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Mumps Rubulavirus

Mumps Virus


Presentation

  • In the present study, we show that the entry of MuV is bipolar, while the release is predominantly from the apical surface in polarized epithelial cells.[ncbi.nlm.nih.gov]
  • Mumps virus was isolated from the cervico-vaginal secretions of a 31-year-old woman presenting with mild signs of oophoritis accompanied by xantholeucorrhoea.[ncbi.nlm.nih.gov]
  • This paper presents treatment of carcinoma of the maxillary sinus with an attenuated mumps virus. The mumps virus was inoculated into two cases of very advanced carcinoma of the maxillary sinus by local and general injection.[ncbi.nlm.nih.gov]
  • Clinical specimens, including buccal swabs, urine, CSF and sera, were collected on a single visit upon presentation for diagnosis.[ncbi.nlm.nih.gov]
  • We present three unusual adult cases of mumps with dyspnea secondary to severe swelling of the salivary glands and review previously reported cases in the literature. Dyspnea developed progressively after the onset of salivary gland swelling.[ncbi.nlm.nih.gov]
Tachycardia
  • A chronic course of disease extending from April to December was found with swelling of the parotid glands, fatigue, low grade fever, episodes of tachycardia and nightswetting.[ncbi.nlm.nih.gov]
Suggestibility
  • While there are multiple conditions driving this re-emergence, convention has suggested that these outbreaks are associated with waning immunity rather than vaccine escape.[ncbi.nlm.nih.gov]
  • Therefore, our data suggested that Rab11 is not a regulator of selective apical release of MuV, although it acts as an activator of virus release from polarized epithelial cells.[ncbi.nlm.nih.gov]
  • Six months later, left canal paresis was still present, but bilateral GBST responses were normal, suggesting that retrolabyrinthine vestibular function had been restored. Mumps virus may affect retrolabyrinthine function as well as the inner ear.[ncbi.nlm.nih.gov]
  • Precise analyses of nucleotide sequences suggested that the 4 viruses isolated in 2010 were not directly derived from the evolution of MuV existing before 2006 in the Yokohama area.[ncbi.nlm.nih.gov]
  • Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. tahir.malik@fda.hhs.gov Abstract Deletion of the small hydrophobic (SH) protein of certain paramyxoviruses has been found to result in attenuation, suggesting[ncbi.nlm.nih.gov]
Nystagmus
  • Neurotologic examinations revealed spontaneous right-beating nystagmus, left canal paresis, absence of vestibular-evoked myogenic potentials in the left ear, and absence of responses to a left galvanic body sway test (GBST).[ncbi.nlm.nih.gov]

Workup

  • (See Workup.) Child with mumps. Even though the mumps virus, Rubulavirus, shares similar morphologic features to human parainfluenza viruses (known as hPIVs, as part of the Paramyxovirus genus), no cross-immunity between these viruses is known.[reference.medscape.com]
Bartonella Henselae
  • henselae, Chlamydia trachomatis and pneumoniae 10 x 01 (test system) 10 x 02 (test system) 10 x 01 (test system) 10 x 02 (test system) FI 2824-1001-1 G FI 2824-1002-1 G FI 2824-1001-1 M * FI 2824-1002-1 M * Central Nervous System Profile 1 (consisting[euroimmun.com]
Chlamydia Trachomatis
  • trachomatis and pneumoniae 10 x 01 (test system) 10 x 02 (test system) 10 x 01 (test system) 10 x 02 (test system) FI 2824-1001-1 G FI 2824-1002-1 G FI 2824-1001-1 M * FI 2824-1002-1 M * Central Nervous System Profile 1 (consisting of 21 different substrates[euroimmun.com]
Treponema Pallidum
  • pallidum field C: HSV-1 and -2, Coxsackie virus type B1 and A9 field D: Echo virus type 7, Borrelia afzelii, burgdorferi (CH), garinii field E: CMV, Candida albicans, krusei*, tropicalis* 10 x 01 (test system) 10 x 02 (test system) 10 x 01 (test system[euroimmun.com]
Toxoplasma Gondii
  • gondii, Treponema pallidum field D: HSV-1 and -2, CMV, Coxsackie virus type B5 field E: Coxsackie virus type A9, Bartonella henselae, Chlamydia trachomatis and pneumoniae 10 x 01 (test system) 10 x 02 (test system) 10 x 01 (test system) 10 x 02 (test[euroimmun.com]
Cytoplasmic Inclusion Bodies
  • Mumps virus (MuV) infection induces formation of cytoplasmic inclusion bodies (IBs). Growing evidence indicates that IBs are the sites where RNA viruses synthesize their viral RNA.[ncbi.nlm.nih.gov]

Treatment

  • Histologically, the virus-treatment caused shrinkage of nuclei and vacuolization of the cytoplasma of tumor cells, but the degenerative changes of tumor cells were not so great as those after chemotherapy or radiotherapy.[ncbi.nlm.nih.gov]
  • This paper presents treatment of carcinoma of the maxillary sinus with an attenuated mumps virus. The mumps virus was inoculated into two cases of very advanced carcinoma of the maxillary sinus by local and general injection.[ncbi.nlm.nih.gov]
  • Despite the availability of a mumps vaccine, outbreaks continue to occur and no treatment options are available. Vitamin A and other naturally occurring retinoids inhibit the replication of MeV in vitro.[ncbi.nlm.nih.gov]
  • Mumps Virus Antigen ORDERING INFORMATION Catalog No: BA103VS Lot No: Lot specific Agent: Mumps virus, strain Enders Culture System: Vero cell culture PREPARATION Mumps virus infected cells are harvested, washed and virus is extracted by alkaline treatment[qedbio.com]
  • Our previous results have shown that treatment of the paramyxovirus simian virus 5 (SV5) with human serum results in deposition of complement C3-derived polypeptides on virion particles.[ncbi.nlm.nih.gov]

Prognosis

  • The process is mostly unilateral and the prognosis usually good. Mumps virus has been one of the most important causes of viral CNS disease (meningitis and encephalitis) in USA; vaccine administration has greatly reduced its incidence.[ibl-international.com]
  • […] cell membrane fusion, ultimately resulting in infection of the host cell the virus replicates in the nasopharynx and regional lymph nodes in the glandular epithelium Prevention measles, mumps, and rubella (MMR) vaccine given over 2 doses in childhood Prognosis[medbullets.com]

Etiology

  • The etiology was confirmed by serology and RNA detection to be mumps virus in 72 % of the cases and 50 % of contacts.[ncbi.nlm.nih.gov]
  • This virus should always be considered among possible etiologic agents causing such neurologic syndromes.[ncbi.nlm.nih.gov]
  • IMPORTANCE: Mumps virus (MuV) is the etiological agent of mumps and causes a systemic infection. However, the precise mechanism by which MuV breaks through the epithelial barriers and achieves a systemic infection remains unclear.[ncbi.nlm.nih.gov]
  • These widely distributed pathogens are among the commonest etiological agents of respiratory infections, causing high morbidity in mortality worldwide.[zci-cervirvac.hr]
  • (See Etiology.) The presence of maternal antibodies typically protects infants younger than 12 months old from the disease. Infections can be a symptomatic in 20-30% of persons.[reference.medscape.com]

Epidemiology

  • Therefore, combined high-quality epidemiological and virological surveillance is necessary for mumps control; it can also be used to observe the changes in epidemiological characteristics and viral transmission of mumps over time after mumps-containing[ncbi.nlm.nih.gov]
  • KEYWORDS: Fusion gene; Haemagglutinin-neuraminidase gene; Molecular epidemiology; Mumps genotype G outbreak; Mumps virus; Small hydrophobic gene[ncbi.nlm.nih.gov]
  • BACKGROUND: The molecular epidemiology of mumps virus (MuV) has been carried out worldwide based on genotyping proposed by the World Health Organisation. However, longitudinal molecular epidemiological studies of MuV are still limited.[ncbi.nlm.nih.gov]
  • The molecular epidemiology of the virus is poorly understood. The present study describes an outbreak of mumps virus infection in Punjab, India.[ncbi.nlm.nih.gov]
  • Abstract Although the WHO recommends the use of genotyping as a tool for epidemiological surveillance for mumps, limited data on mumps virus (MV) genotype circulation that may be used to trace the patterns of virus spread are available.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Determination of postimmunization immune response of individuals to the mumps vaccine Documentation of previous infection with mumps virus in an individual with no previous record of immunization to mumps virus Clinical Information Discusses physiology, pathophysiology[mayocliniclabs.com]

Prevention

  • Centers for Disease Control and Prevention, Nanjing, People's Republic of China. 3 Heilongjiang Provincial Centers for Disease Control and Prevention, Ha'erbin, People's Republic of China. 4 Shandong Provincial Centers for Disease Control and Prevention[ncbi.nlm.nih.gov]
  • The S(79) vaccine can effectively prevent clinical mumps, and a second dose of mumps virus vaccine is necessary for the protection of children in China.[ncbi.nlm.nih.gov]
  • Abstract Mumps is one of the vaccine-preventable childhood diseases and it has not yet been eradicated in Germany.[ncbi.nlm.nih.gov]
  • Infections caused by mumps virus (MuV) have been successfully prevented through vaccination; however, in recent years, an increasing number of mumps outbreaks have been reported within vaccinated populations.[ncbi.nlm.nih.gov]
  • To address this public health problem, the Advisory Committee on Immunization Practices (ACIP) reviewed the available evidence and determined that a third dose of measles, mumps, rubella (MMR) vaccine is safe and effective at preventing mumps.[ncbi.nlm.nih.gov]

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