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Myocardial Fibrosis


Presentation

  • We present the case of a male SSc patient wh presented with critical finger ischemia and concomitant appearance of myocardial fibrosis after sudden interruption of sildenafil treatment.[ncbi.nlm.nih.gov]
  • MF was present in four athletes (range 1-8 g) and not present in five athletes. MF was located near the insertion points of the right ventricular free wall on the left ventricle in three athletes and in the epicardial lateral wall in one athlete.[ncbi.nlm.nih.gov]
  • The present results are the first to demonstrate that fQRS may indicate myocardial fibrosis in patients with hypertension.[ncbi.nlm.nih.gov]
  • Left ventricular ejection fraction was not associated with risk factors but was significantly lower if a myocardial scar was present.[ncbi.nlm.nih.gov]
  • We present a rare case of desmin-related hypertrophic cardiomyopathy, CMR revealed fibrosis in the lateral wall of the left ventricle.[ncbi.nlm.nih.gov]
Congestive Heart Failure
  • A 18-year-old female with unusual type of parchment-like right ventricle died of intractable congestive heart failure was reported. A catheter study revealed the absence of systolic contraction of the right ventricle.[ncbi.nlm.nih.gov]
  • We describe a 27-year-old woman with a 6 year history of severe polymyositis and persistent elevation of creatine phosphokinase-MB isoenzyme who suddenly developed congestive heart failure and bradycardia-tachycardia syndrome.[ncbi.nlm.nih.gov]
  • We report on a 38- year-old man with Becker-Kiener muscular dystrophy (BMD) and dilated cardiomyopathy without clinical symptoms of congestive heart failure who was referred for risk evaluation of sudden cardiac death.[ncbi.nlm.nih.gov]
  • Clinically, may be silent or producing stabile angina pectoralis leading to congestive heart failure.[pathologyatlas.ro]
  • Later in adolescence or adulthood, dilated cardiomyopathy and congestive heart failure occur in roughly two thirds of individuals with ALMS, equally including both those who did and did not previously have infantile disease.[raredr.com]
Cyanotic Congenital Heart Disease
  • Abstract The assumption of the presence of diffuse myocardial fibrosis in long-standing cyanotic congenital heart disease (CHD) inspired us to noninvasively determine the myocardial extracellular volume (ECV) using contrast CMR.[ncbi.nlm.nih.gov]
Heart Disease
  • Abstract Myocardial fibrosis is one of the most common histopathological lesions found in chronic heart diseases. Progressive development of myocardial fibrosis will cause heart failure, an extremely debilitating and life threatening condition.[ncbi.nlm.nih.gov]
  • Abstract The assumption of the presence of diffuse myocardial fibrosis in long-standing cyanotic congenital heart disease (CHD) inspired us to noninvasively determine the myocardial extracellular volume (ECV) using contrast CMR.[ncbi.nlm.nih.gov]
  • KEYWORDS: Congenital heart disease; Ebstein’s anomaly; Exercise capacity; Late gadolinium enhancement; Myocardial fibrosis[ncbi.nlm.nih.gov]
  • Abstract Cardiomyopathy in cystic fibrosis (CF) is an unusual heart disease, mainly characterized by a multifocal fibrosis of the left ventricle. The disorder chiefly occurs in the age group of 1-2 years and leads to fatal cardiac failure.[ncbi.nlm.nih.gov]
  • These include four anatomical and clinical entities : Chronic ischemic heart disease stabile angina pectoralis Acute ischemic heart disease unstabile angina pectoralis myocardium infarct sudden death Etiology : coronary artery atherosclerosis (90 %),[pathologyatlas.ro]
Cardiomegaly
  • A tachycardia of 145 beats per min and radiological evidence of cardiomegaly indicated involvement of the heart, but an ECG failed to show signs of myocarditis or cardiac hypertrophy.[ncbi.nlm.nih.gov]
  • Therefore, most of these cases may be a sequela of myocarditis, and more correctly termed post-myocarditic cardiomegaly.[link.springer.com]
  • […] catheterization 心[臓]カテーテル法 cardiac cycle 心[臓]周期 cardiac death心臓死 cardiac index (CI)心係数 cardiac muscle ( myocardium)心筋 cardiac output 心拍出量 cardiac rupture心[臓]破裂 cardiac silhouette心陰影 cardiac standstill心静止 cardiac tamponade 心タンポナーデ cardiogenic shock 心原性ショック cardiomegaly[tokyo-med.ac.jp]

Treatment

  • Furthermore, the level of NT-proBNP was reduced significantly after TEA plus OMT treatment. Consistent with echocardiography parameters, the LVEF measured by CMR also was increased markedly.[ncbi.nlm.nih.gov]
  • Among possible pharmacological treatments, phosphodiesterase 5 inhibitors are considered in cases of severe non -responsive RP.[ncbi.nlm.nih.gov]
  • The purpose of this study was to assess the effects of 12 weeks of atorvastatin treatment on myocardial fibrosis in patients with hypertension with atherosclerosis. 15 statin-naïve participants (11 males; mean age 67 10 years) with atherosclerosis were[ncbi.nlm.nih.gov]
  • METHODS AND ANALYSIS: A total of 250 patients have been randomised in this double-blinded trial for 2-year treatment with 25 mg daily dose of spironolactone or matched placebo.[ncbi.nlm.nih.gov]
  • The clinical consequences of this finding with respect to surgical treatment are briefly discussed.[ncbi.nlm.nih.gov]

Prognosis

  • CMR is superior to conventional echocardiography for the detection of myocardial fibrosis in desmin-related cardiomyopathy, which may be useful to detect early cardiac involvement and predict the patient prognosis.[ncbi.nlm.nih.gov]
  • Further studies are required to show if syndecan-4 concentrations can be marker for prognosis assessment or disease progression.[ncbi.nlm.nih.gov]
  • PURPOSE: Right ventricular myocardial (RVM) fibrosis may be a significant indicator of prognosis in pulmonary hypertension (PH). To detect the presence of RVM fibrosis in PH subjects, we employed ECG gated 320-slice CT.[ncbi.nlm.nih.gov]
  • BACKGROUND: Even in absence of obstructive coronary artery disease women with angina pectoris have a poor prognosis possibly due to coronary microvascular disease.[ncbi.nlm.nih.gov]
  • Despite rapid improvement of the left ventricular (LV) ejection fraction, recent registry data raise concerns about long-term prognosis.[ncbi.nlm.nih.gov]

Etiology

  • Cardiomyopathies/therapy* Death, Sudden, Cardiac/etiology Death, Sudden, Cardiac/prevention & control Defibrillators, Implantable Electric Countershock/instrumentation Electrocardiography Fibrosis Heart Rate* Humans Magnetic Resonance Imaging Myocardium[ncbi.nlm.nih.gov]
  • The five cases presented discuss the etiology of this fibrosis and its possible relation to myocarditis. The cases involve white women between the ages of 19 and 25 with no previous medical history.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: LGE is a powerful predictor of ventricular arrhythmic risk in patients with ventricular dysfunction, irrespective of ICM and NICM etiology.[ncbi.nlm.nih.gov]
  • These include four anatomical and clinical entities : Chronic ischemic heart disease stabile angina pectoralis Acute ischemic heart disease unstabile angina pectoralis myocardium infarct sudden death Etiology : coronary artery atherosclerosis (90 %),[pathologyatlas.ro]
  • […] dysfunction and, ultimately, the progression toward congestive heart failure. [1] , [2] However, despite being one of the main actors of any cardiac remodeling process, some intrinsic characteristics of MF deposition can typically differentiate the etiology[jcecho.org]

Epidemiology

  • RESEARCH DESIGN AND METHODS: Participants with type 1 diabetes aged 13-39 years without a known history of cardiovascular disease (CVD) ( n 1,441) were recruited into the Diabetes Control and Complications Trial (1983-1993) and subsequently followed in the Epidemiology[ncbi.nlm.nih.gov]
  • Original Research Association of Cardiovascular Risk Factors and Myocardial Fibrosis With Early Cardiac Dysfunction in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study , Bharath[care.diabetesjournals.org]
  • Abstract Epidemiological studies support an independent inverse association between high-density lipoprotein (HDL) cholesterol levels and heart failure incidence.[ncbi.nlm.nih.gov]
  • In epidemiological studies the causes of cardiovascular deaths are sudden death, arrhythmias, heart failure, coronary arteries disease and myocardial infarction.[ncbi.nlm.nih.gov]
  • .), Charité-Universitätsmedizin Berlin, Berlin; and the McGill Pharmacoepidemiology Research Unit, Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal (S.S.). References (25) 1. Nutt JG, Wooten GF.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • There are multiple types of myocardial fibrosis that occur in response to different pathophysiologic stimuli. Recent advances in imaging technology have made detection and quantification of the types of myocardial fibrosis possible.[ncbi.nlm.nih.gov]
  • These observations reflect the complex pathophysiology of hypertrophic cardiomyopathy and may provide clues for the timely recognition of disease progression by imaging techniques capable of quantifying MF. 2016 American Heart Association, Inc.[ncbi.nlm.nih.gov]
  • Quantifying myocardial fibrosis (MF) with myocardial extracellular volume measures acquired during cardiovascular magnetic resonance promises to transform clinical care by advancing pathophysiologic understanding and fostering novel therapeutics.[ncbi.nlm.nih.gov]
  • Myocardial fibrosis is the pathophysiological hallmark of failing heart.[kclpure.kcl.ac.uk]
  • Loss-of-function and gain-of-function models of premature senescence were used to determine its pathophysiological role in myocardial fibrosis.[ncbi.nlm.nih.gov]

Prevention

  • Inhibition of T-cell factor (TCF)/β-catenin-mediated transcription with ICG-001 or genetic loss of β-catenin also prevented TGF-β-induced myofibroblasts formation.[ncbi.nlm.nih.gov]
  • The bottom line is that this shows for the first time that cardiac fibrosis is preventable.”[chemdiv.com]
  • The cardiology community now requires phase 2 and 3 clinical trials to examine strategies for the regression/prevention of MF and eventually biomarkers to identify MF without reliance on cardiovascular magnetic resonance.[ncbi.nlm.nih.gov]
  • GENERAL SIGNIFICANCE: These data suggest that AST may be useful as a preventive/therapeutic agent for cardiac dysfunction and myocardial fibrosis. Copyright 2017 Elsevier B.V. All rights reserved.[ncbi.nlm.nih.gov]
  • Arrhythmias, Cardiac/physiopathology Arrhythmias, Cardiac/therapy Biopsy Cardiomyopathies/complications* Cardiomyopathies/diagnostic imaging Cardiomyopathies/physiopathology Cardiomyopathies/therapy* Death, Sudden, Cardiac/etiology Death, Sudden, Cardiac/prevention[ncbi.nlm.nih.gov]

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