and are extensively vascularized, usually preventing their complete removal 2. [rbcp.org.br]

[…] very rare with an estimated incidence rate of 1 in 25,000 and affecting males up to 30 times more frequently than females. [2] The etiology of the disease remains unknown, but there is a strong correlation with alcohol abuse; abstinence from alcohol prevents [wikidoc.org]

[…] trachea and development of neuropathies. 2 Final comments The identification of this rare disease, the appropriate investigation for the exclusion of differential diagnosis, and early surgical approach as observed in the present case, are important to prevent [bjorl.org]

Alcohol abstinence prevents progression of the disease. [1] Surgical treatment includes lipectomy and liposuction. [1] The use of ultrasound assisted liposuction has also been reported. [5] Surgical intervention is complicated by the increased vascularity [doi.org]