Presentation
The first patient presented in respiratory failure, with radiological features characteristic of hypersensitivity pneumonitis. [ncbi.nlm.nih.gov]
Compost particles present on several retail Oklahoma mushroom samples purchased from the Tulsa area grocery stores were also spread over Starch Nitrate Agar plates and incubated at 55°C. [citation.allacademic.com]
Entire Body System
- Inflammation
Jupiterimages/Photos.com/Getty Images Mushroom spores have the potential to cause ill health, and farmworkers exposed to large quantities of unidentified mushrooms are most at risk of lung inflammation. [sciencing.com]
The inflammation and scarring make it hard to get enough oxygen. The scarring is called pulmonary fibrosis. Breathing in dust or other particles in the air is responsible for some types of interstitial lung diseases. [icdlist.com]
Symptoms such as inflammation, shortness of breath, fatigue, weight loss, cough, fever, chills and body aches may appear after prolonged exposure and inhalation of the chemicals and particles. [empowher.com]
The histopathologic process consists of chronic inflammation of the bronchi and peri-bronchiolar tissue, often with poorly defined granulomas and giant cells in the interstitium or alveoli. Fibrosis and emphysema may develop later on. [radiopaedia.org]
With chronic exposure to the causative antigens, an inflammation and immune response contributes to changes in the lung tissue and the eventual presentation of symptoms. [news-medical.net]
- Fatigue
Symptoms such as inflammation, shortness of breath, fatigue, weight loss, cough, fever, chills and body aches may appear after prolonged exposure and inhalation of the chemicals and particles. [empowher.com]
fatigue, hepatomegaly, splenomegaly, bone probs, bruise, dev delay Hermansky-Pudlak syndrome - albinism, visual probs Presents Rapid SoB - progressive Wheeze Cough Fibrosis on CXR, CT Starts sub-pleural Then works way into lung Honeycomb lung Mx Stop [alancam.com]
Chills, sweating, aching, discomfort and/or fatigue may accompany lung symptoms. Most cases of this disorder are characterized by mild, short episodes that may be misdiagnosed. [rarediseases.org]
Respiratoric
- Cough
fatigue, hepatomegaly, splenomegaly, bone probs, bruise, dev delay Hermansky-Pudlak syndrome - albinism, visual probs Presents Rapid SoB - progressive Wheeze Cough Fibrosis on CXR, CT Starts sub-pleural Then works way into lung Honeycomb lung Mx Stop [alancam.com]
-50% cases affect farm workers Symptoms: 4-6 h post-exposure: fever, rigors, malaise, myalgia, dry cough, dyspnoea (Wheeze and productive cough may develop on repeat high level exposure). [clumsylostmedicalstudent.wordpress.com]
Symptoms may include chills, fever, cough and shortness of breath. Symptoms of chronic hypersensitivity pneumonitis may include a cough, breathlessness, loss of appetite and unplanned weight loss. [sciencing.com]
In the subacute form the shortness of breath and a chronic cough would develop over days or several weeks. [nethealthbook.com]
It causes asthma symptoms such as a chronic cough and wheezing. This condition can be reversed if found early. [saintlukeshealthsystem.org]
- Rhinitis
[…] surface coatings Metallic salts b (of nickel, chromium, vanadium, platinum) Mainly refinery workers (a) Since the respiratory tract is the final common pathway for all inhaled pollutants, many causative allergens are the same as for chronic allergic rhinitis [vula.uct.ac.za]
TL;DR (Too Long; Didn't Read) Exposure to high concentrations of mushroom spores may cause rhinitis, asthma, allergic bronchopulmonary mycoses, allergic fungal sinusitis and hypersensitivity pneumonitis. [sciencing.com]
A 28-year-old man working as an A. bisporus (AB) cultivator developed rhinitis and asthma coinciding with peaks of AB spore counts in the air of the work site. Skin-prick test with extract from AB spores was positive. [phadia.com]
- Rales
These may involve more severe symptoms including fever, crackling sounds during breathing (rales), breathing difficulty, bluish appearance of the skin (cyanosis), and possibly, expectoration of blood 3. [rarediseases.org]
The physician would hear fine inspiratory noises, called rales, by auscultation. In the subacute form the shortness of breath and a chronic cough would develop over days or several weeks. [nethealthbook.com]
- Dyspnea
Their main symptoms were cough (100%), sputum (82.6%), dyspnea (43.5%), and fever with chills (13.0%). Two cases showed increased interstitial lung markings on chest X-ray films. [kjim.org]
Symptoms of this form of pneumonitis is a chronic cough and difficulties to breathe (dyspnea), which may go on for months or years. These children do not thrive and eventually are referred to a pediatrician. [nethealthbook.com]
- Pulmonary Disorder
Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, represents a group of pulmonary disorders mediated by an inflammatory reaction to inhalation of an allergen. [radiopaedia.org]
Cardiovascular
- Cyanosis
These may involve more severe symptoms including fever, crackling sounds during breathing (rales), breathing difficulty, bluish appearance of the skin (cyanosis), and possibly, expectoration of blood 3. [rarediseases.org]
There also is a fever, cyanosis (bluish discoloration of the skin) due to a lack of oxygen being transported through the lungs. Often there is production of a pinkish bubbly sputum. [nethealthbook.com]
- Hypertension
Compensation may be payable Complications: -progressive lung fibrosis -type 1 respiratory failure -pulmonary hypertension and cor pulmonale Prognosis: -the acute form generally resolves if further exposure is prevented -with chronic disease some patients [clumsylostmedicalstudent.wordpress.com]
- Tachycardia
Symptoms The patient presents with an acute shortness of breath, fast heart beat (tachycardia) and fast, shallow breath movements (tachypnea). [nethealthbook.com]
Liver, Gall & Pancreas
- Hepatomegaly
fatigue, hepatomegaly, splenomegaly, bone probs, bruise, dev delay Hermansky-Pudlak syndrome - albinism, visual probs Presents Rapid SoB - progressive Wheeze Cough Fibrosis on CXR, CT Starts sub-pleural Then works way into lung Honeycomb lung Mx Stop [alancam.com]
Neurologic
- Headache
Management - Search tools, duplicate people management, editing tools, submission transfers, many tools to manage a variety of conference management headaches! Click here for more information. [citation.allacademic.com]
MWL presents clinically in sensitized patients with a variety of signs and symptoms, including sudden onset of fever, chills, malaise, cough, headache, chest tightness, shortness of breath and rapid breathing (in the acute form of the disease), with increasing [themushroompeople.com]
Workup
Microbiology
- Thermoactinomyces Vulgaris
No antibodies were found against Streptomyces thermovulgaris, Thermoactinomyces vulgaris and T. sacchari nor against the fungi Aspergillus fumigatus, Penicillium brevicompactum, P. chrysogenum, Scytalidium thermophilum and Trichoderma viride. [ncbi.nlm.nih.gov]
DNA–DNA relatedness among Thermoactinomyces species: Thermoactinomyces candidus as a synonym of Thermoactinomyces vulgaris and Thermoactinomyces thalpophilus as a synonym of Thermoactinomyces sacchari. [jmm.microbiologyresearch.org]
This may include exposure to Saccharopolyspora rectivirgula, Thermoactinomyces vulgaris, Thermoactinomyces viridis, or Thermoactinomyces sacchari. These species are usually found in decaying organic matter, such as compost, hay or sugar cane. [news-medical.net]
Causes: -Farmer’s lung = turning mouldy hay or other vegetable material ( Micropolyspora faeni) -Bird fancier’s and pigeon-fancier’s lung (proteins in bird droppings) -Mushroom worker’s lung = turning mushroom compost (Thermoactinomyces vulgaris) -Malt [clumsylostmedicalstudent.wordpress.com]
- Penicillium
Five different genera of fungi, namely, Aspergillus, Aureobasidium, Cladosporium, Penicillium and Scytalidium, were found at only 10(3) CFU m-3 of air. Agaricus bisporus, used for spawning, was absent. [ncbi.nlm.nih.gov]
Five different genera of fungi, namely, Aspergillus, Aureobasidium, Cladosporium, Penicillium and Scytalidium, were found at only 10 3 CFU m −3 of air. Agaricus bisporus, used for spawning, was absent. [link.springer.com]
Mushroom worker’s lung = turning mushroom compost (Thermoactinomyces vulgaris) -Malt worker’s lung = turning germinating barley ( Aspergillus clavatus) -Bagassosis or sugar worker’s lung ( Thermoactinomyces sacchari) -Cheese washer’s lung = mouldy cheese ( Penicillium [clumsylostmedicalstudent.wordpress.com]
Name of condition: Condition caused by: atypical farmer’s lung (pulmonary mycotoxicosis) exposure to moldy silage when uncapping silo bird fancier’s, hen worker’s and pigeon breeder’s lung exposure to birds’ feathers cheese washer’s lung moldy cheese (Penicillium [nethealthbook.com]
- Alternaria
Enolases are considered to be highly conserved major fungal allergens, but whether these panallergens occur in the Champignon mushroom has not been evaluated yet. (7) An unusual relationship was shown between allergenicity to moulds ( Alternaria alternata [phadia.com]
Pleura
- Pleural Effusion
[…] or other infection, trauma, or disease capable of causing pleural effusion. 4 Cancer: (a) Carcinoma of the lung when associated with: (i) asbestosis or Where there is exposure to airborne asbestos dust. [bclaws.ca]
Treatment
Treatment Options If you develop symptoms of hypersensitivity pneumonitis, contact your doctor. Treatment involves avoiding further exposure. [sciencing.com]
The goal of treatment is to prevent further exposure to the irritant, prevent worsening of the disease, manage symptoms, and help you stay active and healthy. Treatment depends on the type of lung disease. [saintlukeshealthsystem.org]
Treatment depends on the type of exposure and the stage of the disease. It may involve medicines, oxygen therapy, or a lung transplant in severe cases. [icdlist.com]
This book summarises everything you need to know: causes, diagnoses and treatments. I am finding this book very helpful and more importantly very concise. It has most things you need to know about common clinical pathologies. ... [books.google.com]
Prognosis
However, when smokers do develop hypersensitivity pneumonitis, it is more commonly fibrosing disease with a worse prognosis 10. [radiopaedia.org]
Compensation may be payable Complications: -progressive lung fibrosis -type 1 respiratory failure -pulmonary hypertension and cor pulmonale Prognosis: -the acute form generally resolves if further exposure is prevented -with chronic disease some patients [clumsylostmedicalstudent.wordpress.com]
Etiology
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
The etiology of the disease is allergic with a radiographic appearance of alveolitis which may present with consolidation or a reticular pattern. None of the 26 patients exhibited enlargment of the hilar lymph nodes. [ncbi.nlm.nih.gov]
Rognon B, Reboux G, Roussel S, Barrera C, Dalphin JC, Fellrath JM, Monod M, Millon L Draft Genome Sequence of the Principal Etiological Agent of Farmer's Lung Disease, Saccharopolyspora rectivirgula. [medicbind.com]
Microbial aerosols and actinomycetes in etiological considerations of mushroom workers’ lungs. Appl Environ Microbiol 1981; ; 41: 1454 –1460. [Google Scholar] 4. Yoon JH, Shin YK, Park YH. [jmm.microbiologyresearch.org]
Epidemiology
His interests are in incontinence in the elderly, the effects of medication and co-morbidity on continence status and the epidemiology and aetiology of incontinence in the elderly. [books.google.com]
Symptoms, pulmonary function and bronchial reactivity in Western Red Cedar workers compared with those of office workers, Am Rev Respir Dis, 1984;130:1038-1041, ChanYeung M, Wong R, MacLean L, Tan F, Schulzer M, Enarson D, Martin A, Dennis R, Gryzbowski S, Epidemiologic [occupationalasthma.com]
Methods Statistics Trigonometry Medical & Nursing Anatomy Anesthesiology Audiology Bacteriology Biochemistry Bioethics Biomedical Science Cardiology Cardiovascular Childbirth Chiropractic Dentistry Dermatology Diagnostic Imaging Drugs Endocrinology Epidemiology [brainscape.com]
[…] alveolitis” describes the cause and nature of the disease, as follows: Extrinsic refers to an external cause Allergic refers to the hypersensitivity reaction that is characteristic of the disease Alveolitis refers to inflammation of the alveoli in the lungs Epidemiology [news-medical.net]
Epidemiology: -Uncommon = 2% of occupational lung diseases -By far, the most common cause is Farmer’s lung, affecting up to 1 in 10 of the farming community in poor wet areas around the world. -50% cases affect farm workers Symptoms: 4-6 h post-exposure [clumsylostmedicalstudent.wordpress.com]
Pathophysiology
Extrinsic Allergic Alveolitis - Pathology mini tutorial Pathophysiology Extrinsic allergic alveolitis is caused by inhalation of antigens that cause a hypersensitivity reaction in the respiratory system. [news-medical.net]
Prevention
Can occupational lung diseases be prevented? Occupational lung diseases are preventable. The best prevention is to avoid the inhaled substances that cause lung problems. Other preventive measures include: Do not smoke. [saintlukeshealthsystem.org]
How can occupational lung diseases be prevented? The best prevention for occupational lung diseases is avoidance of the inhaled substances that cause lung diseases. [hopkinsmedicine.org]
Prevention of the condition by avoiding or reducing exposure to the allergen is the best course of action. [news-medical.net]
Compensation may be payable Complications: -progressive lung fibrosis -type 1 respiratory failure -pulmonary hypertension and cor pulmonale Prognosis: -the acute form generally resolves if further exposure is prevented -with chronic disease some patients [clumsylostmedicalstudent.wordpress.com]