A frequent conference presenter and speaker who is widely cited in the national media, he is past president of the Section on Clinical Child Psychology (the former Division 12) of the American Psychological Association, and of the International Society [books.google.com]

We present here the first case report of successful treatment of lithium-induced tremor with nadolol, which was selected because the patient had compromised liver function. The patient's liver function tests remained stable with the therapy. [ncbi.nlm.nih.gov]

• Congestive Heart Failure

  The rationale for this pilot study was based on the paradigm shift that was observed with the use of beta-blockers in congestive heart failure, which once contraindicated because of their acute detrimental effects, have now been shown to reduce mortality [ncbi.nlm.nih.gov]

  Tell your doctor if you have asthma, chronic obstructive pulmonary disease, congestive heart failure, heart block, low heart rate, low blood pressure, impaired kidney function, diabetes mellitus, overactive thyroid, or peripheral vascular disease. [clevelandclinic.org]

  Nonallergenic bronchospasm, cerebrovascular insufficiency, well-compensated congestive heart failure (CHF), diabetes mellitus, hyperthyroidism/thyrotoxicosis, liver disease, renal impairment, peripheral vascular disease. [rxlist.com]

  Beta-blockers are known primarily for their reductive effect on heart rate, although this is not the only mechanism of action of importance in congestive heart failure. [en.wikipedia.org]

• Pneumonia

  There were major complications in nine patients treated with ligation (seven had bleeding esophageal ulcers and two had aspiration pneumonia) and two treated with medication (both had bradycardia and dyspnea) (P=0.05). [ncbi.nlm.nih.gov]

  Causes of chest pain include broken or bruised ribs, pleurisy, pneumothorax, shingles, pneumonia, pulmonary embolism, angina, heart attack, costochondritis, pericarditis, aorta or aortic dissection, and reflux esophagitis. [medicinenet.com]

• Hypotension

  Nadolol may reduce reflex orthostatic hypotension. [pdr.net]

  Beta-blockers blunt the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effects. [reference.medscape.com]

  Additive hypotension may occur with other antihypertensives, acute ingestion of alcohol, or nitrates. [nursing.unboundmedicine.com]

  Drug: nsaid s may decrease hypotensive effects; may mask symptoms of a hypoglycemic reaction to insulin, sulfonylureas ; prazosin, terazosin may increase severe hypotensive response to first dose. Absorption: 30–40% of PO dose absorbed. Peak: 2–4 h. [robholland.com]

• Slow Pulse

  Advise patient to notify health care professional if slow pulse, difficulty breathing, wheezing, cold hands and feet, dizziness, confusion, depression, rash, fever, sore throat, unusual bleeding, or bruising occurs. [nursing.unboundmedicine.com]

• Diastolic Hypertension

  Abstract Nadolol was effective and well tolerated as once-daily monotherapy for mild to moderate essential supine diastolic hypertension (SDBP) in 10 young (mean age, 39 years) and 12 elderly (mean age, 68 years) patients in a single-blind, placebo-baseline [ncbi.nlm.nih.gov]

• Dysarthria

  Other clinical signs of toxicity include: anorexia; visual impairment; drowsiness; muscular weakness; fasciculations or myoclonia; ataxia; dysarthria or slurred speech; stupor or coma; confusion or impaired cognition; seizures; and arrhythmias. [pdr.net]

As with any use of β-blocker therapy in a pediatric patient, a cardiac workup is advised before the start of nadolol therapy; blood pressure and heart rate monitoring should be performed at one and two hours after the first dose and continued during dose [ncbi.nlm.nih.gov]

Before the start of treatment with any β-blocker, it is mandatory to carry out a cardiac workup and to monitor the patient’s BP and HR one and two hours after the initial dose and throughout the course of dose escalation. [ajhp.org]

• Norepinephrine Decreased

  If beta-blockers are used with nitroglycerin in patients with angina pectoris, additional hypotensive effects may occur. norepinephrine nadolol increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. [reference.medscape.com]

• Bicarbonate Decreased

  NSAIDs decrease prostaglandin synthesis. aspirin/citric acid/sodium bicarbonate aspirin/citric acid/sodium bicarbonate decreases effects of nadolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. [reference.medscape.com]

• Glucagon Decreased

  Coadministration of glucagon with beta-blockers may have transiently increased pulse and blood pressure. glucagon intranasal glucagon intranasal decreases toxicity of nadolol by sympathetic (adrenergic) effects, including increased blood pressure and [reference.medscape.com]

• Chloride Decreased

  Separate by 2 hours. calcium chloride calcium chloride decreases effects of nadolol by unspecified interaction mechanism. Use Caution/Monitor. calcium citrate calcium citrate decreases effects of nadolol by unspecified interaction mechanism. [reference.medscape.com]

• Third Degree Atrioventricular Block

  Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain types of heart rhythm problems (such as a slow heartbeat, second- or third-degree atrioventricular block), blood circulation problems (such as Raynaud's [webmd.com]

  Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain types of heart rhythm problems (such as a slow heartbeat, second- or third-degree atrioventricular block) blood circulation problems (such as Raynaud's [myhealth.alberta.ca]

Combination treatment attenuated this response and significantly reduced plasma aldosterone. Neither treatment had any effect on plasma noradrenaline levels. [ncbi.nlm.nih.gov]

It is also used in the prophylactic treatment of migraine, and as an adjunct in the treatment of hyperthyroidism. 2011-01-10 Nadolol is administered as an equimolar mixture of the four possible 2,3- cis -diastereoisomers of 5-[3-(tert-butylamino)-2-hydroxypropoxy [ebi.ac.uk]

A hemodynamic response to treatment is associated with a better long-term prognosis. [ncbi.nlm.nih.gov]

Stable cirrhotic patients of mixed etiology underwent an intravenous glucose tolerance test and hyperinsulinemic-euglycemic clamp for the measurement of insulin secretion and insulin sensitivity (n = 16) and a 75-g oral glucose tolerance test (n = 17) [ncbi.nlm.nih.gov]

Part 2, short-term reductions in blood pressure: an overview of randomized drug trials in their epidemiological context. Lancet. 1990; 335:827-38. http://www.ncbi.nlm.nih.gov/pubmed/1969567?dopt=AbstractPlus 107. Alderman MH. [drugs.com]

GLOSSARY AAN = American Academy of Neurology ; AE = adverse event ; CI = confidence interval ; ER = extended-release ; MAM = menstrually associated migraine ; PMP = perimenstrual period ; RCT = randomized controlled trial Epidemiologic studies suggest [doi.org]

Cancer Epidemiology. 38 (3): 279–85. doi:10.1016/j.canep.2014.03.011. PMID 24786858. ^ Kim HY, Jung YJ, Lee SH, Jung HJ, Pak K (2017). "Is Beta-Blocker Use Beneficial in Breast Cancer? A Meta-Analysis". [en.wikipedia.org]

The recent demonstration that beta blockers selectively blunt the increased morning risk of myocardial infarction suggests that these agents block the pathophysiologic consequences of stressors concentrated in the morning. [ncbi.nlm.nih.gov]

BACKGROUND/AIMS: beta-blockers effectively prevent first variceal bleeding (FVB) in cirrhotic patients. In patients with ascites, however, their use might be precluded by a high rate of contraindications and side effects. [ncbi.nlm.nih.gov]

I’ve used Nadolol (Corgard) for migraine prevention for about 15 years, ramped up to 20 mg initially but only been taking 10 mg for the past 8 years. [migraine.com]

Although the mechanism by which Apo-Nadolol tablets 40mg help prevent migraine is not fully known, it is thought to involve prevention of vasoconstriction (blood vessel narrowing) of the internal carotid artery, by blocking beta receptors in the brain [inhousepharmacy.vu]