Here, we report an additional case of a 64-year-old gentleman with leukocytosis, eosinophilia and diffuse mediastinal and general lymphadenopathy. [karger.com]

In the same year, Rao et al. reported a patient with t(8;13)(p11;q12) who presented with leukocytosis, monocytosis, myeloid hyperplasia of bone marrow, and generalized lymphadenopathy due to T-cell lymphoblastic lymphoma (Rao et al., 1998). [atlasgeneticsoncology.org]

Two patients had generalized lymphadenopathy and splenomegaly (cases 137 and 246), and one patient had cervical lymphadenopathy (case 12). [ajcp.oxfordjournals.org]

Cell number of cells with the fusion gene (by FISH or qPCR for negative results) are displayed in red. [ncbi.nlm.nih.gov]

[…] myelomonocytic leukemia with eosinophilia ( Acta Haematol 2002;107:113 ) FGFR1 associated with leukemia / lymphoma should be classified as leukemia / lymphoma associated with FGFR1 rearrangement Molecular / cytogenetics images Images hosted on other servers: FISH [pathologyoutlines.com]

Description: TESTS AVAILABLE: Karyotyping and FISH. [viapath.co.uk]

Test Methodology Fluorescence In Situ Hybridization (FISH) Analysis. Interpretation A positive FISH result indicates deletion of the CHIC2 gene which lies between the FIP1L1 and PDGFRa loci in band 4q12. [beaumontlaboratory.com]

Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378] 9. [guidetopharmacology.org]

Bhide RS, Lombardo LJ, Hunt JT, Cai ZW, Barrish JC, Galbraith S, Jeyaseelan R Sr, Mortillo S, Wautlet BS, Krishnan B, Kukral D, Malone H, Lewin AC, Henley BJ, Fargnoli J. Mol Cancer Ther. 2010 Feb;9(2):369-78. Epub 2010 Jan 26. [atlasgeneticsoncology.org]

Disorders; Eosinophilia in Infectious Diseases; Eosinophilia associated with Immune Deficiency and Immune Dysregulation; Eosinophilia in Dermatologic disorders; Management of Hypereosinophilic Syndromes; and Novel Therapies for Eosinophilic Disorders [books.google.com]

diseases Kimura disease Vasculitis Cyclical eosinophilia Aberrant T cell population associated eosinophilia Also known as lymphocyte variant hypereosinophilia Abnormal T cell population does not meet diagnostic criteria for leukemia or lymphoma Causes [surgpathcriteria.stanford.edu]

Other myeloid leukemia Corresponding ICD-10 Codes C92.7 Other myeloid leukemia Corresponding ICD-10-CM Codes (U.S. only) C92.Z Other myeloid leukemia (effective October 01, 2015) Signs and Symptoms Fever Hypermetabolism Lymph node enlargement Night sweats [seer.cancer.gov]

Table 25.1 Possible clinicopathological features of chronic eosinophilic leukemias Organ or system Features General Fatigue, fever, weight loss, night sweats, headache Hematological Eosinophilia (by definition), variable increase in other leukocytes and [clinicalgate.com]

Case Presentation A 51-year-old Caucasian male presented with severe back pain, night sweats, weight loss and bilateral lower extremity weakness for two weeks. Physical examination showed splenomegaly. [jscimedcentral.com]

Clinics Around 20-25% of patients show systemic and unspecific symptoms like fatigue, night sweats, weight loss and fever and around 20% are asymptomatic (and the disease is detected in routine analyses). [atlasgeneticsoncology.org]

The median age is 44 years (range, 3–84 years). 37 Patients usually have systemic symptoms, including fatigue, night sweats, weight loss, or fever. Lymphadenopathy and hepatosplenomegaly are common. [ajcp.oxfordjournals.org]

205.8 Other myeloid leukemia Corresponding ICD-10 Codes C92.7 Other myeloid leukemia Corresponding ICD-10-CM Codes (U.S. only) C92.Z Other myeloid leukemia (effective October 01, 2015) Signs and Symptoms Fever Hypermetabolism Lymph node enlargement Night [seer.cancer.gov]

Table 25.1 Possible clinicopathological features of chronic eosinophilic leukemias Organ or system Features General Fatigue, fever, weight loss, night sweats, headache Hematological Eosinophilia (by definition), variable increase in other leukocytes and [clinicalgate.com]

Case Presentation A 51-year-old Caucasian male presented with severe back pain, night sweats, weight loss and bilateral lower extremity weakness for two weeks. Physical examination showed splenomegaly. [jscimedcentral.com]

Clinics Around 20-25% of patients show systemic and unspecific symptoms like fatigue, night sweats, weight loss and fever and around 20% are asymptomatic (and the disease is detected in routine analyses). [atlasgeneticsoncology.org]

The median age is 44 years (range, 3–84 years). 37 Patients usually have systemic symptoms, including fatigue, night sweats, weight loss, or fever. Lymphadenopathy and hepatosplenomegaly are common. [ajcp.oxfordjournals.org]

Symptoms related to release of eosinophilic granules occur, commonly skin rash and erythema and less frequently pulmonary, gastrointestinal tract, and/or cardiac manifestations. [ajcp.oxfordjournals.org]

This test should be done where morphology is suggestive of a non-classic MPN. [viapath.co.uk]

This suggests that the clone with both the mutation and the rearrangement had a proliferative advantage over cells with only a FGFR1 rearrangement. [ncbi.nlm.nih.gov]

FISH studies performed on the peripheral blood revealed 4q12 deletion suggestive of the presence of FIP1L1-PDGFRA fusion Image 4. [ajcp.oxfordjournals.org]

The term 8p11 myeloproliferative syndrome was suggested in 1995 by Macdonald et al. (Aguiar et al., 1995; Macdonald et al., 1995) and confirmed as clinical entity (SCLL) by Inhorn et al. (Inhorn et al., 1995). [atlasgeneticsoncology.org]

The phenomenon indicates that different types of myeloid neoplasms associated with PDGFRB rearrangement can transform into one another with the progression of the disease, and to some extent, this transformation suggests the aggravation of disease. [cancerjournal.net]

Most of the patients show a hypercellular bone marrow that leads to a diagnosis of myeloid hyperplasia or a myeloproliferative neoplasm. [atlasgeneticsoncology.org]