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Myoglobinemia

Myoglobinaemia


Presentation

  • Ten of the 12 patients in whom myoglobinemia was present had convulsions. Some degree of renal disturbance was noted in six of seven patients with myoglobinuria. Five patients, including four with renal disturbance, died.[ncbi.nlm.nih.gov]
  • Case presentation A 49-year old Indonesian man presented with fever, chills, and rigors with generalized myalgia and was diagnosed with falciparum malaria based on a positive blood smear.[bmcinfectdis.biomedcentral.com]
  • REPLY To the Editor: We appreciate the concordance of the data presented by Antonelli and Barzilay with our findings.[documents.tips]
  • Common presenting findings are dark urine, myalgia and muscle weakness. Milder episodes can go unnoticed.[pediatriceducation.org]
  • Clinical Presentation The presentation of rhabdomyolysis ranges from very straightforward to very elusive. Patients may complain only of myalgias and weakness.[ahcmedia.com]
Myopathy
  • Myoglobin was detected in the sera of patients with dermatomyositis, polymyositis, scleroderma, and systemic lupus erythematosus (LE) with active myopathy.[ncbi.nlm.nih.gov]
  • […] resistance to phagocytosis, and host substrate utilization New information on changes in body weight Recent findings on fibrocoxib and diclofenac Expanded and reorganized coverage of critical care New material on inborn errors of metabolism and acquired myopathies[books.google.com]
  • .- ) muscular dystrophies and myopathies ( G71 - G72 ) myopathy in amyloidosis ( E85.- ) myopathy in polyarteritis nodosa ( M30.0 ) myopathy in rheumatoid arthritis ( M05.32 ) myopathy in scleroderma ( M34.- ) myopathy in Sjögren's syndrome ( M35.03 )[icd10data.com]
  • Since McArdle’s 1951 description 1 of a man who did not produce lactate during ischemic forearm work, the ischemic exercise test is an established and widely used protocol to screen patients with suspected myopathies caused not only by defects of glycogen[neurology.org]
  • Hypokalemic myopathy and elevation of serum enzymes. Arch Neurol1970;22:335-41. 41. Gross EG, Dexter ID, Roth RG. Hypokalemic myopathy with myoglobinuria associated with licorice ingestion. NEnglJMed 1966;274:602-6. 42.[sjkdt.org]
Dark Urine
  • Any manipulation in diet should be monitored with lower intensity exercise first to make sure the athlete responds well before exposing them to strenuous exercise. • If your athlete reports dark urine a day or two after an exercise session report them[bsmpg.com]
  • Common presenting findings are dark urine, myalgia and muscle weakness. Milder episodes can go unnoticed.[pediatriceducation.org]
  • International Acute kidney injury due to rhabdomyolysis was first described by Bywaters and Beall during World War II; they noted the hypovolemic shock, dark urine, and kidney failure that developed in survivors from the rubbles of the London bombings[emedicine.medscape.com]
  • From the clinical point of view, dark urine and pink serum are indicative of hemolysis whereas dark urine and clear serum suggest rhabdomyolysis [108] .[sjkdt.org]

Workup

  • Rhabdomyolysis Workup. eMedicine. Available from the Internet at (rev. 4/24/14, cited 3/10/15). Author Donna M. D’Alessandro, MD Professor of Pediatrics, University of Iowa Children’s Hospital[pediatriceducation.org]

Treatment

  • Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow.[books.google.com]
  • The mainstay of treatment is generous quantities of intravenous fluids, but may include dialysis or hemofiltration in more severe cases. See more at Wikipedia.org...[dictionary.babylon-software.com]
  • Example sentences with "myoglobinemia", translation memory Immediate surgical decompression by fasciotomy incisions, intensive care treatment including hemofiltration to treat myoglobinemia , intense physical exercise, and mesh-grafting closure of the[glosbe.com]
  • CytoSorb treatment was started on day 6 after admission. Within 8 hours, myoglobin levels decreased from 18,390 ng/ml to 10,020 ng/ml. A second cycle was conducted on day 7 and myoglobin levels again declined from 13,400 ng/ml to 8,359 ng/ml.[cytosorb-therapy.com]
  • Myoglobinemia and myoglobinuria also have been observed after cryosurgical treatment of liver metastases [4,5,6]. However, to our knowledge, myoglobinemia has not been previously reported after radiofrequency ablation.[answers.yahoo.com]

Prognosis

  • Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow.[books.google.com]
  • A total of twenty four cases of acute renal failure due to rhabdomyolysis were studied in Dhaka Medical College in last 3 years in terms of clinical presentation, biochemical parameters including prognosis after treatment.[orion-group.net]
  • The prognosis for recovery of renal function is excellent.[sjkdt.org]

Etiology

  • Alternative etiologies of rhabdomyolysis were excluded with negative Mycoplasma pneumoniae PCR, Chlamydia pneumoniae PCR, Leptospira IgM, and Orientia tsutsugamushi IgG.[bmcinfectdis.biomedcentral.com]
  • The final common pathway in the cellular pathophysiology of rhabdomyolysis, regardless of etiology, is believed to be an impairment of either production or utilization of adenosine triphosphate (ATP).[ahcmedia.com]
  • It is also associated with acute renal failure. rhabdomyolysis Skeletal muscle destruction, with release of myoglobin in blood and urine Etiology Severe exertion–eg, marathons, calisthenics, muscle necrosis due to arterial occlusion, DVT, seizures, drug[medical-dictionary.thefreedictionary.com]
  • Rhabdomyolysis: a review of clinical presentation, etiology, diagnosis, and management. Pediatr Emerg Care . 2008 Apr. 24(4):262-8. [Medline] . Lima RS, da Silva Junior GB, Liborio AB, Daher Ede F. Acute kidney injury due to rhabdomyolysis.[emedicine.medscape.com]
  • His research focuses on epidemiology and etiology of respiratory viruses.[wwwnc.cdc.gov]

Epidemiology

  • His research focuses on epidemiology and etiology of respiratory viruses.[wwwnc.cdc.gov]
  • PubMed Google Scholar Ooi EE, Gubler DJ: Dengue in Southeast Asia: epidemiological characteristics and strategic challenges in disease prevention. Cad Saude Publica. 2009, 25 (Suppl 1): S115-S124.[bmcinfectdis.biomedcentral.com]
  • Epidemiology Frequency United States The frequency of myoglobinuria varies with the incidence of natural disasters and environmental trauma. Epidemics of viral myositis may temporarily increase the incidence in local areas.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow.[books.google.com]
  • The pathophysiology of rhabdomyolysis must be understood on cellular (microscopic) and muscle compartment (macroscopic) levels.[ahcmedia.com]
  • The syndrome of rhabdomyolysis: Pathophysiology and diagnosis. Eur J Intern Med . 2007 Mar. 18(2):90-100. [Medline] . Kilfoyle D, Hutchinson D, Potter H, George P.[emedicine.medscape.com]
  • In 1941, Bywaters and Beall described in detail the pathophysiological mechanisms of ARF due to rhabdomyolysis following crush injuries in victims of bombing raids in World War II [5] .[sjkdt.org]

Prevention

  • Prevention of Acute Renal Failure following myoglobinemia in cases of rhabdomyolysis by means of trapping myoglobin released to circulation following striated muscles injury using a temporary intravenous filter (1, 2) coated with antimyoglobin antibodies[glosbe.com]
  • An Ounce of Prevention .[bsmpg.com]
  • Patients with crush syndrome require extensive transfusion and timely hemodyalysis to prevent multiple organ failure, including renal failure and rapidly progressive DIC.[jstage.jst.go.jp]
  • Early identification, performance of measures to prevent further ischemia and damage, and transport for fasciotomy are necessary to prevent additional limb damage, possible amputation and death. 1 And finally, the presence of a palpable peripheral pulse[emsworld.com]
  • A higher volume of urine flow and a higher urine alkalinity prevent myoglobin from precipitating as readily as it otherwise does.[emedicine.medscape.com]

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