Symptoma

Mycobacterium Abscessus

In this report, we present a case of intra- abdominal M. abscessus presenting as an enlarging mass in a patient on chronic corticosteroid therapy. [journals.lww.com]

It is ubiquitously present in natural waters, decaying vegetation, sewage water, as well as in drinking water tanks and municipal tap water. [uniprot.org]

The choice of therapeutic regimens remains problematic and is discussed with regard to the case presented. [oxfordmedicine.com]

Case Presentation An 85-year-old woman admitted to the hospital due to productive cough, dyspnea, fever, night sweats, weigh lost, hemoptysis, chest pain, anorexia, vomiting, and hematuria is presented here. [intjinfection.com]

The treatment is prolonged; they present a broad resistance profile and sometimes the surgical resection of the tissue is necessary, making healing difficult in some cases. [scielo.org.co]

  • Nightmare

    Mycobacterium abscessus : Environmental Bacterium Turned Clinical Nightmare. Microorganisms 2019, 7, 90. Lopeman, R.C.; Harrison, J.; Desai, M.; Cox, J.A.G. Mycobacterium abscessus: Environmental Bacterium Turned Clinical Nightmare. [preprints.org]

    […] infection. ( 30837150 ) Olmedo-Reneaum A...Cuellar-Rodriguez JM 2019 16 Mycobacterium abscessus pulmonary disease: individual patient data meta-analysis. ( 30880280 ) Kwak N...Yim JJ 2019 17 Mycobacterium abscessus: Environmental Bacterium Turned Clinical Nightmare [malacards.org]

    Mycobacterium abscessus: a new antibiotic nightmare. J Antimicrob Chemother. 2012; 67 (4):810-8. doi: 10.1093/jac/dkr578. [PubMed: 22290346 ]. 12. Bryant JM, Grogono DM, Greaves D, Foweraker J, Roddick I, Inns T, et al. [intjinfection.com]

    “Mycobacterium Abscessus: A New Antibiotic Nightmare.” The Journal of Antimicrobial Chemotherapy 67 ( 4 ): 810 – 18. Nie, Wenjuan, Hongfei Duan, Hairong Huang, Yu Lu, and Naihui Chu. 2015. [biorxiv.org]

    Mycobacterium abscessus : a new antibiotic nightmare. J Antimicrob Chemother. 2012; 67 :810–8. 10.1093/jac/dkr578 [ PubMed ] [ CrossRef ] [ Google Scholar ] 6. Leao SC, Tortoli E, Euzeby JP, Garcia MJ. [ncbi.nlm.nih.gov]

  • Wound Infection

    C) Wound infection over both upper eyelids of a 36-year-old woman; the infection developed 1 week after cosmetic surgery. [ncbi.nlm.nih.gov]

  • Lymphadenopathy

    Other less common CT findings include: air-space consolidation lobar volume loss pleural thickening mediastinal lymphadenopathy Treatment and prognosis M. abscessus is resistant to many antibiotics and thus is very difficult to treat. [radiopaedia.org]

    Disseminated Diseases and Bacteremia Disseminated M. abscessus complex infections, such as lymphadenopathy, SSTIs, pulmonary infections, and bacteremia, are on the rise ( 23 ), and bacteremia caused by M. abscessus complex is most often associated with [ncbi.nlm.nih.gov]

  • Intravenous Administration

    A recent retrospective investigation evaluated the clinical and microbiologic outcome in 107 patients with M. abscessus lung disease, treated with antibiotic combination therapy (4.6 drugs per patient, with a median duration of intravenous administration [omicsonline.org]

    The drugs of choice for initial intravenous administration are amikacin (25 mg/kg 3 /wk) plus cefoxitin (up to 12 g/d given in divided doses) or amikacin (25 mg/kg 3 /wk) plus imipenem (500 mg 2–4 /wk) ( 2 ). [ncbi.nlm.nih.gov]

  • Anorexia

    Case Presentation An 85-year-old woman admitted to the hospital due to productive cough, dyspnea, fever, night sweats, weigh lost, hemoptysis, chest pain, anorexia, vomiting, and hematuria is presented here. [intjinfection.com]

    anorexia, nausea, or diarrhea) associated with oral antibiotic usage after discharge from the hospital occurred in 14 (22%) patients. [atsjournals.org]

  • Papule

    M. abscessus complex skin infection have diverse presentations, including cutaneous nodules (usually tender), erythematous papules/pustules, and papular eruptions or abscesses ( Figure 4 ) ( 19 ). [ncbi.nlm.nih.gov]

  • Skin Lesion

    Skin lesions caused by Mycobacterium abscessus subsp. abscessus. A) Diffuse erythematous papular eruptions on the face and bilateral cervical lymphadenitis in a middle-aged man. [ncbi.nlm.nih.gov]

  • Subcutaneous Nodule

    B) A circumscribed subcutaneous nodule with pus discharge on the right arm of a 12-year-old boy. C) Wound infection over both upper eyelids of a 36-year-old woman; the infection developed 1 week after cosmetic surgery. [ncbi.nlm.nih.gov]

  • Eruptions

    M. abscessus complex skin infection have diverse presentations, including cutaneous nodules (usually tender), erythematous papules/pustules, and papular eruptions or abscesses ( Figure 4 ) ( 19 ). [ncbi.nlm.nih.gov]

  • Sweating

    Case Presentation An 85-year-old woman admitted to the hospital due to productive cough, dyspnea, fever, night sweats, weigh lost, hemoptysis, chest pain, anorexia, vomiting, and hematuria is presented here. [intjinfection.com]

  • Hematuria

    Case Presentation An 85-year-old woman admitted to the hospital due to productive cough, dyspnea, fever, night sweats, weigh lost, hemoptysis, chest pain, anorexia, vomiting, and hematuria is presented here. [intjinfection.com]

  • Meningism

    Central Nervous System Infections Central nervous system (CNS) infections caused by M. abscessus complex are rare, but when they do occur, meningitis and cerebral abscesses are the most common manifestations ( Figure 5 ). [ncbi.nlm.nih.gov]

TREATMENT OF 65 PATIENTS WITH MYCOBACTERIUM ABSCESSUS LUNG DISEASE Treatment No. ( % ) of Patients Treatment completion 41 (63%) Treatment for 24 mo 37 Treatment for 24 mo 4 Treatment incompletion 24 (37%) On the treatment 15 Refused further therapy before [atsjournals.org]

Treatment Several problems regarding treatment of M. abscessus complex infections in different organs are unsolved. [ncbi.nlm.nih.gov]

New studies differentiating M. abscessus subsp. abscessus and M. abscessus subsp. massiliense based on the erm (41) gene demonstrate the latter to have a better prognosis and improved treatment outcomes. [journals.lww.com]

Other less common CT findings include: air-space consolidation lobar volume loss pleural thickening mediastinal lymphadenopathy Treatment and prognosis M. abscessus is resistant to many antibiotics and thus is very difficult to treat. [radiopaedia.org]

Clarithromycin (CAM) susceptibility may influence the prognosis and severity of MabC lung disease. [12], [13], [14], [15] However, drug susceptibility testing (DST) of MAA isolates from patients is currently not well documented, but it may predict outcomes [ijmyco.org]

Results: in 32 patients MAC was identified as etiological agent causing pulmonary disease and in 10 cases, M. abscessus was the agent. 26 (61.9%) of the patients were between 51 and 86 years of age. [scielo.org.co]

Available from: Introduction The Mycobacterium abscessus complex (MabC) comprises a group of rapidly growing mycobacteria (RGM) that represent the most common etiological agents of lung disease. [1], [2], [3] MabC bacteria are resistant to many antibiotics [ijmyco.org]

Disease Burden The global isolation and epidemiology of M. abscessus complex are diverse. [ncbi.nlm.nih.gov]

Recommendations and Guidelines For more information about prevention and treatment of HAIs, see the resources below: CDC. Guidelines for preventing the transmission of m ycobacterium tuberculosis in healthcare settings, 2005. [cdc.gov]

The EIN is funded through a cooperative agreement between the Centers for Disease Control and Prevention and IDSA. [wwwnc.cdc.gov]

The optimal treatment to prevent clinical relapse in these patients has not been well established. At times, antibiotic regimens have also been shown to produce long-term sputum conversion. [omicsonline.org]

An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007 ;175: 367 – 416. Abstract, Medline, Google Scholar 7. [atsjournals.org]