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Myoclonus-Dystonia Syndrome 11

Myoclonus Dystonia


Presentation

  • Dystonia was also present in five patients, with only in one of them dystonia being the presenting symptom.[ojrd.biomedcentral.com]
  • Autosomal dominant GTP-CH deficiency presenting as a dopa-responsive myoclonus-dystonia syndrome is reported from University of Rome, Italy [ 4 ]. A 17-year-old boy presented with myoclonus and later developed dystonia and bradykinesia.[pediatricneurologybriefs.com]
  • Mutations in tubulin genes can have a severe impact on microtubule function and result in heterogeneous clinical presentations.[karger.com]
  • If dystonia is not present or is only a minor component, it may be classified as "hereditary essential myoclonus."[dystoniacanada.org]
Plethora
Feeding Difficulties
  • Intellectual disability-dysmorphism-hypogonadism-diabetes mellitus syndrome Intellectual disability-facial dysmorphism syndrome due to SETD5 haploinsufficiency Intellectual disability-facial dysmorphism-hand anomalies syndrome Intellectual disability-feeding[se-atlas.de]
Kayser-Fleischer Ring
  • No Kayser-Fleischer ring was found, MRI scan of the brain did not reveal any abnormality and biochemical studies for copper profile were within normal limits.[annalsofian.org]
Hypertelorism
  • Note the small triangular-shaped face with prominent forehead and frontal bosses, hypertelorism, small mouth with thin lips, micrognathia with pointed chin, and low posterior-rotated and overfolded ears.[jamanetwork.com]
  • Intellectual disability-seizures-hypotonia-ophthalmologic-skeletal anomalies syndrome Intellectual disability-seizures-macrocephaly-obesity syndrome Intellectual disability-severe speech delay-mild dysmorphism syndrome Intellectual disability-short stature-hypertelorism[se-atlas.de]
Thin Lips
  • Note the small triangular-shaped face with prominent forehead and frontal bosses, hypertelorism, small mouth with thin lips, micrognathia with pointed chin, and low posterior-rotated and overfolded ears.[jamanetwork.com]
Pointed Chin
  • Note the small triangular-shaped face with prominent forehead and frontal bosses, hypertelorism, small mouth with thin lips, micrognathia with pointed chin, and low posterior-rotated and overfolded ears.[jamanetwork.com]
Frontal Bossing
  • Note the small triangular-shaped face with prominent forehead and frontal bosses, hypertelorism, small mouth with thin lips, micrognathia with pointed chin, and low posterior-rotated and overfolded ears.[jamanetwork.com]
Dystonia
  • In myoclonus-dystonia , dystonia often affects one or both hands, causing writer's cramp, or the neck, causing the head to turn (torticollis).[ghr.nlm.nih.gov]
  • Primary dystonia or “pure” dystonia is only physiological in origin.[en.wikipedia.org]
  • Treatment of myoclonus-dystonia syndrome with tetrabenazine. Parkinsonism and Related Disorders, 20 (12), 1423-1426. Treatment of myoclonus-dystonia syndrome with tetrabenazine. / Luciano, Angelo Y.; Jinnah, H.[uthsc.pure.elsevier.com]
  • Acronym DYT11 Synonyms Alcohol-responsive dystonia Dystonia-11 Myoclonic dystonia Myoclonus-dystonia syndrome Keywords Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.[uniprot.org]
Myoclonic Jerking
  • For instance, many people may occasionally experience a myoclonic jerk when falling asleep.[dystonia.org.uk]
  • MD tends to produce myoclonic jerks and dystonia in the upper body.[tremorjournal.org]
  • Five patients showed myoclonic jerks, including negative myoclonus. In all registered patients EEG-EMG coherence analysis and/or back-averaging proved a cortical origin of myoclonus.[ojrd.biomedcentral.com]
  • The clinical presentation of myoclonic jerks and dystonia in combination with arrhythmias in this family pointed to a possible channelopathy.[academic.oup.com]
  • Myoclonus-dystonia (M-D) is a movement disorder characterized by a combination of myoclonic jerks and dystonia. Myoclonus, the principal feature, predominates in the arms and axial muscles and is often responsive to alcohol.[jamanetwork.com]
Behavior Problem
  • Vanier et al. described depression and behavioral problems with aggression and withdrawal as possible psychiatric symptoms that precede the motor signs of NP-C [ 1 ].[ojrd.biomedcentral.com]
Mild Cognitive Impairment
  • Her neurological examination demonstrated mild cognitive impairment, myoclonus-dystonia, and skeletal anomalies. Conclusions: Here, we report the unique phenotype of an adult TUBB2B mutation carrier.[karger.com]

Treatment

  • Treatment of myoclonus-dystonia syndrome with tetrabenazine. Parkinsonism and Related Disorders, 20 (12), 1423-1426. Treatment of myoclonus-dystonia syndrome with tetrabenazine. / Luciano, Angelo Y.; Jinnah, H.[uthsc.pure.elsevier.com]
  • Management of M-D Treatment of physical symptoms The need for treatment depends on the severity of the symptoms – some people find they can cope without treatment.[dystonia.org.uk]
  • […] debilitating symptoms are resistant to drug treatments.[en.wikipedia.org]
  • Myoclonus-Dystonia Syndrome can’t be cured, and the current therapy is mainly aimed to improve the symptoms, which includes medical and surgical treatment. All in all, MDS remains poorly responsive to medical treatment.[omicsonline.org]
  • Management and treatment Treatment plans are individualized to a patient's presenting symptoms.[orpha.net]

Prognosis

  • Prognosis Patients with MDS have normal life-expectancy, but quality of life can be severely affected. The documents contained in this web site are presented for information purposes only.[orpha.net]
  • It is not intended to provide instruction and you should not rely on this information to determine diagnosis, prognosis or a course of treatment. It should not be used in place of a professional consultation with a doctor.[dystonia.org.uk]
  • Opsoclonus-myoclonus syndrome: a new era of improved prognosis? Pediatr Neurol. 2017;72:65-9. Jankovic, J. Therapeutic developments for tics and myoclonus. Mov Disord. 2015;30(11):8. Jankovic J, Shannon KM. Movement disorders.[bcm.edu]

Etiology

  • This region contains an excellent candidate gene for involvement in the etiology of MD, the D2 dopamine receptor ( DRD2 ) gene.[pnas.org]
  • Etiology The only known causative gene of MDS is the epsilon-sarcoglycan ( SGCE ) gene (7q21.3), encoding a transmembrane protein that is part of the dystrophin-associated glycoprotein complex found in skeletal and cardiac muscle.[orpha.net]
  • Movement disorders in children are uncommon and thus are challenged by limited experience of pediatric care providers in the accurate diagnosis of etiology, correct characterization of the clinical phenotype, knowledge of pharmacologic interventions,[journals.lww.com]

Epidemiology

  • Summary Epidemiology The estimated prevalence of MDS in Europe is 1/500,000. Clinical description Disease onset usually occurs in the first or second decade of life.[orpha.net]
  • Bradley 3Bioinformatics Laboratory, Clinical Epidemiology, Biostatistics and Bioinformatics and, Search for other works by this author on: Aldo Jongejan 7Department of Genetics, University of Groningen and Search for other works by this author on: Dineke[academic.oup.com]
Sex distribution
Age distribution

Pathophysiology

  • The authors concluded that cerebellar dysfunction plays a role in pathophysiology of dystonia and that their findings support parasagittal cerebellum involvement in pathogenesis of myoclonus-dystonia, which the authors believe to be different from other[ahcmedia.com]
  • But recognizing the phenomenology and understanding the pathophysiology are essential to ensure appropriate treatment. Hyperkinetic Movement Disorders provides a clinical pathway for effective diagnosis and management of these disorders.[books.google.com]
  • Acetylcholine is involved in the pathophysiology of dystonia within the basal ganglia, although its exact role has not been determined.[en.wikipedia.org]
  • Pathophysiology and treatment of cranial dystonia. Mov Disord. 2002; 17 Suppl 2:S70–4. [ PubMed : 11836760 ] Beukers RJ, Booij J, Weisscher N, Zijlstra F, van Amelsvoort TA, Tijssen MA. Reduced striatal D2 receptor binding in myoclonus-dystonia.[ncbi.nlm.nih.gov]

Prevention

  • Hospital for Sick Children Health A-Z Search a complete list of child health articles expand_more View All Drug A-Z Search a list of articles about medications expand_more View All Learning Hubs Browse a complete list of content groups Healthy Living & Prevention[aboutkidshealth.ca]
  • Genetics), Clinical DNA Testing and DNA Banking - Marshfield, WI, USA TAT : 2-3 weeks price : 750.00 Myoclonus-Dystonia Syndrome via the SGCE Gene method(s): Sequencing, Capillary (Sanger) PreventionGenetics (Prevention Genetics), Clinical DNA Testing[genetests.org]
  • It prevents specific neurotransmitters from reaching the affected muscles, preventing spasms. Botulinum toxin is administered by injection. One dose usually lasts about 3 months. There may be some initial (temporary) pain at the injection site.[medicalnewstoday.com]
  • This study can be regarded as a pilot study due to the relatively small number of patients in each study group ultimately preventing further and more elaborate statistic analysis of the available results.[frontiersin.org]
  • In very extreme cases, sufferers are unable to prevent their eyes from clamping shut so that despite normal vision they are functionally blind.[netdoctor.co.uk]

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