Presentation
This report presents the first case of M. smegmatis pneumonia in an otherwise healthy individual who had no predisposing condition. [ncbi.nlm.nih.gov]
Entire Body System
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Wound Infection
Mycobacterium smegmatis is a non-tuberculous mycobacterium that is usually associated with soft tissue or wound infections in humans. [ncbi.nlm.nih.gov]
two new rapidly growing species related to Mycobacterium smegmatis and associated with human wound infections: a cooperative study from the International Working Group on Mycobacterial Taxonomy. Int. J. Syst. Bacteriol., 1999, 49, 1493-1511. [bacterio.net]
Respiratoric
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Sputum
It is also rapid, with the detection of M. tuberculosis in sputum specimens within 48 h. [ncbi.nlm.nih.gov]
Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum [Research Support, Non-U.S. Gov’t]. PLoS Med, 5 (4), e75. doi: 10.1371/journal.pmed.0050075. [link.springer.com]
a non-chromogenic, fast-growing strain isolated from sputum. Int. J. Syst. Evol. Microbiol., 67, 3174-3181. Original article in IJSEM Online Mycobacterium elephantis Shojaei et al. 2000, sp. nov. [bacterio.net]
Interestingly, meropenem combined with amoxicillin/clavulanate resulted in early clearance of Mtb from patient sputum ( Diacon et al., 2016 ). In fact, the combination might be key to accelerated killing of Mtb ( Gonzalo and Drobniewski, 2013 ). [elifesciences.org]
Treatment
In both situations, treatment incurs increased patient costs and makes them more susceptible to host-drug effects such as liver damage. [ncbi.nlm.nih.gov]
Etiology
[…] megaterium NRS, Micrococcus luteus LA 2971 bacteria, and Rhodotorula rubra, Candida albicans, Kluyveromyces marxianus fungi, Vancomycin (30ug/disc), Erytromycin (15ug/disc), Nystatin 100 Units (10ug/disc) discs were used as standard antibiotics. 2) The etiology [medical-dictionary.thefreedictionary.com]
Abstract Tuberculosis (TB) remains a serious threat to global public health, largely due to the successful manipulation of the host immunity by its etiological agent Mycobacterium tuberculosis. [ncbi.nlm.nih.gov]
Epidemiology
By combining information from molecular epidemiology studies of drug-resistant clinical M. tuberculosis isolates with genetic reconstructions and measurements of aminoglycoside susceptibility and fitness in Mycobacterium smegmatis, we have reconstructed [ncbi.nlm.nih.gov]
Diagnosis and epidemiology of bovine tuberculosis using molecular biology approaches. Veterinary Microbiology, 40: 83-94. [ Links ] 4. Espitia C & Mancilla R (1989). [scielo.br]
Pulmonary nontuberculous mycobacterial disease: new insights into risk factors for susceptibility, epidemiology, and approaches to management in immunocompetent and immunocompromised patients. Curr Infect Dis Rep. 2010;12(3):198–203. [cellandbioscience.biomedcentral.com]
Pathophysiology
Further studies are needed to confirm the findings on pathophysiology and immune defense mechanism of U937 by fibrates during M. tuberculosis infection. [ncbi.nlm.nih.gov]
Prevention
In E. coli and G. stearothermophilus, the α-helices adopt an “up” state where the α-helices enter the α 3 β 3 -domain and prevent the rotor from turning. [pnas.org]
Xylitol is an important sugar that is used as a substitute for commercial dietary sugars to prevent tooth decay and reduce plaque. It is also absorbed more slowly in the bloodstream, so it prevents the negative affects of high blood sugar levels. [microbewiki.kenyon.edu]
The current research may help the identification of some valuable vaccine and drug target candidates and provide foundation for the future design of preventive, diagnostic, and therapeutic strategies against mycobacterial diseases. [ncbi.nlm.nih.gov]