Acronym ATXPC Synonyms Myelocerebellar disorder Disclaimer Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. [uniprot.org]

Myelocerebellar disorder.Granuloma non immunologico Al centro del granuloma è presente il corpo estraneo, sono di norma assenti infiltrati di natura linfocitaria, il corpo estraneo è circondato da macrofagi e al margine del granuloma è presente una reazione [bytikemykinak.xpg.uol.com.br]

This reference guide will be the must-have of any internist or medical professional, as it takes a vast quantity of data across a sweeping grid of disorders, diseases, and presentations, and boils them down to individual parts, facilely indexed, and located [books.google.com]

The designated clinical findings may not be present in all cases of the syndrome. [patient-help.com]

Cerebellar ataxia is a form of ataxia originating in the cerebellum. [1] Non-progressive congenital ataxia (NPCA) is a classical presentation of cerebral ataxias. [en.wikipedia.org]

• Disability

  disability, Hedera type X-linked intellectual disability, Miles-Carpenter type X-linked intellectual disability, Najm type X-linked intellectual disability, Nascimento type X-linked intellectual disability, Pai type X-linked intellectual disability, [se-atlas.de]

  Intellectual Disability, X-Linked, Pai Type +ORPHANET:85325 Intellectual Disability, X-Linked, Stevenson Type +ORPHANET:85329 Intellectual Disability, X-Linked - Hypotonia - Facial Dysmorphism - Aggressive Behavior +ORPHANET:85330 X-Linked Intellectual [sourceforge.net]

  ATAXIA-TELANGIECTASIA; AT Is also known as at1, louis-bar syndrome;louis-bar syndrome Related symptoms: Autosomal recessive inheritance Intellectual disability Seizures Short stature Pica SOURCES: OMIM MONDO ORPHANET More info about ATAXIA-TELANGIECTASIA [mendelian.co]

  Figure1: Absent thumb and Flexor deformity of both hand Figure2: Hyperpigmented (cafe au lait) skin rash Patient also had developmental delay and learning disability. [banglajol.info]

• Movement Disorder

  Dementia 17, DRPLA 2, 13, 19, 21 Psychosis DRPLA, 17 3, 27 (Episodic) Epilepsy 10, DRPLA 17 Movement disorders Chorea DRPLA, 17 1 (Late stage) Myoclonus DRPLA 2, 19 Tremor 2, 8, 12 15, 21, 27 Parkinsonism 3, 9, 12, 17 2, 21 Dystonia 3 17 Ocular disorders [neuromuscular.wustl.edu]

  カテゴリ 神経変性疾患 階層分類 ヒト疾患 [BR: jp08402 ] 神経系疾患 神経変性疾患 H01616 脊髄小脳変性症 ICD-11 による疾患分類 [BR: jp08403 ] 08 Diseases of the nervous system Movement disorders 8A03 Ataxic disorders H01616 脊髄小脳変性症 特定疾患 (難病) [ jp08407.html ] H01616 治療薬 プロチレリン酒石酸塩水和物 [DR: D02007 ] [kegg.jp]

  […] disability Rare genetic medullar disease Rare genetic movement disorder Rare genetic myoclonus Rare genetic neurological disorder Rare genetic parkinsonian disorder Rare genetic syndromic intellectual disability Rare genetic tremor disorder Rare hereditary [se-atlas.de]

  Movement Disorders. 7 (2): 95–109. doi : 10.1002/mds.870070202. PMID 1584245. ^ Multiple System Atrophy~differential at eMedicine ^ Manto, Mario; Marien, Peter (2015). [en.wikipedia.org]

  Cerebellar Dysfunction: Anatomy Cerebellar parts Functions Signs Posterior (Flocculo-nodular lobe) Archicerebellum Body equilibrium Eye movements Eye movement disorders: Nystagmus; Vestibulo-ocular reflex (VOR) Postural and gait dysfunction Midline (Vermis [slideshare.net]

• Falling

  Ehrlich P: Über einen Fall von Anamie mit Bemerkungen über regenerative Veranderungen des Knochenmarks. Charite Ann 13:300, 1888. 3. Chauffard M: Un cas d’anémie pernicieuse aplastique. Bull Soc Med Hop Paris 21:313, 1904. 4. [patient-help.com]

  […] philtrum Communicating hydrocephalus Pectus excavatum Posteriorly rotated ears Macrotia Sparse hair Obstructive sleep apnea Joint hypermobility Dysuria Upper airway obstruction Central apnea Triangular face Highly arched eyebrow Spinal cord compression Falls [mendelian.co]

• Congestive Heart Failure

  heart failure Multiple epiphyseal dysplasia Albinism Impaired pain sensation Polyphagia Inflammation of the large intestine External genital hypoplasia Truncal obesity Adrenal insufficiency Decreased muscle mass Failure to thrive in infancy Increased [mendelian.co]

  heart failure syndrome X-linked intellectual disability-cerebellar hypoplasia syndrome X-linked intellectual disability-corpus callosum agenesis-spastic quadriparesis syndrome X-linked intellectual disability-craniofacioskeletal syndrome X-linked intellectual [se-atlas.de]

• Dysphagia

  Neurofibromatosis type i -1622200 Nf3b -1622400 Neurofibromatosis-pheochromocytoma-duodenal carcinoid syndrome -1623000 Neuromata mucosal with endocrine tumors -1630000 Nevi flammei familial multiple -1632000 Linear sebaceous nevus syndrome -1643300 Odontoma-dysphagia [julesberman.blogspot.com]

  Dyslexia Nuclear cataract Opisthotonus Neuronal loss in central nervous system Anxiety Brain atrophy Increased serum lactate Developmental regression Abnormal pyramidal sign Hypothyroidism Respiratory failure Progressive Congenital onset Cerebral atrophy Dysphagia [mendelian.co]

  DIAGNOSIS  Recognize progressive ataxia syndrome and associated features  Oculomotor : slow saccades  Bulbar : facial, temporal, tongue atrophy, fasciculation,  cough, dysphagia  UMN : brisk reflexes, spasticity, Babinski  Extrapyramidal : bradykinesia [slideshare.net]

• Hiccup

  Degeneration Cervical Dysplasia Cervical Herniated Disc Cervical Radiculopathy Cervical Spondylitis Cervical Spondylolisthesis Cervical Sprain Cervicitis Cervicogenic Headache Cervicooculoacoustic Syndrome Chiari Malformation Type 1 Chiari's Deformity Chronic Hiccups [healthgrades.com]

  Heterophobia Heterotaxia (generic term) Heterotaxia autosomal dominant type Heterotaxy with polysplenia or asplenia Heterotaxy, visceral, X-linked Hexosaminidases A and B deficiency Hh HHH syndrome Hi Hib–Hip • Hir–Hiv Hib–Hip Hibernian fever, familial Hiccups [sosu.us]

• Heart Disease

  disease, gastrointestinal difficulties and hypogonadism. [banglajol.info]

  […] block progressive, familial Heart block Heart defect round face congenital retarded development Heart defect tongue hamartoma polysyndactyly Heart defects limb shortening Heart hand syndrome Spanish type Heart hypertrophy, hereditary Heart situs anomaly [sosu.us]

  […] defects syndrome Brain calcification, Rajab type Brain demyelination due to methionine adenosyltransferase deficiency Brain dopamine-serotonin vesicular transport disease Brain malformation-congenital heart disease-postaxial polydactyly syndrome Brain-lung-thyroid [se-atlas.de]

  Disease +ORPHANET:2519 Microcephaly - Seizures - Intellectual Disability - Heart Disease ORPHANET:251 Multiple Epiphyseal Dysplasia ORPHANET:2521 Microcephaly - Cleft Palate ORPHANET:2523 Microcephaly - Brain Defect - Spasticity - Hypernatremia @@ -6955,11 [sourceforge.net]

• Hypotension

  Atrophy - Deafness Ophthalmoplegia Opsoclonus Myoclonus Opthalmoplegia - Ataxia - Hypoacusis Optic Atrophy Optic Nerve Disorder Optic Neuritis Optic Pathway Glioma Opticoacoustic Nerve Atrophy Dementia Optic-Spinal Form of Multiple Sclerosis Orthostatic Hypotension [healthgrades.com]

  […] respiratory chain enzyme deficiencies, Multiple self healing squamous epi the lioma, Multiple sulfatase deficiency, Multiple synostoses syndrome 1, Multiple synostoses syndrome 2, Multiple system atrophy, Multiple system atrophy (MSA) with orthostatic hypotension [yumpu.com]

• Vascular Disease

  Varicella Zoster Vascular Dementia Vascular Disease Vascular Headache Vascular Malformations of the Brain Vascular Neuropathy Vasculitis Vasovagal Attack Vein of Galen Aneurysm Vertigo Vestibular Neuritis Vestibular Seizure Viral Meningitis Visual Field [healthgrades.com]

  disease CLN8 disease CLN9 disease COASY protein-associated neurodegeneration COFS syndrome COG1-CDG COG4-CDG COG5-CDG COG7-CDG COG8-CDG COL4A1-related familial vascular leukoencephalopathy Canavan disease Cancer-associated retinopathy Cap myopathy Carbon [se-atlas.de]

• Orthostatic Hypotension

  Hypotension Orthostatic Intolerance Orthostatic Tremor Osteomyelitis Overuse Injuries Pain Disorder Panic Attack Panic Disorder Papilledema Paracusia Paradoxical Vocal Cord Dysfunction Paralysis Paraneoplastic Cerebellar Degeneration Paraneoplastic Limbic [healthgrades.com]

  hypotension, Multiple vertebral anomalies unusual facies, Mumps, Munchausen by proxy syndrome, Mungan syndrome, MURCS association, Muscle eye brain disease, Muscular atrophy ataxia retinitis pigmentosa and diabetes mellitus, Muscular dystrophy, Muscular [yumpu.com]

• Pruritus

  Downturned corners of mouth Hip dysplasia Amenorrhea Spontaneous abortion Febrile seizures Esotropia Full cheeks Small hand Infertility Short foot Tapered finger Stroke Arachnodactyly Hypogonadism Hypermetropia Polymicrogyria Short palm Genu valgum Pruritus [mendelian.co]

• Tinnitus

  Familial Temporal Lobe Epilepsy Temporal Lobe Seizure Tempormandibular Joint Pain Tension Headache Tertiary Syphilis Thiamine Deficiency Thigh Strain Third Nerve Palsy Thoracic Disc Disorders Thoracic Disorders Thromboembolism Thrombosis Tic Disorders Tinnitus [healthgrades.com]

  Megalencephaly Redundant skin Hip contracture Back pain Limited elbow extension Genu varum Cubitus valgus Disproportionate short-limb short stature Short femoral neck Tibial bowing Chronic otitis media Overfolded helix Spondyloepiphyseal dysplasia Anal stenosis Tinnitus [mendelian.co]

• Muscular Atrophy

  atrophy Proximal spinal muscular atrophy type 1 Proximal spinal muscular atrophy type 2 Proximal spinal muscular atrophy type 3 Proximal spinal muscular atrophy type 4 Pseudoprogeria syndrome Psychogenic movement disorders Psychomotor retardation due [se-atlas.de]

  Progressive External Ophthalmoplegia Progressive Familial Myoclonic Epilepsy Progressive Multifocal Leukoencephalopathy Progressive Muscular Atrophy Progressive Spinal Muscular Atrophy Progressive Spinobulbar Muscular Atrophy Progressive Supranuclear [healthgrades.com]

  Multiple system atrophy (MSA) with orthostatic hypotension, Multiple vertebral anomalies unusual facies, Mumps, Munchausen by proxy syndrome, Mungan syndrome, MURCS association, Muscle eye brain disease, Muscular atrophy ataxia retinitis pigmentosa [yumpu.com]

  * Multiple vertebral anomalies unusual facies Mum-Mut * Mumps * Munchausen by proxy syndrome * Muscle-eye-brain syndrome * Muscular atrophy ataxia retinitis pigmentosa diabetes mellitus * Muscular dystrophy congenital infantile cataract hypogonadism [en.academic.ru]

  Multiple vertebral anomalies unusual facies Mum-Mut Mumps Munchausen by proxy syndrome Muscle-eye-brain syndrome Muscular atrophy ataxia retinitis pigmentosa diabetes mellitus Muscular dystrophy congenital infantile cataract hypogonadism Muscular dystrophy [thefullwiki.org]

• Myopathy

  […] and mental retardation hypospadias, Myopathy mitochondrial cataract, Myopathy ophthalmoplegia hypoacousia areflexia, Myopathy with lysis of myofibrils, Myopathy limb-girdle with bone fragility, Myopathy mitochondrial progressive with congenital cataract [yumpu.com]

  […] syndrome * Myopathy ophthalmoplegia hypoacousia areflexia * Myopathy tubular aggregates * Myopathy with lactic acidosis and sideroblastic anemia * Myopathy with lysis of myofibrils * Myopathy, centronuclear * Myopathy, desmin storage * Myopathy, McArdle [en.academic.ru]

  Myopathy ophthalmoplegia hypoacousia areflexia Myopathy tubular aggregates Myopathy with lactic acidosis and sideroblastic anemia Myopathy with lysis of myofibrils Myopathy, centronuclear Myopathy, desmin storage Myopathy, McArdle type Myopathy, myotubular [thefullwiki.org]

  Distal myopathy with anterior tibial onset Distal myopathy with early respiratory muscle involvement Distal myopathy with posterior leg and anterior hand involvement Distal myopathy, Welander type Distal myotilinopathy Distal nebulin myopathy Distal [se-atlas.de]

• Aggressive Behavior

  Behavior +ORPHANET:85330 X-Linked Intellectual Disability - Corpus Callosum Agenesis - Spastic Quadriparesis +ORPHANET:85331 Intellectual Disability, X-Linked - Hypogonadism - Ichthyosis - Obesity - Short Stature ORPHANET:85334 X-Linked Neurodegenerative [sourceforge.net]

  X-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome X-linked intellectual disability-hypogonadism-ichthyosis-obesity-short stature syndrome X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive [se-atlas.de]

• Dysuria

  […] distance Osteopetrosis Thick vermilion border Malar flattening Myelitis Joint laxity Hypoxemia Myelopathy Long philtrum Communicating hydrocephalus Pectus excavatum Posteriorly rotated ears Macrotia Sparse hair Obstructive sleep apnea Joint hypermobility Dysuria [mendelian.co]

• Ataxia

  Ataxia-pancytopenia (AP) syndrome is seen as a cerebellar ataxia, variable hematologic cytopenias, and predisposition to marrow failing and myeloid leukemia, connected with monosomy 7 sometimes. benefit for clones which have dropped the mutant allele [hiv-proteases.com]

  Cerebellar ataxia is a form of ataxia originating in the cerebellum. [1] Non-progressive congenital ataxia (NPCA) is a classical presentation of cerebral ataxias. [en.wikipedia.org]

  Research of Myelocerebellar Disorder has been linked to Monosomy, Ataxia, Cerebellar Ataxia, Atrophy, Pancytopenia. [novusbio.com]

  […] descriptionSAMD9L-related ataxia-pancytopenia (ATXPC) syndrome is characterized by cerebellar ataxia, variable hematologic cytopenias, and predisposition to marrow failure, myelodysplasia, and myeloid leukemia, sometimes associated with monosomy 7. [gepedia.com]

  Genetic Ataxias • Mendelian AR and AD ataxias have a higher frequency than other genetic ataxias. • Prevalence – 1/50,000 - Friedreich’s ataxia (FRDA1) • 1/100,000 - Ataxia Telangectasia (AT), dominant SCAs • AR ataxias – Multi-system disorders with extra-neural [slideshare.net]

• Cerebellar Ataxia

  ataxia Sensory ataxia Spinocerebellar ataxia Vestibulocerebellar syndrome References [ edit ] ^ "Cerebellar ataxia". [en.wikipedia.org]

  Ataxia-pancytopenia: syndrome of cerebellar ataxia, hypoplastic anemia, monosomy 7, and acute myelogenous leukemia. Cancer Genet Cytogenet 1981; 4:189-196. [2] Daghistani D, Curless R, Toledano SR, Ayyar DR. [familialcancerdatabase.nl]

  […] descriptionSAMD9L-related ataxia-pancytopenia (ATXPC) syndrome is characterized by cerebellar ataxia, variable hematologic cytopenias, and predisposition to marrow failure, myelodysplasia, and myeloid leukemia, sometimes associated with monosomy 7. [gepedia.com]

  Format Definition An autosomal dominant disorder characterized by cerebellar ataxia, variable hematologic cytopenias, and predisposition to bone marrow failure and myeloid leukemia. [uniprot.org]

  SAMD9L-related ataxia-pancytopenia (ATXPC) syndrome is characterized by cerebellar ataxia, variable hematologic cytopenias, and predisposition to marrow failure, myelodysplasia, and myeloid leukemia, sometimes associated with monosomy 7. [ncbi.nlm.nih.gov]

• Nystagmus

  Nystagmus, dysmetria, increased deep tendon reflexes, and clonus are common. Gait impairment and other neurologic abnormalities are slowly progressive. [gepedia.com]

  Interictal nystagmus or mild ataxia. Provoked by exercise and stress not startle. ½ pts have headache. [slideshare.net]

  Neurologic features variably include slowly progressive cerebellar ataxia or balance impairment with cerebellar atrophy and periventricular white matter T2 hyperintensities in brain MRI, horizontal and vertical nystagmus, dysmetria, dysarthria, pyramidal [rarediseases.info.nih.gov]

  […] prominent in SCA 7 & DRPLA Ataxia Truncal: SCA 1 ; 2 ; 6 ; 14 ; 28 ; 31 ; 36 Tremor Head or Hand: SCA 8, 12, 15-16, 19, 27 Palatal: SCA 20 Normal lifespan: SCA 6, 11 Eye 60 Slow saccades Early/prominent: SCA 2, 7 Late: SCA 1, 3, 28 Very rarely: SCA 6 Nystagmus [neuromuscular.wustl.edu]

• Dysautonomia

  Sprain Memory Loss Mental Disorders Related to Alzheimers Mental Retardation - Epilepsy Migraine Migraine, Hormone-Induced Migrainous Vertigo Mild Cognitive Impairment Mild Headache Motor Neuron Disease Motor Neuropathy Motor Neuropathy, Peripheral With Dysautonomia [healthgrades.com]

  Scleroderma * Morphea, generalized * Morquio disease, type A * Morquio disease, type B * Morquio syndrome * Morrison Young syndrome * Morse Rawnsley Sargent syndrome * Motor neuron disease * Motor neuro-ophthalmic disorders * Motor neuropathy peripheral dysautonomia [en.academic.ru]

  […] syndrome Morphea Scleroderma Morphea, generalized Morquio disease, type A Morquio disease, type B Morquio syndrome Morrison Young syndrome Morse Rawnsley Sargent syndrome Motor neuron disease Motor neuro-ophthalmic disorders Motor neuropathy peripheral dysautonomia [thefullwiki.org]

• Stroke

  Stroke-Like Aphasia Stroke-Like Dysarthria Subacute Sclerosing Panencephalitis Subarachnoid Hemorrhage Subdural Hematoma Subdural Hemorrhage Supranuclear Ocular Palsy Swallowing Disorders Syncope Syncope, Familial Neurocardiogenic Syphilitic Aseptic [healthgrades.com]

  […] immunodeficiency, Neonatal adrenoleukodystrophy, Neonatal hemochromatosis, Neonatal herpes, Neonatal hypothyroidism, Neonatal intrahepatic cholestasis caused by citrin deficiency, Neonatal meningitis, Neonatal ovarian cyst, Neonatal progeroid syndrome, Neonatal stroke [yumpu.com]

  "Behavioural intervention effects in dysarthria following stroke: communication effectiveness, intelligibility and dysarthria impact". International Journal of Language & Communication Disorders. 42 (2): 131–53. doi : 10.1080/13682820600861776. [en.wikipedia.org]

  Etiology • Degenerative – MSA, Progressive myoclonic epilepsy • Stroke – cerebellar, thalamic, brainstem, pontomedullary junction, lesions causing ataxic hemiparesis • Tumors- Medulloblastoma, Astrocytoma, Ependymoma, Hemangioblastoma, Metastasis, Meningioma [slideshare.net]

  Central sleep apnea Thoracolumbar kyphosis Micropenis Prominent forehead Narrow forehead Downturned corners of mouth Hip dysplasia Amenorrhea Spontaneous abortion Febrile seizures Esotropia Full cheeks Small hand Infertility Short foot Tapered finger Stroke [mendelian.co]

Treatment Please input treatment information here. You can also add sub-section(s) at will. Labs working on this disease Please input related labs here. References Please input treatment information here. [pediascape.org]

CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. [diseaseinfosearch.org]

It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice . [uniprot.org]

Metropolitan areas commonly pro- vide treatment via a few options, including hospitals and free-standing treatment centers. [sarcomacancer.org]

"Treatment of cerebellar ataxia with buspirone: a double-blind study". The Lancet. 348 (9029): 759. doi : 10.1016/S0140-6736(05)65674-7. PMID 8806320. ^ Mackenzie, Catherine; Lowit, Anja (2007). [en.wikipedia.org]

Toxicity prognosis is also compound by means of the duration of toxicity (Trotti et al. 2007). [waittfoundation.org]

Synonyms ataxia - pancytopenia Etiology Please input defination information here. Diagnosis Please input defination information here. Symptoms Please input defination information here. Treatment Please input treatment information here. [pediascape.org]

They are organised into groups, and further divided into clinical, etiological or histopathological sub-types. [orpha.net]

ETIOLOGY AND PATHOGENESIS Immune suppression of marrow by autoreactive T lymphocytes Toxic injury to stem and/or progenitor cells (eg, certain chemotherapy or drugs) (see Table 3–2 ) Inherited intrinsic stem cell defect (eg, Fanconi anemia) TABLE 3–2 [hemonc.mhmedical.com]

Etiology and Pathogenesis Thirteen complementation groups, defined by somatic cell hybridization, are associated with the development of Fanconi anemia. 221 A complementation group is a genetic subgroup. [patient-help.com]

Etiology • Degenerative – MSA, Progressive myoclonic epilepsy • Stroke – cerebellar, thalamic, brainstem, pontomedullary junction, lesions causing ataxic hemiparesis • Tumors- Medulloblastoma, Astrocytoma, Ependymoma, Hemangioblastoma, Metastasis, Meningioma [slideshare.net]

Epidemiology or cause Fanconi Anemia is an uncommon disorder and is estimated to be present in 1 in 1 million individuals. [patient-help.com]

It was suggested that the prevalency was considered common according to epidemiologic and retrospective studies. [astakask.com]

616204 616291 616354 616719 607250 616948 616949 617133 文献 PMID: 19440741 著者 Anheim M, Fleury M, Monga B, Laugel V, Chaigne D, Rodier G, Ginglinger E, Boulay C, Courtois S, Drouot N, Fritsch M, Delaunoy JP, Stoppa-Lyonnet D, Tranchant C, Koenig M タイトル Epidemiological [genome.jp]

Epidemiology  ADCA- 5/100,000 FA 5/100,000  Among ADCAs  SCA 1 - 5.6 %  SCA 2 - 15.2 %  SCA 3 - 20.8 %  SCA 6 - 15.2 %  SCA 7 - 4.5 %  -ve F/H - 6.8% + CAG repeats, 5.2% FA*  apparently recessive- 4.4% +CAG rpts, 11.24% FA Moseley et al: Neurology [slideshare.net]

"Pathophysiology of cerebellar ataxia". Movement Disorders. 7 (2): 95–109. doi : 10.1002/mds.870070202. PMID 1584245. ^ Multiple System Atrophy~differential at eMedicine ^ Manto, Mario; Marien, Peter (2015). [en.wikipedia.org]

Is chronic lung disease in low birth weight infants preventable? A survey of eight centers. ‎ Página 84 - Tanner JM, Whitehouse RH, Marubini E, Resele LF. The adolescent growth spurt of boys and girls of the Harpenden growth study. ‎ [books.google.es]

Other therapies include androgens to raise the hemoglobin and platelet count, G-CSF and GM-CSF for neutropenia Definitive treatment includes bone marrow transplant for marrow failure in FA patients. 5 Preventive measures can be taken by prenatal testing [banglajol.info]

Certain forms of peripheral neuropathy can be prevented. More than one type of nerve may be affected at the same time. [neuropathydamage.club]

Preventing migraine headaches. What is Butterbur? Syndromes Breathing support Never put anything in the ear canal without first consulting a health care provider. [waittfoundation.org]