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Mycobacterium Abscessus


Presentation

  • In this report, we present a case of intra- abdominal M. abscessus presenting as an enlarging mass in a patient on chronic corticosteroid therapy.[journals.lww.com]
  • It is ubiquitously present in natural waters, decaying vegetation, sewage water, as well as in drinking water tanks and municipal tap water.[uniprot.org]
  • The choice of therapeutic regimens remains problematic and is discussed with regard to the case presented.[oxfordmedicine.com]
  • The treatment is prolonged; they present a broad resistance profile and sometimes the surgical resection of the tissue is necessary, making healing difficult in some cases.[scielo.org.co]
  • Case Presentation An 85-year-old woman admitted to the hospital due to productive cough, dyspnea, fever, night sweats, weigh lost, hemoptysis, chest pain, anorexia, vomiting, and hematuria is presented here.[intjinfection.com]
Mediastinal Lymphadenopathy
  • Other less common CT findings include: air-space consolidation lobar volume loss pleural thickening mediastinal lymphadenopathy Treatment and prognosis M. abscessus is resistant to many antibiotics and thus is very difficult to treat.[radiopaedia.org]
Wound Infection
  • C) Wound infection over both upper eyelids of a 36-year-old woman; the infection developed 1 week after cosmetic surgery.[ncbi.nlm.nih.gov]
Lymphadenopathy
  • Other less common CT findings include: air-space consolidation lobar volume loss pleural thickening mediastinal lymphadenopathy Treatment and prognosis M. abscessus is resistant to many antibiotics and thus is very difficult to treat.[radiopaedia.org]
  • Disseminated Diseases and Bacteremia Disseminated M. abscessus complex infections, such as lymphadenopathy, SSTIs, pulmonary infections, and bacteremia, are on the rise ( 23 ), and bacteremia caused by M. abscessus complex is most often associated with[ncbi.nlm.nih.gov]
Weight Loss
  • Systemic symptoms include malaise, fatigue, and weight loss in advance disease. [6] The diagnosis of M. abscessus pulmonary infection requires the presence of symptoms, radiologic abnormalities, and microbiologic cultures.[en.wikipedia.org]
Weakness
  • Key weaknesses of our study include that we were unable establish a temporal relationship between antibiotic prescribing and inducible phenotypic resistance as we did not have the relevant ethics approval to link to patient records.[biorxiv.org]
  • After the establishment of a reliable drug susceptibility test, we found that the fluoroquinolones, such as ciprofloxacin and moxifloxacin, showed moderate in vitro activity against M. abscessus isolates from patients, whereas doxycycline showed very weak[atsjournals.org]
Anorexia
  • Case Presentation An 85-year-old woman admitted to the hospital due to productive cough, dyspnea, fever, night sweats, weigh lost, hemoptysis, chest pain, anorexia, vomiting, and hematuria is presented here.[intjinfection.com]
  • ., anorexia, nausea, or diarrhea) associated with oral antibiotic usage after discharge from the hospital occurred in 14 (22%) patients.[atsjournals.org]
Purulent Sputum
  • Clinical symptoms of lung infection vary in scope and intensity but commonly include chronic cough, often with purulent sputum. Haemoptysis may also be present.[en.wikipedia.org]
Chronic Cough
  • Clinical symptoms of lung infection vary in scope and intensity but commonly include chronic cough, often with purulent sputum. Haemoptysis may also be present.[en.wikipedia.org]
Hemoptysis
  • Case Presentation An 85-year-old woman admitted to the hospital due to productive cough, dyspnea, fever, night sweats, weigh lost, hemoptysis, chest pain, anorexia, vomiting, and hematuria is presented here.[intjinfection.com]
  • The indications for surgery included failure of sputum conversion (n 6), sputum relapse after initial conversion (n 2), and complications such as recurrent hemoptysis despite negative sputum conversion (n 6).[atsjournals.org]
Aspiration
  • Isolated mycobacteria from her bronchoalveolar lavage fluid and gastric aspirate were identified as MABC by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry and M. abscessus subsp. massiliense was ultimately identified[dovepress.com]
Papule
  • M. abscessus complex skin infection have diverse presentations, including cutaneous nodules (usually tender), erythematous papules/pustules, and papular eruptions or abscesses ( Figure 4 ) ( 19 ).[ncbi.nlm.nih.gov]
Skin Lesion
  • Skin lesions caused by Mycobacterium abscessus subsp. abscessus. A) Diffuse erythematous papular eruptions on the face and bilateral cervical lymphadenitis in a middle-aged man.[ncbi.nlm.nih.gov]
Subcutaneous Nodule
  • B) A circumscribed subcutaneous nodule with pus discharge on the right arm of a 12-year-old boy. C) Wound infection over both upper eyelids of a 36-year-old woman; the infection developed 1 week after cosmetic surgery.[ncbi.nlm.nih.gov]
Confusion
  • The frequently changing nomenclature to describe RGM is a source of confusion for clinicians.[atsjournals.org]
Hematuria
  • Case Presentation An 85-year-old woman admitted to the hospital due to productive cough, dyspnea, fever, night sweats, weigh lost, hemoptysis, chest pain, anorexia, vomiting, and hematuria is presented here.[intjinfection.com]

Treatment

  • TREATMENT OF 65 PATIENTS WITH MYCOBACTERIUM ABSCESSUS LUNG DISEASE Treatment No. ( % ) of Patients Treatment completion 41 (63%) Treatment for 24 mo 37 Treatment for 24 mo 4 Treatment incompletion 24 (37%) On the treatment 15 Refused further therapy before[atsjournals.org]
  • Long-term sputum conversion is uncommon, following antibiotic treatment [ 4 - 5 ].[omicsonline.org]
  • Treatment with macrolide was found to be protective against early treatment failure (OR, 0.13; 95% CI, 0.002–1.8; P .04).[ncbi.nlm.nih.gov]
  • Macrolide susceptibility is key for successful treatment of M. abscessus subsp. massiliense.[journals.lww.com]

Prognosis

  • New studies differentiating M. abscessus subsp. abscessus and M. abscessus subsp. massiliense based on the erm (41) gene demonstrate the latter to have a better prognosis and improved treatment outcomes.[journals.lww.com]
  • Other less common CT findings include: air-space consolidation lobar volume loss pleural thickening mediastinal lymphadenopathy Treatment and prognosis M. abscessus is resistant to many antibiotics and thus is very difficult to treat.[radiopaedia.org]
  • Clarithromycin (CAM) susceptibility may influence the prognosis and severity of MabC lung disease. [12], [13], [14], [15] However, drug susceptibility testing (DST) of MAA isolates from patients is currently not well documented, but it may predict outcomes[ijmyco.org]

Etiology

  • Results: in 32 patients MAC was identified as etiological agent causing pulmonary disease and in 10 cases, M. abscessus was the agent. 26 (61.9%) of the patients were between 51 and 86 years of age.[scielo.org.co]
  • Available from: Introduction The Mycobacterium abscessus complex (MabC) comprises a group of rapidly growing mycobacteria (RGM) that represent the most common etiological agents of lung disease. [1], [2], [3] MabC bacteria are resistant to many antibiotics[ijmyco.org]

Epidemiology

  • Disease Burden The global isolation and epidemiology of M. abscessus complex are diverse.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Prevention

  • Recommendations and Guidelines For more information about prevention and treatment of HAIs, see the resources below: CDC. Guidelines for preventing the transmission of m ycobacterium tuberculosis in healthcare settings, 2005.[cdc.gov]
  • The EIN is funded through a cooperative agreement between the Centers for Disease Control and Prevention and IDSA.[wwwnc.cdc.gov]
  • The optimal treatment to prevent clinical relapse in these patients has not been well established. At times, antibiotic regimens have also been shown to produce long-term sputum conversion.[omicsonline.org]
  • An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007 ;175: 367 – 416. Abstract, Medline, Google Scholar 7.[atsjournals.org]

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