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Mycoplasma


Presentation

  • The present case illustrates that antimicrobial susceptibility of Mycoplasma strains is not necessarily predictable and that antibiotic therapy should therefore be guided by in vitro susceptibility testing. Copyright 2016 Elsevier Inc.[ncbi.nlm.nih.gov]
  • A 20-year-old man presented with a 1-month history of blurry vision. Prior to presentation, he completed a 1-week course of oral levofloxacin for community-acquired pneumonia. His visual acuity was 20/25 in the right eye and 20/30 in the left eye.[jamanetwork.com]
  • Results: A 23 year old woman with a history of migraines presented with one day of headache, nausea, vomiting, fever, and vertical diplopia in the context of an upper respiratory tract infection.[neurology.org]
Subcutaneous Mass
  • Conversely, subcutaneous masses generated from uninfected BPH-1 cells contained more lymphocytes ( Figure 5 ).[doi.org]
Renal Stone
  • Clinically, Ureaplasma spp. have been cultured directly from renal stones, and these organisms have been isolated from voided urine in 31 of 247 patients (13%) with metabolic stones, compared to 43 of 145 patients (30%) with infection stones ( P 0.001[doi.org]
Cesarean Section
  • Additional information regarding the pathogenicity of ureaplasmas in the neonatal lung was obtained by Walsh et al. ( 326 ) through intratracheal inoculation of ureaplasmas into premature baboons delivered by cesarean section.[doi.org]

Workup

  • The results of a full uveitis workup were negative for antinuclear antibody, rheumatoid factor, antineutrophil cytoplasmic antibody, HLA-B27, angiotensin-converting enzyme, Lyme disease, syphilis, and B henselae .[jamanetwork.com]
  • An extensive infectious and autoimmune workup was pursued. Mycoplasma IgM serology (enzyme immunoassay and confirmatory immunoflourescence) returned positive. She was treated with a course of azithromycin and IvIG with rapid improvement.[neurology.org]
  • Department of Paediatrics, Nordsjællands Hospital, Hillerød, Denmark and Department of Clinical Microbiology, Herlev Hospital, Herlev, Denmark) sponsored this study by financing the microbiological analyses that was done supplementary to the clinical workups[journals.plos.org]
Polyps
  • Fifty-eight cases of colon carcinoma and 49 cases of adenomarous polyp were chosen for detection.[doi.org]

Treatment

  • Plasmocin Treatment (25 mg/ml): to eliminate mycoplasmas, use at 25 µg/ml for 2 weeks.[invivogen.com]
  • Appropriate empirical antimicrobial treatment is necessary to achieve an optimal therapeutic outcome.[ncbi.nlm.nih.gov]
  • Mycoplasma-EX has been shown to be effective with only one treatment, destroying mycoplasmas permanently within 2-3 hours using the non-antibiotic Initial Treatment Reagent only.[promokine.info]
  • CrossRef Google Scholar Fleckenstein E, Uphoff CC and Drexler HG (1994) Effective treatment of mycoplasma contamination in cell lines with enrofloxazin (Baytril). Leukemia 8: 1424–1434.[doi.org]
  • Treatment efficacy, treatment failures and selection of macrolide resistance in patients with high load of Mycoplasma genitalium during treatment of male urethritis with josamycin. BMC infectious diseases 2015;15:40.[mshc.org.au]

Prognosis

  • Links: clinical features investigations treatment of mycoplasma pneumonia complications prognosis[gpnotebook.co.uk]
  • Treatment and prognosis Most patients recover well although a small proportion of patients may develop bronchiectasis in the affected region or Swyer James syndrome . Promoted articles (advertising)[radiopaedia.org]
  • What Is the Prognosis? This infection often causes wheezing in children with asthma or reactive airways. Most people fully recover from this infection, even when antibiotics are not used. The death rate is quite low.[healthychildren.org]
  • Prognosis The disease is slowly progressive (it may evolve over 10 to 30 years after the initial presentation). The prognosis depends on the stage at diagnosis. The documents contained in this web site are presented for information purposes only.[orpha.net]

Etiology

  • Defining the microbial etiology of culture-negative prosthetic joint infection (PJI) can be challenging. Metagenomic shotgun sequencing is a new tool to identify organisms undetected by conventional methods.[ncbi.nlm.nih.gov]
  • Mycoplasma pneumoniae , a common respiratory pathogen, has been implicated as an etiology of encephalitis.[pediatrics.aappublications.org]
  • The etiology of preterm delivery is multifactorial, with infectious etiologies accounting for 25%–30% of these deliveries [ 56 ].[doi.org]
  • Clinical etiologic, and histopathologic features of Stevens-Johnson syndrome during an 8-year period at Mayo clinic. Mayo Clin.[frontiersin.org]

Epidemiology

  • A few epidemiological studies, however, continue to raise concern over such a linkage.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • In sequencing these genomes researchers hope to increase understanding of the pathophysiology of the pathogen, by identifying virulence factors.[microbewiki.kenyon.edu]
  • Pathophysiology Mycoplasma organisms cause infection primarily as extracellular parasites, attaching to the surface of ciliated and nonciliated epithelial cells of the respiratory and genital tracts.[emedicine.medscape.com]
  • To appreciate why microbial infection may predispose a preterm infant to develop long-term respiratory dysfunction, it is first important to review what is known about the pathophysiology of BPD and the inflammatory potential of microorganisms such as[doi.org]

Prevention

  • Plasmocin prophylactic can be used as a routine addition in liquid media to prevent mycoplasma and more generally bacterial contamination in mammalian cell cultures.[invivogen.com]
  • PubMed Google Scholar Uphoff CC and Drexler HG (2001) Prevention of mycoplasma contamination in leukemia-lymphoma cell lines. Human Cell 14: 244–247.[doi.org]
  • Catalog #: VZA-2021 Sales unit: items MycoZap TM Plus-CL Antibiotic formulation for prevention of bacteria, fungi and mycoplasma contaminations in cell line cultures.[bioscience.lonza.com]
  • […] particular emphasis on the most reliable detection methods; (3) the various methods available for the elimination of mycoplasmas highlighting antibiotic treatment; and (4) the recommended procedures and working protocols for the detection, elimination and prevention[ncbi.nlm.nih.gov]

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