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Myoglobinemia

Myoglobinaemia


Presentation

  • Ten of the 12 patients in whom myoglobinemia was present had convulsions. Some degree of renal disturbance was noted in six of seven patients with myoglobinuria. Five patients, including four with renal disturbance, died.[ncbi.nlm.nih.gov]
  • Case presentation A 49-year old Indonesian man presented with fever, chills, and rigors with generalized myalgia and was diagnosed with falciparum malaria based on a positive blood smear.[bmcinfectdis.biomedcentral.com]
  • REPLY To the Editor: We appreciate the concordance of the data presented by Antonelli and Barzilay with our findings.[documents.tips]
  • Common presenting findings are dark urine, myalgia and muscle weakness. Milder episodes can go unnoticed.[pediatriceducation.org]
  • Clinical Presentation The presentation of rhabdomyolysis ranges from very straightforward to very elusive. Patients may complain only of myalgias and weakness.[ahcmedia.com]
Lymphedema
  • Lymphedema Jeanwan Kang III. Miscellaneous 8. Portal Hypertension Masato Fujiki, Koji Hashimoto, and Charles Miller 9. Hemodialysis Access Lee Kirksey 10. Vasculitis Carol A. Langford[books.google.com]
Hepatosplenomegaly
  • His heart sounds were dual, lungs were clear, and there was no hepatosplenomegaly on abdominal examination. The neurological examination was also normal. He did not have a rash.[bmcinfectdis.biomedcentral.com]
Myopathy
  • Abstract Myoglobin was detected in the sera of patients with dermatomyositis, polymyositis, scleroderma, and systemic lupus erythematosus (LE) with active myopathy.[ncbi.nlm.nih.gov]
  • .- ) muscular dystrophies and myopathies ( G71 - G72 ) myopathy in amyloidosis ( E85.- ) myopathy in polyarteritis nodosa ( M30.0 ) myopathy in rheumatoid arthritis ( M05.32 ) myopathy in scleroderma ( M34.- ) myopathy in Sjögren's syndrome ( M35.03 )[icd10data.com]
  • Since McArdle’s 1951 description 1 of a man who did not produce lactate during ischemic forearm work, the ischemic exercise test is an established and widely used protocol to screen patients with suspected myopathies caused not only by defects of glycogen[neurology.org]
  • Because of the problem of metabolizing glycogen, McArdle’s disease is called a metabolic myopathy, glycogen storage disease type 5. Who’s on third? McArdle’s disease results from defects (mutations) in genes.[mda.org]
  • Enteroviruses have been implicated in the pathogenesis of human neuromuscular diseases because of their association with certain acute and chronic acquired myopathies and paralytic motor neuron syndromes ( 23 ).[wwwnc.cdc.gov]
Dark Urine
  • Any manipulation in diet should be monitored with lower intensity exercise first to make sure the athlete responds well before exposing them to strenuous exercise. • If your athlete reports dark urine a day or two after an exercise session report them[bsmpg.com]
  • Common presenting findings are dark urine, myalgia and muscle weakness. Milder episodes can go unnoticed.[pediatriceducation.org]

Workup

  • Rhabdomyolysis Workup. eMedicine. Available from the Internet at (rev. 4/24/14, cited 3/10/15). Author Donna M. D’Alessandro, MD Professor of Pediatrics, University of Iowa Children’s Hospital[pediatriceducation.org]
Rickettsia Typhi
  • Rickettsia typhi IgG returned positive at a titre of 1:256, and the patient was given seven days of doxycycline at 100 mg twice daily. However, no rising titre was detected on the convalescent sample.[bmcinfectdis.biomedcentral.com]
Plasmodium Falciparum

Treatment

  • […] and other new treatments; and the neurologic effects of illicit drug use.[books.google.com]
  • The mainstay of treatment is generous quantities of intravenous fluids, but may include dialysis or hemofiltration in more severe cases. See more at Wikipedia.org...[dictionary.babylon-software.com]
  • Example sentences with "myoglobinemia", translation memory Immediate surgical decompression by fasciotomy incisions, intensive care treatment including hemofiltration to treat myoglobinemia, intense physical exercise, and mesh-grafting closure of the[glosbe.com]
  • CytoSorb treatment was started on day 6 after admission. Within 8 hours, myoglobin levels decreased from 18,390 ng/ml to 10,020 ng/ml. A second cycle was conducted on day 7 and myoglobin levels again declined from 13,400 ng/ml to 8,359 ng/ml.[cytosorb-therapy.com]
  • Myoglobinemia and myoglobinuria also have been observed after cryosurgical treatment of liver metastases [4,5,6]. However, to our knowledge, myoglobinemia has not been previously reported after radiofrequency ablation.[answers.yahoo.com]

Prognosis

  • A total of twenty four cases of acute renal failure due to rhabdomyolysis were studied in Dhaka Medical College in last 3 years in terms of clinical presentation, biochemical parameters including prognosis after treatment.[orion-group.net]

Etiology

  • It is also associated with acute renal failure. rhabdomyolysis Skeletal muscle destruction, with release of myoglobin in blood and urine Etiology Severe exertion–eg, marathons, calisthenics, muscle necrosis due to arterial occlusion, DVT, seizures, drug[medical-dictionary.thefreedictionary.com]
  • The final common pathway in the cellular pathophysiology of rhabdomyolysis, regardless of etiology, is believed to be an impairment of either production or utilization of adenosine triphosphate (ATP).[ahcmedia.com]
  • Alternative etiologies of rhabdomyolysis were excluded with negative Mycoplasma pneumoniae PCR, Chlamydia pneumoniae PCR, Leptospira IgM, and Orientia tsutsugamushi IgG.[bmcinfectdis.biomedcentral.com]
  • Continued research on adults with HPeV3 infection is needed to further understand the etiology and epidemiology of HPeV3. Dr Mizuta is the vice-director of Yamagata Prefectural Institute of Public Health, Yamagata, Japan.[wwwnc.cdc.gov]

Epidemiology

  • His research focuses on epidemiology and etiology of respiratory viruses. Top Harvala H, Simmonds P. Human parechoviruses: biology, epidemiology and clinical significance. J Clin Virol. 2009 ; 45 : 1 – 9. DOI PubMed Stanway G.[wwwnc.cdc.gov]
  • PubMed Google Scholar Ooi EE, Gubler DJ: Dengue in Southeast Asia: epidemiological characteristics and strategic challenges in disease prevention. Cad Saude Publica. 2009, 25 (Suppl 1): S115-S124.[bmcinfectdis.biomedcentral.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of rhabdomyolysis must be understood on cellular (microscopic) and muscle compartment (macroscopic) levels.[ahcmedia.com]

Prevention

  • Prevention of Acute Renal Failure following myoglobinemia in cases of rhabdomyolysis by means of trapping myoglobin released to circulation following striated muscles injury using a temporary intravenous filter (1, 2) coated with antimyoglobin antibodies[glosbe.com]
  • Patients with crush syndrome require extensive transfusion and timely hemodyalysis to prevent multiple organ failure, including renal failure and rapidly progressive DIC.[jstage.jst.go.jp]
  • An Ounce of Prevention.[bsmpg.com]
  • CONCLUSIONS: Myoglobinemia might be monitored to prevent distressed newborns from transitory renal tubular defect, justifying forced diuresis and urinary alkalosis.[moh-it.pure.elsevier.com]
  • Early identification, performance of measures to prevent further ischemia and damage, and transport for fasciotomy are necessary to prevent additional limb damage, possible amputation and death. 1 And finally, the presence of a palpable peripheral pulse[emsworld.com]

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