We present the case of a male SSc patient wh presented with critical finger ischemia and concomitant appearance of myocardial fibrosis after sudden interruption of sildenafil treatment. [ncbi.nlm.nih.gov]

A third or fourth heart sound and tachycardia may be present. Signs of pulmonary congestion are present in patients with left-sided disease. Causes A specific single etiology of EMF has not been established. [emedicine.medscape.com]

• Congestive Heart Failure

  A 18-year-old female with unusual type of parchment-like right ventricle died of intractable congestive heart failure was reported. A catheter study revealed the absence of systolic contraction of the right ventricle. [ncbi.nlm.nih.gov]

  Clinically, may be silent or producing stabile angina pectoralis leading to congestive heart failure. [pathologyatlas.ro]

• Cyanotic Congenital Heart Disease

  Abstract The assumption of the presence of diffuse myocardial fibrosis in long-standing cyanotic congenital heart disease (CHD) inspired us to noninvasively determine the myocardial extracellular volume (ECV) using contrast CMR. [ncbi.nlm.nih.gov]

• Heart Disease

  Abstract Myocardial fibrosis is one of the most common histopathological lesions found in chronic heart diseases. Progressive development of myocardial fibrosis will cause heart failure, an extremely debilitating and life threatening condition. [ncbi.nlm.nih.gov]

  These include four anatomical and clinical entities : Chronic ischemic heart disease stabile angina pectoralis Acute ischemic heart disease unstabile angina pectoralis myocardium infarct sudden death Etiology : coronary artery atherosclerosis (90 %), [pathologyatlas.ro]

• Cardiomegaly

  A tachycardia of 145 beats per min and radiological evidence of cardiomegaly indicated involvement of the heart, but an ECG failed to show signs of myocarditis or cardiac hypertrophy. [ncbi.nlm.nih.gov]

  Therefore, most of these cases may be a sequela of myocarditis, and more correctly termed post-myocarditic cardiomegaly. [link.springer.com]

  […] catheterization 心[臓]カテーテル法 cardiac cycle 心[臓]周期 cardiac death心臓死 cardiac index (CI)心係数 cardiac muscle (= myocardium)心筋 cardiac output 心拍出量 cardiac rupture心[臓]破裂 cardiac silhouette心陰影 cardiac standstill心静止 cardiac tamponade 心タンポナーデ cardiogenic shock 心原性ショック cardiomegaly [tokyo-med.ac.jp]

Furthermore, the level of NT-proBNP was reduced significantly after TEA plus OMT treatment. Consistent with echocardiography parameters, the LVEF measured by CMR also was increased markedly. [ncbi.nlm.nih.gov]

A longer steroid treatment duration was found to be associated with a lower age‐related increase in myocardial fibrosis burden. [musculardystrophynews.com]

The no-intent-to-treat group was randomized into 2 subgroups: group ND-NT (no dysfunction-no treatment), in which patients received all necessary, guideline-based treatment for their condition but no treatment for cardiomyopathy or heart failure; and [neurologyadvisor.com]

CMR is superior to conventional echocardiography for the detection of myocardial fibrosis in desmin-related cardiomyopathy, which may be useful to detect early cardiac involvement and predict the patient prognosis. [ncbi.nlm.nih.gov]

These have yielded new insights into disease prognosis and response to treatment. [heart.bmj.com]

Cardiomyopathies/therapy* Death, Sudden, Cardiac/etiology Death, Sudden, Cardiac/prevention & control Defibrillators, Implantable Electric Countershock/instrumentation Electrocardiography Fibrosis Heart Rate* Humans Magnetic Resonance Imaging Myocardium [ncbi.nlm.nih.gov]

In a novel study Assomull et al. [ 40 ] examined patients with new-onset heart failure of unknown etiology. They examined the diagnostic accuracy of LGE to determine the etiology of heart failure in this patient collective. [omicsonline.org]

Original Research Association of Cardiovascular Risk Factors and Myocardial Fibrosis With Early Cardiac Dysfunction in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study, Bharath [care.diabetesjournals.org]

DESIGN AND METHODS: Participants with type 1 diabetes aged 13-39 years without a known history of cardiovascular disease (CVD) ( n = 1,441) were recruited into the Diabetes Control and Complications Trial (1983-1993) and subsequently followed in the Epidemiology [ncbi.nlm.nih.gov]

References Nieminen MS, Harjola VP (2005) Definition and epidemiology of acute heart failure syndromes. [omicsonline.org]

There are multiple types of myocardial fibrosis that occur in response to different pathophysiologic stimuli. Recent advances in imaging technology have made detection and quantification of the types of myocardial fibrosis possible. [ncbi.nlm.nih.gov]

Myocardial fibrosis is the pathophysiological hallmark of failing heart. [kclpure.kcl.ac.uk]

Inhibition of T-cell factor (TCF)/β-catenin-mediated transcription with ICG-001 or genetic loss of β-catenin also prevented TGF-β-induced myofibroblasts formation. [ncbi.nlm.nih.gov]

The bottom line is that this shows for the first time that cardiac fibrosis is preventable.” [chemdiv.com]