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Mycoplasma Penetrans


Presentation

  • Abstract Mycoplasma penetrans is a mycoplasma species newly isolated from the urine of human immunodeficiency virus (HIV)-infected individuals and presents the only case in which an association has been found between antibodies against a mycoplasma and[ncbi.nlm.nih.gov]
  • The focus was on the 46-kDa protein that is present in M. penetrans strain HF-2 but not in the type strain, GTU.[ncbi.nlm.nih.gov]
  • Abstract The aim of the present study was to determine the frequency of IgG, IgA, and IgM antibodies to Mycoplasma penetrans in HIV-1-infected patients and in patients with sexually transmitted diseases.[ncbi.nlm.nih.gov]
  • The enzyme seems to be present as a membrane-associated precursor of 50 kDa and as a peripheral membrane monomeric polypeptide of 40 kDa that is easily removed by washing of cells with isotonic buffers and in the aqueous phase upon Triton partitioning[ncbi.nlm.nih.gov]
  • In this work we present the crystal structures of the three enzymes composing the gene cluster of the arginine deiminase pathway from M. penetrans: arginine deiminase (ADI), ornithine carbamoyltransferase (OTC) and carbamate kinase (CK).[ncbi.nlm.nih.gov]
Hypoxemia
  • On day 4 severe respiratory distress and hypoxemia developed, requiring a ventilator, and the patient was admitted to the intensive care unit. Livedo reticularis was noted, and methylprednisolone (125 mg q8h i.v.) was administered.[doi.org]
Intravenous Drugs
  • Abstract Antibodies to Mycoplasma penetrans were found at an unusually high frequency in male homosexuals with AIDS (55 of 149; 37%) and in human immunodeficiency virus (HIV)-infected asymptomatic homosexuals (13 of 49; 26.5%) but not in intravenous drug[ncbi.nlm.nih.gov]
Pathologist
  • After the double staining with lead and uranium, sections were examined under transmission electron microscope and photographed by a senior pathologist.[doi.org]
Respiratory Distress
  • Three days before hospital admission, she became ill with respiratory distress, generalized weakness, anorexia, and inability to walk.[doi.org]
  • The M.penetrans HF‐2 strain was isolated from a previously healthy HIV‐negative patient suffering from severe respiratory distress caused by M.penetrans infection‐associated systemic disease ( 17 ).[doi.org]
Pertussis
  • Here, we describe a 78-kDa protein from M. penetrans, designated MYPE9110, that exhibits sequence similarity to known ADP-ribosyltransferases (ADPRTs) such as Bordetella pertussis pertussis toxin and Mycoplasma pneumoniae community-acquired respiratory[ncbi.nlm.nih.gov]
Hypertension
  • On admission to the hospital (day 1), physical examination showed severe pallor, a swollen cervical lymph node, slight edema of both legs, tachycardia, and no hypertension.[doi.org]

Workup

Helicobacter Pylori
  • Carcinogenesis of Helicobacter pylori. Gastroenterology 133 : 659–672. De Marzo AM, Platz EA, Sutcliffe S, Xu J, Grönberg H, Drake CG et al. (2007). Inflammation in prostate carcinogenesis. Nat Rev Cancer 7 : 56–69.[doi.org]
  • Mycoplasma penetrans also possesses CDSs encoding cytotoxic factors such as one similar to a predicted vacuolation‐inducing cytotoxin‐related molecule CagA of Helicobacter pylori (MYPE4730), hemolysin (MYPE1500), protease (MYPE700, MYPE8500) and endonuclease[doi.org]
Bordetella Pertussis
  • Here, we describe a 78-kDa protein from M. penetrans, designated MYPE9110, that exhibits sequence similarity to known ADP-ribosyltransferases (ADPRTs) such as Bordetella pertussis pertussis toxin and Mycoplasma pneumoniae community-acquired respiratory[ncbi.nlm.nih.gov]
Giardia Lamblia
  • (D) Topology-based sequence alignment of CK from Mycoplasma penetrans, Enterococcus faecalis, Pyrococcus furiosus and Giardia lamblia.[doi.org]

Treatment

  • In addition, proteinase K treatment of the M. penetrans cells resulted in removal of the capsule, suggesting that polypeptides may contribute in anchoring it to the membrane or in its stability.[ncbi.nlm.nih.gov]
  • On day 3, the antibiotic treatment was changed to ceftazidime (1 gm q8h i.v.).[doi.org]
  • In vivo labeling of PG and DPG by growing the cells with radioactive palmitate or oleate, followed by snake venom phospholipase A2 treatment, enabled us to assess the positional distribution of fatty acids in these lipids.[ncbi.nlm.nih.gov]
  • There have also been cases of malignant pleural effusion, when patients exhibited chronic M. penetrans infection with various immunodeficiencies (such as HIV infections or anticancer treatment).[en.wikipedia.org]

Etiology

  • Mycoplasma penetrans, a rare bacterium so far only found in HIV-infected persons, was isolated in the blood and throat of a non-HIV-infected patient with primary antiphospholipid syndrome (whose etiology and pathogenesis are unknown).[ncbi.nlm.nih.gov]
  • The analysis of the results will allow to decide on algorithms to be used for the etiologic diagnosis of CAP.[uantwerpen.be]
  • One application of multiplex PCR is to increase the ability of clinicians to determine the causative agent in diseases with an unknown etiology such as CFS, FMS, RA, and GWS.[thearthritiscenter.com]
  • , Birmingham, Alabama, USA Cite This Article Abstract Mycoplasma penetrans , a rare bacterium so far only found in HIV-infected persons, was isolated in the blood and throat of a non-HIV-infected patient with primary antiphospholipid syndrome (whose etiology[wwwnc.cdc.gov]
  • […] respiratory tract with bacteremic dissemination, particularly in persons with antibody deficiencies, indicating the importance of the humoral immune system in host defense against these organisms. [9] Ureaplasma species are the most common nonbacterial etiologies[emedicine.medscape.com]

Epidemiology

  • M. penetrans is apparently transmitted sexually through homosexual activity and is epidemiologically linked to formation of KS in homosexual men with AIDS. Parallel tests with M. genitalium revealed no similar link to KS in the same study sample.[ncbi.nlm.nih.gov]
  • An epidemiological survey of Mycoplasma hominis and Ureaplasma urealyticum in gynaecological outpatients, Rome, Italy . Epidemiology & Infection 2013 ; 141 : 2650 – 2657 . 13. Haggerty , CL , Ness , RB .[cambridge.org]
  • Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections. FEMS Microbiol. Rev. 2008, 32, 956-973. Go to original source... Go to PubMed...[mmsl.cz]
  • Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections. FEMS Microbiol. Rev. 32 :956-973. Balish, M.F. , and D.C. Krause. 2006. Mycoplasmas: a distinct cytoskeleton for wall-less bacteria. J.[miamioh.edu]
Sex distribution
Age distribution

Prevention

  • A marked decrease in the extent of vacuolation was observed when peroxide accumulation was partially prevented by alpha-tocopherol.[ncbi.nlm.nih.gov]
  • Mycoplasma penetrans was isolated from one (50%) of two patients in Centers for Disease Control and Prevention (CDC) group B and from five (55.5%) of nine pediatric patients with AIDS (CDC group C).[ncbi.nlm.nih.gov]
  • The inhibitory effect of Concanavalin A-Sepharose was partially prevented by sugars in the order methyl-alpha-D-mannopyranoside and methyl-alpha-D-glucopyranoside but not methyl-alpha-D-galactopyranoside.[ncbi.nlm.nih.gov]
  • Hence, more attention should be paid to prevention and treatment of Mpe infection in patients with immunodeficiency.[doi.org]
  • Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions.[doi.org]

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