These neurological problems include recurrent seizures (epilepsy), movement disorders, impaired speech (dysarthria), loss of sensation in the arms and legs (peripheral neuropathy), decline in intellectual function (dementia), hallucinations, and depression [icdlist.com]

Metabolic Myopathy Acid maltase or acid alpha-1,4-glucosidase deficiency (Pompe's disease) Glycogen storage disorders 3-11 Carnitine deficiency Fatty acid oxidation defects Carnitine palmitoyl transferase deficiency Mitochondrial Myopathy Myoclonic epilepsy [clevelandclinicmeded.com]

myoclonic epilepsy and ragged red fibers or Kearns-Sayre syndrome). [the-rheumatologist.org]

Shapira et al and Mart et al have each described pairs of sibs with a distinctive condition consisting of onset during the first decade of diminution of growth rate, episodes of vomiting, headache and acidosis, a myopathy and the later development of epilepsy [annalsofneurosciences.org]

In the muscular dystrophies, which tend to manifest in childhood or adolescence, dyspnea, cardiac abnormalities, contractures, scapular winging, calf hypertrophy, and skeletal deformities may be present in addition to slowly progressive weakness. [clevelandclinicmeded.com]

The most myopathic patients have noted increased dyspnea on exertion while on statins. [sdhva.com]

Very high triglyceride levels can also cause hepatosplenomegaly, paresthesias, dyspnea, and confusion. High levels of LDL can cause arcus corneae and tendinous xanthomas at the Achilles, elbow, and knee tendons and over metacarpophalangeal joints. [merckmanuals.com]

Distress Syndrome 235 Chapter 14 Diffuse Parenchymal Lung Disease 242 Chapter 15 Pulmonary Vascular Disease 263 Chapter 23 Hepatic and Bowel Disease 365 CHapter 24 Metabolic and Endocrine Disorders 370 Chapter 25 Rheumatic and Connective Tissue Disorders [books.google.com]

There was no history of respiratory distress, bulbar weakness, cranial nerve disturbances, episodes of encephalopathy or cardiac symptoms. There was no family history of similar illness. [annalsofian.org]

Manifestations in infantile-onset patients are hypotonia, hypoketotic hypoglycemic encephalopathy, hepatomegaly and cardiomyopathy. [annalsofian.org]

Hepatomegaly, macroglossia, cardiomegaly and early respiratory muscle involvement are common in infantile and childhood varieties. Infantile form is fatal before 2 years of age. [annalsofneurosciences.org]

CDS is due to mutations in α/β-hydrolase domain-containing protein 5 ( ABHD5 ) and is characterized by non-bullous congenital ichthyosiform erythroderma (NCIE), hepatomegaly, and liver steatosis. [omicsonline.org]

Another rare disorder linked to CPT II deficiency is manifest in infancy as hypoketotic hypoglycemia, hepatomegaly and hepatic failure, cardiomegaly and arrhythmias, lethargy, seizure, and coma. [emedicine.medscape.com]

Extraocular muscle weakness Peripheral neuropathy Migraine headaches Seizures Stroke Diabetes mellitus Cardiac arrhythmias Acid maltase deficiency or glycogen storage disorder type 2 Approximately 1 in 40,000 newborns Proximal girdle weakness Macroglossia, hepatomegaly [clevelandclinicmeded.com]

disease (e.g., those who had a history of coronary heart disease, diabetes, hypertension, and other coronary heart disease risk factors). 8-12 Four of these trials showed a 15% to 37% reduction in coronary heart disease events in those treated for 3.2 [uspreventiveservicestaskforce.org]

disease (CHD) and stroke. [gugulipid.com]

Safety and efficacy of long‐term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post‐hoc analysis. [jaha.ahajournals.org]

Patients with an extensive family history of heart disease should also be screened by measuring Lp(a) levels. [merckmanuals.com]

Success and Proliferation of Statins Cholesterol lowering therapy with HMGCoA reductase inhibitors (statins) convincingly reduces death and myocardial infarction among patients with coronary heart disease Application of the National Cholesterol Education [sdhva.com]

Disease 263 Chapter 23 Hepatic and Bowel Disease 365 CHapter 24 Metabolic and Endocrine Disorders 370 Chapter 25 Rheumatic and Connective Tissue Disorders 384 Chapter 26 Psychogenic Dyspnoea 392 PART D INTERPRETATION OF RESPIRATORY FUNCTION TESTS 397 [books.google.com]

Procedural approaches are reserved for patients with severe hyperlipidemia (LDL cholesterol 300 mg/dL ( 7.74 mmol/L) and no vascular disease. [merckmanuals.com]

Pulmonary vascular disease is probably more common than suspected. [err.ersjournals.com]

Genetically elevated C‐reactive protein and ischemic vascular disease. N Engl J Med. 2008 ; 359:1897–1908. [jaha.ahajournals.org]

It may manifest before 2 years of age as Pompe’s disease with infantile weakness, hypotonia, heart failure, and early death. A second variety begins in early childhood with truncal, proximal, and respiratory muscle weakness. [rheumaknowledgy.com]

Cardiomyopathy and congestive heart failure are common and may be the direct cause of death. Pathologically, the muscle shows marked increase in the number of lipid droplets, mainly in type I muscle fibers. [emedicine.medscape.com]

failure Critical illness myopathy At least as prevalent as critical illness neuropathy Affects approximately 60% of patients with prolonged ICU stay Symmetrical proximal distal muscle weakness Critical illness neuropathy Failure to wean off ventilation [clevelandclinicmeded.com]

The patients usually die before 12 months of age due to heart failure and respiratory weakness (12, 16 and 20). Childhood-onset form. [annalsofneurosciences.org]

Spinal muscular atrophy. Congenital hypomyelinating neuropathies. It may be difficult to distinguish myopathy from peripheral neuropathy. [patient.info]

In addition, adult onset spinal muscular atrophy, including X-linked bulbospinal muscular atrophy, usually presents with proximal muscle weakness and mimics the typical pattern of a myopathy. [clinicalgate.com]

The disease is characterized by profound fatigue and disability lasting for at least 6 mo, episodes of cognitive dysfunction, sleep disturbance, autonomic abnormalities, chronic or intermittent pain syndromes, microbiome abnormalities ( 1 ), cerebral [pnas.org]