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Mycobacterium Intracellulare


Presentation

  • A case of preseptal cellulitis caused by Mycobacterium intracellulare is presented.[ncbi.nlm.nih.gov]
Cervical Lymphadenopathy
  • The patient was a 45-year-old Japanese female with fever, loss of body weight and cervical lymphadenopathy.[ncbi.nlm.nih.gov]
Sore Throat
  • An 81-year-old man was admitted to the hospital with a severe sore throat and a low grade fever. A chest radiograph showed bilateral diffuse reticulonodular shadows. By fluorescent stain for mycobacteria, his sputum smear showed acid-fast bacteria.[ncbi.nlm.nih.gov]
Exertional Dyspnea
  • A 35-year-old man with a six-month history of progressive exertional dyspnea was referred to our institution.[ncbi.nlm.nih.gov]
Dysphagia
  • We believe our patient is the first reported to have dysphagia due to silicotic adenopathy complicated by an atypical mycobacteriosis.[ncbi.nlm.nih.gov]
Gagging
  • GG [ 27 ] AGC GGC TGC TGG GTG ATC ATC IS 900 TGG ACA ATG ACG GTT ACG GAG GTG G [ 37 ] CGC AGA GGC TGC AAG TCG TGG IS 901 CGA CGA CAG GAG TAG CGG TAT GGC [ 38 ] CCG TGC TGC GAG TTG CTT GAT GAG IS 1311 GCG TGA GGC TCT GTG GTG AA [ 37 ] ATG ACG ACC GCT[bmcinfectdis.biomedcentral.com]
Fracture
  • The infection later progressed, involving generalized lymphadenopathy, liver splenic and cutaneous abscesses, pulmonary infiltration, pleural effusion, and costal fracture.[ncbi.nlm.nih.gov]
Osteoporosis
  • No juxta-articular osteoporosis or evidence of chondrolysis was seen (Fig. 2).[healio.com]

Workup

  • (See Workup.) In general, MAC infection is treated with 2 or 3 antimicrobials for at least 12 months. Commonly used first-line drugs include macrolides (clarithromycin or azithromycin), ethambutol, and rifamycins (rifampin, rifabutin).[homeopathyworldcommunity.ning.com]
Bilateral Hilar Adenopathy
  • Initial chest x-rays revealed moderate bilateral hilar adenopathy consistent with the diagnosis of sarcoidosis. Also seen was a 3 cm calcification in the spleen which may have represented a large granuloma (Fig. 1).[healio.com]
Joint Space Narrowing
  • We suspected a mycobacterial or fungal etiology because the changes described were consistent with infection by indolent organisms which do not cause rapid development of juxta-articular osteoporosis, joint space narrowing (secondary to chondrolysis),[healio.com]
Periostal Elevation
  • elevation in me patella suggested that osteomyelitis was also present.[healio.com]
Colitis
  • We present a case of a woman with medically refractory ulcerative colitis (UC) who developed severe bronchiectasis, bronchitis, bronchiolitis and Mycobacterium intracellulare (MAC) infection 2 years after total colectomy.[ncbi.nlm.nih.gov]
  • There are some cases where malabsorption or colitis have been associated with heavy infection with Mycobacterium avium intracellulare as the only isolated potential pathogen.[histopathology-india.net]
Multiple Ulcerations
  • A 53-year-old woman had multiple ulcerative skin lesions caused by Mycobacterium intracellulare.[ncbi.nlm.nih.gov]
  • All Rights Reserved [Skip to Content Landing] Download PDF Full Text Cite This Permissions December 1981 Arch Dermatol. 1981;117(12):794-796. doi:10.1001/archderm.1981.01650120040019 Full Text • A 53-year-old woman had multiple ulcerative skin lesions[jamanetwork.com]

Treatment

  • Bedaquiline shows potential for the treatment of M. intracellulare lung disease, but optimization of treatment regimens is required to prevent the emergence of mmpT5 variants and microbiological relapse.[ncbi.nlm.nih.gov]
  • Today, the recommended treatment consists of a combination of macrolides, ethambutol and a rifamycin continued for at least 12 months after conversion to negative cultures. 1 In general, MAC treatment is lengthy and results are poor with a pooled treatment[academic.oup.com]
  • By developing a genotyping strategy, it would be possible to define isolations as colonisation, chronic infection or re-infection, thereby contributing to decisions regarding treatment.[gallipoliresearch.com.au]

Prognosis

  • The patients with serotype 4 had a significantly poorer prognosis than patients with other serotypes.[jcm.asm.org]
  • CONCLUSIONS: Patients with M intracellulare lung disease exhibited a more severe presentation and had a worse prognosis than patients with M avium lung disease in terms of disease progression and treatment response.[ncbi.nlm.nih.gov]
  • Clinical observations, with special reference to factors influencing prognosis, Rev. Infect.[books.google.es]
  • Prognosis depends on the form of the disease. In the upper lobe cavitary form, lung destruction is usually progressive and can lead to respiratory failure and death if successful treatment is not instituted.[radiopaedia.org]
  • Little is known regarding the prognosis of untreated stable MAC-LD.[erj.ersjournals.com]

Etiology

  • Abstract Mycobacterium avium complex (MAC) is the most common etiologic organisms of nontuberculous mycobacteria (NTM) lung disease.[ncbi.nlm.nih.gov]
  • ., An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis, Science, 244, 362, 1989. ‎[books.google.es]
  • […] in immunosuppressed patients; however, immunocompetent hosts have also been described. 6 Nontuberculous mycobacterial DNA has been isolated from the cutaneous lesions of sarcoidosis in 16 of 20 patients in previous studies. 7 Given the still-unknown etiology[jddonline.com]
  • M avium paratuberculosis is a well-known cause of paratuberculosis (Johne Disease) in cattle, but its role in the etiology of Crohn disease in humans remains to be proven.[emedicine.medscape.com]

Epidemiology

  • KEYWORDS: Geographic origin; MAC; Molecular epidemiology; Mycobacterium avium subsp. hominissuis; Mycobacterium intracellulare; VNTR[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Effective prevention and therapy of MAC has the potential to contribute substantially to improved quality of life and duration of survival for HIV-infected persons. [12] Pathophysiology [ edit ] Mycobacterium avium complex is the most commonly found form[en.wikipedia.org]

Prevention

  • Montreal, Quebec, Canada. 5 National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Chang Bai Road, Changping District, Beijing 102206, China.[ncbi.nlm.nih.gov]
  • Guidelines for the prevention and treatment of opportunistic infections in HIV-exp osed and HIV-infected children: Recommendations from the national institutes of health, centers for disease control and prevention, the HIV medicine association of the[acgcasereports.gi.org]
  • An official ATS/IDSA statement: diagnosis, treatment and prevention of nontuberculous mycobacterial diseases . Am J Respir Crit Care Med 2007 ; 175: 367 – 416 . Google Scholar Crossref Medline ISI 2. Song, H, Lee, H, Choi, G.[journals.sagepub.com]
  • Among her publications on health sociology are “Crisis Prevention and Management during SARS Outbreak, Singapore , Emerging Infectious Diseases, 10, 2: 364-368, 2004, with HP Lee; “Traditional Healing Systems and the Ethos of Science, Social Science and[books.google.es]

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