Critical Essential Core Tested Community Questions (4) (M2.PY.4684) A 21-year-old man presents to the clinic complaining of feeling tired during the day. [medbullets.com]

It can take a number of years for this symptom to progress to a point of concern and for other related symptoms to present. [sleepassociation.org]

Excessive daytime sleepiness (EDS) is the main symptom and is present in 100% of patients with narcolepsy. [medicinenet.com]

Typical cataplexy not present, though atypical or uncertain episodes may be reported. [patient.info]

• Fatigue

  Startling stimuli, stress, physical fatigue, or sleepiness may also be important triggers or factors that exacerbate cataplexy. The person is usually alert and oriented during the event despite the inability to respond during the event. [holistic-online.com]

  Thank you, Jack I'm really sorry to hear this, Jack I can sympathise in a way, because I was diagnosed with Chronic Fatigue Syndrome while in school and it got particularly severe, even leaving me housebound for a few months, in my final year of school [thestudentroom.co.uk]

  Patients may describe this symptom as being tired, fatigued, sleepy, feeling lazy, or having low energy. [medicinenet.com]

  People who have EDS often report feeling very fatigued or having low energy. Some related symptoms of EDS are mental cloudiness, lack of energy, depressed mood, extreme exhaustion and automatic behavior. [sleepassociation.org]

• Asymptomatic

  As a clinical history is not specific, and some infections are asymptomatic, we cannot exclude H1N1 infection as an aetiological factor in some cases. It seems unlikely, however, that previous infection would be more likely in vaccinated patients. [bmj.com]

• Unconsciousness

  As she fights through the cataplexy, Wheaton experiences micronaps, short bursts of unconsciousness. “To see this in video form, it really helps to capture the extremes of what cataplexy can do to you. [today.com]

• Sighing

  *sigh* But I agree because what the hell else am I supposed to do and they’ve been very nice and everything. June 3rd. 11am. A week later, a nurse from my primary care physician’s office called me. [the-orbit.net]

• Bulimia Nervosa

  Nervosa, Seasonal Affective Disorder, Essential Hypertension Schizophrenia Show all 23 NPY1R neuropeptide Y receptor Y1 4q32.2 Proliferative Vitreoretinopathy, Angina Pectoris, Morbid Obesity Obesity Show all 4 NPY5R neuropeptide Y receptor Y5 4q32.2 [genecards.weizmann.ac.il]

• Ankylosis

  With Broad Thumb And Toes, Multiple Synostoses Syndrome 1, Proximal Symphalangism, Multiple Synostosis Syndrome 1, Multiple Synostoses Syndrome, Brachydactyly, Type B2, Tracheoesophageal Fistula, Esophageal Atresia, Ankylosis, Otosclerosis, Brachydactyly [genecards.weizmann.ac.il]

• Night Sweats

  Autonomic symptoms have been reported in narcoleptic patients and include pupillary abnormalities, fainting spells, erectile dysfunction, night sweats, gastric problems, low body temperature, systemic hypotension, dry mouth, heart palpitations, headache [patient.info]

• Dry Eyes

  The most frequent side effects are called "anticholinergic side effects," including dry mouth, dry eyes, blurred vision, urine retention, constipation, impotence, increased appetite, drowsiness, nervousness, confusion, restlessness, and headache. [medicinenet.com]

  Eye Syndrome, Neuroaxonal Dystrophy, Diabetic Neuropathy, Charcot-Marie-Tooth Disease Type 1A, Demyelinating Disease, Charcot-Marie-Tooth Disease Type 1, Schizophrenia Meningitis Show all 13 NTF4 neurotrophin 4 19q13.33 Head Injury, Glaucoma 1, Open [genecards.weizmann.ac.il]

• Pupillary Abnormality

  Autonomic symptoms have been reported in narcoleptic patients and include pupillary abnormalities, fainting spells, erectile dysfunction, night sweats, gastric problems, low body temperature, systemic hypotension, dry mouth, heart palpitations, headache [patient.info]

• Denial

  Do I sound like someone in denial? Or like someone trying to talk myself into the diagnosis? I’m not sure. Maybe I should run a poll. [the-orbit.net]

• Drop Attacks

  Cataplexy - may mimic drop attacks, syncope, seizures/epilepsy, transient ischaemic attack, periodic paralysis (channelopathies), psychiatric disorder, or cataplectic-like episodes (the latter can occur in healthy people). [patient.info]

• Dropping Things

  Reduced muscle tone may be minimal, occur in a few muscle groups, and cause head drooping, slurred speech, or dropping things from the hand; or it may be so severe that total body paralysis occurs, resulting in complete collapse wherein the person is [holistic-online.com]

• Tantrums

  I got the sense that she’d dealt with some actual tantrums, because she was so apologetic. At the last sleep test, I was struggling to stay awake even before it started, but the computer started acting up. [the-orbit.net]

Awareness was aroused and referrals to specialist and diagnostic workup expedited only after the media attention from Sweden broke out in August 2010. [journals.plos.org]

Monitoring during treatment - baseline electrocardiogram pre-treatment; monitor blood pressure and heart rate/rhythm; stop treatment if these are abnormal. [patient.info]

The history of its treatment originated with traditional stimulants, such as methylphenidate and the amphetamine—which are still used—but, he said, “they have significant adverse effects. [neurologylive.com]

Non-drug treatments Non-drug treatments include education of the patient and family members and modification of behavior patterns. [medicinenet.com]

In all cases in that controlled trial, the confusion resolved soon after termination of treatment. [xyremhcp.com]

Patients who have narcolepsy with cataplexy have been found to be more impulsive and more prone to binge eating than patients without cataplexy and controls. [ 28 ] There is a high risk of obesity and metabolic syndrome. [ 10 ] Prognosis [ 4, 29 ] Symptoms [patient.info]

What is the Prognosis of Narcolepsy? (Outcomes/Resolutions) The prognosis of Narcolepsy is determined by the severity of its signs and symptoms. [dovemed.com]

[…] heterogeneous disease conditions, but the hypocretin systems are often impaired. 2, 3 Gaining the basic knowledge of symptomatic narcolepsy in immune-mediated conditions will be not only useful for selecting the most appropriate treatment and predicting the prognosis [jamanetwork.com]

Narcolepsy pathophysiology is linked to loss of signaling by hypocretin-producing neurons; an autoimmune etiology possibly triggered by some environmental agent may precipitate hypocretin neuronal loss. [dovepress.com]

Since narcolepsy is also tightly associated with HLA antigen positivity (HLA DR2/DQB1*0602), an involvement of autoimmune mechanisms in its etiology is suggested, but this has not been proven yet. 1 Narcolepsy also occurs during the course of various [jamanetwork.com]

So you can see why scientists get petulant when the press reports that Dr Mephistopheles has found The gene for homosexuality, schizophrenia, gout or any other traits with complex causation (or etiology αἰτιολογία as we like to call it to bamboozle outsiders [geneticdisorders.info]

The etiology of primary enuresis is likely to be multifactorial. A strong family history of enuresis is often present. [aafp.org]

(Etiology) Narcolepsy is caused by the deficiency of hypocretins (also known as orexins). Hypocretins (hypocretin 1 and hypocretin 2) are neurotransmitters in the brain. [dovemed.com]

Epidemiology, evaluation of the sleepy patient, diagnostic investigations including neuroimaging, subjective and objective testing, cognitive effects of sleepiness, motor vehicle driving issues, medico-legal aspects of sleepiness, and therapy are also [books.google.com]

The findings, from one of the largest known studies of narcolepsy epidemiologic patterns, are the latest piece of the puzzle for European health officials who have been investigating a link between narcolepsy and vaccination with Pandemrix, a monovalent [cidrap.umn.edu]

Other epidemiological approaches to assessing the association have been adopted. [bmj.com]

The epidemiology of narcolepsy. Sleep. 2007 Jan 1. 30(1):13-26. [Medline]. Silber MH, Krahn LE, Olson EJ, Pankratz VS. The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study. Sleep. 2002 Mar 15. 25(2):197-202. [medscape.com]

Orexin/ataxin-3 mice provide a valuable model for studying the pathophysiology and treatment of narcolepsy. [ncbi.nlm.nih.gov]

Sleep Neurology p. 989-1004 August 2017, Vol.23, No.4 doi: 10.1212/CON.0000000000000492 REVIEW ARTICLES Article Related Links Abstract Purpose of Review: This article focuses on the clinical presentation, pathophysiology, diagnosis, differential diagnosis [journals.lww.com]

Narcolepsy pathophysiology is linked to loss of signaling by hypocretin-producing neurons; an autoimmune etiology possibly triggered by some environmental agent may precipitate hypocretin neuronal loss. [dovepress.com]

Narcolepsy: Pathophysiology and neuropsychological changes. Behav Neurol. 2003. 14(3,4):89-98. [Medline]. Burgess CR, Scammell TE. Narcolepsy: neural mechanisms of sleepiness and cataplexy. J Neurosci. 2012 Sep 5. 32(36):12305-11. [Medline]. [medscape.com]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Narcolepsy affects 0.02% to 0.05% of the population and the onset of symptoms often occurs in adolescence. [mayocliniclabs.com]

Use the filters to find everything you need. node teaser Accident prevention/safety Be aware of situations where you are likely to be at risk of falling asleep or suffer from a cataplexy attack and inform others around you It may clearly be hazardous [narcolepsy.org.uk]

The study, published in the February 6 issue of Vaccine, was conducted by members of the Vaccine Adverse Events Surveillance and Communication (VAESCO) consortium based on a request from their partners at the European Centre for Disease Prevention and [cidrap.umn.edu]

This temporary immobility during REM sleep may prevent your body from acting out dream activity. Not everyone with sleep paralysis has narcolepsy, however. Many people without narcolepsy experience some episodes of sleep paralysis. [mayoclinic.org]

Immunotherapy to prevent hypocretin neuronal death is reviewed. [dovepress.com]

[…] neurons and prevent chronic sleep-related symptoms. [jamanetwork.com]