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Mumps

Mumps Infection

Mumps (epidemic parotitis) is an acute, systemic viral disease caused by the mumps virus, a member of the family Paramyxoviridae. It is characterized by the swelling of the salivary glands, typically the parotid glands.


Presentation

Mumps is characterized by the following features.

Prodromal phase: Initially, there is a prodromal phase in which the patient suffers from malaise and low-grade fever.

Parotitis: After the prodromal feature, the classical, tender enlargement of the parotid gland starts developing. In around 75% of the cases, the enlargement is bilateral. Usually, there is swelling of only one gland in the initial stage and the second gland enlarges after one to three days. Sometimes, the second gland may enlarge after the recovery of the first gland.

Complications: The common complications of mumps include orchitis, oophoritis, meningitis and pancreatitis. If meningitis or orchitis develop as complications of mumps, high grade fever may also be seen [4].

  • Orchitis: Orchitis is a known complication of mumps [5]. It occurs in around 25 to 40% of the postpubertal men suffering from mumps. Bilateral orchitis is present in 33% of the cases. Orchitis typically develops 7 to 10 days after the onset of parotitis. Rarely, the patient may become sterile.
  • Oophoritis: Inflammation of the ovaries is a common complication of mumps and is suggested by lower abdominal pain and enlargement of the ovaries.
  • Meningitis: Meningitis is also a frequent complication of mumps infection [6]. It develops in around 30% of the patients suffering from mumps. It presents with headache, neck stiffness, fever and lethargy.
  • Pancreatitis: Mumps is responsible for up to 5% of the cases of pancreatitis; however it is not yet clear whether or not it is actually caused by mumps virus. It presents with upper abdominal pain, nausea and vomiting.
  • Other rare complications of mumps include neuritis of the vestibulocochlear nerve (causing transient hearing loss and labrynthitis), encephalitis, Guillain-Barre syndrome, thyroiditis, hepatitis, myocarditis, nephritis and thrombocytopenia.
Splenomegaly
  • Admission examinations showed severe pancytopenia, liver dysfunction, hyperferritinemia, fibrinopenia, elevated lactalase dehydrase, bilateral pulmonary inflammation and pleural effusion, abdominal lymphadenopathy, and splenomegaly.[ncbi.nlm.nih.gov]
Abdominal Lymphadenopathy
  • Admission examinations showed severe pancytopenia, liver dysfunction, hyperferritinemia, fibrinopenia, elevated lactalase dehydrase, bilateral pulmonary inflammation and pleural effusion, abdominal lymphadenopathy, and splenomegaly.[ncbi.nlm.nih.gov]
Fever
  • A-13-year-old girl presented with diabetic ketoacidosis with convincing clinical signs of parotitis (fever, drooling of saliva, inability to swallow with development of bilateral parotid swelling) and pancreatitis (fever, abdominal pain and vomiting),[ncbi.nlm.nih.gov]
  • Mumps is a common childhood viral disease characterized by fever and swelling of the parotid gland. The prognosis is generally good, although some complications, such as encephalitis (0.1%), exist.[ncbi.nlm.nih.gov]
  • On hospitalization day 3, the fever stayed high, and painful swelling in the right testicle was reported. A bone marrow biopsy evaluation and serological tests were then performed.[ncbi.nlm.nih.gov]
  • Commons, l'archivio di file multimediali liberi Jump to navigation Jump to search Mumps or epidemic parotitis is a disease of humans caused by a paramyxovirus that produces painful swelling of the salivary glands (classically the parotid gland) and fever[commons.wikimedia.org]
  • Prodromal phase: Initially, there is a prodromal phase in which the patient suffers from malaise and low-grade fever. Parotitis: After the prodromal feature, the classical, tender enlargement of the parotid gland starts developing.[symptoma.com]
Malaise
  • A previously healthy 22-year-old woman presented with acute, unilateral facial and neck swelling, associated with fever and malaise.[ncbi.nlm.nih.gov]
  • Patients often present with nonspecific viral symptoms of fever, myalgias, and malaise. More specific features include facial swelling (parotitis) in 95% and/or testicular pain (orchitis).[radiopaedia.org]
  • Other symptoms include low-grade fever , malaise , headache , and possible swelling of other salivary glands . The diagnosis of mumps is largely based on clinical findings.[amboss.com]
  • Initial symptoms are typically non-specific, such as headache, malaise and fever, followed within a day by the characteristic swelling of the parotid (salivary) glands.[who.int]
  • Prodromal phase: Initially, there is a prodromal phase in which the patient suffers from malaise and low-grade fever. Parotitis: After the prodromal feature, the classical, tender enlargement of the parotid gland starts developing.[symptoma.com]
Chills
  • This will include pain, swelling, loss of appetite, headache, sore throat, fever and chills. The frustrating part of living with mumps is not being able to get out and see people.[familydoctor.org]
  • Symptoms include lower abdominal pain, fever and chills. Orchitis does not result in infertility for adolescents or adult men. Females could suffer from oophoritis and/or mastitis.[livestrong.com]
  • Symptoms include chills, headache, poor appetite, fever, and a feeling of illness, followed by swelling of the salivary glands. The diagnosis is based on typical symptoms.[msdmanuals.com]
  • This can sometimes lead to the diagnosis being missed. [ 4 ] Orchitis presents with chills, sweats, headache and backache with swinging temperature and severe local testicular pain and tenderness.[patient.info]
Vomiting
  • A 66-year-old Chinese man presented to our department with a 1-month speech barrier and 1 day of vomiting. He had the history of high blood sugar, the history of high blood pressure and the history of Vitiligo.[ncbi.nlm.nih.gov]
  • A-13-year-old girl presented with diabetic ketoacidosis with convincing clinical signs of parotitis (fever, drooling of saliva, inability to swallow with development of bilateral parotid swelling) and pancreatitis (fever, abdominal pain and vomiting),[ncbi.nlm.nih.gov]
  • Case 1 was a three-year-old girl with bilateral parotid swelling, vomiting and walking disorder. One year after cochlear implant insertion, speech perception did not develop despite of good pure tone thresholds.[ncbi.nlm.nih.gov]
  • The five patients (all males, aged 1 to 9) presented with fever, vomiting, or headache as the initial symptoms (day 0), suggesting meningitis, at 13 to 21 days after mumps vaccination.[ncbi.nlm.nih.gov]
  • Salient clinical indicators of CNS involvement include headache, fever, nausea, vomiting, and nuchal rigidity.[emedicine.com]
Nausea
  • A 56-year-old Japanese man had suffered from nausea and generalized fatigue for two days before being transferred to our hospital in a confused state.[ncbi.nlm.nih.gov]
  • Five hours postsurgery, the patient experienced bilateral parotid enlargement with no other discomfort, such as pain, fever, skin redness, itching, hives, nausea, vomiting, or respiratory abnormalities. We thought the diagnosis was iodide mumps.[ncbi.nlm.nih.gov]
  • Salient clinical indicators of CNS involvement include headache, fever, nausea, vomiting, and nuchal rigidity.[emedicine.com]
  • Treatment Complications Orchitis ( 10% of cases; most c ommon complication in post-pubertal males ) Primarily unilateral , although bilateral in 15% of cases Sudden onset of fever , nausea, vomiting On examination: swollen and tender affected testicle[amboss.com]
Parotid Swelling
  • Case 2 was an eight-year-old girl with bilateral parotid swelling. A cochlear implant enabled her to improve hearing perception.[ncbi.nlm.nih.gov]
  • We discuss the case and the literature surrounding this condition and remind clinicians that mumps should be considered as a diagnosis in the presence of submandibular gland swelling in the absence of typical parotid swelling associated with mumps.[ncbi.nlm.nih.gov]
  • A-13-year-old girl presented with diabetic ketoacidosis with convincing clinical signs of parotitis (fever, drooling of saliva, inability to swallow with development of bilateral parotid swelling) and pancreatitis (fever, abdominal pain and vomiting),[ncbi.nlm.nih.gov]
  • We report an acute bilateral parotid swelling in a patient after electroconvulsive therapy anesthesia.[ncbi.nlm.nih.gov]
  • A child presented to our department with parotid swelling and fever. Persistent tachycardia with irregular pulse led to further cardiac work up which showed decreased ejection fraction and raised serum cardiac enzymes, indicating myocardial damage.[ncbi.nlm.nih.gov]
Jaw Pain
  • Symptoms include fatigue, fever, swollen salivary glands, rash, and jaw pain and can last a few weeks. Once exposed, it can take between 12 to 25 days for symptoms to appear.[abc17news.com]
  • DPH has instructed doctors to consider mumps as a diagnostic possibility “regardless of vaccination history,” and to isolate patients for five days after the onset of symptoms — swollen neck glands, headache, jaw pain and fever.[bostonherald.com]
  • In addition to swollen glands in the neck, symptoms of mumps include fever, headache, earache, jaw pain, fatigue, and loss of appetite. People who previously had mumps are considered immune from a second infection.[bostonglobe.com]
  • Others may feel extremely ill and be unable to eat because of jaw pain, and a few will develop serious complications. Men and adolescent boys can develop pain or swelling in their testicles, which rarely results in sterility.[access.tarrantcounty.com]
Otalgia
  • Tenderness of the parotid glands and otalgia often precede parotitis, which is bilateral in 95% of cases. 8 The swelling can be extensive enough to interfere with speech and chewing, and can even cause trismus. 13 The intraoral entry point to the duct[web.archive.org]
Arthritis
  • Neuritis, arthritis, nephritis, thyroiditis and pericarditis have all been reported. Transient and mild mastitis (uncommon - can occur in either sex).[patient.info]
  • Rare complications include arthritis, meningitis , encephalitis , pancreatitis , deafness, and inflammation of the heart.[emedicinehealth.com]
Facial Swelling
  • More specific features include facial swelling (parotitis) in 95% and/or testicular pain (orchitis). Serum IgM antibody testing can be used to confirm a case of mumps, if necessary. Mumps is a single-stranded RNA paramyxovirus 2.[radiopaedia.org]
  • Individuals with facial swelling (swollen neck or cheek) should consult their health care provider or SCHD at (901)222-9243 and stay in isolation for five days after onset or until testing negative.[shelbytnhealth.com]
  • Tests and diagnosis of mumps Normally, mumps can be diagnosed by its symptoms alone, especially by examining the facial swelling.[medicalnewstoday.com]
Headache
  • Symptoms can also include: fever, headache or earache, tiredness, sore muscles, dry mouth, trouble talking, chewing or swallowing, or loss of appetite.[phac-aspc.gc.ca]
  • Mumps may also infect the: Central nervous system Pancreas Testes Symptoms of mumps may include: Face pain Fever Headache Sore throat Loss of appetite Swelling of the parotid glands (the largest salivary glands, located between the ear and the jaw) Swelling[nlm.nih.gov]
  • The five patients (all males, aged 1 to 9) presented with fever, vomiting, or headache as the initial symptoms (day 0), suggesting meningitis, at 13 to 21 days after mumps vaccination.[ncbi.nlm.nih.gov]
  • Upper respiratory symptoms, fever, and headache are common, with unilateral or bilateral parotitis, and the virus may spread to other systems. Diagnosis is clinical, though polymerase chain reaction and immunoglobulin testing are available.[ncbi.nlm.nih.gov]
Akinesia
  • Several days later, he presented with various neurological abnormalities, including akinesia, mutism, dysphagia, and uncontrolled respiratory disorder. Mumps encephalitis was diagnosed.[ncbi.nlm.nih.gov]
Testicular Pain
  • More specific features include facial swelling (parotitis) in 95% and/or testicular pain (orchitis). Serum IgM antibody testing can be used to confirm a case of mumps, if necessary. Mumps is a single-stranded RNA paramyxovirus 2.[radiopaedia.org]
  • In males who have gone through puberty, two or three of every 10 will experience testicular pain and swelling. Not everyone will have the typical symptoms; many infected people will just have respiratory symptoms without any swollen glands.[adultvaccination.org]
  • This can sometimes lead to the diagnosis being missed. [ 4 ] Orchitis presents with chills, sweats, headache and backache with swinging temperature and severe local testicular pain and tenderness.[patient.info]
  • Other symptoms may include testicular pain (in males), abdominal pain , seizures , stiff neck, and difficulty swallowing . Orchitis (inflammation of one or both testicles) is the most feared complication of mumps.[emedicinehealth.com]

Workup

Mumps is easily diagnosed on clinical grounds. However, the following investigations are helpful in confirming the diagnosis.

  • Blood tests demonstrate a relative lymphocytosis is seen in case of mumps infection.
  • Serum amylase is commonly elevated with or without pancreatitis because of salivary gland involvement [7].
  • Examination of the cerebrospinal fluid (CSF) shows lymphocytic pleocytosis along with normal to low glucose in case of meningitis [8] [9].
  • Mumps is confirmed by isolation of the virus from the saliva or cerebrospinal fluid; or by the demonstration of a fourfold rise in complement fixing antibodies.
Complement Fixing Antibody
  • Mumps is confirmed by isolation of the virus from the saliva or cerebrospinal fluid; or by the demonstration of a fourfold rise in complement fixing antibodies. The treatment of mumps is supportive and symptomatic.[symptoma.com]
  • However, if an acute CNS complication is suspected, paired sera are usually sent for the estimation of complement fixing antibodies to measles.[encyclopedia.com]

Treatment

The treatment of mumps is supportive and symptomatic. Mumps does not require any specific antiviral therapy as the illness is self-limiting.

Isolation: The patient suffering from mumps should be isolated until the swelling of the parotid gland(s) subsides.

Bed rest: During the febrile period of the disease, the patient should be advised to have bed rest.

Painkillers: Non-steroidal anti-inflammatory drugs (NSAIDs) such as paracetamol and ibuprofen are used to treat the pain of parotitis. Application of warm or cold compresses topically over the parotid gland may soothe the pain.

The complications of mumps are treated as follows.

Orchitis: In case of orchitis, the scrotum should be suspended with support and ice bags should be applied to keep their temperature from rising to dangerously high levels. Analgesics are given for pain. Injection of 1% procaine solution in the spermatic cord at the external inguinal ring also reduces pain. Injection of hydrocortisone followed by oral prednisolone is also helpful in reducing the pain and inflammation [10].

Meningitis: In case of meningitis, cerebral edema is treated by the use of mannitol and steroids. If the patient is experiencing fits, antiseizure medication may also be given.

Pancreatitis: The treatment of pancreatitis is symptomatic.

Prognosis

In the patients with uncomplicated disease, the prognosis is excellent. Patients who develop complications may have chronic morbidity but fatality is still extremely rare. Even if the patients develop meningitis or encephalitis, the prognosis remains favorable, although there may be sensorineural deafness. Even then, the hearing loss is rarely permanent. Similarly, total loss of fertility in patients with orchitis is extremely rare and no loss of fertility is seen in case of oophoritis.

Mumps infection is also linked to the development of type 1 diabetes mellitus [2] [3].

Etiology

Mumps is caused by a paramyxovirus. The virus spreads by respiratory droplets and its infection is facilitated by lack of immunization against mumps and compromised immunity in the patient [1].

Epidemiology

Mumps was a very common disease several decades ago but nowadays, with the advent of MMR vaccine, the prevalence has greatly reduced in the developed countries. The incidence is highly variable from country to country depending upon the efficiency of their immunization programs.

Most of the patients of mumps are children of school age. Males and females are equally affected. However, the complications of the central nervous system are up to 3 times more common in males.

Sex distribution
Age distribution

Pathophysiology

Once the virus enters the body via respiratory droplets, it disseminates through the bloodstream into the parotid glands and several other sites such as the nervous system, the testes, ovaries etc. There is active inflammation and cellular infiltration that causes enlargement and pain of the parotid glands.

Prevention

Mumps can be prevented by proper immunization in children. Currently, the vaccine of choice is MMR (that covers mumps, measles and rubella) [11]. It should be given at the age of 12 months and then followed up with a second dose after another 12 months. Avoidance of contact with any active case of mumps is also helpful in prevention.

Summary

Mumps is a common viral disease of children that produces tender inflammation and enlargement of the parotid gland(s). The causal agent is a paramyxovirus and infectivity occurs by respiratory droplets, saliva and urine. The disease is self-limiting and the treatment is symptomatic and supportive unless there are complications.

Patient Information

Mumps is a viral disease of children in which the parotid salivary glands become enlarged and painful. It is a highly contagious disease and spreads through respiratory droplets. The disease is usually not dangerous and the patient is treated only with painkillers unless there are complications. Mumps can be prevented by proper vaccination.

References

Article

  1. Vigneron P. [Mumps. Epidemiology, diagnosis, etiology, prevention]. La Revue du praticien. Dec 1 2000;50(19):2177-2181.
  2. Ratzmann KP. Does mumps infection play a role in the etiology and pathogenesis of insulin-dependent diabetes mellitus? Medecine interne. Oct-Dec 1986;24(4):245-252.
  3. Hyoty H, Leinikki P, Reunanen A, et al. Mumps infections in the etiology of type 1 (insulin-dependent) diabetes. Diabetes research. Nov 1988;9(3):111-116.
  4. Rodriguez-Vidigal F, Redondo L, Aguilar FJ, Vera A, Munoz-Sanz A. [Lymphocytic meningitis by mumps virus: epidemiologic, clinical, serologic and evolutive analysis of 28 cases]. Enfermedades infecciosas y microbiologia clinica. Apr 1999;17(4):176-179.
  5. Manson AL. Mumps orchitis. Urology. Oct 1990;36(4):355-358.
  6. Behar M. [Mumps meningitis]. La Semana medica. Apr 7 1960;116:435-443.
  7. Lagunilla Martinez FL. [Amylase in the blood and infantile mumps infections]. Acta pediatrica espanola. Dec 1962;20:737-750.
  8. Tashima CK. CSF pleocytosis after mumps. The New England journal of medicine. Jun 12 1969;280(24):1362.
  9. Wilfert CM. Low CSF sugar in mumps. The New England journal of medicine. Jul 10 1969;281(2):106.
  10. Martynkin AS, Timchenko VN, Ignat'eva Iu D. [Post-mumps orchitis: sequelae, treatment and prevention]. Pediatriia. 1987(6):95-98.
  11. Elliman D, Sengupta N, El Bashir H, Bedford H. Measles, mumps, and rubella: prevention. Clinical evidence. 2007;2007.

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Last updated: 2019-07-11 22:55