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Mycobacterium Tuberculosis


Presentation

  • Intraocular tuberculosis is uncommon and has various clinical presentations. Lack of specific clinical clues can make the diagnosis challenging.[ncbi.nlm.nih.gov]
  • A discussion, including review of current literature, regarding presentation, diagnosis, and treatment of tuberculous monoarthritis follows.[ncbi.nlm.nih.gov]
  • Often, the diagnosis can be challenging as autoimmune and infectious causes may present in a similar fashion.[ncbi.nlm.nih.gov]
  • We present the case of a patient with Mycobacterium tuberculosis pericarditis presenting in pregnancy with recurrent pericardial effusions.[ncbi.nlm.nih.gov]
  • Whereas the latter is more common, the first two presentations are rare.[ncbi.nlm.nih.gov]
Fishing
  • METHODS: We analysed the possible variations in the genomic instability of Mycobacterium-infected macrophages using the DNA breakage detection fluorescence in situ hybridisation (DBD-FISH) technique with a whole human genome DNA probe.[ncbi.nlm.nih.gov]
  • Etymology: N.L. gen. masc. n. shottsii, of Shotts, named after Emmett Shotts, an American fish bacteriologist.[bacterio.net]
  • Meena, Dhira Rani Saha, Rajagopal Raman, Paulraj Rajamani, Abhijit Mitra, Shibnath Mazumder and Srinivasa M Srinivasula, Calcium and Superoxide-Mediated Pathways Converge to Induce Nitric Oxide-Dependent Apoptosis in Mycobacterium fortuitum-Infected Fish[doi.org]
Wound Infection
  • The sternum wound infection, caused by Mycobacterium tuberculosis after a cardiac surgery, is an extremely rare postoperative complication. It requires a high degree of suspicion for a correct diagnosis.[ncbi.nlm.nih.gov]
  • ., two new rapidly growing species related to Mycobacterium smegmatis and associated with human wound infections: a cooperative study from the International Working Group on Mycobacterial Taxonomy. Int. J. Syst. Bacteriol., 1999, 49, 1493-1511.[bacterio.net]
Plethora
  • In contrast, macrophages engaged a plethora of responses including IFN signaling and communication between innate and adaptive immune cells to induce granuloma formation.[ncbi.nlm.nih.gov]
Regurgitation
  • Here we report a case of a 40-year-old woman who developed an ascending aortic aneurysm with severe aortic regurgitation caused by Mycobacterium tuberculosis.[ncbi.nlm.nih.gov]
Diastolic Murmur
  • A 40-year-old Sri Lankan female who presented with exertional breathlessness (NYHA II) and weight loss for 4 weeks duration was found to have collapsing pulse and early diastolic murmur at left sternal edge.[ncbi.nlm.nih.gov]
Monoarthritis of the Knee
  • The emerging role of arthroscopy as a diagnostic and treatment modality for tuberculous monoarthritis of the knee is discussed. VI.[ncbi.nlm.nih.gov]
Knee Pain
  • Thus, we present the case of a five-year-old male patient, from the Pacific coast of Colombia, with chronic morning knee pain and stiffness thought to be caused by an autoimmune disease.[ncbi.nlm.nih.gov]
Skin Plaque
  • Here, there is a report of a 38-year-old man who presented with non-pruritic skin plaques, caused by isoniazid-resistant Mycobacterium tuberculosis, over his buttock, inguinal area and earlobe.[ncbi.nlm.nih.gov]
Hyperkeratosis
  • Patients have a typical cutaneous involvement with hyperkeratosis especially on the soles and palms and early shedding of primary teeth. Internal organs involvement such as liver abscess has been presented as case reports.[ncbi.nlm.nih.gov]
Blurred Vision
  • RESULTS: A 27-year-old woman of tuberculous meningitis was referred to us complaining of blurred vision for 2 days.[ncbi.nlm.nih.gov]
Retinal Pigmentation
  • Purpose: Mycobacterium tuberculosis (Mtb) bacilli have been found in retinal pigment epithelial (RPE) cells from uveitis patients without signs of systemic tuberculosis (TB) infection.[ncbi.nlm.nih.gov]
Diplopia
  • We present the case of a 9-year-old female with systemic lupus erythematosus (SLE), treated with prednisone and cyclophosphamide, who was admitted to the emergency department with a 2-week history of fever, headache, malaise, fatigue, and diplopia 3 years[ncbi.nlm.nih.gov]
Altered Mental Status
  • We present a case from Uganda demonstrating Ultra positivity in urine from an HIV-infected patient presenting with altered mental status and urinary incontinence, and no other signs of active pulmonary or extrapulmonary TB.[ncbi.nlm.nih.gov]
Hyporeflexia
  • Physical examination showed limitation of abduction of the right eye, Kernig and Brudzinski signs, and hyporeflexia.[ncbi.nlm.nih.gov]
Dysuria
  • The disease may have a variable course, from a mild self-limiting, through common symptoms like: dysuria, hematuria, abdominal pain, tumor, to severe renal failure, with eosinophilic infiltration of the other organs and systemic complications.[ncbi.nlm.nih.gov]
Incontinence
  • We present a case from Uganda demonstrating Ultra positivity in urine from an HIV-infected patient presenting with altered mental status and urinary incontinence, and no other signs of active pulmonary or extrapulmonary TB.[ncbi.nlm.nih.gov]
Urinary Incontinence
  • We present a case from Uganda demonstrating Ultra positivity in urine from an HIV-infected patient presenting with altered mental status and urinary incontinence, and no other signs of active pulmonary or extrapulmonary TB.[ncbi.nlm.nih.gov]

Workup

Mediastinal Mass
  • We present an extremely rare case of a 62-year-old immunocompetent patient with pleural tuberculosis confirmed by surgical pleural biopsies, who presented with a large mediastinal mass and evidence of pulmonary artery invasion on CT scanning and endobronchial[ncbi.nlm.nih.gov]
Left Pleural Effusion
  • Chest x-ray demonstrated a left pleural effusion. Contrast-enhanced CT showed free abdominal fluid. Thoracentesis revealed a chylothorax, and paracentesis a chylous ascites.[ncbi.nlm.nih.gov]
Gram-Positive Rods
  • Structure Nocardia organisms are Gram-positive rods, which in old cultures or clinical specimens may appear as branching chains resembling fungal hyphae.[ncbi.nlm.nih.gov]
  • The strains are strictly aerobic, nonmotile, non-spore-forming, acid-fast, Gram-positive rods. The colonies on 5% sheep blood agar are nonphotochromogenic and intermediate between smooth and rough.[bacterio.net]

Treatment

  • Prompt identification of the underlying cause of HLH is important as it guides treatment decisions. Early initiation of appropriate treatment (eg, anti-TB treatment) reduces morbidity and mortality.[ncbi.nlm.nih.gov]
  • Three patients completed TB treatment. One patient, who was homeless at the time of diagnosis, began TB treatment but was lost to follow-up by DOHMH.[ncbi.nlm.nih.gov]
  • The emerging role of arthroscopy as a diagnostic and treatment modality for tuberculous monoarthritis of the knee is discussed. VI.[ncbi.nlm.nih.gov]
  • Abstract Although tuberculosis treatment is dependent on drug-susceptibility testing (DST) and molecular drug-resistance detection, treatment failure and relapse remain a challenge.[ncbi.nlm.nih.gov]
  • The wide range of presentations among patients with extrapulmonary tuberculosis can make diagnosis and treatment difficult.[ncbi.nlm.nih.gov]

Prognosis

  • Its prognosis is poor and optimal therapy has not been determined. Tuberculous meningitis has a high mortality in those also infected with HIV, especially in the developing world, and better therapies are urgently needed.[ncbi.nlm.nih.gov]
  • The prognosis of open pulmonary tuberculosis: a clinical-statistical analysis. J. Am. Med. Assoc. 114, 1954–1955 (1940). 7. Barry, C.E. III et al. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nat. Rev.[doi.org]
  • […] usually in the lungs) to other organs and tissues via the bloodstream Skin lesions are small (millet-sized) red spots that develop into ulcers and abscesses More likely in immunocompromised patients, eg HIV , AIDS, cancer The patient is generally sick Prognosis[dermnetnz.org]
  • The prognosis of open pulmonary tuberculosis: a clinical-statistical analysis . J. Am. Med. Assoc. 114 , 1954–1955 (1940). 7. Barry, C.E. III et al. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies . Nat. Rev.[nature.com]

Etiology

  • Potential etiological factors include: tumors, allergy, parasitic infections, trauma.[ncbi.nlm.nih.gov]
  • The clinical and radiological diagnostic criteria for tuberculous aortitis need to be set out in case of aneurysmal aortic disease in the absence of apparent etiology.[ncbi.nlm.nih.gov]
  • Mycobacterium tuberculosis (MTB) is an etiological agent of tuberculosis, a disease claiming million of lives every year across the world. MTB has two sHSPs: sHSP16.3 (a 16.3 kDa protein) and Acr2 (a 17.8 kDa protein).[ncbi.nlm.nih.gov]
  • Demonstrating mycobacterial antigens is useful in establishing mycobacterial etiology and can be used as an alternative method to the conventional Ziehl-Neelsen method.[biocare.net]

Epidemiology

  • KEYWORDS: China; molecular epidemiology; recent transmission; tuberculosis[ncbi.nlm.nih.gov]
  • […] contact tracing and epidemiological analysis.[doi.org]
  • All isolates were previously typed by spoligotyping and IS6110-RFLP, and for each strain epidemiological records were available ( 14, 24 ). Forty-four isolates with no known epidemiological links were chosen within 12 groups (Table 2 ).[doi.org]
  • Five loci were excluded for lack of robustness and/or stability in serial isolates or isolates from epidemiologically linked patients.[ncbi.nlm.nih.gov]
  • The majority of unrelated isolates (by epidemiology and RFLP typing) were also identified by VNTR typing.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Thus, new insights into the pathophysiological features of the Mtb complex strains are required for development of novel vaccines and for control of MDR/XDR Mtb infection, eventually leading to refinement of treatment regimens and the health care system[ncbi.nlm.nih.gov]
  • Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Each year, Mycobacterium tuberculosis accounts for approximately 1.4 million deaths and is responsible for 9 million newly diagnosed[mayomedicallaboratories.com]
  • Our findings that M. tuberculosis is able to accumulate cholesterol in the presence of alternative nutrients and use it when cholesterol is the sole carbon source in vitro may facilitate future studies into the pathophysiology of this important deadly[ncbi.nlm.nih.gov]
  • Rubinsztein, Regulation of Mammalian Autophagy in Physiology and Pathophysiology, Physiological Reviews, 90, 4, (1383), (2010).[doi.org]

Prevention

  • […] for Disease Control and Prevention, Beijing, China. 2 Beijing Center for Diseases Prevention and Control, Beijing 100013, China. 3 State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control[ncbi.nlm.nih.gov]
  • The dental office did not have infection prevention and control policies related to TB identification, prevention or education. The coworker's TST conversion indicated a recent infection, likely owed to occupational transmission.[ncbi.nlm.nih.gov]
  • We also review the available literature regarding the prevalence of tuberculosis infection following solid organ transplant and management of high-risk patients, including the role for isoniazid preventative therapy.[ncbi.nlm.nih.gov]
  • Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts.[ncbi.nlm.nih.gov]
  • Mycobacterium tuberculosis positive blood culture showed systemic prevalence of the Mycobacteria, however, prophylactic therapy was able to prevent a clinical manifestation of tuberculosis in the recipient.[ncbi.nlm.nih.gov]

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