Two patients had generalized lymphadenopathy and splenomegaly (cases 137 and 246), and one patient had cervical lymphadenopathy (case 12). [ajcp.oxfordjournals.org]

Two patients had generalized lymphadenopathy and splenomegaly (cases 137 and 246), and one patient had cervical lymphadenopathy (case 12). [ajcp.oxfordjournals.org]

Conventional cytogenetics (karyotyping) will detect the majority of abnormalities involving PDGFRB and FGFR1, but florescence in situ hybridization (FISH)/molecular studies are required to detect factor interacting with PAP (FIP1L1)-PDGFRA as the characteristic [ncbi.nlm.nih.gov]

For these considerations, one can submit peripheral blood for FISH - BCR/ABL t(9;22), FISH -del 4q12; and PCR for JAK2 V617F mutation. [mplnet.com]

Description: TESTS AVAILABLE: Karyotyping and FISH. [viapath.co.uk]

Test Methodology Fluorescence In Situ Hybridization (FISH) Analysis. Interpretation A positive FISH result indicates deletion of the CHIC2 gene which lies between the FIP1L1 and PDGFRa loci in band 4q12. [beaumontlaboratory.com]

Analysis by FISH confirmed FGFR1 gene rearrangement in all samples. [ajcp.oxfordjournals.org]

Outstanding images make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. [books.google.com]

[…] survivals of less than 18 months (since individuals meeting these criteria for TKI resistance may often live longer than 18 months), or whether a new conceptual framework for defining AP disease in the modern TKI era needs to be considered by clinicians and pathologists [hematology.org]

He is member and fellow of Royal College of Pathologists, UK. He is currently Medical Director of National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi and Director Stem Cell Research. [actamedicainternational.com]

• In 2014, a clinical advisory committee (CAC) composed of 100 pathologists, haematologists, oncologists and geneticists from around the world convened to propose revisions to the fourth edition of the WHO classification. 3. [slideshare.net]

However, we have observed other pathologists use this designation as a diagnosis in pathology reports, with resulting clinicians’ dissatisfaction. [ajcp.oxfordjournals.org]

A 35-year-old male was admitted to hospital in September 1989 with severe pain and swelling in the right ankle. No fever and no systemic symptoms were observed. [cancerres.aacrjournals.org]

Concurrent computerized tomography (CT) of the abdomen and pelvis also detected enlarged retroperitoneal lymph nodes, a large abdominal mass, and bone metastases. A CT guided biopsy of the abdominal mass revealed low-grade follicular lymphoma. [hoajonline.com]

diseases Kimura disease Vasculitis Cyclical eosinophilia Aberrant T cell population associated eosinophilia Also known as lymphocyte variant hypereosinophilia Abnormal T cell population does not meet diagnostic criteria for leukemia or lymphoma Causes [surgpathcriteria.stanford.edu]

As in the case described here, some patients also displayed skin lesions, and it is conceivable that these arise as a consequence of aberrant PDGFRB signaling because this receptor is normally involved in wound healing and repair of skin lesions. [cancerres.aacrjournals.org]

Subsequently, the patient developed worsening of the back pain and lower extremity numbness. CBC at this time showed leukocytosis (9,900/µl) with absolute eosinophils of 3,000/µl. [jscimedcentral.com]

Case 90 was from a man who had severe back pain, splenomegaly, and bilateral pelvic lymphadenopathy. A fine-needle aspiration of the lymph node showed myeloid sarcoma. [ajcp.oxfordjournals.org]

(Wright Giemsa stained peripheral blood smear, original magnification 1000x) A markedly hypercellular bone marrow with myeloid hyperplasia including many eosinophils is appreciated. [atlasgeneticsoncology.org]